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Drug Development and Industrial Pharmacy Volume 20, 1994 - Issue 4
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Research Article

Use of CACO-2 Cells as an in vitro Intestinal Absorption and Metabolism Model

Liang-Shang Gan Department of Drug Metabolism, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
,
Cindy Eads Department of Drug Metabolism, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
,
Tara Niederer Department of Drug Metabolism, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
,
Avis Bridgers Department of Drug Metabolism, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
,
Souzan Yanni Department of Drug Metabolism, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
,
Poe-Hirr Hsyu Department of Clinical Pharmacology, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
,
Fred J. Pritchard Department of Clinical Pharmacology, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
&
Dhiren Thakker Department of Drug Metabolism, Glaxo Inc. Research Institute, Research Triangle Park, NC, 27709
 show all
Pages 615-631 | Published online: 20 Oct 2008

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Michael Wirth, Gerhard Hamilton & Franz Gabora. (1998) Lectin-Mediated Drug Targeting: Quantification of Binding and Internalization of Wheat germ Agglutinin and Solatium tuberosum Lectin Using Caco-2 and HT-29 Cells. Journal of Drug Targeting 6:2, pages 95-104.
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S. E. Ball, J. A. Scatina, S. F. Sisenwine & G. L. Fisher. (1995) The Application of In Vitro Models of Drug Metabolism and Toxicity in Drug Discovery and Drug Development. Drug and Chemical Toxicology 18:1, pages 1-28.
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Articles from other publishers (23)

Donald J. AbrahamEdward H. Kerns, Xun Zhang & Li Di. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 31 .
Baolin Wang, Yimeng Lu, Rong Wang, Shumeng Liu, Xiaolong Hu & Hao Wang. (2020) Transport and metabolic profiling studies of amentoflavone in Caco-2 cells by UHPLC-ESI-MS/MS and UHPLC-ESI-Q-TOF-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 189, pages 113441.
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Henry P. Diehl, Aldyn Wildey, Vivitri D. Prasasty & Teruna J. Siahaan. 2020. Nanotechnology for Oral Drug Delivery. Nanotechnology for Oral Drug Delivery 7 25 .
Akihiro Furukawa, Chad E. Townsend, Joshua Schwochert, Cameron R. Pye, Maria A. Bednarek & R. Scott Lokey. (2016) Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry. Journal of Medicinal Chemistry 59:20, pages 9503-9512.
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Per Artursson, Katrin Palm & Kristina Luthman. (2012) Caco-2 monolayers in experimental and theoretical predictions of drug transport. Advanced Drug Delivery Reviews 64, pages 280-289.
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Donald J. AbrahamEdward H. Kerns, Li Di & Guy T. Carter. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 47 72 .
Michael Jozwiakowski & Paul Myrdal. 2008. Water-Insoluble Drug Formulation, Second Edition. Water-Insoluble Drug Formulation, Second Edition 531 566 .
Mitsuru Sugawara, Shota Kadomura, Xin He, Yoh Takekuma, Naonori Kohri & Katsumi Miyazaki. (2005) The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled-release formulations. European Journal of Pharmaceutical Sciences 26:1, pages 1-8.
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Allen Cato & Lynda SuttonDavid Duch & Robert Ferris. 2002. Clinical Drug Trials And Tribulations, Revised And Expanded. Clinical Drug Trials And Tribulations, Revised And Expanded.
Nishit Modi. 2002. Pharmacokinetics in Drug Discovery and Development. Pharmacokinetics in Drug Discovery and Development.
Elizabeth E. Sugg, Lawrence Birkemo, Liang-Shang L. Gan & Timothy K. Tippin. 2002. Integration of Pharmaceutical Discovery and Development. Integration of Pharmaceutical Discovery and Development 507 524 .
Per Artursson, Katrin Palm & Kristina Luthman. (2001) Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1. Advanced Drug Delivery Reviews 46:1-3, pages 27-43.
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Zhen Wang, Cornelis E. C. A. Hop, Kwan H. Leung & JianMei Pang. (2000) Determination ofin vitro permeability of drug candidates through a Caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry. Journal of Mass Spectrometry 35:1, pages 71-76.
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I. M. Twiss, O. Pas, W. Ramp-Koopmanschap, J. Den Hartigh & P. Vermeij. (1999) The Effects of Nitrogen-Containing Bisphosphonates on Human Epithelial (Caco-2) Cells, an In Vitro Model for Intestinal Epithelium. Journal of Bone and Mineral Research 14:5, pages 784-791.
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Laurence Barthe, John Woodley & Georges Houin. (2009) Gastrointestinal absorption of drugs: methods and studies. Fundamental & Clinical Pharmacology 13:2, pages 154-168.
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Thierry Boxus, Roland Touillaux, Georges Dive & Jacqueline Marchand-Brynaert. (1998) Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates. Bioorganic & Medicinal Chemistry 6:9, pages 1577-1595.
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L. Barthe, J. F. Woodley, S. Kenworthy & G. Houin. (1998) An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine. European Journal of Drug Metabolism and Pharmacokinetics 23:2, pages 313-323.
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P Augustijns, P Annaert, P Heylen, G Van den Mooter & R Kinget. (1998) Drug absorption studies of prodrug esters using the Caco-2 model: evaluation of ester hydrolysis and transepithelial transport. International Journal of Pharmaceutics 166:1, pages 45-53.
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Gian Camenisch, Gerd Folkers & Han van de Waterbeemd. (1997) Comparison of passive drug transport through Caco-2 cells and artificial membranes. International Journal of Pharmaceutics 147:1, pages 61-70.
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Per Artursson, Katrin Palm & Kristina Luthman. (1996) Caco-2 monolayers in experimental and theoretical predictions of drug transport. Advanced Drug Delivery Reviews 22:1-2, pages 67-84.
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Han van De Waterbeemd, Gian Camenisch, Gerd Folkers & Oleg A. Raevsky. (2006) Estimation of Caco‐2 Cell Permeability using Calculated Molecular Descriptors. Quantitative Structure-Activity Relationships 15:6, pages 480-490.
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Anthony Adson, Philip S. Burton, Thomas J. Raub, Craig L. Barsuhn, Kenneth L. Audus & Norman F.H. Ho. (1995) Passive Diffusion of Weak Organic Electrolytes across Caco‐2 Cell Monolayers: Uncoupling the Contributions of Hydrodynamic, Transcellular, and Paracellular Barriers. Journal of Pharmaceutical Sciences 84:10, pages 1197-1204.
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Michèle Deldime, Jean-Luc Dewez, Yves-Jacques Schneider & Jacqueline Marchand-Brynaert. (1995) Reactivity assay of surface carboxyl chain-ends of poly(ethylene terephthalate) (PET) film and track-etched microporous membranes using fluorine labelled- and/or 3H-labelled derivatization reagents: tandem analysis by X-ray photoelectron spectroscopy (XPS) and liquid scintillation counting (LSC). Applied Surface Science 90:1, pages 1-14.
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