599
Views
52
CrossRef citations to date
0
Altmetric
Research Article

Design and evaluation of injectable niclosamide nanocrystals prepared by wet media milling technique

, , , &
Pages 1416-1424 | Received 27 Jun 2014, Accepted 29 Jul 2014, Published online: 10 Sep 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Yongjie Wang, Jinghong Rong, Jiaozhen Zhang, Yu Liu, Xuelian Meng, Hejian Guo, Hongsheng Liu & Lijiang Chen. (2017) Morphology, in vivo distribution and antitumor activity of bexarotene nanocrystals in lung cancer. Drug Development and Industrial Pharmacy 43:1, pages 132-141.
Read now
Juntao Yin, Peiqing Wang, Yuyun Yin, Yantao Hou & Xiaoyong Song. (2017) Optimization on biodistribution and antitumor activity of tripterine using polymeric nanoparticles through RES saturation. Drug Delivery 24:1, pages 1891-1897.
Read now
Xingwang Zhang, Yong Zhang, Tianpeng Zhang, Jianping Zhang & Baojian Wu. (2015) Significantly enhanced bioavailability of niclosamide through submicron lipid emulsions with or without PEG-lipid: a comparative study. Journal of Microencapsulation 32:5, pages 496-502.
Read now

Articles from other publishers (49)

Prashanth Reddy Kolimi, Amruta Prabhakar Padakanti, Naveen Kolagani, Srikanth Ponneganti, Vijayakumar Gangipangi, Sudhagar Selvaraju, Radhakrishnanand Pullapanthula, Amit Alexander & Naveen Chella. (2023) Polymeric amorphous dispersion as a carrier to enhance the in vitro dissolution in vivo pharmacokinetics and cytotoxicity of niclosamide. Polymers for Advanced Technologies 34:12, pages 3696-3710.
Crossref
Elizaveta S. Meteleva, Elizaveta A. Roenko & Nikolay E. Polyakov. (2023) Increase of solubility and transmembrane permeability of niclosamide from its mechanochemically synthesized solid dispersions. Chimica Techno Acta 10:3.
Crossref
Mengbi Yang, Amy Q. Wang, Elias C. Padilha, Pranav Shah, Natalie R. Hagen, China Ryu, Khalida Shamim, Wenwei Huang & Xin Xu. (2023) Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug. Frontiers in Pharmacology 14.
Crossref
SHWETA VIBHUTE, ADITI KASAR, HRISHIKESH MAHALE, MAHESH GAIKWAD & MADHUR KULKARNI. (2023) NICLOSAMIDE: A POTENTIAL TREATMENT OPTION FOR COVID-19. International Journal of Applied Pharmaceutics, pages 50-56.
Crossref
Syamprasad Np, Nitin Madje, Jayasri Bachannagari, Arun Kumar Jannu, Siddhi Jain, Kalyani Tene, Shantanu Pa, V.G.M. Naidu & Naveen Chella. (2023) Niclosamide nanocrystal for enhanced in-vivo efficacy against gastrointestinal stromal tumor via regulating EGFR/STAT-3/DR-4 axis. Journal of Drug Delivery Science and Technology, pages 104221.
Crossref
Miguel O. Jara & Robert O. WilliamsIIIIII. (2023) The challenge of repurposing niclosamide: Considering pharmacokinetic parameters, routes of administration, and drug metabolism. Journal of Drug Delivery Science and Technology, pages 104187.
Crossref
Zhan Wang, Junyi Ren, Jinxiu Du, Huan Wang, Jia Liu & Guiling Wang. (2022) Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases. International Journal of Molecular Sciences 23:24, pages 16116.
Crossref
Geradius Deogratias, Daniel M. Shadrack, Joan J.E. Munissi, Grace A. Kinunda, Fortunatus R. Jacob, Regina P. Mtei, Rose J. Masalu, Issakwisa Mwakyula, Lucy W. Kiruri & Stephen S. Nyandoro. (2022) Hydrophobic π-π stacking interactions and hydrogen bonds drive self-aggregation of luteolin in water. Journal of Molecular Graphics and Modelling 116, pages 108243.
Crossref
A. I. Varlamova, I. A. Arkhipov, S. S. Khalikov & M. V. Arisov. (2022) Modifcation of anthelmintic drugs by nanotechnology (review). Russian Journal of Parasitology 16:2, pages 213-229.
Crossref
Feifei Huang, Xiaohong Jiang, Marwa A. Sallam, Xingwang Zhang & Wei He. (2022) A Nanocrystal Platform Based on Metal-Phenolic Network Wrapping for Drug Solubilization. AAPS PharmSciTech 23:3.
Crossref
S. S. Khalikov, M. M. Il’in, B. V. Lokshin, D. S. Kabanov, T. A. Fedotcheva & N. L. Shimanovsky. (2022) Development of New Dosage forms of Niclosamide with Increased Solubility and Cytotoxic Activity. Pharmaceutical Chemistry Journal 55:11, pages 1229-1233.
Crossref
Jiraporn Ousingsawat, Raquel Centeio, Inês Cabrita, Khaoula Talbi, Oliver Zimmer, Moritz Graf, Achim Göpferich, Rainer Schreiber & Karl Kunzelmann. (2022) Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease. International Journal of Molecular Sciences 23:3, pages 1085.
Crossref
Said A. H. Vuai, Mtabazi G. Sahini, Isaac Onoka, Lucy W. Kiruri & Daniel M. Shadrack. (2021) Cation–π interactions drive hydrophobic self-assembly and aggregation of niclosamide in water. RSC Advances 11:52, pages 33136-33147.
Crossref
Meng Cheng, Qiaoming Liu, Tiantian Gan, Yuanying Fang, Pengfei Yue, Yongbing Sun, Yi Jin, Jianfang Feng & Liangxing Tu. (2021) Nanocrystal-Loaded Micelles for the Enhanced In Vivo Circulation of Docetaxel. Molecules 26:15, pages 4481.
Crossref
Miguel O. Jara, Zachary N. Warnken, Sawittree Sahakijpijarn, Chaeho Moon, Esther Y. Maier, Dale J. Christensen, John J. Koleng, Jay I. Peters, Sarah D. Hackman Maier & Robert O. Williams III. (2021) Niclosamide inhalation powder made by thin-film freezing: Multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters. International Journal of Pharmaceutics 603, pages 120701.
Crossref
Khalida Shamim, Miao Xu, Xin Hu, Emily M Lee, Xiao Lu, Ruili Huang, Pranav Shah, Xin Xu, Catherine Z. Chen, Min Shen, Hui Guo, Lu Chen, Zina Itkin, Richard T. Eastman, Paul Shinn, Carleen Klumpp-Thomas, Sam Michael, Anton Simeonov, Donald C. Lo, Guo-li Ming, Hongjun Song, Hengli Tang, Wei Zheng & Wenwei Huang. (2021) Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection. Bioorganic & Medicinal Chemistry Letters 40, pages 127906.
Crossref
James J. Hobson, Alison C. Savage, Andrew B. Dwyer, Catherine Unsworth, Jonathan Massam, Usman Arshad, Henry Pertinez, Helen Box, Lee Tatham, Rajith K. R. Rajoli, Megan Neary, Joanne Sharp, Anthony Valentijn, Christopher David, Paul Curley, Neill J. Liptrott, Tom O. McDonald, Andrew Owen & Steve P. Rannard. (2021) Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection . Nanoscale 13:13, pages 6410-6416.
Crossref
XingGang He, MaoLin Li, WenChong Ye & Wen Zhou. (2021) Discovery of degradable niclosamide derivatives able to specially inhibit small cell lung cancer (SCLC). Bioorganic Chemistry 107, pages 104574.
Crossref
Miguel O. Jara, Zachary N. Warnken & Robert O. WilliamsIIIIII. (2021) Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study. Pharmaceutics 13:1, pages 97.
Crossref
Ozlem Coban, Zeynep Aytac, Zehra Irem Yildiz & Tamer Uyar. (2021) Colon targeted delivery of niclosamide from β-cyclodextrin inclusion complex incorporated electrospun Eudragit® L100 nanofibers. Colloids and Surfaces B: Biointerfaces 197, pages 111391.
Crossref
Mohamed Abdella, Bahaa Abdella & Chandrajit Lahiri. 2021. Microbial and Natural Macromolecules. Microbial and Natural Macromolecules 373 400 .
A. I. Varlamova, S. O. Movsesyan, I. A. Arkhipov, S. S. Khalikov, M. V. Arisov, P. P. Kochetkov, V. E. Abramov, M. M. Il’in & B. V. Lokshin. (2021) Biological Activity and Pharmacokinetic Behavior of Fenbendazole Integrated into a Supramolecular Delivery System with Licorice Extract and Sodium Dioctyl Sulfosuccinate. Biology Bulletin 47:6, pages 549-558.
Crossref
Brice Martin, Johanne Seguin, Maxime Annereau, Thomas Fleury, René Lai-Kuen, Giovanni Neri, Anita Lam, Marcel Bally, Nathalie Mignet & Yohann Corvis. (2020) Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties. Scientific Reports 10:1.
Crossref
Eupa Ray, Kalpesh Vaghasiya, Ankur Sharma, Rahul Shukla, Rehan Khan, Anil Kumar & Rahul Kumar Verma. (2020) Autophagy-Inducing Inhalable Co-crystal Formulation of Niclosamide-Nicotinamide for Lung Cancer Therapy. AAPS PharmSciTech 21:7.
Crossref
Bwalya A. Witika, Pedzisai A. Makoni, Scott K. Matafwali, Billy Chabalenge, Chiluba Mwila, Aubrey C. Kalungia, Christian I. Nkanga, Alain M. Bapolisi & Roderick B. Walker. (2020) Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches. Nanomaterials 10:9, pages 1649.
Crossref
Mahdi Hatamipour, Mahmoud R. Jaafari, Amir A. Momtazi-Borojeni, Mahin Ramezani & Amirhossein Sahebkar. (2020) Evaluation of the Anti-Tumor Activity of Niclosamide Nanoliposomes Against Colon Carcinoma. Current Molecular Pharmacology 13:3, pages 245-250.
Crossref
Gireesh B. Reddy, David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham & William C. Eward. (2020) Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma. Molecular Cancer Therapeutics 19:7, pages 1448-1461.
Crossref
Qiang Fu, Xin Jin, Zhenhai Zhang & Huixia Lv. (2020) Preparation and in vitro antitumor effects on MDA-MB-231 cells of niclosamide nanocrystals stabilized by poloxamer188 and PBS. International Journal of Pharmaceutics 584, pages 119432.
Crossref
Bwalya A. Witika, Vincent J. Smith & Roderick B. Walker. (2020) A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of Self-Assembling Nano Co-Crystals. Pharmaceutics 12:2, pages 182.
Crossref
David Needham. 2020. Biomaterials for Cancer Therapeutics. Biomaterials for Cancer Therapeutics 599 723 .
Mahdi Hatamipour, Mahmoud R. Jaafari, Amir A. Momtazi-Borojeni, Mahin Ramezani & Amirhossein Sahebkar. (2019) Nanoliposomal Encapsulation Enhances In Vivo Anti-Tumor Activity of Niclosamide against Melanoma. Anti-Cancer Agents in Medicinal Chemistry 19:13, pages 1618-1626.
Crossref
Menna Assem, Omneya Mohammed Khowessah & Dalia Ghorab. (2019) Nano-crystallization as a tool for the enhancement of beclomethasone dipropionate dermal deposition: Formulation, in vitro characterization and ex vivo study. Journal of Drug Delivery Science and Technology 54, pages 101318.
Crossref
Eduardo José Barbosa, Raimar Löbenberg, Gabriel Lima Barros de Araujo & Nádia Araci Bou-Chacra. (2019) Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities. European Journal of Pharmaceutics and Biopharmaceutics 141, pages 58-69.
Crossref
Viral Patel, Om Prakash Sharma & Tejal A. Mehta. (2019) Impact of Process Parameters on Particle Size Involved in Media Milling Technique Used for Preparing Clotrimazole Nanocrystals for the Management of Cutaneous Candidiasis. AAPS PharmSciTech 20:5.
Crossref
Maya A. Farha & Eric D. Brown. (2019) Drug repurposing for antimicrobial discovery. Nature Microbiology 4:4, pages 565-577.
Crossref
Michela Mazzon, Ana Ortega-Prieto, Douglas Imrie, Christin Luft, Lena Hess, Stephanie Czieso, Joe Grove, Jessica Skelton, Laura Farleigh, Joachim Bugert, Edward Wright, Nigel Temperton, Richard Angell, Sally Oxenford, Michael Jacobs, Robin Ketteler, Marcus Dorner & Mark Marsh. (2019) Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry. Viruses 11:2, pages 176.
Crossref
Brice Martin Couillaud, Philippe Espeau, Nathalie Mignet & Yohann Corvis. (2018) State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation. ChemMedChem 14:1, pages 8-23.
Crossref
Xingwang Zhang, Huijie Xing, Yue Zhao & Zhiguo Ma. (2018) Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs. Pharmaceutics 10:3, pages 74.
Crossref
Flavia Fontana, Patrícia Figueiredo, Pei Zhang, Jouni T. Hirvonen, Dongfei Liu & Hélder A. Santos. (2018) Production of pure drug nanocrystals and nano co-crystals by confinement methods. Advanced Drug Delivery Reviews 131, pages 3-21.
Crossref
Ying Xie & Yuan Yao. (2018) Octenylsuccinate hydroxypropyl phytoglycogen enhances the solubility and in-vitro antitumor efficacy of niclosamide. International Journal of Pharmaceutics 535:1-2, pages 157-163.
Crossref
Wei Chen, Robert A. MookJr.Jr., Richard T. Premont & Jiangbo Wang. (2018) Niclosamide: Beyond an antihelminthic drug. Cellular Signalling 41, pages 89-96.
Crossref
Vishwas Pardhi, Rahul B Chavan, Rajesh Thipparaboina, Sowjanya Thatikonda, VGM Naidu & Nalini R Shastri. (2017) Preparation, characterization, and cytotoxicity studies of niclosamide loaded mesoporous drug delivery systems. International Journal of Pharmaceutics 528:1-2, pages 202-214.
Crossref
A. S. Zhirnik, Yu. P. Semochkina, E. Yu. Moskaleva, N. I. Krylov, I. A. Tubasheva, S. L. Kuznetsov & E. A. Vorontsov. (2017) Molecular mechanisms of antitumor activity of the polymeric form of niclosamide with respect to human colorectal cancer cells. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 11:3, pages 301-307.
Crossref
Tiesong Zhang, Jing Ma, Chao Li, Ken Lin, Fan Lou, Hongchao Jiang, Yingqin Gao, Yanli Yang, Cheng Ming & Biao Ruan. (2017) Core-shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers. Oncology Reports 37:3, pages 1653-1661.
Crossref
A.S. Zhirnik, Y.P. Semochkina, E.Yu. Moskaleva, N.I. Krylov, I.A. Tubasheva, S.L. Kuznetsov & E.A. Vorontsov. (2017) Antineoplastic mechanisms of niclosamide-loaded nanoparticles in human colorectal cancer cells. Biomeditsinskaya Khimiya 63:2, pages 132-138.
Crossref
Rajesh Thipparaboina, Rahul B. Chavan & Nalini R. Shastri. 2017. Particulate Technology for Delivery of Therapeutics. Particulate Technology for Delivery of Therapeutics 291 316 .
Om Prakash Sharma, Viral Patel & Tejal Mehta. (2016) Design of experiment approach in development of febuxostat nanocrystal: Application of Soluplus® as stabilizer. Powder Technology 302, pages 396-405.
Crossref
Ulrike Wais, Alexander W. Jackson, Tao He & Haifei Zhang. (2016) Nanoformulation and encapsulation approaches for poorly water-soluble drug nanoparticles. Nanoscale 8:4, pages 1746-1769.
Crossref
Chongkai Zhai, Mingda Wang, Hea-Jong Chung, Yanyan Jin, Hyeon Jin Kim & Seong-Tshool Hong. (2022) Noncovalent Nanoformulation of a Drug Candidate with Limited Systemic Delivery for Systemic Oral Delivery as Much as a Typical Common Oral Drug. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.