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Drug Development and Industrial Pharmacy Volume 21, 1995 - Issue 5
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Research Article

Evaluation of Bilayer Tablet Machines—A Case Study

Shun Por Li Pharmaceutical Technology and Engineering, Rhone-Poulenc Rorer Pharmaceuticals Inc., Fort Washington, PA
,
Marshall G. Karth Central Research, Rhone-Poulenc Rorer Pharmaceuticals Inc, Collegeville, PA
,
Kenneth M. Feld Affinity Pharmaceutics, Fort Washington, PA
,
Louis C. Di Paolo Pharmaceutical Technology and Engineering, Rhone-Poulenc Rorer Pharmaceuticals Inc., Fort Washington, PA
,
Chandrashekar M. Pendharkar Johnson & Johnson Merck Consumer Pharmaceuticals Co., Fort Washington, PA
&
Robert O. Williams Pharmaceutical Technology and Engineering, Rhone-Poulenc Rorer Pharmaceuticals Inc., Fort Washington, PA
Pages 571-590 | Published online: 20 Oct 2008

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Divyakant Desai, Jennifer Wang, Hong Wen, Xuhong Li & Peter Timmins. (2013) Formulation design, challenges, and development considerations for fixed dose combination (FDC) of oral solid dosage forms. Pharmaceutical Development and Technology 18:6, pages 1265-1276.
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Articles from other publishers (13)

Dong Han Won, Heejun Park, Jeong-Woong Seo, Sun Woo Jang, Eun-Sol Ha & Min-Soo Kim. (2022) Active coating of immediate-release evogliptin tartrate to prepare fixed dose combination tablet with sustained-release metformin HCl. International Journal of Pharmaceutics 623, pages 121927.
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Mayuri B. PatilAvish D. MaruJayshree S. Bhadane. (2021) Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride. Asian Journal of Research in Pharmaceutical Sciences, pages 273-279.
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Mayuri B. PatilPriyanka M. SalveShital V. SonawaneAvish D. MaruJayshree S. BhadaneRajendra K. Surawase. (2021) Technologies in Bilayer Tablet Manufacturing: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology, pages 253-258.
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Dong Han Won, Heejun Park, Eun-Sol Ha, Hwan-Ho Kim, Sun Woo Jang & Min-Soo Kim. (2021) Optimization of bilayer tablet manufacturing process for fixed dose combination of sustained release high-dose drug and immediate release low-dose drug based on quality by design (QbD). International Journal of Pharmaceutics 605, pages 120838.
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Muneeba Akhtar, Muhammad Jamshaid, Muhammad Zaman & Agha Zeeshan Mirza. (2020) Bilayer tablets: A developing novel drug delivery system. Journal of Drug Delivery Science and Technology 60, pages 102079.
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Thi-Tram Nguyen, Hye-Ryeong Park, Cheol-Hee Cho, Kyu-Mok Hwang & Eun-Seok Park. (2020) Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator. International Journal of Pharmaceutics 582, pages 119308.
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Tomasz Blicharski, Katarzyna Swiader, Anna Serefko, Sylwia Kulczycka-Mamona, Michal Kolodziejczyk & Aleksandra Szopa. (2019) Challenges in technology of bilayer and multi-layer tablets: a mini-review. Current Issues in Pharmacy and Medical Sciences 32:4, pages 229-235.
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Marco Bellini, Mathias Walther & Roland Bodmeier. (2019) Evaluation of manufacturing process parameters causing multilayer tablets delamination. International Journal of Pharmaceutics 570, pages 118607.
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Valjon Demiri, Sandra Stranzinger, Paul Rinner, Michael Piller, Stephan Sacher, Josef Lingitz, Johannes Khinast & Sharareh Salar-Behzadi. (2018) Gluing Pills Technology: A novel route to multilayer tablet manufacturing. International Journal of Pharmaceutics 548:1, pages 672-681.
Crossref
Y. Qiu, X. He, L. Zhu & B. Chen. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 555 591 .
Admassu Abebe, Ilgaz Akseli, Omar Sprockel, Niranjan Kottala & Alberto M. Cuitiño. (2014) Review of bilayer tablet technology. International Journal of Pharmaceutics 461:1-2, pages 549-558.
Crossref
Niranjan Kottala, Admassu Abebe, Omar Sprockel, James Bergum, Faranak Nikfar & Alberto M. Cuitiño. (2012) Evaluation of the Performance Characteristics of Bilayer Tablets: Part I. Impact of Material Properties and Process Parameters on the Strength of Bilayer Tablets. AAPS PharmSciTech 13:4, pages 1236-1242.
Crossref
Yihong Qiu & Guohua Zhang. 2009. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 501 517 .

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