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Drug Development and Industrial Pharmacy Volume 41, 2015 - Issue 10
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Research Article

Spray drying of drug-swellable dispersant suspensions for preparation of fast-dissolving, high drug-loaded, surfactant-free nanocomposites

Mohammad AzadOtto H. York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ, USA
,
Colby ArteagaOtto H. York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ, USA
,
Beshoy AbdelmalekOtto H. York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ, USA
,
Rajesh DavéOtto H. York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ, USA
&
Ecevit BilgiliOtto H. York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, NJ, USACorrespondence[email protected]
Pages 1617-1631 | Received 18 Aug 2014, Accepted 08 Oct 2014, Published online: 27 Oct 2014

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Jin Xie, Yijing Luo, Yang Liu, Yueqin Ma, Pengfei Yue & Ming Yang. (2019) Novel redispersible nanosuspensions stabilized by co-processed nanocrystalline cellulose–sodium carboxymethyl starch for enhancing dissolution and oral bioavailability of baicalin. International Journal of Nanomedicine 14, pages 353-369.
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Wenbao Zuo, Wenjing Qu, Na Li, Rui Yu, Yanhui Hou, Yanhua Liu, Guojing Gou & Jianhong Yang. (2018) Fabrication of multicomponent amorphous bufadienolides nanosuspension with wet milling improves dissolution and stability. Artificial Cells, Nanomedicine, and Biotechnology 46:7, pages 1513-1522.
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Scott M. Krull, Zhelun Ma, Meng Li, Rajesh N. Davé & Ecevit Bilgili. (2016) Preparation and characterization of fast dissolving pullulan films containing BCS class II drug nanoparticles for bioavailability enhancement. Drug Development and Industrial Pharmacy 42:7, pages 1073-1085.
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Mozhgan Sadeghi, Salar Hemmati & Hamed Hamishehkar. (2016) Synthesis of a novel superdisintegrant by starch derivatization with polysuccinimide and its application for the development of Ondansetron fast dissolving tablet. Drug Development and Industrial Pharmacy 42:5, pages 769-775.
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Zun Huang, Sven Staufenbiel & Roland Bodmeier. (2022) Incorporation of itraconazole nano-co-crystals into multiparticulate oral dosage forms. European Journal of Pharmaceutics and Biopharmaceutics 176, pages 75-86.
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Mohammad Azad, Gulenay Guner, Afolawemi Afolabi, Rajesh Davé & Ecevit Bilgili. (2021) Impact of solvents during wet stirred media milling of cross-linked biopolymer suspensions. Advanced Powder Technology 32:12, pages 4562-4575.
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Félix Boussoufi, Marc Pousthomis, Alexis Kuntzmann, Michele D’Amico, Gilles Patriarche & Benoit Dubertret. (2021) Spray-Drying Polymer Encapsulation of CsPbBr 3 Perovskite Nanocrystals with Enhanced Photostability for LED Downconverters . ACS Applied Nano Materials 4:7, pages 7502-7512.
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Meng Li, Casey Furey, Jeffrey Skros, Olivia Xu, Mahbubur Rahman, Mohammad Azad, Rajesh Dave & Ecevit Bilgili. (2021) Impact of Matrix Surface Area on Griseofulvin Release from Extrudates Prepared via Nanoextrusion. Pharmaceutics 13:7, pages 1036.
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Roya Koshani, Mandana Tavakolian & Theo G. M. van de Ven. (2020) Cellulose-based dispersants and flocculants. Journal of Materials Chemistry B 8:46, pages 10502-10526.
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Belal Al Zaitone & Abdulrahim Al-Zahrani. (2020) Modeling Drying Behavior of an Aqueous Chitosan Single Droplet Using the Reaction Engineering Approach. AAPS PharmSciTech 21:8.
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Mahbubur Rahman, Alexander Coelho, James Tarabokija, Stephanie Ahmad, Keanu Radgman & Ecevit Bilgili. (2020) Synergistic and antagonistic effects of various amphiphilic polymer combinations in enhancing griseofulvin release from ternary amorphous solid dispersions. European Journal of Pharmaceutical Sciences 150, pages 105354.
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Xuemin Gao, Bing Wang, Qiuhong Liu, Chen Liu, Mao Li, Kamalesh K. Sirkar & Dengyue Chen. (2020) Fluid Dynamic and Heat Transfer Simulations of Solid Hollow Fiber Cooling Crystallizer for Continuous Synthesis of Drug Nanoparticles. Crystal Growth & Design 20:6, pages 4020-4029.
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Yijing Luo, Zengzhu Zhang, Guiting Huang, Huaping Yu, Yueqin Ma, Qin Zheng & Pengfei Yue. (2020) Roles of maltodextrin and inulin as matrix formers on particle performance of inhalable drug nanocrystal-embedded microparticles. Carbohydrate Polymers 235, pages 115937.
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Mahbubur Rahman, Stephanie Ahmad, James Tarabokija, Nathaniel Parker & Ecevit Bilgili. (2020) Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component. Pharmaceutics 12:3, pages 197.
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Mahbubur Rahman, Stephanie Ahmad, James Tarabokija & Ecevit Bilgili. (2020) Roles of surfactant and polymer in drug release from spray-dried hybrid nanocrystal-amorphous solid dispersions (HyNASDs). Powder Technology 361, pages 663-678.
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Mahbubur Rahman, Faustin Arevalo, Alexander Coelho & Ecevit Bilgili. (2019) Hybrid nanocrystal–amorphous solid dispersions (HyNASDs) as alternative to ASDs for enhanced release of BCS Class II drugs. European Journal of Pharmaceutics and Biopharmaceutics 145, pages 12-26.
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Saikishore Meruva, Prajwal Thool, Shyam Karki, William Bowen, Indrajit Ghosh & Sumit Kumar. (2019) Downstream processing of irbesartan nanocrystalline suspension and mini-tablet development – Part II. International Journal of Pharmaceutics 568, pages 118509.
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Sadegh Poozesh & Ecevit Bilgili. (2019) Scale-up of pharmaceutical spray drying using scale-up rules: A review. International Journal of Pharmaceutics 562, pages 271-292.
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Rayehe Teymouri Rad, Simin Dadashzadeh, Alireza Vatanara, Sonia Alavi, Elham Ghasemian & Seyed Alireza Mortazavi. (2019) Tadalafil nanocomposites as a dry powder formulation for inhalation, a new strategy for pulmonary arterial hypertension treatment. European Journal of Pharmaceutical Sciences 133, pages 275-286.
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Hyeok Kwon, Eun-Ji Heo, Young-Hwan Kim, Sarah Kim, Young-Ha Hwang, Ji-Mi Byun, Se Cheon, Sang Park, Dong Kim, Kwan Cho, Han-Joo Maeng & Dong-Jin Jang. (2019) Development and Evaluation of Poorly Water-Soluble Celecoxib as Solid Dispersions Containing Nonionic Surfactants Using Fluidized-Bed Granulation. Pharmaceutics 11:3, pages 136.
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Ecevit Bilgili, Mahbubur Rahman, Danny Palacios & Faustin Arevalo. (2018) Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution from spray-dried nanocomposites. Advanced Powder Technology 29:12, pages 2941-2956.
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Mohammad A. Azad, Lucas Sievens-Figueroa & Rajesh N. Davé. (2018) Fast release of liquid antisolvent precipitated fenofibrate at high drug loading from biocompatible thin films. Advanced Powder Technology 29:12, pages 2907-2919.
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M. Li, I. Suriel, J. Vekaria, J. Proske, P. Orbe, M. Armani, R.N. Dave & E. Bilgili. (2018) Impact of dispersants on dissolution of itraconazole from drug-loaded, surfactant-free, spray-dried nanocomposites. Powder Technology 339, pages 281-295.
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Hye-In Kim, Sang Park, Seok Park, Jewon Lee, Kwan Cho, Jun-Pil Jee, Hee-Cheol Kim, Han-Joo Maeng & Dong-Jin Jang. (2018) Development and Evaluation of a Reconstitutable Dry Suspension to Improve the Dissolution and Oral Absorption of Poorly Water-Soluble Celecoxib. Pharmaceutics 10:3, pages 140.
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Anagha Bhakay, Mahbubur Rahman, Rajesh Dave & Ecevit Bilgili. (2018) Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing Aspects and Challenges. Pharmaceutics 10:3, pages 86.
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A. Bhakay, R. N. Davé & E. Bilgili. (2017) Quiescent and Agitated Redispersion as a Tool for Evaluating Dispersant Effectiveness in Dissolution Enhancement of Drug-Laden Nanocomposites. AAPS PharmSciTech 19:1, pages 436-447.
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Yingchong Chen, Yang Liu, Junnan Xu, Jin Xie, Yueqin Ma, Pengfei Yue, Qin Zheng & Ming Yang. (2018) Design and evaluation of nanocomposite microparticles to enhance dissolution and oral bioavailability of andrographolide. Powder Technology 323, pages 219-229.
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Mark Davis & Gavin Walker. (2018) Recent strategies in spray drying for the enhanced bioavailability of poorly water-soluble drugs. Journal of Controlled Release 269, pages 110-127.
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Meng Li, Nicolas Ioannidis, Costas Gogos & Ecevit Bilgili. (2017) A comparative assessment of nanocomposites vs. amorphous solid dispersions prepared via nanoextrusion for drug dissolution enhancement. European Journal of Pharmaceutics and Biopharmaceutics 119, pages 68-80.
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Yanxian Hou, Jingbo Shao, Qiang Fu, Jingru Li, Jin Sun & Zhonggui He. (2017) Spray-dried nanocrystals for a highly hydrophobic drug: Increased drug loading, enhanced redispersity, and improved oral bioavailability. International Journal of Pharmaceutics 516:1-2, pages 372-379.
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Mohammad Azad, Jacqueline Moreno, Ecevit Bilgili & Rajesh Davé. (2016) Fast dissolution of poorly water soluble drugs from fluidized bed coated nanocomposites: Impact of carrier size. International Journal of Pharmaceutics 513:1-2, pages 319-331.
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Íris Duarte, M. Luísa Corvo, Pedro Serôdio, João Vicente, João F. Pinto & Márcio Temtem. (2016) Production of nano-solid dispersions using a novel solvent-controlled precipitation process — Benchmarking their in vivo performance with an amorphous micro-sized solid dispersion produced by spray drying. European Journal of Pharmaceutical Sciences 93, pages 203-214.
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Meng Li, Nicole Lopez & Ecevit Bilgili. (2016) A study of the impact of polymer–surfactant in drug nanoparticle coated pharmatose composites on dissolution performance. Advanced Powder Technology 27:4, pages 1625-1636.
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Meng Li, Mohammad Azad, Rajesh Davé & Ecevit Bilgili. (2016) Nanomilling of Drugs for Bioavailability Enhancement: A Holistic Formulation-Process Perspective. Pharmaceutics 8:2, pages 17.
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Scott M. Krull, Ramana Susarla, Afolawemi Afolabi, Meng Li, Ye Ying, Zafar Iqbal, Ecevit Bilgili & Rajesh N. Davé. (2015) Polymer strip films as a robust, surfactant-free platform for delivery of BCS Class II drug nanoparticles. International Journal of Pharmaceutics 489:1-2, pages 45-57.
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