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Hemoglobin
international journal for hemoglobin research
Volume 15, 1991 - Issue 5
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Original Article

The XMN I Site (-158, C→T) 5′ to ttle Gγ GENE: Correlation with the Senegalese Haplotype and Gγ Globin Expression

S. K. Ballas Cardeza Foundation for Hematologic Research Department of Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
C. A. Talacki Cardeza Foundation for Hematologic Research Department of Medicine, Thomas Jefferson University, Philadelphia, PA, 19107, USA
,
K. Adachi Division of Hematolngy, Children's Hospital of Philadelphia and the Department of Pediatrics, Human Genetics University of Pennsylvania, Philadelphia, PA, 19104, USA
,
E. Schwartz Division of Hematolngy, Children's Hospital of Philadelphia and the Department of Pediatrics, Human Genetics University of Pennsylvania, Philadelphia, PA, 19104, USA
,
S. Surrey Division of Hematolngy, Children's Hospital of Philadelphia and the Department of Pediatrics, Human Genetics University of Pennsylvania, Philadelphia, PA, 19104, USA
&
E. Rappaport Division of Hematolngy, Children's Hospital of Philadelphia and the Department of Pediatrics, Human Genetics University of Pennsylvania, Philadelphia, PA, 19104, USA
Pages 393-405 | Received 04 Mar 1991, Accepted 21 Jun 1991, Published online: 07 Jul 2009

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Fan Jiang, Jian Li, Jian-Ying Zhou, Can Liao & Dong-Zhi Li. (2019) Regulatory Single Nucleotide Polymorphism rs368698783 (G>A): a Genetic Modifier of Hb F Production Only under Erythropoietic Stress Characteristic for β-Globin Chain Deficiency?. Hemoglobin 43:1, pages 73-75.
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Sandro Eridani & Andrea Mosca. (2011) Fetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia. Journal of Blood Medicine 2, pages 23-30.
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Kleber Yotsumoto Fertrin & Fernando Ferreira Costa. (2010) Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment. Expert Review of Hematology 3:4, pages 443-458.
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Svetlana Pulis, Christian A. Scerri, Pierre Schembri Wismayer, Ruth Galdies, Stephanie Bezzina Wettinger & Alex E. Felice. (2007) Developmental Effect of the XmnI Site on Gγ-Globin Gene Expression Among Newborn Hb F-Malta-I [Gγ117(G19)His→Arg, CAT→CGT] Heterozygotes and Adult β+-Thalassemia Homozygotes. Hemoglobin 31:1, pages 71-82.
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S. K. Ballas & M. J. Marcolina. (2000) Determinants of Red Cell Survival and Erythropoietic Activity in Patients with Sickle Cell Anemia in the Steady State. Hemoglobin 24:4, pages 277-286.
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M. F. H. Carver & T. H. J. Huisman. (1997) International Hemoglobin Information Center Variant List. Hemoglobin 21:6, pages 505-506.
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S. K. Ballas, R. N. Gay & F. F. Chehab. (1997) Is Hb A2 Elevated in Adults with Sickle-A-Thalassemi (βS/βS; -α/-α). Hemoglobin 21:5, pages 405-420.
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. (1996) Variants of the Alpha Chain. Hemoglobin 20:3, pages 215-312.
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M. H. Steinberg. (1996) Modulation of the Phenotypic Diversity of Sickle Cell Anemia. Hemoglobin 20:1, pages 1-19.
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. (1994) International Hemoglobin Information Center. Hemoglobin 18:2, pages 77-161.
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. (1993) Variants of the Alpea Chain. Hemoglobin 17:2, pages 89-177.
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. (1992) Variants of the Alpha Chain. Hemoglobin 16:3, pages 127-213.
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Articles from other publishers (19)

Justin K. Kirkham, Jeremie H. Estepp, Mitch J. Weiss & Sara R. Rashkin. (2023) Genetic Variation and Sickle Cell Disease Severity. JAMA Network Open 6:10, pages e2337484.
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Giulia Hardouin, Elisa MagrinAlice Corsia, Marina Cavazzana, Annarita MiccioMichaela Semeraro. (2023) Sickle Cell Disease: From Genetics to Curative Approaches. Annual Review of Genomics and Human Genetics 24:1, pages 255-275.
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Alicia K. Chang, Carly C. Ginter Summarell, Parendi T. Birdie & Vivien A. Sheehan. (2018) Genetic modifiers of severity in sickle cell disease. Clinical Hemorheology and Microcirculation 68:2-3, pages 147-164.
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Joseph F. McLaughlin & Samir K. Ballas. (2016) High mortality among children with sickle cell anemia and overt stroke who discontinue blood transfusion after transition to an adult program. Transfusion 56:5, pages 1014-1021.
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Li Liu, Alexander Pertsemlidis, Liang-Hao Ding, Michael D Story, Martin H Steinberg, Paola Sebastiani, Carolyn Hoppe, Samir K Ballas & Betty S Pace. (2016) Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease. Experimental Biology and Medicine 241:7, pages 706-718.
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M. Vinciguerra, C. Passarello, F. Cassarà, F. Leto, M. Cannata, G. Calvaruso, R. Di Maggio, D. Renda, A. Maggio & A. Giambona. (2016) Co-heredity of silent CAP + 1570 T>C ( HBB :c*96T>C) defect and severe β-thal mutation: a cause of mild β-thalassemia intermedia . International Journal of Laboratory Hematology 38:1, pages 17-26.
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Margherita Vinciguerra, Cristina Passarello, Filippo Leto, Filippo Cassarà, Monica Cannata, Aurelio Maggio & Antonino Giambona. (2015) Co-inheritance of the rare β hemoglobin variants Hb Yaounde, Hb Görwihl and Hb City of Hope with other alterations in globin genes: impact in genetic counseling. European Journal of Haematology 94:4, pages 322-329.
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Sandro Eridani, Francesca Avemaria & Andrea Mosca. (2014) Reactivation of Fetal Hemoglobin in Thalassemia and Sickle Cell Disease. Thalassemia Reports 4:2, pages 2196.
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Marília Rocha Laurentino, Pedro Aurio Maia Filho, Maritza Cavalcante Barbosa, Izabel Cristina Justino Bandeira, Lilianne Brito da Silva Rocha & Romelia Pinheiro Gonçalves. (2014) Influence of βS-globin haplotypes hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia. Revista Brasileira de Hematologia e Hemoterapia 36:2, pages 121-125.
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Santosh L. Saraf, Robert E. Molokie, Mehdi Nouraie, Craig A. Sable, Lori Luchtman-Jones, Gregory J. Ensing, Andrew D. Campbell, Sohail R. Rana, Xiao M. Niu, Roberto F. Machado, Mark T. Gladwin & Victor R. Gordeuk. (2014) Differences in the clinical and genotypic presentation of sickle cell disease around the world. Paediatric Respiratory Reviews 15:1, pages 4-12.
Crossref
Sasiwan Kerdpoo, Ektong Limweeraprajak & Thanusak Tatu. (2014) Effect of Swiss-type heterocellular HPFH from XmnI-Gγ and HBBP1 polymorphisms on HbF, HbE, MCV and MCH levels in Thai HbE carriers. International Journal of Hematology 99:3, pages 338-344.
Crossref
Hooshang Nemati, Zohreh Rahimi & Gholamreza Bahrami. (2009) The Xmn1 polymorphic site 5′ to the Gγ gene and its correlation to the Gγ:Aγ ratio, age at first blood transfusion and clinical features in β-Thalassemia patients from Western Iran. Molecular Biology Reports 37:1, pages 159-164.
Crossref
Samir K. Ballas, Jason K. Baxter & Gaye Riddick. (2006) Folate supplementation and twinning in patients with sickle cell disease. American Journal of Hematology 81:4, pages 296-297.
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M. H. Steinberg. (2005) Predicting clinical severity in sickle cell anaemia. British Journal of Haematology 129:4, pages 465-481.
Crossref
Donald J. AbrahamConstance Tom Noguchi, Alan N. Schechter, John D. Haley & Donald J. Abraham. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 443 477 .
Sharada A. Sarnaik & Samir K. Ballas. (2001) Molecular characteristics of pediatric patients with sickle cell anemia and stroke. American Journal of Hematology 67:3, pages 179-182.
Crossref
Jayany Nath, David K Jin, Riaz Rahman, Samir K Ballas & Olcay A Batuman. (1998) Successful Medical Management of Orbital Abscess in a Patient With Sickle Cell Anemia. Ophthalmic Surgery, Lasers and Imaging Retina 29:10, pages 860-863.
Crossref
Samir K. Ballas, Shiping P. Cai, Thomas Gabuzda & Farid F. Chehab. (1997) Molecular basis of asymptomatic β-thalassemia major in an African American individual. American Journal of Medical Genetics 69:2, pages 196-199.
Crossref
A. D. Adekile & T. H. J. Huisman. (1993) Hb F in sickle cell anemia. Experientia 49:1, pages 16-27.
Crossref

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