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Original Article

Interpolyelectrolyte complexes of Eudragit® E PO with sodium alginate as potential carriers for colonic drug delivery: monitoring of structural transformation and composition changes during swellability and release evaluating

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Pages 1439-1451 | Received 17 Nov 2008, Accepted 21 Apr 2009, Published online: 20 Nov 2009

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Read on this site (4)

Simona De Robertis, Maria Cristina Bonferoni, Lisa Elviri, Giuseppina Sandri, Carla Caramella & Ruggero Bettini. (2015) Advances in oral controlled drug delivery: the role of drug–polymer and interpolymer non-covalent interactions. Expert Opinion on Drug Delivery 12:3, pages 441-453.
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Tin Wui Wong & Harjoh Nurulaini. (2012) Sustained-release alginate-chitosan pellets prepared by melt pelletization technique. Drug Development and Industrial Pharmacy 38:12, pages 1417-1427.
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Josias Hamman & Jan Steenekamp. (2012) Excipients with specialized functions for effective drug delivery. Expert Opinion on Drug Delivery 9:2, pages 219-230.
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Antonio Moroni, William Drefko & Gerard Thone. (2011) Formulations of zero-order, pH-dependent, sustained release matrix systems by ionotropic gelation of alginate-containing mixtures. Drug Development and Industrial Pharmacy 37:2, pages 216-224.
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Articles from other publishers (31)

Jonas Schlauersbach, Simon Hanio, Martina Raschig, Bettina Lenz, Oliver Scherf-Clavel & Lorenz Meinel. (2022) Bile and excipient interactions directing drug pharmacokinetics in rats. European Journal of Pharmaceutics and Biopharmaceutics 178, pages 65-68.
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Clara Luisa Domínguez-Delgado, Zubia Akhtar, Godfrey Awuah-Mensah, Braden Wu & Hugh David Charles Smyth. (2022) Effects of Process and Formulation Parameters on Submicron Polymeric Particles Produced by a Rapid Emulsion-Diffusion Method. Nanomaterials 12:2, pages 229.
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Aleksandra V. Bukhovets, Alexander Y. Sitenkov & Rouslan I. Moustafine. (2021) Comparative evaluation study of polycomplex carriers based on Eudragit® EPO / S100 copolymers prepared in different media . Polymers for Advanced Technologies 32:7, pages 2761-2769.
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Jonas Schlauersbach, Simon Hanio, Bettina Lenz, Sahithya P.B. Vemulapalli, Christian Griesinger, Ann-Christin Pöppler, Cornelius Harlacher, Bruno Galli & Lorenz Meinel. (2021) Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection. Journal of Controlled Release 330, pages 36-48.
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A. V. Bukhovets, A. Y. Sitenkov & R. I. Moustafine. (2020) Interpolymer Complexes Based on Eudragit<sup>®</sup> EPO/Eudragit<sup>®</sup> S100 as Carriers for Oral Controlled Drug Delivery Systems. Drug development & registration 9:3, pages 36-43.
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Aleksandra V. Bukhovets, Nikoletta Fotaki, Vitaliy V. Khutoryanskiy & Rouslan I. Moustafine. (2020) Interpolymer Complexes of Eudragit® Copolymers as Novel Carriers for Colon-Specific Drug Delivery. Polymers 12:7, pages 1459.
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Fabrice Ofridam, Noureddine Lebaz, Émilie Gagnière, Denis Mangin & Abdelhamid Elaissari. (2020) Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100. Polymers for Advanced Technologies 31:6, pages 1270-1279.
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João C. Campos, Domingos C. Ferreira, Sofia Lima, Salette Reis & Paulo J. Costa. (2019) Swellable polymeric particles for the local delivery of budesonide in oral mucositis. International Journal of Pharmaceutics 566, pages 126-140.
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Sabrina Sepúlveda-Rivas, Hans Fritz, Camila Valenzuela, Carlos Santiviago & Javier Morales. (2019) Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety. Pharmaceutics 11:3, pages 103.
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Melanie Hebe Hughes, Héctor Juan Prado, María Cecilia Rodríguez, Karina Michetti, Patricia Inés Leonardi & María Cristina Matulewicz. (2018) Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release. Marine Biotechnology 20:6, pages 706-717.
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V. V. Khutoryanskiy, R. Yu. Smyslov & A. V. Yakimansky. (2018) Modern Methods for Studying Polymer Complexes in Aqueous and Organic Solutions. Polymer Science, Series A 60:5, pages 553-576.
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Annalisa Dalmoro, Alexander Y. Sitenkov, Sara Cascone, Gaetano Lamberti, Anna Angela Barba & Rouslan I. Moustafine. (2017) Hydrophilic drug encapsulation in shell-core microcarriers by two stage polyelectrolyte complexation method. International Journal of Pharmaceutics 518:1-2, pages 50-58.
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Ye Huang, Ping Yong, Yan Chen, Yuting Gao, Weixiong Xu, Yongkang Lv, Liming Yang, Rui L. Reis, Rogério P. Pirraco & Jie Chen. (2017) Micellization and gelatinization in aqueous media of pH- and thermo-responsive amphiphilic ABC (PMMA 82 -b-PDMAEMA 150 -b-PNIPAM 65 ) triblock copolymer synthesized by consecutive RAFT polymerization . RSC Advances 7:46, pages 28711-28722.
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Annalisa Dalmoro, Alexander Y. Sitenkov, Gaetano Lamberti, Anna Angela Barba & Rouslan I. Moustafine. (2016) Ultrasonic atomization and polyelectrolyte complexation to produce gastroresistant shell-core microparticles. Journal of Applied Polymer Science 133:6, pages n/a-n/a.
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Wasfy M. Obeidat, Ali Nokhodchi & Hatim Alkhatib. (2015) Evaluation of Matrix Tablets Based on Eudragit®E100/Carbopol®971P Combinations for Controlled Release and Improved Compaction Properties of Water Soluble Model Drug Paracetamol. AAPS PharmSciTech 16:5, pages 1169-1179.
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Young Ju Son, Younghee Kim, Woo Jin Kim, Seo Young Jeong & Hyuk Sang Yoo. (2015) Antibacterial Nanofibrous Mats Composed of Eudragit for pH-Dependent Dissolution. Journal of Pharmaceutical Sciences 104:8, pages 2611-2618.
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Ali Nokhodchi, Dasha Palmer, Kofi Asare-Addo, Marina Levina & Ali Rajabi-Siahboomi. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 23 49 .
Sonia Lefnaoui & Nadji Moulai-Mostefa. (2015) Polyelectrolyte complex based on carboxymethyl-kappa-carrageenan and Eudragit RL 30D as prospective carriers for sustained drug delivery. Chemical Engineering Research and Design 97, pages 165-174.
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R. I. Moustafine. (2014) Role of macromolecular interactions of pharmaceutically acceptable polymers in functioning oral drug delivery systems. Russian Journal of General Chemistry 84:2, pages 364-367.
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Natnicha Khuathan & Thaned Pongjanyakul. (2014) Modification of quaternary polymethacrylate films using sodium alginate: Film characterization and drug permeability. International Journal of Pharmaceutics 460:1-2, pages 63-72.
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R. I. Moustafine, A. V. Bukhovets, A. Y. Sitenkov, V. A. Kemenova, P. Rombaut & G. Van den Mooter. (2013) Eudragit E PO as a Complementary Material for Designing Oral Drug Delivery Systems with Controlled Release Properties: Comparative Evaluation of New Interpolyelectrolyte Complexes with Countercharged Eudragit L100 Copolymers. Molecular Pharmaceutics 10:7, pages 2630-2641.
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Se-Kwon KimHéctor Prado, María Matulewicz, Pablo Bonelli & Ana Cukierman. 2013. Marine Biomaterials. Marine Biomaterials 603 632 .
Rouslan I. Moustafine, Andrey V. Bodrov, Vera A. Kemenova, Patrick Rombaut & Guy Van den Mooter. (2012) Drug release modification by interpolymer interaction between countercharged types of Eudragit® RL 30D and FS 30D in double-layer films. International Journal of Pharmaceutics 439:1-2, pages 17-21.
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Héctor J. Prado, María C. Matulewicz, Pablo R. Bonelli & Ana L. Cukierman. (2012) Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes. International Journal of Pharmaceutics 429:1-2, pages 12-21.
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Chunmei Gao, Mingzhu Liu, Jun Chen & Chen Chen. (2012) Physicochemical characterization and drug release properties of PDMAEMA/OSA Semi-IPN hydrogels with microporous structure. Polymers for Advanced Technologies 23:3, pages 389-397.
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Jiucun Chen, Mingzhu Liu, Honghong Gong, Yinjuan Huang & Chen Chen. (2011) Synthesis and Self-Assembly of Thermoresponsive PEG- b -PNIPAM- b -PCL ABC Triblock Copolymer through the Combination of Atom Transfer Radical Polymerization, Ring-Opening Polymerization, and Click Chemistry . The Journal of Physical Chemistry B 115:50, pages 14947-14955.
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R. I. Mustafin, A. V. Bukhovets, A. Yu. Sitenkov, V. R. Garipova, V. A. Kemenova, P. Rombaut & G. Van den Mooter. (2011) Synthesis and characterization of a new carrier based on Eudragit® EPO/S100 interpolyelectrolyte complex for controlled colon-specific drug delivery. Pharmaceutical Chemistry Journal 45:9, pages 568-574.
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Tin Wui Wong. (2011) Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery. Journal of Pharmacy and Pharmacology 63:12, pages 1497-1512.
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Jiucun Chen, Mingzhu Liu, Chen Chen, Honghong Gong & Chunmei Gao. (2011) Synthesis and Characterization of Silica Nanoparticles with Well-Defined Thermoresponsive PNIPAM via a Combination of RAFT and Click Chemistry. ACS Applied Materials & Interfaces 3:8, pages 3215-3223.
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R. I. Mustafin, A. B. Bilan, A. V. Bukhovets & V. A. Kemenova. (2011) Comparative study of structural and compositional changes of polycomplex matrices based on Eudragit® EPO and Eudragit® L100. Pharmaceutical Chemistry Journal 45:2, pages 114-117.
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Rouslan I. Moustafine, Valerija L. Bobyleva, Aleksandra V. Bukhovets, Venera R. Garipova, Tatyana V. Kabanova, Vera A. Kemenova & Guy Van Den Mooter. (2011) Structural Transformations During Swelling of Polycomplex Matrices Based on Countercharged (meth)acrylate Copolymers (EudragitR EPO/EudragitR L 100-55). Journal of Pharmaceutical Sciences 100:3, pages 874-885.
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