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Drug Development and Industrial Pharmacy Volume 37, 2011 - Issue 6
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Review Article

Enhanced in vivo absorption of CB-1 antagonist in rats via solid solutions prepared by hot-melt extrusion

L.S. RanzaniESTEVE Lab, Pharmaceutical Innovation and Pharmacokinetic department, Poligono Industrial c/Sant Marti, Barcelona, SpainCorrespondence[email protected]
,
J. FontESTEVE Lab, Pharmaceutical Innovation and Pharmacokinetic department, Poligono Industrial c/Sant Marti, Barcelona, Spain
,
F. GalimanyESTEVE Lab, Pharmaceutical Innovation and Pharmacokinetic department, Poligono Industrial c/Sant Marti, Barcelona, Spain
,
A. SantanachESTEVE Lab, Pharmaceutical Innovation and Pharmacokinetic department, Poligono Industrial c/Sant Marti, Barcelona, Spain
,
A.M. Gomez-GomarESTEVE Lab, Pharmaceutical Innovation and Pharmacokinetic department, Poligono Industrial c/Sant Marti, Barcelona, Spain
,
G. CasadevallESTEVE Lab, Pharmaceutical Innovation and Pharmacokinetic department, Poligono Industrial c/Sant Marti, Barcelona, Spain
&
A. GryczkeEvonick Rohm GmbH Pharma Polymere, Darmstadt, Germany
 show all
Pages 694-701 | Received 08 Jun 2010, Accepted 25 Oct 2010, Published online: 13 Jan 2011

Citations (16)

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Sophia Yui Kau Fong, Annette Bauer-Brandl & Martin Brandl. (2017) Oral bioavailability enhancement through supersaturation: an update and meta-analysis. Expert Opinion on Drug Delivery 14:3, pages 403-426.
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Mohammad A. Altamimi & Steven H. Neau. (2016) Use of the Flory–Huggins theory to predict the solubility of nifedipine and sulfamethoxazole in the triblock, graft copolymer Soluplus. Drug Development and Industrial Pharmacy 42:3, pages 446-455.
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Elena Ravina-Eirin, J. L. Gomez-Amoza & Ramón Martínez-Pacheco. (2015) Drug dispersion degree and drug dissolution rate in Hybrane S1200-based instant-release matricial particles prepared by hot melt extrusion. Drug Development and Industrial Pharmacy 41:6, pages 1000-1005.
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Bo Lang, James W. McGinity & Robert O. Williams$suffix/text()$suffix/text(). (2014) Hot-melt extrusion – basic principles and pharmaceutical applications. Drug Development and Industrial Pharmacy 40:9, pages 1133-1155.
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Michael M. Leane, Wayne Sinclair, Feng Qian, Raja Haddadin, Alan Brown, Mike Tobyn & Andrew B. Dennis. (2013) Formulation and process design for a solid dosage form containing a spray-dried amorphous dispersion of ibipinabant. Pharmaceutical Development and Technology 18:2, pages 359-366.
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Weibin Deng, Soumyajit Majumdar, Abhilasha Singh, Sejal Shah, Noorullah Naqvi Mohammed, Seongbong Jo, Elanor Pinto, Divya Tewari, Thomas Durig & Michael A. Repka. (2013) Stabilization of fenofibrate in low molecular weight hydroxypropylcellulose matrices produced by hot-melt extrusion. Drug Development and Industrial Pharmacy 39:2, pages 290-298.
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Min Yang, Peng Wang & Costas Gogos. (2013) Prediction of acetaminophen’s solubility in poly(ethylene oxide) at room temperature using the Flory–Huggins theory. Drug Development and Industrial Pharmacy 39:1, pages 102-108.
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Vivek S. Dave, Raafat M. Fahmy, Dennis Bensley & Stephen W. Hoag. (2012) Eudragit® RS PO/RL PO as rate-controlling matrix-formers via roller compaction: Influence of formulation and process variables on functional attributes of granules and tablets. Drug Development and Industrial Pharmacy 38:10, pages 1240-1253.
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Weijia Zheng, Akash Jain, Dimitris Papoutsakis, Rose-Marie Dannenfelser, Riccardo Panicucci & Sudhakar Garad. (2012) Selection of oral bioavailability enhancing formulations during drug discovery. Drug Development and Industrial Pharmacy 38:2, pages 235-247.
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Articles from other publishers (7)

Dajun D. Sun, Hong Wen & Lynne S. Taylor. (2016) Non-Sink Dissolution Conditions for Predicting Product Quality and In Vivo Performance of Supersaturating Drug Delivery Systems. Journal of Pharmaceutical Sciences 105:9, pages 2477-2488.
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Milica Stanković, Henderik W. Frijlink & Wouter L.J. Hinrichs. (2015) Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization. Drug Discovery Today 20:7, pages 812-823.
Crossref
Jenna L. Terebetski, John J. Cummings, Scott E. Fauty & Bozena Michniak-Kohn. (2014) Combined Use of Crystalline Sodium Salt and Polymeric Precipitation Inhibitors to Improve Pharmacokinetic Profile of Ibuprofen through Supersaturation. AAPS PharmSciTech 15:5, pages 1334-1344.
Crossref
Sejal Shah, Sindhuri Maddineni, Jiannan Lu & Michael A. Repka. (2013) Melt extrusion with poorly soluble drugs. International Journal of Pharmaceutics 453:1, pages 233-252.
Crossref
Karl Kolter. 2013. Melt Extrusion. Melt Extrusion 83 105 .
Ping Gao & Yi Shi. (2012) Characterization of Supersaturatable Formulations for Improved Absorption of Poorly Soluble Drugs. The AAPS Journal 14:4, pages 703-713.
Crossref
Kathrin Nollenberger & Jessica Albers. 2012. Hot‐Melt Extrusion: Pharmaceutical Applications. Hot‐Melt Extrusion: Pharmaceutical Applications 113 144 .

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