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Hemoglobin
international journal for hemoglobin research
Volume 38, 2014 - Issue 5
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Research Article

N-Acetylcysteine Supplementation Reduces Oxidative Stress and DNA Damage in Children with β-Thalassemia

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Pages 359-364 | Received 25 Jan 2014, Accepted 12 Mar 2014, Published online: 15 Sep 2014

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Read on this site (5)

Khadijeh Rasaeifar, Saeed Zavareh, Maryam Hajighasem-Kashani & Meysam Nasiri. (2023) Effects of pulsed electromagnetic fields and N-acetylcysteine on transplantation of vitrified mouse ovarian tissue. Electromagnetic Biology and Medicine 42:2, pages 67-80.
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George J Kontoghiorghes & Christina N Kontoghiorghe. (2019) Prospects for the introduction of targeted antioxidant drugs for the prevention and treatment of diseases related to free radical pathology. Expert Opinion on Investigational Drugs 28:7, pages 593-603.
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Jirawan Panachan, Daranee Chokchaichamnankit, Churat Weeraphan, Chantragan Srisomsap, Patarabutr Masaratana, Suneerat Hatairaktham, Narumol Panichkul, Jisnuson Svasti & Ruchaneekorn W. Kalpravidh. (2019) Differentially expressed plasma proteins of β-thalassemia/hemoglobin E patients in response to curcuminoids/vitamin E antioxidant cocktails. Hematology 24:1, pages 300-307.
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Natthaphat Siri-Angkul, Siriporn C Chattipakorn & Nipon Chattipakorn. (2018) Diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients. Expert Review of Hematology 11:6, pages 471-479.
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Sirinart Kumfu, Juthamas Khamseekaew, Siripong Palee, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2018) A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice. Free Radical Research 52:1, pages 70-79.
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Articles from other publishers (32)

Mobin Ghazaiean, Aily Aliasgharian, Hossein Karami & Hadi Darvishi-Khezri. (2023) Ebselen: A promising therapy protecting cardiomyocytes from excess iron in iron-overloaded thalassemia patients. Open Medicine 18:1.
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Mohammad Farzandway, Daniel Elieh-Ali-Komi, Ehsan Mohammadi Noori, Farjam Goudarzi, Rezan Ashayeri Ahmadabad, Azadeh Eshraghi, Zahra Mirzaasgari, Seyed Mohammad Navabi & Amir Kiani. (2023) Investigation of the effect of N-acetylcysteine on serum levels of oxidative inflammatory biomarkers in patients with stroke. Beni-Suef University Journal of Basic and Applied Sciences 12:1.
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Sezaneh Haghpanah, Mahnaz Hosseini-Bensenjan, Omid reza Zekavat, Mohammadreza Bordbar, Mehran Karimi, Mani Ramzi & Naeimehossadat Asmarian. (2023) The effect of Vitamin E and N-acetyl cysteine on oxidative status and hemoglobin level in transfusion-dependent thalassemia patients: A systematic review and meta-analysis. Iranian Journal of Blood and Cancer 15:1, pages 22-35.
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Fatemeh EbrahimiSaeed Zavareh & Meysam Nasiri. (2023) The Combination of Estradiol and N -Acetylcysteine Reduces Ischemia–Reperfusion Injuries of Mice Autografted Ovarian Tissue . Biopreservation and Biobanking.
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Mohamed A. Farag, Bishoy Abib, Zhiwei Qin, Xiaolei Ze & Sara E. Ali. (2023) Dietary macrominerals: Updated review of their role and orchestration in human nutrition throughout the life cycle with sex differences. Current Research in Food Science 6, pages 100450.
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Jiancheng Yang, Qinghua Tang & Yuhong Zeng. (2022) Melatonin: Potential avenue for treating iron overload disorders. Ageing Research Reviews 81, pages 101717.
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Guangbin ChenHongzhou Lu. (2022) Oral high-dose acetylcysteine: Effective against the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)?. Drug Discoveries & Therapeutics 16:3, pages 139-141.
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Rocío Celeste Gambaro, Analía Seoane & Gisel Padula. (2022) Vitamin E protective effects on genomic and cellular damage caused by paediatric preventive supplementation for anaemia: an experimental model. British Journal of Nutrition, pages 1-10.
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Rayan Bou-Fakhredin, Lucia De Franceschi, Irene Motta, Assaad A. Eid, Ali T. Taher & Maria Domenica Cappellini. (2022) Redox Balance in β-Thalassemia and Sickle Cell Disease: A Love and Hate Relationship. Antioxidants 11:5, pages 967.
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Sirinart Kumfu, Siriporn C Chattipakorn & Nipon Chattipakorn. (2022) Iron overload cardiomyopathy: Using the latest evidence to inform future applications. Experimental Biology and Medicine 247:7, pages 574-583.
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Hiren R. Modi, Qihong Wang, Sarah J. Olmstead, Elizabeth S. Khoury, Nirnath Sah, Yu Guo, Payam Gharibani, Rishi Sharma, Rangaramanujam M. Kannan, Sujatha Kannan & Nitish V. Thakor. (2021) Systemic administration of dendrimer N‐acetyl cysteine improves outcomes and survival following cardiac arrest. Bioengineering & Translational Medicine 7:1.
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Sezaneh Haghpanah, Nader Cohan, Mohammadreza Bordbar, Asghar Bazrafshan, Mehran Karimi, Soheila Zareifar, Sanaz Safaei, Azam Aramesh, Mohamad Moghadam, Saeid Amiri Zadeh Fard & Omid Reza Zekavat. (2020) Effects of three months of treatment with vitamin E and N-acetyl cysteine on the oxidative balance in patients with transfusion-dependent β-thalassemia. Annals of Hematology 100:3, pages 635-644.
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Annelies Johanna van Vuren, Eduard Johannes van Beers & Richard van Wijk. (2021) A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency. Frontiers in Physiology 11.
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Anna Zalewska, Sara Zięba, Paula Kostecka-Sochoń, Agnieszka Kossakowska, Małgorzata Żendzian-Piotrowska, Jan Matczuk & Mateusz Maciejczyk. (2020) NAC Supplementation of Hyperglycemic Rats Prevents the Development of Insulin Resistance and Improves Antioxidant Status but Only Alleviates General and Salivary Gland Oxidative Stress. Oxidative Medicine and Cellular Longevity 2020, pages 1-15.
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Somdet Srichairatanakool, Pimpisid Koonyosying & Suthat Fucharoen. 2020. Personalized Medicine, in Relation to Redox State, Diet and Lifestyle. Personalized Medicine, in Relation to Redox State, Diet and Lifestyle.
Andreas Daiber & Stefan Chlopicki. (2020) Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies. Free Radical Biology and Medicine 157, pages 15-37.
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Sirinart Kumfu, Siriporn Chattipakorn & Nipon Chattipakorn. 2020. Pathology. Pathology 117 126 .
Loutfy H. MadkourLoutfy H. Madkour. 2020. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses. Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses 631 665 .
Natticha Sumneang, Sirinart Kumfu, Juthamas Khamseekaew, Natthaphat Siri-Angkul, Suthat Fucharoen, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2019) Combined iron chelator with N-acetylcysteine exerts the greatest effect on improving cardiac calcium homeostasis in iron-overloaded thalassemic mice. Toxicology 427, pages 152289.
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Işik Odaman Al, Ali Ayçiçek, Gizem Ersoy, Cengiz Bayram, Salim Neşelioğlu & Özcan Erel. (2019) Thiol Disulfide Homeostasis and Ischemia-modified Albumin Level in Children With Beta-Thalassemia. Journal of Pediatric Hematology/Oncology 41:7, pages e463-e466.
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Homa Nomani, Golnaz Bayat, Amirhossein Sahebkar, Amir Farjam Fazelifar, Farveh Vakilian, Vahid Jomezade, Thomas P. Johnston & Amir Hooshang Mohammadpour. (2018) Atrial fibrillation in β‐thalassemia patients with a focus on the role of iron‐overload and oxidative stress: A review. Journal of Cellular Physiology 234:8, pages 12249-12266.
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Nawapong Patpan, Ratana Banjerdpongchai, Adisak Tantiworawit, Juthathip Poofery, Phimphan Komonrit, Kanda Fanhchaksai, Thanawat Rattanathammethee, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada & Pimlak Charoenkwan. (2019) The Effect of Transfusion-Dependent Thalassemia Patient’s Serum on Peripheral Blood Mononuclear Cell Viability. Journal of Cell Death 12, pages 117906601882353.
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Richard Eugene Frye. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 331 348 .
Richard Eugene Frye. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 301 330 .
Cristina Vassalle, Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Anna Spasiano, Calogera Gerardi, Angelo Zuccarelli, Tommaso Casini, Riccardo Righi, Massimiliano Missere, Vincenzo Positano, Rudina Ndreu & Alessia Pepe. (2018) Relationship between uric acid levels and cardiometabolic findings in a large cohort of β-thalassemia major patients. Biomarkers in Medicine 12:4, pages 341-348.
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Noelia Clemente Plaza, Manuel Reig García-Galbis & Rosa Martínez-Espinosa. (2018) Effects of the Usage of l-Cysteine (l-Cys) on Human Health. Molecules 23:3, pages 575.
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Elizabeth Nance, Siva P. Kambhampati, Elizabeth S. Smith, Zhi Zhang, Fan Zhang, Sarabdeep Singh, Michael V. Johnston, Rangaramanujam M. Kannan, Mary E. Blue & Sujatha Kannan. (2017) Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome. Journal of Neuroinflammation 14:1.
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Ali Bazi, Iraj Shahramian, Hajar Yaghoobi, Majid Naderi & Hakim Azizi. (2017) The Role of Immune System in Thalassemia Major: A Narrative Review. Journal of Pediatrics Review 6:2.
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Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–Butuner, Irundika H.K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio Di Lisa & Andreas Daiber. (2017) European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology 13, pages 94-162.
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Suwakon Wongjaikam, Sirinart Kumfu, Juthamas Khamseekaew, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2017) Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine. Scientific Reports 7:1.
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Husseen Manafikhi, Gregor Drummen, Maura Palmery & Ilaria Peluso. (2017) Total Antioxidant Capacity in beta-thalassemia: A systematic review and meta-analysis of case-control studies. Critical Reviews in Oncology/Hematology 110, pages 35-42.
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Aygun Kuyumcu, Asli Akyol, Zehra Buyuktuncer, M Mahir Ozmen & Halit Tanju Besler. (2015) Improved oxidative status in major abdominal surgery patients after N-acetyl cystein supplementation. Nutrition Journal 14:1.
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