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Hemoglobin
international journal for hemoglobin research
Volume 15, 1991 - Issue 4
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Original Article

Monozygotic Twins with Sickle Cell Anemia and Discordant Clinical Courses: Clinical and Laboratory Studies

R. R. Amin Hematology/Oncology Unit, Department of Medicine, Mount Sinai Hospital, University of Health Sciences/The Chicago Medical School, Chicago, IL, 60608
,
R. M. Bauersachs Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA
,
H. J. Meiszlman Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA
,
N. Hlohandas Department of Laboratory Medicine, Cancer Research Institute, University of California, San Francisco, CA
,
R. P. Hebbel Department of Medicine, University of Minnesota Medical School, Minneapolis, MN
,
P. E. Bowen Department of Nutrition and Medical Dietetics, University of Illinois at Chicago, Chicago, 11
,
R. A. Schlegel Depriment of Molecular Biology, Penn State University, University Park, PA
,
P. Williamson Biology Department, Amberst College, Amherst, MA
&
M. P. Westerman Hematology/Oncology Unit, Department of Medicine, Mount Sinai Hospital, University of Health Sciences/The Chicago Medical School, Chicago, IL, 60608
 show all
Pages 247-256 | Received 08 Feb 1991, Accepted 24 Apr 1991, Published online: 07 Jul 2009

Citations (19)

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Swee Lay Thein. (2011) Genetic Modifiers of Sickle Cell Disease. Hemoglobin 35:5-6, pages 589-606.
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Articles from other publishers (18)

Keri Oxendine Harp, Alaijah Bashi, Felix Botchway, Yvonne Dei-Adomakoh, Shareen A. Iqbal, Michael D. Wilson, Andrew A. Adjei, Jonathan K. Stiles & Adel Driss. (2022) MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria. Journal of Clinical Medicine 11:3, pages 500.
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Thomas N. WilliamsSwee Lay Thein. (2018) Sickle Cell Anemia and Its Phenotypes. Annual Review of Genomics and Human Genetics 19:1, pages 113-147.
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Katarzyna Klimczewska, Anna Kasperczuk & Aneta Suwińska. 2018. Cell Fate in Mammalian Development. Cell Fate in Mammalian Development 105 149 .
Swee Lay Thein. 2017. Gene and Cell Therapies for Beta-Globinopathies. Gene and Cell Therapies for Beta-Globinopathies 27 57 .
Lijuan Ji, Li Chen, Ping Wu, Dominic F. Gervasio & Chenxin Cai. (2016) Highly Selective Fluorescence Determination of the Hematin Level in Human Erythrocytes with No Need for Separation from Bulk Hemoglobin. Analytical Chemistry 88:7, pages 3935-3944.
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Kate Gardner & Swee Lay Thein. 2016. Sickle Cell Anemia. Sickle Cell Anemia 371 397 .
Anupam Aich, Melissa Freundlich & Peter G. Vekilov. (2015) The free heme concentration in healthy human erythrocytes. Blood Cells, Molecules, and Diseases 55:4, pages 402-409.
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Anupam Aich, Weichun Pan & Peter G. Vekilov. (2015) Thermodynamic mechanism of free heme action on sickle cell hemoglobin polymerization. AIChE Journal 61:9, pages 2861-2870.
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Veselina Uzunova, Weichun Pan, Vassiliy Lubchenko & Peter G. Vekilov. (2012) Control of the nucleation of sickle cell hemoglobin polymers by free hematin. Faraday Discussions 159, pages 87.
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Veselina V. Uzunova, Weichun Pan, Oleg Galkin & Peter G. Vekilov. (2010) Free Heme and the Polymerization of Sickle Cell Hemoglobin. Biophysical Journal 99:6, pages 1976-1985.
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Weichun Pan, Peter G. Vekilov & Vassiliy Lubchenko. (2010) Origin of Anomalous Mesoscopic Phases in Protein Solutions. The Journal of Physical Chemistry B 114:22, pages 7620-7630.
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Petra J.G. Zwijnenburg, Hanne Meijers-Heijboer & Dorret I. Boomsma. (2010) Identical but not the same: The value of discordant monozygotic twins in genetic research. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, pages n/a-n/a.
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Swee Lay Thein. (2008) Genetic modifiers of the β-haemoglobinopathies. British Journal of Haematology 141:3, pages 357-366.
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Peter G. Vekilov. (2007) Sickle-cell haemoglobin polymerization: is it the primary pathogenic event of sickle-cell anaemia?. British Journal of Haematology 139:2, pages 173-184.
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Oleg Galkin, Weichun Pan, Luis Filobelo, Rhoda Elison Hirsch, Ronald L. Nagel & Peter G. Vekilov. (2007) Two-Step Mechanism of Homogeneous Nucleation of Sickle Cell Hemoglobin Polymers. Biophysical Journal 93:3, pages 902-913.
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M. W. WEATHERALL, D. R. HIGGS, H. WEISS, D. J. WEATHERALL & G. R. SERJEANT. (2005) Phenotype/genotype relationships in sickle cell disease: a pilot twin study. Clinical and Laboratory Haematology 27:6, pages 384-390.
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Martin H. Steinberg, Ersi Voskaridou, Abdullah Kutlar, Dimitris Loukopoulos, Mabel Koshy, Samir K. Ballas, Oswaldo Castro & Franca Barton. (2003) Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease. American Journal of Hematology 72:2, pages 121-126.
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C. Anthony Blau. (1998) 10 Current status of stem cell therapy and prospects for gene therapy for the disorders of globin synthesis. Baillière's Clinical Haematology 11:1, pages 257-275.
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