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Research Article

Enhancement by sodium caprate and sodium deoxycholate of the gastrointestinal absorption of berberine chloride in rats

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Pages 1447-1456 | Received 10 Jun 2012, Accepted 15 Aug 2012, Published online: 01 Oct 2012

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Teruo Murakami, Erik Bodor & Nicholas Bodor. (2023) Approaching strategy to increase the oral bioavailability of berberine, a quaternary ammonium isoquinoline alkaloid: part 2. development of oral dosage formulations. Expert Opinion on Drug Metabolism & Toxicology 19:3, pages 139-148.
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Yuan Kong, Lin Li, Lin-Guo Zhao, Pan Yu & Dong-Dong Li. (2022) A patent review of berberine and its derivatives with various pharmacological activities (2016–2020). Expert Opinion on Therapeutic Patents 32:2, pages 211-223.
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Sam Maher, Caroline Geoghegan & David J. Brayden. (2021) Intestinal permeation enhancers to improve oral bioavailability of macromolecules: reasons for low efficacy in humans. Expert Opinion on Drug Delivery 18:2, pages 273-300.
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Mitali H. Patel, Veenu P. Mundada & Krutika K. Sawant. (2019) Fabrication of solid lipid nanoparticles of lurasidone HCl for oral delivery: optimization, in vitro characterization, cell line studies and in vivo efficacy in schizophrenia. Drug Development and Industrial Pharmacy 45:8, pages 1242-1257.
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Fiona McCartney, John P. Gleeson & David J. Brayden. (2016) Safety concerns over the use of intestinal permeation enhancers: A mini-review. Tissue Barriers 4:2.
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Seung Rim Hwang, In Jae Kim & Jin Woo Park. (2015) Formulations of deoxycholic for therapy: a patent review (2011 – 2014). Expert Opinion on Therapeutic Patents 25:12, pages 1423-1440.
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Christian Tscheik, Ingolf E. Blasig & Lars Winkler. (2013) Trends in drug delivery through tissue barriers containing tight junctions. Tissue Barriers 1:2.
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Articles from other publishers (24)

Nobuhiro Mori, Keisuke Oda, Hideki Takakura, Yusuke Tanaka, Tomoharu Yokooji & Teruo Murakami. (2023) Comparison of Berberine Bioavailability between Oral and Rectal Administrations in Rats. Biological and Pharmaceutical Bulletin 46:11, pages 1639-1642.
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Célia Marques, Maria Helena Fernandes & Sofia A. Costa Lima. (2023) Elucidating Berberine’s Therapeutic and Photosensitizer Potential through Nanomedicine Tools. Pharmaceutics 15:9, pages 2282.
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Yang Gao, Jianmei Sun, Shucong Wang, Lisong Huxiao, Yali Xu & Hailong Zhang. (2023) DSPE-PEG polymer enhanced berberine absorption specifically in the small intestine of rats through paracellular passway. Journal of Pharmacy and Pharmacology 75:7, pages 931-939.
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Fengjiao Xu, Meiyan Liu, Yating Liao, Ya Zhou, Peng Zhang, Youlin Zeng & Zhonghua Liu. (2022) Improvement of anticancer effect of berberine by salt formation modifications. Phytomedicine 104, pages 154314.
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Maisarah Azman, Akmal H. Sabri, Qonita Kurnia Anjani, Mohd Faiz Mustaffa & Khuriah Abdul Hamid. (2022) Intestinal Absorption Study: Challenges and Absorption Enhancement Strategies in Improving Oral Drug Delivery. Pharmaceuticals 15:8, pages 975.
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Md Ali Mujtaba, Md Habban Akhter, Md. Sarfaraz Alam, Mohammad Daud Ali & Afzal Hussain. (2022) An Updated Review on Therapeutic Potential and Recent Advances in Drug Delivery of Berberine: Current Status and Future Prospect. Current Pharmaceutical Biotechnology 23:1, pages 60-71.
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Shikha Lohan, Teenu Sharma, Sumant Saini, Arti Singh, Anil Kumar, Kaisar Raza, Jalseen Kaur & Bhupinder Singh. (2021) Galactosylated nanoconstructs of Berberine with enhanced Biopharmaceutical and cognitive potential: A preclinical evidence in Alzheimer ‘s disease. Journal of Drug Delivery Science and Technology 66, pages 102695.
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Sarika Narade & Yogesh Pore. (2021) ASSESSMENT OF PERMEABILITY BEHAVIOR OF BERBERINE CHLORIDE ACROSS GOAT INTESTINAL MEMBRANE IN PRESENCE OF NATURAL BIOPOTENTIATOR CURCUMIN. INDIAN DRUGS 58:4, pages 23-27.
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Feifei Qiu, Weihui Lu, Shulin Ye, Huazhen Liu, Qiaohuang Zeng, Haiding Huang, Chun-Ling Liang, Yuchao Chen, Fang Zheng, Qunfang Zhang, Chuan-Jian Lu & Zhenhua Dai. (2021) Berberine Promotes Induction of Immunological Tolerance to an Allograft via Downregulating Memory CD8+ T-Cells Through Altering the Gut Microbiota. Frontiers in Immunology 12.
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Meng Li, Wenjun Zhou, Yanqi Dang, Chunlin Li, Guang Ji & Li Zhang. (2020) Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice. Biomedicine & Pharmacotherapy 132, pages 110953.
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Xiaolei Ma, Tingting Zhang, Zhigang Luo, Xiaolin Li, Miao Lin, Rui Li, Peng Du, Xiaoyou Yu, Chen Ma, Pengju Yan, Jin Su, Lulu Wang, Yuhuan Li & Jiandong Jiang. (2020) Functional nano-vector boost anti-atherosclerosis efficacy of berberine in Apoe() mice. Acta Pharmaceutica Sinica B 10:9, pages 1769-1783.
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Belén Begines, Tamara Ortiz, María Pérez-Aranda, Guillermo Martínez, Manuel Merinero, Federico Argüelles-Arias & Ana Alcudia. (2020) Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects. Nanomaterials 10:7, pages 1403.
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Sok Kuan Wong, Kok-Yong Chin & Soelaiman Ima-Nirwana. (2020) Berberine and musculoskeletal disorders: The therapeutic potential and underlying molecular mechanisms. Phytomedicine 73, pages 152892.
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Hui-Hui Guo, Chen-Lin Feng, Wen-Xuan Zhang, Zhi-Gang Luo, Hong-Juan Zhang, Ting-Ting Zhang, Chen Ma, Yun Zhan, Rui Li, Song Wu, Zeper Abliz, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Lu-Lu Wang, Wen-Sheng Zheng, Yan-Xing Han & Jian-Dong Jiang. (2019) Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. Nature Communications 10:1.
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Jingfu Jia, Kerong Zhang, Xue Zhou, Dan Zhou & Fahuan Ge. (2018) Precise Dissolution Control and Bioavailability Evaluation for Insoluble Drug Berberine via a Polymeric Particle Prepared Using Supercritical CO2. Polymers 10:11, pages 1198.
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Yanwen Wang & Jeffrey A. Zidichouski. (2018) Update on the Benefits and Mechanisms of Action of the Bioactive Vegetal Alkaloid Berberine on Lipid Metabolism and Homeostasis. Cholesterol 2018, pages 1-17.
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Y. Gao, X. Jin, Y. Sun, F.F. Xu & M. Zhang. (2018) Production and investigation of sustained berberine pellet drug release system. Advanced Powder Technology 29:3, pages 682-691.
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Antonello Santini & Ettore Novellino. (2017) Nutraceuticals in hypercholesterolaemia: an overview. British Journal of Pharmacology 174:11, pages 1450-1463.
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Mohamed Amine Djebbi, Alae Elabed, Zaineb Bouaziz, Moulay Sadiki, Soumya Elabed, Philippe Namour, Nicole Jaffrezic-Renault & Abdesslem Ben Haj Amara. (2016) Delivery system for berberine chloride based on the nanocarrier ZnAl-layered double hydroxide: Physicochemical characterization, release behavior and evaluation of anti-bacterial potential. International Journal of Pharmaceutics 515:1-2, pages 422-430.
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Guofei Li, Fan Yang, Mei Liu, Xianying Su, Mingming Zhao & Limei Zhao. (2016) Development and application of a UPLC-MS/MS method for simultaneous determination of fenofibric acid and berberine in rat plasma: application to the drug-drug pharmacokinetic interaction study of fenofibrate combined with berberine after oral administrati. Biomedical Chromatography 30:7, pages 1075-1082.
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Chang-Shun Liu, Yu-Rong Zheng, Ying-Feng Zhang & Xiao-Ying Long. (2016) Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia 109, pages 274-282.
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David J. Brayden, Sam Maher, Bojlul Bahar & Edwin Walsh. (2015) Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol. European Journal of Pharmaceutics and Biopharmaceutics 94, pages 194-206.
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David J. Brayden & Edwin Walsh. (2014) Efficacious Intestinal Permeation Enhancement Induced by the Sodium Salt of 10-undecylenic Acid, A Medium Chain Fatty Acid Derivative. The AAPS Journal 16:5, pages 1064-1076.
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Chandraiah Godugu, Apurva R. Patel, Ravi Doddapaneni, Jaganmohan Somagoni & Mandip Singh. (2014) Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid. PLoS ONE 9:3, pages e89919.
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