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Research Article

Design, characterization and ex vivo evaluation of chitosan film integrating of insulin nanoparticles composed of thiolated chitosan derivative for buccal delivery of insulin

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Pages 691-698 | Received 08 Nov 2013, Accepted 19 Jan 2014, Published online: 14 Feb 2014

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Nusaiba K. Al-Nemrawi, Sara S. M. Alsharif, Karem H. Alzoubi & Rami Q. Alkhatib. (2019) Preparation and characterization of insulin chitosan-nanoparticles loaded in buccal films. Pharmaceutical Development and Technology 24:8, pages 967-974.
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Yu Tian, Mine Orlu, Herman J. Woerdenbag, Mariagiovanna Scarpa, Olga Kiefer, Dina Kottke, Erica Sjöholm, Heidi Öblom, Niklas Sandler, Wouter L. J. Hinrichs, Henderik W. Frijlink, Jörg Breitkreutz & J. Carolina Visser. (2019) Oromucosal films: from patient centricity to production by printing techniques. Expert Opinion on Drug Delivery 16:9, pages 981-993.
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Zahra Mahdizadeh Barzoki, Zahra Emam-Djomeh, Elaheh Mortazavian, Ali Akbar Moosavi-Movahedi & M. Rafiee Tehrani. (2016) Formulation, in vitro evaluation and kinetic analysis of chitosan–gelatin bilayer muco-adhesive buccal patches of insulin nanoparticles. Journal of Microencapsulation 33:7, pages 613-624.
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Articles from other publishers (34)

Kwadwo Mfoafo, Rahul Mittal, Adrien Eshraghi, Yadollah Omidi & Hossein Omidian. (2023) Thiolated polymers: An overview of mucoadhesive properties and their potential in drug delivery via mucosal tissues. Journal of Drug Delivery Science and Technology 85, pages 104596.
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Saily Shinde, Mihir Ghonge & Harsha Kathpalia. (2023) Recent Updates on Oral and Dermal Film-based Formulations and their Applications. Current Drug Delivery 20:4, pages 335-349.
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Varsha V. Nair, Pablo Cabrera, Constanza Ramírez-Lecaros, Miguel O. Jara, David J. Brayden & Javier O. Morales. (2023) Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles – An update. International Journal of Pharmaceutics 636, pages 122789.
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Shazia Bashir, Rawan Fitaihi & Hend E. Abdelhakim. (2023) Advances in formulation and manufacturing strategies for the delivery of therapeutic proteins and peptides in orally disintegrating dosage forms. European Journal of Pharmaceutical Sciences 182, pages 106374.
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Nimisha Srivastava & Sahifa Aslam. (2022) Recent Advancements and Patents on Buccal Drug Delivery Systems: A Comprehensive Review. Recent Patents on Nanotechnology 16:4, pages 308-325.
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Mutasem Rawas-Qalaji, Hnin Ei Thu & Zahid Hussain. (2022) Oromucosal delivery of macromolecules: Challenges and recent developments to improve bioavailability. Journal of Controlled Release 352, pages 726-746.
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Diaa Al-Domi, Ayat Bozeya & Mohamed Al-Fandi. (2022) Development of an Insulin Nano-delivery System through Buccal Administration. Current Drug Delivery 19:8, pages 889-901.
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Sevdenur Erzengin, Ece Guler, Enfal Eser, Elif Beyzanur Polat, Oguzhan Gunduz & Muhammet Emin Cam. (2022) In vitro and in vivo evaluation of 3D printed sodium alginate/polyethylene glycol scaffolds for sublingual delivery of insulin: Preparation, characterization, and pharmacokinetics. International Journal of Biological Macromolecules 204, pages 429-440.
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Shery Jacob, Anroop B. Nair, Sai H. S. Boddu, Bapi Gorain, Nagaraja Sreeharsha & Jigar Shah. (2021) An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems. Pharmaceutics 13:8, pages 1206.
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Valentina Andretto, Annalisa Rosso, Stéphanie Briançon & Giovanna Lollo. (2021) Nanocomposite systems for precise oral delivery of drugs and biologics. Drug Delivery and Translational Research 11:2, pages 445-470.
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Sabine Szunerits, Sorin Melinte, Alexandre Barras, Quentin Pagneux, Anna Voronova, Amar Abderrahmani & Rabah Boukherroub. (2021) The impact of chemical engineering and technological advances on managing diabetes: present and future concepts. Chemical Society Reviews 50:3, pages 2102-2146.
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Christoph Federer, Markus Kurpiers & Andreas Bernkop-Schnürch. (2020) Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications. Biomacromolecules 22:1, pages 24-56.
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Martina M. Tzanova, Ellen Hagesaether & Ingunn Tho. (2021) Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy. International Journal of Pharmaceutics 592, pages 120100.
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Eva Sanchez Armengol & Flavia Laffleur. 2021. Chitosan for Biomaterials IV. Chitosan for Biomaterials IV 191 212 .
Eylul Cetindag, John Pentangelo, Thierry Arrieta Cespedes & Rajesh N. Davé. (2020) Effect of solvents and cellulosic polymers on quality attributes of films loaded with a poorly water-soluble drug. Carbohydrate Polymers 250, pages 117012.
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Wai-Houng Chou, Ariel Galaz, Miguel O. Jara, Alexander Gamboa & Javier O. Morales. (2020) Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs. Pharmaceutics 12:12, pages 1168.
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Amogh Vaidya & Samir Mitragotri. (2020) Ionic liquid-mediated delivery of insulin to buccal mucosa. Journal of Controlled Release 327, pages 26-34.
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Angela Fabiano, Denise Beconcini, Chiara Migone, Anna Maria Piras & Ylenia Zambito. (2020) Quaternary Ammonium Chitosans: The Importance of the Positive Fixed Charge of the Drug Delivery Systems. International Journal of Molecular Sciences 21:18, pages 6617.
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Rabinarayan Parhi. (2020) Drug delivery applications of chitin and chitosan: a review. Environmental Chemistry Letters 18:3, pages 577-594.
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Ana S. Macedo, Pedro M. Castro, Luís Roque, Natália G. Thomé, Catarina P. Reis, Manuela E. Pintado & Pedro Fonte. (2020) Novel and revisited approaches in nanoparticle systems for buccal drug delivery. Journal of Controlled Release 320, pages 125-141.
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Giuseppina Sandri, Marco Ruggeri, Silvia Rossi, Maria Cristina Bonferoni, Barbara Vigani & Franca Ferrari. 2020. Nanotechnology for Oral Drug Delivery. Nanotechnology for Oral Drug Delivery 225 250 .
Susan Hua. (2019) Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration. Frontiers in Pharmacology 10.
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Phuong H.L. Tran, Wei Duan & Thao T.D. Tran. (2019) Recent developments of nanoparticle-delivered dosage forms for buccal delivery. International Journal of Pharmaceutics 571, pages 118697.
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Safoura Salar, Majid Jafari, S. Fatemeh Kaboli & Faramarz Mehrnejad. (2019) The role of intermolecular interactions on the encapsulation of human insulin into the chitosan and cholesterol-grafted chitosan polymers. Carbohydrate Polymers 208, pages 345-355.
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Rabinarayan Parhi. 2019. Sustainable Agriculture Reviews 36. Sustainable Agriculture Reviews 36 175 239 .
Miguel Montenegro-Nicolini, Patricio E. Reyes, Miguel O. Jara, Parameswara R. Vuddanda, Andrónico Neira-Carrillo, Nicole Butto, Sitaram Velaga & Javier O. Morales. (2018) The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems. AAPS PharmSciTech 19:8, pages 3376-3387.
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Javier O Morales & David J Brayden. (2017) Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles. Current Opinion in Pharmacology 36, pages 22-28.
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Soledad Montero-Padilla, Sitaram Velaga & Javier O. Morales. (2016) Buccal Dosage Forms: General Considerations for Pediatric Patients. AAPS PharmSciTech 18:2, pages 273-282.
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Yuri Ikeuchi-Takahashi, Ayaka KobayashiHiraku Onishi. (2017) Development of Polyethylene Glycol and Hard Fat-Based Mucoadhesive Tablets Containing Various Types of Polyvinyl Alcohols as Mucoadhesive Polymers for Buccal Application. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:6, pages 867-877.
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Sandra J. Morantes, Diana M. Buitrago, José F. Ibla, Yenny M. García, Gloria I. Lafaurie & Jenny E. Parraga. 2017. Biopolymer-Based Composites. Biopolymer-Based Composites 107 138 .
Ye Tian, Yujiao Sun, Xiaodan Wang, Georgios Kasparis & Shirui Mao. 2016. Nanobiomaterials in Drug Delivery. Nanobiomaterials in Drug Delivery 515 572 .
Davide A. D. Cassani, Lina Altomare, Luigi De Nardo & Fabio Variola. (2015) Physicochemical and nanomechanical investigation of electrodeposited chitosan:PEO blends. Journal of Materials Chemistry B 3:13, pages 2641-2650.
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Javier O. Morales, Siyuan Huang, Robert O. WilliamsIIIIII & Jason T. McConville. (2014) Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery. Colloids and Surfaces B: Biointerfaces 122, pages 38-45.
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