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Research Article

Development and evaluation of chitosan and chitosan derivative nanoparticles containing insulin for oral administration

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Pages 2037-2044 | Received 30 Sep 2014, Accepted 20 Apr 2015, Published online: 26 May 2015

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Mojgan Nejabat, Mohammad Reza Kalani, Masoud Nejabat & Farzin Hadizadeh. (2022) Molecular dynamic and in vitro evaluation of chitosan/tripolyphosphate nanoparticles as an insulin delivery system at two different pH values. Journal of Biomolecular Structure and Dynamics 40:20, pages 10153-10161.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2021) Fabrication techniques for the preparation of orally administered insulin nanoparticles. Journal of Drug Targeting 29:4, pages 365-386.
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Chun Y. Wong, Jorge Martinez, Jian Zhao, Hani Al-Salami & Crispin R. Dass. (2020) Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization. Drug Development and Industrial Pharmacy 46:8, pages 1238-1252.
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Munawar Mohammed, Holly Mansell, Ahmed Shoker, Kishor M. Wasan & Ellen K. Wasan. (2019) Development and in vitro characterization of chitosan-coated polymeric nanoparticles for oral delivery and sustained release of the immunosuppressant drug mycophenolate mofetil. Drug Development and Industrial Pharmacy 45:1, pages 76-87.
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Xiaomei Wang, Dan Cheng, Linglin Liu & Xuejun Li. (2018) Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery. Pharmaceutical Development and Technology 23:4, pages 351-357.
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Francivandi Coelho Barbosa, Milena Costa da Silva, Henrique Nunes da Silva, Danyllo Albuquerque, Allyson Antônio Ribeiro Gomes, Suédina Maria de Lima Silva & Marcus Vinícius Lia Fook. (2020) Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review. Polymers 12:11, pages 2499.
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Chun Y. Wong, Hani Al-Salami & Crispin R. Dass. (2020) Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro. Journal of Drug Delivery Science and Technology 57, pages 101738.
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Suzanne Gascon, Angéla Giraldo Solano, Wiam El Kheir, Hélène Therriault, Pierre Berthelin, Bettina Cattier, Bernard Marcos, Nick Virgilio, Benoit Paquette, Nathalie Faucheux & Marc-Antoine Lauzon. (2020) Characterization and Mathematical Modeling of Alginate/Chitosan-Based Nanoparticles Releasing the Chemokine CXCL12 to Attract Glioblastoma Cells. Pharmaceutics 12:4, pages 356.
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Cíntia Marques, Claudia Som, Mélanie Schmutz, Olga Borges & Gerrit Borchard. (2020) How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept. Frontiers in Bioengineering and Biotechnology 8.
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Urarika Luesakul, Songchan Puthong, Kanokwan Sansanaphongpricha & Nongnuj Muangsin. (2020) Quaternized chitosan-coated nanoemulsions: A novel platform for improving the stability, anti-inflammatory, anti-cancer and transdermal properties of Plai extract. Carbohydrate Polymers 230, pages 115625.
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Chun Y. Wong, Giuseppe Luna, Jorge Martinez, Hani Al-Salami & Crispin R. Dass. (2019) Bio-nanotechnological advancement of orally administered insulin nanoparticles: Comprehensive review of experimental design for physicochemical characterization. International Journal of Pharmaceutics 572, pages 118720.
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Chengyun Yan, Jiwei Gu, Yuguang Lv, Weiguo Shi, Zhan Huang & Ying Liao. (2019) 5β-Cholanic Acid/Glycol Chitosan Self-Assembled Nanoparticles (5β-CHA/GC-NPs) for Enhancing the Absorption of FDs and Insulin by Rat Intestinal Membranes. AAPS PharmSciTech 20:1.
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Marc-Antoine Lauzon, Bernard Marcos & Nathalie Faucheux. (2018) Characterization of alginate/chitosan-based nanoparticles and mathematical modeling of their SpBMP-9 release inducing neuronal differentiation of human SH-SY5Y cells. Carbohydrate Polymers 181, pages 801-811.
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Safoura Salar, Faramarz Mehrnejad, Reza H. Sajedi & Javad Mohammadnejad Arough. (2017) Chitosan nanoparticles-trypsin interactions: Bio-physicochemical and molecular dynamics simulation studies. International Journal of Biological Macromolecules 103, pages 902-909.
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Anivaldo Pereira Duarte Junior, Eraldo José Madureira Tavares, Taís Vanessa Gabbay Alves, Márcia Regina de Moura, Carlos Emmerson Ferreira da Costa, José Otávio Carréra Silva Júnior & Roseane Maria Ribeiro Costa. (2017) Chitosan nanoparticles as a modified diclofenac drug release system. Journal of Nanoparticle Research 19:8.
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Marjan Motiei & Soheila Kashanian. (2017) Novel amphiphilic chitosan nanocarriers for sustained oral delivery of hydrophobic drugs. European Journal of Pharmaceutical Sciences 99, pages 285-291.
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J. Hecq, K. Amighi & J. Goole. (2016) Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery. Journal of Drug Delivery Science and Technology 36, pages 192-200.
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Deepak Pathania, Divya Gupta, N.C. Kothiyal, Gaurav sharma, G.E. Eldesoky & Mu. Naushad. (2016) Preparation of a novel chitosan-g-poly(acrylamide)/Zn nanocomposite hydrogel and its applications for controlled drug delivery of ofloxacin. International Journal of Biological Macromolecules 84, pages 340-348.
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