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Research Article

The Influence of Tablet Shape and Pan Speed on Intra-tablet Film Coating Uniformity

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Pages 1239-1243 | Published online: 20 Oct 2008

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Read on this site (5)

Linda A. Felton. (2018) Use of polymers for taste-masking pediatric drug products. Drug Development and Industrial Pharmacy 44:7, pages 1049-1055.
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A. Galí, E. García-Montoya, M. Ascaso, P. Pérez-Lozano, J. R. Ticó, M. Miñarro & J. M. Suñé-Negre. (2016) Improving tablet coating robustness by selecting critical process parameters from retrospective data. Pharmaceutical Development and Technology 21:6, pages 688-697.
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Nikhil Malewar, Makarand Avachat, Shirish Kulkarni & Varsha Pokharkar. (2015) Design and evaluation of novel barrier layer technologies for controlling venlafaxine hydrochloride release from tablet dosage form. Pharmaceutical Development and Technology 20:5, pages 588-597.
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Faiezah A. A. Mohamed, Matthew Roberts, Linda Seton, James L. Ford, Marina Levina & Ali R. Rajabi-Siahboomi. (2015) Film-coated matrix mini-tablets for the extended release of a water-soluble drug. Drug Development and Industrial Pharmacy 41:4, pages 623-630.
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Ekneet Sahni & Bodhisattwa Chaudhuri. (2012) Experimental and modeling approaches in characterizing coating uniformity in a pan coater: A literature review. Pharmaceutical Development and Technology 17:2, pages 134-147.
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Articles from other publishers (38)

Beata Sarecka-Hujar, Beata Szulc-Musioł, Michał Meisner & Piotr Duda. (2022) The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide. Processes 10:10, pages 1934.
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Vaibhav Dubey, Manjit Jaiswal, Ritika Puri & Vimal Arora. (2022) Effect of coating material on dissolution profile of BCS class 1 anti-epileptic extended-release tablets. Materials Today: Proceedings 68, pages 774-779.
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Preksha Vinchhi & Mayur M. Patel. 2022. Optimization of Pharmaceutical Processes. Optimization of Pharmaceutical Processes 103 133 .
Krisztina Ludasi, Orsolya Jójárt-Laczkovich, Tamás Sovány, Béla Hopp, Tamás Smausz, Attila Andrásik, Tamás Gera, Zsolt Kovács & Géza Regdon jr. (2021) Anti-counterfeiting protection, personalized medicines − Development of 2D identification methods using laser technology. International Journal of Pharmaceutics 605, pages 120793.
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Eun Ji Kim, Ji Hyeon Kim, Min-Soo Kim, Seong Hoon Jeong & Du Hyung Choi. (2021) Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification. Pharmaceutics 13:6, pages 919.
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Juliana Radtke, Raphael Wiedey & Peter Kleinebudde. (2019) Effect of coating time on inter- and intra-tablet coating uniformity. European Journal of Pharmaceutical Sciences 137, pages 104970.
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P.R. Wahl, A. Peter, M. Wolfgang & J.G. Khinast. (2019) How to measure coating thickness of tablets: Method comparison of optical coherence tomography, near-infrared spectroscopy and weight-, height- and diameter gain. European Journal of Pharmaceutics and Biopharmaceutics 142, pages 344-352.
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Bumjoon Cha, Shaun C. Galbraith, Huolong Liu, Seo-Young Park, Zhuangrong Huang, Thomas O’Connor, Sau Lee & Seongkyu Yoon. (2019) A Thermodynamic Balance Model for Liquid Film Drying Kinetics of a Tablet Film Coating and Drying Process. AAPS PharmSciTech 20:5.
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Norzaida Yusof, Joshua Green, Kate Pitt, Omid Arjmandi-Tash, Andrew I. Campbell, Hossein Ahmadian, Hossam Tantawy & Rachel Smith. (2019) A novel method for the analysis of particle coating behaviour via contact spreading in a tumbling drum: Effect of coating liquid viscosity. Powder Technology 351, pages 102-114.
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Elena Macchi & Linda A. Felton. (2016) Influence of relative humidity during coating on polymer deposition and film formation. International Journal of Pharmaceutics 510:1, pages 116-124.
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Majid Rasouli, Olivier Dubé, François Bertrand & Jamal Chaouki. (2016) Investigating the dynamics of cylindrical particles in a rotating drum using multiple radioactive particle tracking. AIChE Journal 62:8, pages 2622-2634.
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Anjali M. Agrawal & Preetanshu Pandey. (2015) Scale Up of Pan Coating Process Using Quality by Design Principles. Journal of Pharmaceutical Sciences 104:11, pages 3589-3611.
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H.R. Norouzi, R. Zarghami & N. Mostoufi. (2015) Insights into the granular flow in rotating drums. Chemical Engineering Research and Design 102, pages 12-25.
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Ben Freireich, Rahul Kumar, William Ketterhagen, Ke Su, Carl Wassgren & J. Axel Zeitler. (2015) Comparisons of intra-tablet coating variability using DEM simulations, asymptotic limit models, and experiments. Chemical Engineering Science 131, pages 197-212.
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Luqman Hakim Hassan, Ku Zilati Ku Shaari & Zakaria Man. (2014) Urea Hardness Optimization in a Fluidized Bed Coating Equipment Using Taguchi Design Method. Applied Mechanics and Materials 699, pages 111-117.
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Ku Zilati Ku Shaari, Luqman Hakim Hassan & Zakaria Man. (2014) Optimization of Coating Thickness in a Tangential Fluidized Bed. Applied Mechanics and Materials 625, pages 131-135.
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Preetanshu Pandey, Dilbir S. Bindra & Linda A. Felton. (2013) Influence of Process Parameters on Tablet Bed Microenvironmental Factors During Pan Coating. AAPS PharmSciTech 15:2, pages 296-305.
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Matteo Ottavian, Massimiliano Barolo & Salvador García-Muñoz. (2014) Multivariate Image and Texture Analysis to Investigate the Erosion Mechanism of Film-coated Tablets: An Industrial Case Study. Journal of Pharmaceutical Innovation 9:1, pages 5-15.
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Daniela Brock, J. Axel Zeitler, Adrian Funke, Klaus Knop & Peter Kleinebudde. (2013) Evaluation of critical process parameters for intra-tablet coating uniformity using terahertz pulsed imaging. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 1122-1129.
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Miriam Haaser, Kaisa Naelapää, Keith C. Gordon, Michael Pepper, Jukka Rantanen, Clare J. Strachan, Philip F. Taday, J. Axel Zeitler & Thomas Rades. (2013) Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 1095-1102.
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Nikhil Malewar, Makarand Avachat, Varsha Pokharkar & Shirish Kulkarni. (2013) Controlled Release of Ropinirole Hydrochloride from a Multiple Barrier Layer Tablet Dosage Form: Effect of Polymer Type on Pharmacokinetics and IVIVC. AAPS PharmSciTech 14:3, pages 1178-1189.
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Olivier Dubé, Ebrahim Alizadeh, Jamal Chaouki & François Bertrand. (2013) Dynamics of non-spherical particles in a rotating drum. Chemical Engineering Science 101, pages 486-502.
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Madhusudhan Kodam, Jennifer Curtis, Bruno Hancock & Carl Wassgren. (2012) Discrete element method modeling of bi-convex pharmaceutical tablets: Contact detection algorithms and validation. Chemical Engineering Science 69:1, pages 587-601.
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Daniele Suzzi, Gregor Toschkoff, Stefan Radl, Daniel Machold, Simon D. Fraser, Benjamin J. Glasser & Johannes G. Khinast. (2012) DEM simulation of continuous tablet coating: Effects of tablet shape and fill level on inter-tablet coating variability. Chemical Engineering Science 69:1, pages 107-121.
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Ben Freireich, William R. Ketterhagen & Carl Wassgren. (2011) Intra-tablet coating variability for several pharmaceutical tablet shapes. Chemical Engineering Science 66:12, pages 2535-2544.
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X. Y. Liu, X. Xu & Y. Y. Zhang. (2011) Experimental Study on Time Features of Particle Motion in Rotating Drums. Chemical Engineering & Technology 34:6, pages 997-1002.
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William R. Ketterhagen. (2011) Modeling the motion and orientation of various pharmaceutical tablet shapes in a film coating pan using DEM. International Journal of Pharmaceutics 409:1-2, pages 137-149.
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Ekneet Sahni, Robert Yau & Bodhisattwa Chaudhuri. (2011) Understanding granular mixing to enhance coating performance in a pan coater: Experiments and simulations. Powder Technology 205:1-3, pages 231-241.
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Kyung-Min Lee, Paul R. Armstrong, J. Alex Thomasson, Ruixiu Sui, Mark Casada & Timothy J. Herrman. (2010) Development and Characterization of Food-Grade Tracers for the Global Grain Tracing and Recall System. Journal of Agricultural and Food Chemistry 58:20, pages 10945-10957.
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Shayne Cox GadSacide Alsoy Altinkaya. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Ben Freireich & Carl Wassgren. (2010) Intra-particle coating variability: Analysis and Monte-Carlo simulations. Chemical Engineering Science 65:3, pages 1117-1124.
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Louise Ho, Ronny Müller, Cornelia Krüger, Keith C. Gordon, Peter Kleinebudde, Michael Pepper, Thomas Rades, Yaochun Shen, Philip F. Taday & J. Axel Zeitler. (2010) Investigating dissolution performance critical areas on coated tablets: A case study using terahertz pulsed imaging. Journal of Pharmaceutical Sciences 99:1, pages 392-402.
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Ronny Mueller & Peter Kleinebudde. (2007) Prediction of tablet velocity in pan coaters for scale-up. Powder Technology 173:1, pages 51-58.
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Preetanshu Pandey & Richard Turton. (2005) Movement of different-shaped particles in a pan-coating device using novel video-imaging techniques. AAPS PharmSciTech 6:2, pages E237-E244.
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Sandeepa Sandadi, Preetanshu Pandey & Richard Turton. (2004) In situ, near real-time acquisition of particle motion in rotating pan coating equipment using imaging techniques. Chemical Engineering Science 59:24, pages 5807-5817.
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George W. Smith, Graeme S. Macleod & John T. Fell. (2003) Mixing efficiency in side-vented coating equipment. AAPS PharmSciTech 4:3, pages 71-75.
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Susanne Tobiska & Peter Kleinebudde. (2003) Coating uniformity and coating efficiency in a Bohle Lab-Coaterusing oval tablets. European Journal of Pharmaceutics and Biopharmaceutics 56:1, pages 3-9.
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Susanne Tobiska & Peter Kleinebudde. (2001) A simple method for evaluating the mixing efficiency of a new type of pan coater. International Journal of Pharmaceutics 224:1-2, pages 141-149.
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