686
Views
61
CrossRef citations to date
0
Altmetric
Original Article

Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol® Dispersing

, , , , &
Pages 1064-1078 | Received 07 Oct 2009, Accepted 25 Jan 2010, Published online: 05 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Amira Motawea, Thanaa Borg, Manal Tarshoby & Abd El-Gawad H. Abd El-Gawad. (2017) Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam. Pharmaceutical Development and Technology 22:3, pages 445-456.
Read now
Majeed Ullah, Izhar Hussain & Changquan Calvin Sun. (2016) The development of carbamazepine-succinic acid cocrystal tablet formulations with improved in vitro and in vivo performance. Drug Development and Industrial Pharmacy 42:6, pages 969-976.
Read now
Bo Lang, Sha Liu, James W. McGinity & Robert O. Williams$suffix/text()$suffix/text(). (2016) Effect of hydrophilic additives on the dissolution and pharmacokinetic properties of itraconazole-enteric polymer hot-melt extruded amorphous solid dispersions. Drug Development and Industrial Pharmacy 42:3, pages 429-445.
Read now
Justin R. Hughey, Justin M. Keen, Ryan C. Bennett, Sakae Obara & James W. McGinity. (2015) The incorporation of low-substituted hydroxypropyl cellulose into solid dispersion systems. Drug Development and Industrial Pharmacy 41:8, pages 1294-1301.
Read now
Emilie Gue, Susanne Muschert, Jean-Francois Willart, Florence Danede, Elisabeth Delcourt-Debruyne, Marc Descamps & Juergen Siepmann. (2015) Accelerated ketoprofen release from spray-dried polymeric particles: importance of phase transitions and excipient distribution. Drug Development and Industrial Pharmacy 41:5, pages 838-850.
Read now
Ryan C. Bennett, Chris Brough, Dave A. Miller, Kevin P. O’Donnell, Justin M. Keen, Justin R. Hughey, Robert O. Williams$suffix/text()$suffix/text() & James W. McGinity. (2015) Preparation of amorphous solid dispersions by rotary evaporation and KinetiSol Dispersing: approaches to enhance solubility of a poorly water-soluble gum extract. Drug Development and Industrial Pharmacy 41:3, pages 382-397.
Read now
Yan He, Hongfei Liu, Zhiyong Xie, Qiongfeng Liao, Xiaoping Lai & Zhiyun Du. (2014) PVP and surfactant combined carrier as an effective absorption enhancer of poorly soluble astilbin in vitro and in vivo. Drug Development and Industrial Pharmacy 40:2, pages 237-243.
Read now
Prateek Dani, Vibha Puri & A. K. Bansal. (2014) Solubility advantage from amorphous etoricoxib solid dispersions. Drug Development and Industrial Pharmacy 40:1, pages 92-101.
Read now
Takatsune Yoshida, Ippei Kurimoto, Keiichi Yoshihara, Hiroyuki Umejima, Naoki Ito, Shunsuke Watanabe, Kazuhiro Sako & Akihiko Kikuchi. (2013) Effect of aminoalkyl methacrylate copolymer E/ HCl on in vivo absorption of poorly water-soluble drug. Drug Development and Industrial Pharmacy 39:11, pages 1698-1705.
Read now
Zhi-Liang Zhang, Yuan Le, Jie-Xin Wang, Hong Zhao & Jian-Feng Chen. (2012) Development of stabilized itraconazole nanodispersions by using high-gravity technique. Drug Development and Industrial Pharmacy 38:12, pages 1512-1520.
Read now
Maria A. Miller, James DiNunzio, Michal E. Matteucci, Baltej S. Ludher, Robert O. Williams & Keith P. Johnston. (2012) Flocculated amorphous itraconazole nanoparticles for enhanced in vitro supersaturation and in vivo bioavailability. Drug Development and Industrial Pharmacy 38:5, pages 557-570.
Read now
Weijia Zheng, Akash Jain, Dimitris Papoutsakis, Rose-Marie Dannenfelser, Riccardo Panicucci & Sudhakar Garad. (2012) Selection of oral bioavailability enhancing formulations during drug discovery. Drug Development and Industrial Pharmacy 38:2, pages 235-247.
Read now
Marjana Dürrigl, Maja Lusina Kregar, Anita Hafner, Maja Šegvić Klarić & Jelena Filipović-Grčić. (2011) Mupirocin calcium microencapsulation via spray drying: feed solvent influence on microparticle properties, stability and antimicrobial activity. Drug Development and Industrial Pharmacy 37:12, pages 1402-1414.
Read now

Articles from other publishers (48)

Tanvi Parmar, Pramod Kadu & Pravin Kale. (2023) Critical Strategies for Drug Precipitation Inhibition: A Review with the Focus on Poorly Soluble Drugs. Current Drug Delivery 20:5, pages 497-507.
Crossref
Isaac Corum, Angela Spangenberg, Krystal Miller, Sandra Kucera & Dave Miller. (2023) Minimization of Acid-Catalyzed Degradation in KinetiSol Processing through HPMCAS Neutralization. Molecular Pharmaceutics 20:3, pages 1599-1612.
Crossref
Stephen A. Thompson, Daniel A. DavisJr.Jr., James C. DiNunzio, Charlie Martin, Robert O. WilliamsIIIIII & Feng Zhang. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 327 376 .
Xiangyu Ma, Daniel Ellenberger, Kevin P. O’Donnell & Robert O. WilliamsIIIIII. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 33 102 .
Daniel A. DavisJr.Jr., Rishi Thakkar, Mohammed Maniruzzaman, Dave A. Miller & Robert O. WilliamsIIIIII. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 599 650 .
Durgesh K. Jha, Devanshi S. Shah & Purnima D. Amin. (2021) Effect of Hypromellose Acetate Succinate Substituents on Miscibility Behavior of Spray-dried Amorphous Solid Dispersions: Flory–Huggins Parameter Prediction and Validation. Carbohydrate Polymer Technologies and Applications 2, pages 100137.
Crossref
Andrea Pugliese, Michael Toresco, Daniel McNamara, Dinu Iuga, Anuji Abraham, Michael Tobyn, Lucy E. Hawarden & Frédéric Blanc. (2021) Drug–Polymer Interactions in Acetaminophen/Hydroxypropylmethylcellulose Acetyl Succinate Amorphous Solid Dispersions Revealed by Multidimensional Multinuclear Solid-State NMR Spectroscopy. Molecular Pharmaceutics 18:9, pages 3519-3531.
Crossref
Maria C. Paisana, Paulo R. Lino, Patricia D. Nunes, João F. Pinto, João Henriques & Ana Mafalda Paiva. (2021) Laser diffraction as a powerful tool for amorphous solid dispersion screening and dissolution understanding. European Journal of Pharmaceutical Sciences 163, pages 105853.
Crossref
Ha Ryeong Lee, Hyun Jin Park, Jun Soo Park, Dong Woo Park, Myoung Jin Ho, Dong Yoon Kim, Hyo Chun Lee, Eun Jeong Kim, Woo Heon Song, Jun Sang Park, Yong Seok Choi & Myung Joo Kang. (2021) Montelukast microsuspension with hypromellose for improved stability and oral absorption. International Journal of Biological Macromolecules 183, pages 1732-1742.
Crossref
Donald J. AbrahamShobha N. Bhattachar, Jeffrey S. Tan, Stephen Dion Stamatis & Jon Hilden. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 34 .
Asmita Adhikari & James E. Polli. (2020) Characterization of Grades of HPMCAS Spray Dried Dispersions of Itraconazole Based on Supersaturation Kinetics and Molecular Interactions Impacting Formulation Performance. Pharmaceutical Research 37:10.
Crossref
Yiwei Tian, Esther Jacobs, David S. Jones, Colin P. McCoy, Han Wu & Gavin P. Andrews. (2020) The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion platform. International Journal of Pharmaceutics 586, pages 119545.
Crossref
Zahari Vinarov, Gabriela Gancheva, Nikola Burdzhiev & Slavka Tcholakova. (2020) Solubilization of itraconazole by surfactants and phospholipid-surfactant mixtures: interplay of amphiphile structure, pH and electrostatic interactions. Journal of Drug Delivery Science and Technology 57, pages 101688.
Crossref
Xiangyu Ma, Felix Müller, Siyuan Huang, Michael Lowinger, Xu Liu, Rebecca Schooler & Robert O. WilliamsIIIIII. (2020) Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt Extrusion. Pharmaceutics 12:4, pages 379.
Crossref
Andrea Pugliese, Lucy E. Hawarden, Anuji Abraham, Michael Tobyn & Frédéric Blanc. (2020) Solid state nuclear magnetic resonance studies of hydroxypropylmethylcellulose acetyl succinate polymer, a useful carrier in pharmaceutical solid dispersions. Magnetic Resonance in Chemistry.
Crossref
Yoshiaki Umemoto, Shinya Uchida, Takatsune Yoshida, Ken Shimada, Hiroyuki Kojima, Akira Takagi, Shimako Tanaka, Yasuharu Kashiwagura & Noriyuki Namiki. (2020) An effective polyvinyl alcohol for the solubilization of poorly water-soluble drugs in solid dispersion formulations. Journal of Drug Delivery Science and Technology 55, pages 101401.
Crossref
Nayan G. Solanki, Kyle Lam, Md Tahsin, Suhas G. Gumaste, Ankita V. Shah & Abu T.M. Serajuddin. (2019) Effects of Surfactants on Itraconazole-HPMCAS Solid Dispersion Prepared by Hot-Melt Extrusion I: Miscibility and Drug Release. Journal of Pharmaceutical Sciences 108:4, pages 1453-1465.
Crossref
Daniel J. Ellenberger, Dave A. Miller, Sandra U. Kucera & Robert O. WilliamsIIIIII. (2018) Generation of a Weakly Acidic Amorphous Solid Dispersion of the Weak Base Ritonavir with Equivalent In Vitro and In Vivo Performance to Norvir Tablet. AAPS PharmSciTech 19:5, pages 1985-1997.
Crossref
Daniel J. Ellenberger, Dave A. Miller & Robert O. WilliamsIIIIII. (2018) Expanding the Application and Formulation Space of Amorphous Solid Dispersions with KinetiSol®: a Review. AAPS PharmSciTech 19:5, pages 1933-1956.
Crossref
Estelle J.A. Suys, David K. Chalmers, Colin W. Pouton & Christopher J.H. Porter. (2018) Polymeric Precipitation Inhibitors Promote Fenofibrate Supersaturation and Enhance Drug Absorption from a Type IV Lipid-Based Formulation. Molecular Pharmaceutics 15:6, pages 2355-2371.
Crossref
TengIan Chan & Defang Ouyang. (2018) Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations. Asian Journal of Pharmaceutical Sciences 13:3, pages 248-254.
Crossref
Scott V. Jermain, Chris Brough & Robert O. WilliamsIIIIII. (2018) Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery – An update. International Journal of Pharmaceutics 535:1-2, pages 379-392.
Crossref
Riikka Laitinen, Korbinian Löbmann, Holger Grohganz, Petra Priemel, Clare J. Strachan & Thomas Rades. (2017) Supersaturating drug delivery systems: The potential of co-amorphous drug formulations. International Journal of Pharmaceutics 532:1, pages 1-12.
Crossref
Justin S. LaFountaine, Leena Kumari Prasad, Dave A. Miller, James W. McGinity & Robert O. WilliamsIIIIII. (2017) Mucoadhesive amorphous solid dispersions for sustained release of poorly water soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics 113, pages 157-167.
Crossref
Zhenbao Li, Meiyu Zhang, Chang Liu, Shiwei Zhou, Wenjuan Zhang, Tianyang Wang, Mei Zhou, Xiaohong Liu, Yongjun Wang, Yinghua Sun & Jin Sun. (2017) Development of Liposome containing sodium deoxycholate to enhance oral bioavailability of itraconazole. Asian Journal of Pharmaceutical Sciences 12:2, pages 157-164.
Crossref
Justin R. Hughey. 2017. Poorly Soluble Drugs. Poorly Soluble Drugs 393 418 .
Chris Brough, Dave A. Miller, Daniel Ellenberger, Dieter Lubda & Robert O. WilliamsIIIIII. (2016) Use of Polyvinyl Alcohol as a Solubility Enhancing Polymer for Poorly Water-Soluble Drug Delivery (Part 2). AAPS PharmSciTech 17:1, pages 180-190.
Crossref
Justin S. LaFountaine, Leena Kumari Prasad, Chris Brough, Dave A. Miller, James W. McGinity & Robert O. WilliamsIIIIII. (2015) Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions. AAPS PharmSciTech 17:1, pages 120-132.
Crossref
Justin S. LaFountaine, James W. McGinity & Robert O. WilliamsIIIIII. (2015) Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review. AAPS PharmSciTech 17:1, pages 43-55.
Crossref
Abbe Haser, James C. DiNunzio, Charlie Martin, James W. McGinity & Feng Zhang. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 383 435 .
Daniel Ellenberger, Kevin P. O’Donnell & Robert O. WilliamsIIIIII. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 41 120 .
Leena Kumari Prasad, Justin R. Hughey, James W. McGinity, Dave A. Miller & Robert O. WilliamsIIIIII. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 691 740 .
Yan He & Chris Ho. (2015) Amorphous Solid Dispersions: Utilization and Challenges in Drug Discovery and Development. Journal of Pharmaceutical Sciences 104:10, pages 3237-3258.
Crossref
Rajendra Narayan Dash, Habibuddin Mohammed, Touseef Humaira & Atla Venkateshwara Reddy. (2015) Solid supersaturatable self-nanoemulsifying drug delivery systems for improved dissolution, absorption and pharmacodynamic effects of glipizide. Journal of Drug Delivery Science and Technology 28, pages 28-36.
Crossref
Ryan C Bennett, Justin M Keen, Yunxia (Vivian) Bi, Stuart Porter, Thomas Dürig & James W McGinity. (2015) Investigation of the interactions of enteric and hydrophilic polymers to enhance dissolution of griseofulvin following hot melt extrusion processing. Journal of Pharmacy and Pharmacology 67:7, pages 918-938.
Crossref
Padma Narayan, William W. PorterIIIIII, Meinolf Brackhagen & Christopher Tucker. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 43 .
Majeed Ullah, Hanif Ullah, Ghulam Murtaza, Qaisar Mahmood & Izhar Hussain. (2015) Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets. BioMed Research International 2015, pages 1-10.
Crossref
Jenna L. Terebetski, John J. Cummings, Scott E. Fauty & Bozena Michniak-Kohn. (2014) Combined Use of Crystalline Sodium Salt and Polymeric Precipitation Inhibitors to Improve Pharmacokinetic Profile of Ibuprofen through Supersaturation. AAPS PharmSciTech 15:5, pages 1334-1344.
Crossref
Sen Xu & Wei-Guo Dai. (2013) Drug precipitation inhibitors in supersaturable formulations. International Journal of Pharmaceutics 453:1, pages 36-43.
Crossref
James C. DiNunzio & Dave A. Miller. 2013. Melt Extrusion. Melt Extrusion 161 203 .
Ping Gao & Yi Shi. (2012) Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs. The AAPS Journal 14:4, pages 703-713.
Crossref
Justin R. Hughey, Justin M. Keen, Dave A. Miller, Chris Brough & James W. McGinity. (2012) Preparation and characterization of fusion processed solid dispersions containing a viscous thermally labile polymeric carrier. International Journal of Pharmaceutics 438:1-2, pages 11-19.
Crossref
James C. DiNunzio, Feng Zhang, Charlie Martin & James W. McGinity. 2012. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 311 362 .
Kevin P. O’Donnell & Robert O. WilliamsIIIIII. 2012. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 27 93 .
Justin R. Hughey & James W. McGinity. 2012. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 569 602 .
Justin R. Hughey, Justin M. Keen, Chris Brough, Sophie Saeger & James W. McGinity. (2011) Thermal processing of a poorly water-soluble drug substance exhibiting a high melting point: The utility of KinetiSol® Dispersing. International Journal of Pharmaceutics 419:1-2, pages 222-230.
Crossref
Taro Yamashita, Shunsuke Ozaki & Ikuo Kushida. (2011) Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide. International Journal of Pharmaceutics 419:1-2, pages 170-174.
Crossref
Justin R. Hughey, James C. DiNunzio, Ryan C. Bennett, Chris Brough, Dave A. Miller, Hua Ma, Robert O. WilliamsIIIIII & James W. McGinity. (2010) Dissolution Enhancement of a Drug Exhibiting Thermal and Acidic Decomposition Characteristics by Fusion Processing: A Comparative Study of Hot Melt Extrusion and KinetiSol® Dispersing. AAPS PharmSciTech 11:2, pages 760-774.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.