Advanced search
Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 16, 1992 - Issue 1-2
Submit an article Journal homepage
23
Views
27
CrossRef citations to date
0
Altmetric
Original Article

Types of Thalassemia Among Patients Attending a Large University Clinic in Kuala Lumpur, Malaysia

E. George Department of Pathology, Faculty of Medicine National University of Malaysia, Jalan Raja Muda, 50300, Kuala Lumpur, Malaysia
,
H-J. Li Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
Y-J. Fei Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
A. L. Reese Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
E. Baysal Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
B. Cepreganova Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
J. B. Wilson Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
L-H. Gu Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
J. F. Nechtman Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
T. A. Stoming Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
J-C. Liu Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
,
J. F. Codrington Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
&
T. H. J. Huisman Department of Biochemistry and Molecular Biology, Laboratory of Protein Chemistry Medical College of Georgia, Augusta, GA, 30912-2100, USA
 show all
Pages 51-66 | Received 02 Sep 1991, Accepted 18 Dec 1991, Published online: 07 Jul 2009

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Waseem Chauhan, Mohammad Afzal, Zeeba Zaka-ur-Rab & Md Salik Noorani. (2021) A Novel Frameshift Mutation, Deletion of HBB:c.199_202delAAAG [Codon 66/67 (-AAAG)] in β-Thalassemia Major Patients from the Western Region of Uttar Pradesh, India. The Application of Clinical Genetics 14, pages 77-85.
Read now
Roshan Colah, Ajit Gorakshakar & Anita Nadkarni. (2010) Global burden, distribution and prevention of β-thalassemias and hemoglobin E disorders. Expert Review of Hematology 3:1, pages 103-117.
Read now
Jin Ai Mary Anne Tan, Pui See Chin, Yean Ching Wong, Kim Lian Tan, Lee Lee Chan & Elizabeth George. (2006) Characterisation and confirmation of rare beta‐thalassaemia mutations in the Malay, Chinese and Indian ethnic groups in Malaysia. Pathology 38:5, pages 437-441.
Read now
Georgi D. Efremov. (2001) FORTY-FOUR YEARS (1955–1999) DEVOTED TO HEMOGLOBIN RESEARCH: TITUS H. J. HUISMAN (1923–1999). Hemoglobin 25:2, pages 125-168.
Read now
Suthat Fucharoen & Pranee Winichagoon. (1997) Hemoglobinopathies in Southeast Asia: Molecular Biology and Clinical Medicine. Hemoglobin 21:4, pages 299-319.
Read now
A. Merat, M. Haghshenas, Z. Mostafavi Pour, M. W. Plonczynski, A. N. Harrell, M. B. Coleman & M. H. Steinberg. (1993) β-Thalassemia in Southwestern Iran. Hemoglobin 17:5, pages 427-437.
Read now

Articles from other publishers (21)

Hanan Kamel M. Saad, Wan Rohani Wan Taib, Azly Sumanty Ab Ghani, Imilia Ismail, Futoon Abedrabbu Al-Rawashde, Belal Almajali, Maysa Alhawamdeh, Alawiyah Awang Abd Rahman, Abdullah Saleh Al-wajeeh & Hamid Ali Nagi Al-Jamal. (2023) HBB Gene Mutations and Their Pathological Impacts on HbE/β-Thalassaemia in Kuala Terengganu, Malaysia. Diagnostics 13:7, pages 1247.
Crossref
Meric A. Altinoz, Francesca Magnoni, Aysel Ozpinar & Giovanni Corso. 2023. Hereditary Gastric and Breast Cancer Syndrome. Hereditary Gastric and Breast Cancer Syndrome 405 422 .
Waseem Chauhan, Rafat Fatma, Zeeba Zaka-ur-Rab & Mohammad Afzal. (2022) Direct sequencing of β-globin gene reveals a rare combination of two exonic and two intronic variants in a β-thalassemia major patient: a case report. Journal of Medical Case Reports 16:1.
Crossref
Pornswan Wasant, Carmencita Padilla, Stephen Lam, Meow‐Keong Thong & Poh‐San Lai. (2019) Asia Pacific Society of Human Genetics (APSHG) from conception to 2019: 13 years of collaboration to tackle congenital malformation and genetic disorders in Asia. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 181:2, pages 155-165.
Crossref
Danny Xuan Rong Koh, Raja Zahratul Azma Raja Sabudin, Malisa Mohd Yusoff, Noor Hamidah Hussin, Rahimah Ahmad, Ainoon Othman & Endom Ismail. (2017) Molecular Characterisation of α - and β -Thalassaemia among Indigenous Senoi Orang Asli Communities in Peninsular Malaysia . Annals of Human Genetics 81:5, pages 205-212.
Crossref
Lai Kuan Teh, Elizabeth George, Mei I Lai, Jin Ai Mary Anne Tan, Lily Wong & Patimah Ismail. (2013) Molecular basis of transfusion dependent beta-thalassemia major patients in Sabah. Journal of Human Genetics 59:3, pages 119-123.
Crossref
E. George, Lai Kuan Teh, Jama Tan, Mei I. Lai & Lily Wong. (2013) HbA2 levels in β-thalassaemia carriers with the Filipino β0-deletion: are the levels higher than what is found with non-deletional forms of β0-thalassaemia?. Pathology 45:1, pages 62-65.
Crossref
Q. Shazia, Z. H. Mohammad, Taibur Rahman & Hossain Uddin Shekhar. (2012) Correlation of Oxidative Stress with Serum Trace Element Levels and Antioxidant Enzyme Status in Beta Thalassemia Major Patients: A Review of the Literature. Anemia 2012, pages 1-7.
Crossref
Jessica Van Ziffle, Wendy Yang & Farid F. Chehab. (2011) Homozygous Deletion of Six Olfactory Receptor Genes in a Subset of Individuals with Beta-Thalassemia. PLoS ONE 6:2, pages e17327.
Crossref
Xiaokun Liu, Hai Yang Law, Yuen Ming Tan & Yan Hong. (2010) High-throughput β-thalassemia carrier screening by allele-specific Q-primer real-time polymerase chain reaction. Analytical Biochemistry 404:1, pages 97-99.
Crossref
Shirley Henderson, Adele Timbs, Janice McCarthy, Alice Gallienne, Margaretha Van Mourik, Gillian Masters, Alison May, Mohamed S.M. Khalil, Anna Schuh & John Old. (2009) Incidence of haemoglobinopathies in various populations — The impact of immigration. Clinical Biochemistry 42:18, pages 1745-1756.
Crossref
V. Nadarajan, P. Sthaneshwar & G. I. Eow. (2008) Use of red blood cell indices for the identification of iron deficiency among blood donors. Transfusion Medicine 18:3, pages 184-189.
Crossref
Dollyn Liying Quek, Yen-Yek Ng, Wen Wang, Arnold S.C. Tan, Guek-Im Tang-Lim, Ivy S.L. Ng, Hai-Yang Law & Samuel S. Chong. (2007) Rapid carrier screening for β-thalassemia by single-step allele-specific PCR and detection. Clinical Biochemistry 40:5-6, pages 427-430.
Crossref
Meow-Keong Thong, J. A. M. A. Tan, K. L. Tan & S. F. Yap. (2005) Characterisation of β-globin Gene Mutations in Malaysian Children: A Strategy for the Control of β-Thalassaemia in a Developing Country. Journal of Tropical Pediatrics 51:6, pages 328-333.
Crossref
K.L. Tan, J.A.M.A. Tan, Y.C. Wong, Y.C. Wee, M.K. Thong & S.F. Yap. (2001) Combine-ARMS: A Rapid and Cost-Effective Protocol for Molecular Characterization of β-Thalassemia in Malaysia. Genetic Testing 5:1, pages 17-22.
Crossref
D.J. Weatherall & J.B. Clegg. 2001. The Thalassaemia Syndromes. The Thalassaemia Syndromes 733 821 .
Jonathan Flint, Rosalind M. Harding, Anthony J. Boyce & John B. Clegg. (1998) 1 The population genetics of the haemoglobinopathies. Baillière's Clinical Haematology 11:1, pages 1-51.
Crossref
D. D. Pobedimskaya, T. P. Molchanova, S. Streichman & T. H. J. Huisman. (2006) Compound heterozygosity for two α‐globin gene defects, Hb taybe (α1; 38 or 39 minus thr) and a poly a mutation (α2; AATAAA → AATAAG), results in a severe hemolytic anemia. American Journal of Hematology 47:3, pages 198-202.
Crossref
R. Liang, S. Liang, N. H. Jiang, X‐J. Wen, J‐B. Zhao, J. F. Nechtman, T. A. Stoming & T. H. J. Huisman. (2008) α and β thalassaemia among Chinese children in Guangxi Province, P.R. China: molecular and haematological characterization. British Journal of Haematology 86:2, pages 351-354.
Crossref
Vladimir Divoky, Erol Baysal, Reyhan Öner, M. Akif Çürük, Emmitt L. D. WalkerIIIIII, Karel Indrak & Titus H. J. Huisman. (1994) The T→C mutation at position +96 of the untranslated region 3′ to the terminating codon of the β-globin gene is a rare polymorphism that does not cause a β-thalassemia as previously ascribed. Human Genetics 93:1, pages 77-78.
Crossref
Vladimir Divoky, Emmanuel Bissé, Jerry B. Wilson, Li-Hao Gu, Heinrich Wieland, Irene Heinrichs, John F. Prior & Huisman Titus H.J.. (1992) Heterozygosity for the IVS-I-5(G→C) mutation with a G→A change at codon 18 (Val→Met; Hb Baden) in cis and a T→G mutation at codon 126 (Val→Gly; Hb Djonburi) in trans resulting in a thalassemia intermedia. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1180:2, pages 173-179.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.