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Research Article

Combination of β-cyclodextrin inclusion complex and self-microemulsifying drug delivery system for photostability and enhanced oral bioavailability of methotrexate: novel technique

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Pages 918-927 | Received 19 Feb 2012, Accepted 01 Aug 2012, Published online: 24 Sep 2012

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Dong Shik Kim, Jung Hyun Cho, Jong Hyuck Park, Jung Suk Kim, Eon Soo Song, Jaewook Kwon, Bhupendra Raj Giri, Sung Giu Jin, Kyeong Soo Kim, Han-Gon Choi & Dong Wuk Kim. (2019) Self-microemulsifying drug delivery system (SMEDDS) for improved oral delivery and photostability of methotrexate. International Journal of Nanomedicine 14, pages 4949-4960.
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Aamir Aman, Saba Ali, Panupong Mahalapbutr, Kuakarun Krusong, Peter Wolschann & Thanyada Rungrotmongkol. (2023) Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies . RSC Advances 13:39, pages 27244-27254.
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Mrugank Pandya, Bappaditya Chatterjee & Srikar Ganti. (2022) Self-emulsifying Drug Delivery System for Oral Anticancer Therapy: Constraints and Recent Development. Current Pharmaceutical Design 28:31, pages 2538-2553.
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Bhupendra Raj Giri, Jung Suk Kim, Jong Hyuck Park, Sung Giu Jin, Kyeong Soo Kim, Fakhar ud Din, Han Gon Choi & Dong Wuk Kim. (2021) Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium. Pharmaceutics 13:1, pages 111.
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Aristote B. Buya, Ana Beloqui, Patrick B. Memvanga & Véronique Préat. (2020) Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery. Pharmaceutics 12:12, pages 1194.
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Ana J. Coutinho, Sofia A. Costa Lima, Carlos M.M. Afonso & Salette Reis. (2020) Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate. International Journal of Biological Macromolecules 158, pages 180-188.
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Zsolt Preisz, Zoltán Nagymihály, Beáta Lemli, László Kollár & Sándor Kunsági-Máté. (2020) Weak Interaction of the Antimetabolite Drug Methotrexate with a Cavitand Derivative. International Journal of Molecular Sciences 21:12, pages 4345.
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Sedigheh Azizi, Hamed Nosrati, Ali Sharafi & Hossein Danafar. (2019) Preparation of bismuth sulfide nanoparticles as targeted biocompatible nano‐radiosensitizer and carrier of methotrexate. Applied Organometallic Chemistry 34:1.
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Mamunur Rashid, Mohd Yaseen Malik, Sandeep K. Singh, Swati Chaturvedi, Jiaur R Gayen & Muhammad Wahajuddin. (2019) Bioavailability Enhancement of Poorly Soluble Drugs: The Holy Grail in Pharma Industry. Current Pharmaceutical Design 25:9, pages 987-1020.
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Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi & Hossein Danafar. (2018) Amphiphilic Y shaped miktoarm star copolymer for anticancer hydrophobic and hydrophilic drugs codelivery: Synthesis, characterization, in vitro , and in vivo biocompatibility study . Journal of Biomedical Materials Research Part A 106:11, pages 2817-2826.
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Iliya Kritskiy, Roman Kumeev, Tatyana Volkova, Dmitry Shipilov, Natalya Kutyasheva, Mikhail Grachev & Irina Terekhova. (2018) Selective binding of methotrexate to monomeric, dimeric and polymeric cyclodextrins. New Journal of Chemistry 42:17, pages 14559-14567.
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Agnieszka Popielec & Thorsteinn Loftsson. (2017) Effects of cyclodextrins on the chemical stability of drugs. International Journal of Pharmaceutics 531:2, pages 532-542.
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Xiuyan Wang & Husheng Yan. (2017) Methotrexate-loaded porous polymeric adsorbents as oral sustained release formulations. Materials Science and Engineering: C 78, pages 598-602.
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Jie Xiao, Yong Cao & Qingrong Huang. (2017) Edible Nanoencapsulation Vehicles for Oral Delivery of Phytochemicals: A Perspective Paper. Journal of Agricultural and Food Chemistry 65:32, pages 6727-6735.
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Raj Kumar Thapa, Han-Gon Choi, Jong Oh Kim & Chul Soon Yong. (2017) Analysis and optimization of drug solubility to improve pharmacokinetics. Journal of Pharmaceutical Investigation 47:2, pages 95-110.
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Zhongcheng Ke, Zhenghai Zhang, Hao Wu, Xiaobin Jia & Youjie Wang. (2017) Optimization and evaluation of Oridonin-loaded Soluplus ® -Pluronic P105 mixed micelles for oral administration. International Journal of Pharmaceutics 518:1-2, pages 193-202.
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A. Saneja, N. Alam, R.D. Dubey & P.N. Gupta. 2016. Nanoarchitectonics for Smart Delivery and Drug Targeting. Nanoarchitectonics for Smart Delivery and Drug Targeting 379 404 .
Anuj G. Agrawal, Ashok Kumar & Paraag S. Gide. (2015) Self emulsifying drug delivery system for enhanced solubility and dissolution of glipizide. Colloids and Surfaces B: Biointerfaces 126, pages 553-560.
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Yasuo InoueNoboru SekiyaMasanobu YamamotoDaisuke Iohara, Fumitoshi Hirayama & Kaneto Uekama. (2015) Formation of the Ternary Inclusion Complex of Limaprost with α- and β-Cyclodextrins in Aqueous Solution. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 63:5, pages 318-325.
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