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Drug Development and Industrial Pharmacy Volume 41, 2015 - Issue 3
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Research Article

Self-assembled liquid crystalline nanoparticles as an ophthalmic drug delivery system. Part II: optimization of formulation variables using experimental design

Djamila AchouriIMBE, UMR CNRS, Aix-Marseille Université, Marseille, France, ;Thèse CIFRE Horus Pharma, St Laurent du Var, France, ;Laboratoire de Pharmacie Galénique Industrielle et Cosmétologie, Faculté de Pharmacie, Marseille, France,
,
Michelle SergentLaboratoire d'Instrumentation et Sciences Analytiques, Faculté des Sciences et Techniques, Campus de St Jérôme, Marseille, France,
,
Alain TonettoPlateforme PRATIM, Fédération des Sciences Chimiques de Marseille, Aix-Marseille Université, Marseille, France,
,
Philippe PiccerelleIMBE, UMR CNRS, Aix-Marseille Université, Marseille, France, ;Laboratoire de Pharmacie Galénique Industrielle et Cosmétologie, Faculté de Pharmacie, Marseille, France,
,
Véronique AndrieuLaboratoire de Pharmacie Galénique Industrielle et Cosmétologie, Faculté de Pharmacie, Marseille, France, ;Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UMR CNRS, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, Marseille, France, and Correspondence[email protected]
&
Virginie HornebecqLaboratoire MADIREL, CNRS – UMR, Aix-Marseille Université, Centre de St Jérôme, Marseille, France
Pages 493-501 | Received 22 Apr 2013, Accepted 07 Jan 2014, Published online: 13 Feb 2014

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Ana Vitoria Pupo Silvestrini, Angelo Luis Caron, Juliana Viegas, Fabíola Garcia Praça & Maria Vitoria Lopes Badra Bentley. (2020) Advances in lyotropic liquid crystal systems for skin drug delivery. Expert Opinion on Drug Delivery 17:12, pages 1781-1805.
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Junfeng Ban, Yan Zhang, Xin Huang, Guanghan Deng, Dongzhi Hou, Yanzhong Chen & Zhufen Lu. (2017) Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone. International Journal of Nanomedicine 12, pages 1329-1339.
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Liling Mei, Yecheng Xie, Hui Jing, Ying Huang, Jintian Chen, Hao Ran, Xin Pan & Chuanbin Wu. (2017) A novel design for stable self-assembly cubosome precursor-microparticles enhancing dissolution of insoluble drugs. Drug Development and Industrial Pharmacy 43:8, pages 1239-1243.
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Stavros N. Politis, Paolo Colombo, Gaia Colombo & Dimitrios M. Rekkas. (2017) Design of experiments (DoE) in pharmaceutical development. Drug Development and Industrial Pharmacy 43:6, pages 889-901.
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Huifeng Di, Haiyan Wu, Ying Gao, Weihua Li, Dongna Zou & Chuanhai Dong. (2016) Doxorubicin- and cisplatin-loaded nanostructured lipid carriers for breast cancer combination chemotherapy. Drug Development and Industrial Pharmacy 42:12, pages 2038-2043.
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Fuhong Qin, Li Zeng, Yongtao Zhu, Jingjing Cao, Xiaohui Wang & Wei Liu. (2016) Preparation and evaluation of a timolol maleate drug–resin ophthalmic suspension as a sustained-release formulation in vitro and in vivo. Drug Development and Industrial Pharmacy 42:4, pages 535-545.
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Sakshi Priya, Gorantla Srividya, Nittala Sarath Chandra, Prem Prakash Singh, Ranendra N. Saha, Priyadarshini Sathe, Jayabalan Nirmal & Gautam Singhvi. (2023) Loteprednol etabonate loaded lyotropic liquid crystalline nanoparticles in-situ ophthalmic gel: Qbd driven optimization and in-vitro, ex-vivo evidence of sustained precorneal residence time. Journal of Drug Delivery Science and Technology 89, pages 105081.
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Mohamed A. El-Gendy, Mai Mansour, Mona I. A. El-Assal, Rania A. H. Ishak & Nahed D. Mortada. (2023) Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy. Pharmaceutics 15:3, pages 954.
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Shreya Kaul, Upendra Nagaich & Navneet Verma. (2021) Preclinical assessment of nanostructured liquid crystalline particles for the management of bacterial keratitis: in vivo and pharmacokinetics study. Drug Delivery and Translational Research 12:7, pages 1719-1737.
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Amol Shete, Sameer Nadaf, Rajendra Doijad & Suresh Killedar. (2021) Liquid Crystals: Characteristics, Types of Phases and Applications in Drug Delivery. Pharmaceutical Chemistry Journal 55:2, pages 106-118.
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Arisha Mahmood, Vamshi Krishna Rapalli, Tejashree Waghule, Srividya Gorantla & Gautam Singhvi. (2021) Luliconazole loaded lyotropic liquid crystalline nanoparticles for topical delivery: QbD driven optimization, in-vitro characterization and dermatokinetic assessment. Chemistry and Physics of Lipids 234, pages 105028.
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Shihui Yu, Guoxin Tan, Dandan Liu, Xinggang Yang & Weisan Pan. (2017) Nanostructured lipid carrier (NLC)-based novel hydrogels as potential carriers for nepafenac applied after cataract surgery for the treatment of inflammation: design, characterization and in vitro cellular inhibition and uptake studies. RSC Advances 7:27, pages 16668-16677.
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Rui Liu, Shuangshuang Wang, Shiming Fang, Jialu Wang, Jingjing Chen, Xingguo Huang, Xin He & Changxiao Liu. (2016) Liquid Crystalline Nanoparticles as an Ophthalmic Delivery System for Tetrandrine: Development, Characterization, and In Vitro and In Vivo Evaluation. Nanoscale Research Letters 11:1.
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Kariane M. Nunes, Cristian C.C. Teixeira, Renata C.K. Kaminski, Victor H.V. Sarmento, Renê O. Couto, Sandra H. Pulcinelli & Osvaldo Freitas. (2016) The Monoglyceride Content Affects the Self-Assembly Behavior, Rheological Properties, Syringeability, and Mucoadhesion of In Situ–Gelling Liquid Crystalline Phase. Journal of Pharmaceutical Sciences 105:8, pages 2355-2364.
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Krishna Sanka, Deepthi Suda & Vasudha Bakshi. (2016) Optimization of solid-self nanoemulsifying drug delivery system for solubility and release profile of clonazepam using simplex lattice design. Journal of Drug Delivery Science and Technology 33, pages 114-124.
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