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Drug Development and Industrial Pharmacy Volume 21, 1995 - Issue 19
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Research Article

Requirements for the Production of Microtablets: Suitability of Direct-Compression Excipients Estimated from Powder Characteristics and Flow Rates

J. Flemming Department of Pharmaceutical Technology, University of Hamburg, Hamburg, Germany
&
J. B. Mielck Department of Pharmaceutical Technology, University of Hamburg, Hamburg, Germany
Pages 2239-2251 | Published online: 20 Oct 2008

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Aleksandar Aleksovski, Rok Dreu, Mirjana Gašperlin & Odon Planinšek. (2015) Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups. Expert Opinion on Drug Delivery 12:1, pages 65-84.
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Faiezah A. A. Mohamed, Matthew Roberts, Linda Seton, James L. Ford, Marina Levina & Ali R. Rajabi-Siahboomi. (2013) Production of extended release mini-tablets using directly compressible grades of HPMC. Drug Development and Industrial Pharmacy 39:11, pages 1690-1697.
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Matthew Roberts, Daniele Vellucci, Shabbir Mostafa, Cedric Miolane & Delphine Marchaud. (2012) Development and evaluation of sustained-release Compritol® 888 ATO matrix mini-tablets. Drug Development and Industrial Pharmacy 38:9, pages 1068-1076.
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Kenta Goto, Hisakazu Sunada, Kazumi Danjo & Yorinobu Yonezawa. (1999) Pharmaceutical Evaluation of Multipurpose Excipients for Direct Compressed Tablet Manufacture: Comparisons of the Capabilities of Multipurpose Excipients with Those in General Use. Drug Development and Industrial Pharmacy 25:8, pages 869-878.
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Articles from other publishers (26)

Ard Lura & Jörg Breitkreutz. (2022) Manufacturing of mini-tablets. Focus and impact of the tooling systems. Journal of Drug Delivery Science and Technology 72, pages 103357.
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Arkadiusz Hejduk & Janina Lulek. (2022) Dispensing of minitablets – Has the problem been resolved?. International Journal of Pharmaceutics 619, pages 121666.
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Salman MohdQazi Majaz AAbrarul HaqSandip Raut. (2022) An Overview of Pharmaceutical Mini Tablet. Research Journal of Pharmaceutical Dosage Forms and Technology, pages 94-102.
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Guendalina Zuccari, Silvana Alfei, Danilo Marimpietri, Valentina Iurilli, Paola Barabino & Leonardo Marchitto. (2022) Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics. Pharmaceuticals 15:1, pages 108.
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Arkadiusz Hejduk, Michał Teżyk, Emilia Jakubowska, Klaudia Krüger & Janina Lulek. (2022) Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin. AAPS PharmSciTech 23:1.
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Cheol-Hee Cho, Ju-Young Kim & Eun-Seok Park. (2021) Utilization of a compaction simulator to formulate mini-tablets containing high dose of acyclovir. Journal of Drug Delivery Science and Technology 64, pages 102602.
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Emma Hellberg, Annica Westberg, Patrik Appelblad & Sofia Mattsson. (2021) Evaluation of dissolution techniques for orally disintegrating mini-tablets. Journal of Drug Delivery Science and Technology 61, pages 102191.
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Ard Lura, Guillaume Tardy, Peter Kleinebudde & Jörg Breitkreutz. (2020) Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions. International Journal of Pharmaceutics: X 2, pages 100061.
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Bereket Yohannes, Xue Liu, Gary Yacobian & Alberto M. Cuitiño. (2018) Particle size induced heterogeneity in compacted powders: Effect of large particles. Advanced Powder Technology 29:12, pages 2978-2986.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2018) Investigation on the impact of powder arching in small die filling. International Journal of Pharmaceutics 551:1-2, pages 42-51.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2018) Understanding effects of process parameters and forced feeding on die filling. European Journal of Pharmaceutical Sciences 122, pages 105-115.
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Junshu Zhao, David Yin, Jasmine Rowe, Sherif Badawy, Faranak Nikfar & Preetanshu Pandey. (2018) Understanding the Factors That Control the Quality of Mini-Tablet Compression: Flow, Particle Size, and Tooling Dimension. Journal of Pharmaceutical Sciences 107:4, pages 1204-1208.
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Hui Ping Goh, Paul Wan Sia Heng & Celine Valeria Liew. (2017) Understanding die fill variation during mini-tablet production. International Journal of Pharmaceutics 534:1-2, pages 279-286.
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Ugurlu Timucin. (2017) Mini Tablets: A Short Review-Revision. Open Journal of Chemistry, pages 012-022.
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Marina Levina, Hue Voung & Ali R. Rajabi-Siahboomi. 2017. Multiparticulate Drug Delivery. Multiparticulate Drug Delivery 95 118 .
Eirik Hagen, Fredrik Sandberg Løding, Sofia Mattsson & Ingunn Tho. (2016) Use of interactive mixtures to obtain mini-tablets with high dose homogeneity for paediatric drug delivery. Journal of Drug Delivery Science and Technology 34, pages 51-59.
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Aleksandar Aleksovski, Matevž Luštrik, Rok Šibanc & Rok Dreu. (2015) Design and evaluation of a specific, bi-phase extended release system based on differently coated mini-tablets. European Journal of Pharmaceutical Sciences 75, pages 114-122.
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Sejal R. Ranmal, Susan A. Barker & Catherine Tuleu. 2014. Pediatric Formulations. Pediatric Formulations 153 170 .
Corinna Tissen, Katharina Woertz, Joerg Breitkreutz & Peter Kleinebudde. (2011) Development of mini-tablets with 1mm and 2mm diameter. International Journal of Pharmaceutics 416:1, pages 164-170.
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Nikolaos Vlachos & Isaac T.H. Chang. (2011) Investigation of flow properties of metal powders from narrow particle size distribution to polydisperse mixtures through an improved Hall-flowmeter. Powder Technology 205:1-3, pages 71-80.
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Kari Seppälä, Jyrki Heinämäki, Juha Hatara, Lassi Seppälä & Jouko Yliruusi. (2010) Development of a New Method to Get a Reliable Powder Flow Characteristics Using Only 1 to 2 g of Powder. AAPS PharmSciTech 11:1, pages 402-408.
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Niklas Sandler & David Wilson. (2010) Prediction of granule packing and flow behavior based on particle size and shape analysis. Journal of Pharmaceutical Sciences 99:2, pages 958-968.
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K. Kachrimanis, M. Petrides & S. Malamataris. (2005) Flow rate of some pharmaceutical diluents through die-orifices relevant to mini-tableting. International Journal of Pharmaceutics 303:1-2, pages 72-80.
Crossref
Yvonne S. L. Lee, Richard Poynter, Fridrun Podczeck & J. Michael Newton. (2000) Development of a dual approach to assess powder flow from avalanching behavior. AAPS PharmSciTech 1:3, pages 44-52.
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Fridrun Podczeck, Simon Blackwell, Matthew Gold & J.Michael Newton. (1999) The filling of granules into hard gelatine capsules. International Journal of Pharmaceutics 188:1, pages 59-69.
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P. Lennartz & J.B. Mielck. (1998) Minitabletting: improving the compactability of paracetamol powder mixtures. International Journal of Pharmaceutics 173:1-2, pages 75-85.
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