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Drug Development and Industrial Pharmacy Volume 35, 2009 - Issue 11
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Original Article

Physicochemical and preclinical pharmacokinetic and toxicological evaluation of LK-423—a new phthalimido-desmuramyl-dipeptide derivative with immunomodulating activity

Polona Smrdel Lek Pharmaceuticals, Ljubljana, Slovenia; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
,
Iztok Grabnar Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
,
Igor Locatelli Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
,
Manica Černe Lek Pharmaceuticals, Ljubljana, Slovenia
,
Samo Andrenšek Lek Pharmaceuticals, Ljubljana, Slovenia
,
Nataša Kovačič Erico Velenje, Institute of Ecological Research, Velenje, Slovenia
,
Albin Kristl Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
,
Marija Bogataj Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
,
Uroš Urleb Lek Pharmaceuticals, Ljubljana, Slovenia; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
&
Aleš Mrhar Faculty of Pharmacy, University of Ljubljana, Ljubljana, SloveniaCorrespondence[email protected]
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Pages 1293-1304 | Received 28 Aug 2008, Accepted 11 Mar 2009, Published online: 16 Oct 2009

Citations (9)

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Amit K. Shah, Christy M. Wyandt & Steven P. Stodghill. (2013) Physico chemical characterization of a novel anti-cancer agent and its comparison to Taxol®. Drug Development and Industrial Pharmacy 39:1, pages 89-101.
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Polona Smrdel, Manica Černe, Marija Bogataj, Uroš Urleb & Aleš Mrhar. (2010) Enhanced therapeutic effect of LK-423 in treating experimentally induced colitis in rats when administered in colon delivery microcapsules. Journal of Microencapsulation 27:7, pages 572-582.
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Articles from other publishers (7)

Samo Guzelj, Špela Bizjak & Žiga Jakopin. (2022) Discovery of Desmuramylpeptide NOD2 Agonists with Single-Digit Nanomolar Potency. ACS Medicinal Chemistry Letters 13:8, pages 1270-1277.
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Samo Guzelj, Sanja Nabergoj, Martina Gobec, Stane Pajk, Veronika Klančič, Bram Slütter, Ruža Frkanec, Adela Štimac, Primož Šket, Janez Plavec, Irena Mlinarič-Raščan & Žiga Jakopin. (2021) Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant Activity . Journal of Medicinal Chemistry 64:11, pages 7809-7838.
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Rosana Ribić, Ranko Stojković, Lidija Milković, Mariastefania Antica, Marko Cigler & Srđanka Tomić. (2019) Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides. Beilstein Journal of Organic Chemistry 15, pages 1805-1814.
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Martina Gobec, Tihomir Tomašič, Adela Štimac, Ruža Frkanec, Jurij Trontelj, Marko Anderluh, Irena Mlinarič-Raščan & Žiga Jakopin. (2018) Discovery of Nanomolar Desmuramylpeptide Agonists of the Innate Immune Receptor Nucleotide-Binding Oligomerization Domain-Containing Protein 2 (NOD2) Possessing Immunostimulatory Properties. Journal of Medicinal Chemistry 61:7, pages 2707-2724.
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Martina Gobec, Irena Mlinarič-Raščan, Marija Sollner Dolenc & Žiga Jakopin. (2016) Structural requirements of acylated Gly- l -Ala- d -Glu analogs for activation of the innate immune receptor NOD2. European Journal of Medicinal Chemistry 116, pages 1-12.
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Žiga Jakopin, Martina Gobec, Irena Mlinarič-Raščan & Marija Sollner Dolenc. (2012) Immunomodulatory Properties of Novel Nucleotide Oligomerization Domain 2 (Nod2) Agonistic Desmuramyldipeptides. Journal of Medicinal Chemistry 55:14, pages 6478-6488.
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Žiga Jakopin, Emanuela Corsini, Martina Gobec, Irena Mlinarič-Raščan & Marija Sollner Dolenc. (2011) Design, synthesis and biological evaluation of novel desmuramyldipeptide analogs. European Journal of Medicinal Chemistry 46:9, pages 3762-3777.
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