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Drug Development and Industrial Pharmacy Volume 42, 2016 - Issue 10
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Research Articles

Formulation design, in vitro characterizations and anti-malarial investigations of artemether and lumefantrine-entrapped solid lipid microparticles

Chinazom AgboDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria;
,
Chukwuebuka UmeyorNanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria; Correspondence[email protected]
,
Franklin KenechukwuDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria;
,
John OgbonnaDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria;
,
Salome ChimeDepartment of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
,
Charles LovelynDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria;
,
Obumneme AgubataDepartment of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
,
Kenneth OfokansiDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria;
&
Anthony AttamaDrug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria;
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Pages 1708-1721 | Received 14 Aug 2015, Accepted 21 Mar 2016, Published online: 19 Apr 2016

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Tushar Kanti Rajwar, Deepak Pradhan, Jitu Halder, Vineet Kumar Rai, Biswakanth Kar, Goutam Ghosh & Goutam Rath. (2023) Opportunity in nanomedicine to counter the challenges of current drug delivery approaches used for the treatment of malaria: a review. Journal of Drug Targeting 31:4, pages 354-368.
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Articles from other publishers (16)

Li Kar Stella Tan, Chee Wun How, Liang Ee Low, Boon Hoong Ong, Jian Sheng Loh, Su-Yin Lim, Yong Sze Ong & Jhi Biau Foo. (2023) Magnetic-guided targeted delivery of zerumbone/SPION co-loaded in nanostructured lipid carrier into breast cancer cells. Journal of Drug Delivery Science and Technology 87, pages 104830.
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Chinazom Precious Agbo, Timothy Chukwuebuka Ugwuanyi, Osita Christopher Eze, Adaeze Linda Onugwu, Adaeze Chidiebere Echezona, Chinekwu Sherridan Nwagwu, Samuel Wisdom Uzondu, John Dike Ogbonna, Lydia Onyinyechi Ugorji, Petra Obioma Nnamani, Paul Achile Akpa, Joy Nneji Reginald-Opara, John Onyebuchi Ogbodo, Christopher McConville, Anthony Amaechi Attama, Mumuni Audu Momoh & Kenneth Chibuzor Ofokansi. (2023) Quinine: Redesigned and Rerouted. Processes 11:6, pages 1811.
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Franklin Chimaobi Kenechukwu, Marcos Lopes Dias, Roberto Pinto Cucinelli Neto & Eduardo Ricci-Júnior. (2022) Compatibilized Biopolymer-based Core–shell Nanoparticles: A New Frontier in Malaria Combo-therapy. Journal of Pharmaceutical Innovation 18:2, pages 594-620.
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Anthony A. Attama, Chinazom P. Agbo, Ozioma B. Onokala, Franklin C. Kenechukwu, Mercy E. Ugwueze, Chukwuemeka C. Mbah, Chukwuebuka E. Umeyor, Emmanuel M. Uronnachi & Petra O. Nnamani. 2023. Nanotechnology in Herbal Medicine. Nanotechnology in Herbal Medicine 119 194 .
Tochukwu Chimdindu Okeke, Chukwuebuka Emmanuel Umeyor, Ifeanyi Thaddeus Nzekwe, Immaculeta Chikamnele Umeyor, Ngozi Maryann Nebolisa, Emmanuel Maduabuchi Uronnachi, Calistus Dozie Nwakile, Chizoba Austinline Ekweogu, Omoirri Moses Aziakpono & Anthony Amaechi Attama. (2022) Formulation Development of Azadirachta indica Extract as Nanosuppository to Improve its Intrarectal Delivery for the Treatment of Malaria. Recent Advances in Drug Delivery and Formulation 16:3, pages 217-233.
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Chime Salome Amarachi, Anthony Amaechi Attama & Godswill Chukwunweike Onunkwo. (2022) Assessment of the Anti-Malarial Properties of Dihydroartemisinin- Piperaquine Phosphate Solid Lipid-Based Tablets. Recent Advances in Anti-Infective Drug Discovery 17:2, pages 103-117.
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Kashif Shakeel, Farhan Jalees Ahmad, Ranjit Kumar Harwansh & Mohammad Akhlaquer Rahman. (2022) β-Artemether and Lumefantrine Dual Drug Loaded Lipid Nanoparticles: Physicochemical Characterization, Pharmacokinetic Evaluation and Biodistribution Study. Pharmaceutical Nanotechnology 10:3, pages 210-219.
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Tze Ning Hiew, Dmitry Y. Zemlyanov & Lynne S. Taylor. (2021) Balancing Solid-State Stability and Dissolution Performance of Lumefantrine Amorphous Solid Dispersions: The Role of Polymer Choice and Drug–Polymer Interactions. Molecular Pharmaceutics 19:2, pages 392-413.
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Adaeze Linda Onugwu, Chinazom Precious Agbo, Chinekwu Sherridan Nwagwu, Samuel Emeka Uzondu, Adaeze Chidiebere Echezona, John Dike Nwabueze Ogbonna, Franklin Chimaobi Kenechukwu, Chukwuebuka Emmanuel Umeyor, Emmanuel Maduabuchi Uronnachi, Paul Achile Akpa, Mumuni Audu Momoh, Petra Obioma Nnamani, Christel Charlotte Müller-Goymann & Anthony Amaechi Attama. (2021) Development of lipid-based microsuspensions for improved ophthalmic delivery of gentamicin sulphate. Therapeutic Delivery 12:9, pages 671-683.
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Chinazom Precious Agbo, Timothy Chukwuebuka Ugwuanyi, Wilfred Ikechukwu Ugwuoke, Christopher McConville, Anthony Amaechi Attama & Kenneth Chibuzor Ofokansi. (2021) Intranasal artesunate-loaded nanostructured lipid carriers: A convenient alternative to parenteral formulations for the treatment of severe and cerebral malaria. Journal of Controlled Release 334, pages 224-236.
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Niraj S. Trasi, Sonal V. Bhujbal, Dmitry Y. Zemlyanov, Qi (Tony) Zhou & Lynne S. Taylor. (2020) Physical stability and release properties of lumefantrine amorphous solid dispersion granules prepared by a simple solvent evaporation approach. International Journal of Pharmaceutics: X 2, pages 100052.
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Sandip Pawar & Pravin Shende. (2020) 22 factorial design-based biocompatible microneedle arrays containing artemether co-loaded with lumefantrine nanoparticles for transepidermal delivery. Biomedical Microdevices 22:1.
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Chukwuebuka E. Umeyor, Onyedikachi Obachie, Rozeeta Chukwuka & Anthony Attama. (2019) Development Insights of Surface Modified Lipid Nanoemulsions of Dihydroartemisinin for Malaria Chemotherapy: Characterization, and in vivo Antimalarial Evaluation. Recent Patents on Biotechnology 13:2, pages 149-165.
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Jay Prakash Jain, F. Joel Leong, Lan Chen, Sampath Kalluri, Vishal Koradia, Daniel S. Stein, Marie-Christine Wolf, Gangadhar Sunkara & Jagannath Kota. (2017) Bioavailability of Lumefantrine Is Significantly Enhanced with a Novel Formulation Approach, an Outcome from a Randomized, Open-Label Pharmacokinetic Study in Healthy Volunteers. Antimicrobial Agents and Chemotherapy 61:9.
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John Dike N. Ogbonna, Anthony A. Attama, Kenneth C. Ofokansi, Sanjay B. Patil & Ganesh D. Basarkar. (2017) Optimization of formulation processes using Design Expert ® Software for preparation of polymeric blends-artesunate-amodiaquine HCl microparticles. Journal of Drug Delivery Science and Technology 39, pages 36-49.
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Anthony A. Attama, Franklin C. Kenechukwu, Ebele B. Onuigbo, Petra O. Nnamani, Nicholas Obitte, Jahn H. Finke, Sascha Pretor & Christel C. Müller-Goymann. (2016) Solid lipid nanoparticles encapsulating a fluorescent marker (coumarin 6) and antimalarials – artemether and lumefantrine: evaluation of cellular uptake and antimalarial activity. European Journal of Nanomedicine 8:3, pages 129-138.
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