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Drug Development and Industrial Pharmacy Volume 20, 1994 - Issue 14
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Research Article

Moisture-Activated dry Granulation in a high Shear Mixer

L. H. Christensen NYCOMED DAK, Department of Pharmaceutical Development, Lergravsvej 59, DK-2300, Copenhagen, Denmark
,
H. E. Johansen NYCOMED DAK, Department of Pharmaceutical Development, Lergravsvej 59, DK-2300, Copenhagen, Denmark
&
T. Schaefer Department of Pharmaceutics, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark
Pages 2195-2213 | Published online: 20 Oct 2008

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Aniruddha M. Railkar & Joseph B. Schwartz. (2000) Evaluation and Comparison of a Moist Granulation Technique to Conventional Methods. Drug Development and Industrial Pharmacy 26:8, pages 885-889.
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Giovanni Filippo Palmieri, Roberta Grifantini, Piera Di Martino & Sante Martelli. (2000) Emulsion/Solvent Evaporation as an Alternative Technique in Pellet Preparation. Drug Development and Industrial Pharmacy 26:11, pages 1151-1158.
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Articles from other publishers (15)

Andres Letona, Sungahm Ahn, Suyeon An, Daebeom Yun, Young-Rok Kim, Mario Muralles & Donghwa Chung. (2023) High-Shear Granulation of Hygroscopic Probiotic-Encapsulated Skim Milk Powder: Effects of Moisture-Activation and Resistant Maltodextrin. Pharmaceuticals 16:2, pages 217.
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Mizuki Yamada, Agata Ishikawa, Shun Muramatsu, Takayuki Furuishi, Yoshinori Onuki, Kaori Fukuzawa & Etsuo Yonemochi. (2022) Study of Orally Disintegrating Tablets Using Erythritol as an Excipient Produced by Moisture-Activated Dry Granulation (MADG). Pharmaceuticals 15:8, pages 1004.
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Sarvesh S. Sabnis, Shikhar D. Singh & Parag R. Gogate. (2022) Improvements in azithromycin recrystallization using ultrasound for size reduction. Ultrasonics Sonochemistry 83, pages 105922.
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Agata Ishikawa, Hiroshi TakasakiAtsushi SakuraiTakuma KatayamaKoichi WadaTakayuki Furuishi, Kaori Fukuzawa, Yasuko Obata & Etsuo Yonemochi. (2021) Manufacturability and Properties of Granules and Tablets Using the Eco-Friendly Granulation Method Green Fluidized Bed Granulation Compared to Direct Compression. Chemical and Pharmaceutical Bulletin 69:5, pages 447-455.
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Bjad K. Almutairy, El-Sayed Khafagy, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Bader B. Alsulays, Abdullah S. Alshetaili, Sultan M. Alshehri & Mohamed H. Fayed. (2020) Enhancing the Poor Flow and Tableting Problems of High Drug-Loading Formulation of Canagliflozin Using Continuous Green Granulation Process and Design-of-Experiment Approach. Pharmaceuticals 13:12, pages 473.
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Alhussain H. Aodah, Mohamed H. Fayed, Ahmed Alalaiwe, Bader B. Alsulays, Mohammed F. Aldawsari & El-Sayed Khafagy. (2020) Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach. Pharmaceutics 12:7, pages 598.
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Hiroshi Takasaki, Atsushi Sakurai, Takuma Katayama, Yuka Matsuura, Naoko Ohyagi, Masashi Mizoguchi, Junichi Takano, Koichi Wada, Koh Matsui, Takuya Nagato, Agata Ishikawa & Etsuo Yonemochi. (2019) Importance of free water in controlling granule and tablet properties in a novel granulation method, green fluidized bed granulation (GFBG). International Journal of Pharmaceutics 570, pages 118647.
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Hiroshi Takasaki, Atsushi Sakurai, Takuma Katayama, Yuka Matsuura, Naoko Ohyagi, Koichi Wada, Agata Ishikawa & Etsuo Yonemochi. (2019) Novel, lean and environment-friendly granulation method: Green fluidized bed granulation (GFBG). International Journal of Pharmaceutics 557, pages 18-25.
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Ajit S. Narang & Sherif I.F. Badawy. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 825 840 .
Y. Liu, M. R. Thompson, K. P. O'Donnell & S. Ali. (2017) Heat assisted twin screw dry granulation. AIChE Journal 63:11, pages 4748-4760.
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Kailas K. Moravkar, Tariq M. Ali, Jaywant N. Pawar & Purnima D. Amin. (2017) Application of moisture activated dry granulation (MADG) process to develop high dose immediate release (IR) formulations. Advanced Powder Technology 28:4, pages 1270-1280.
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Hiroshi Takasaki, Etsuo Yonemochi, Masanori Ito, Koichi Wada & Katsuhide Terada. (2016) The effect of water activity on granule characteristics and tablet properties produced by moisture activated dry granulation (MADG). Powder Technology 294, pages 113-118.
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Hiroshi Takasaki, Etsuo Yonemochi, Roman Messerschmid, Masanori Ito, Koichi Wada & Katsuhide Terada. (2013) Importance of excipient wettability on tablet characteristics prepared by moisture activated dry granulation (MADG). International Journal of Pharmaceutics 456:1, pages 58-64.
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Herbert StickerHerbert Sticker. 2003. Arzneiformen-Entwicklung. Arzneiformen-Entwicklung 39 71 .
Sabine Inghelbrecht & Jean Paul Remon. (1998) Reducing dust and improving granule and tablet quality in the roller compaction process. International Journal of Pharmaceutics 171:2, pages 195-206.
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