217
Views
48
CrossRef citations to date
0
Altmetric
Research Article

The Influence of Five Selected Processing and Formulation Variables on the Particle Size, Particle Size Distribution, and Friability of Pellets Produced in a Rotary Processor

&
Pages 39-46 | Published online: 20 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

Nikhil C. Loka, Kalyan K. Saripella, Colin A. Pinto & Steven H. Neau. (2018) Use of extrusion aids for successful production of Kollidon® CL-SF pellets by extrusion–spheronization. Drug Development and Industrial Pharmacy 44:4, pages 632-642.
Read now
Sonia Pandey, S. M. Vijayendra Swamy, Arti Gupta, Akshay Koli, Swagat Patel, Furqan Maulvi & Bhavin Vyas. (2018) Multiple response optimisation of processing and formulation parameters of pH sensitive sustained release pellets of capecitabine for targeting colon . Journal of Microencapsulation 35:3, pages 259-271.
Read now
A. A. Karatzas, S. N. Politis & D. M. Rekkas. (2017) Development of rapidly dissolving pellets within the Quality by Design approach. Drug Development and Industrial Pharmacy 43:5, pages 770-779.
Read now
Florian Priese, Toni Frisch & Bertram Wolf. (2015) Comparison of film-coated retarded release pellets manufactured by layering technique or by bed rotor pelletization. Pharmaceutical Development and Technology 20:4, pages 417-425.
Read now
Julien Scala-Bertola, Jan Gajdziok, Miloslava Rabišková, François Bonneaux, Thomas Lecompte, Anne Sapin & Philippe Maincent. (2009) Pellets for oral administration of low-molecular-weight heparin. Drug Development and Industrial Pharmacy 35:12, pages 1503-1510.
Read now
Eva Gryczová, Miloslava Rabišková, David Vetchý & Kateřina Krejčová. (2008) Pellet Starters in Layering Technique Using Concentrated Drug Solution. Drug Development and Industrial Pharmacy 34:12, pages 1381-1387.
Read now
Adam Häring, David Vetchý, Lucie Janovská, Kateřina Krejčová & Miloslava Rabišková. (2008) Differences in Characteristics of Pellets Prepared by Different Pelletization Methods. Drug Development and Industrial Pharmacy 34:3, pages 289-296.
Read now
Yogesh M. Rane, Rajshree C. Mashru, Mayur G. Sankalia, Vijay B. Sutariya,Punit P. Shah. (2007) Investigations on Factors Affecting Chitosan for Dissolution Enhancement of Oxcarbazepine by Spray Dried Microcrystal Formulation With an Experimental Design Approach. Drug Development and Industrial Pharmacy 33:9, pages 1008-1023.
Read now
L. Gu, C.V. Liew, J.L.P. Soh & P.W.S. Heng. (2006) Feasibility of Eliminating Premixing for the Production of Pellets in a Rotary Processor. Pharmaceutical Development and Technology 11:2, pages 159-165.
Read now
Kateřina Krejčová, Miloslava Rabišková, David Vetchý, Ermin Polášek, Václav Tomášek & Alena Prokopová. (2006) The Influence of Drug Solubility and Particle Size on the Pellet Formulation in a Rotoprocessor. Drug Development and Industrial Pharmacy 32:5, pages 585-593.
Read now
Beatrice Nkem Chukwumezie, Mark Wojcik, Paul Malak, Frank D'Amico & Moji Christianah Adeyeye. (2004) Factorial Design in the Spheronization of Ibuprofen Microparticulates Using the Rotor Disk Fluid‐Bed Technology. Pharmaceutical Development and Technology 9:1, pages 49-62.
Read now
L. Gu, C. V. Liew & P. W.S. Heng. (2004) Wet Spheronization by Rotary Processing—A Multistage Single‐Pot Process for Producing Spheroids. Drug Development and Industrial Pharmacy 30:2, pages 111-123.
Read now
Stefaan Vervarcke, Frans Ollevier, Renaat Kinget & Armand Michoel. (2002) Development of a Lag Time Coating for Drug-Layered Fish Feed Pellets. Pharmaceutical Development and Technology 7:4, pages 471-480.
Read now
Jakob Kristensen, Torben Schæfer & Peter Kleinebudde. (2002) Development of Fast-Disintegrating Pellets in a Rotary Processor. Drug Development and Industrial Pharmacy 28:10, pages 1201-1212.
Read now
Jakob Kristensen, Torben Schæfer & Peter Kleinebudde. (2000) Direct Pelletization in a Rotary Processor Controlled by Torque Measurements. I. Influence of Process Variables. Pharmaceutical Development and Technology 5:2, pages 247-256.
Read now
Celine V. Liew, Lucy S. C. Wan & Paul W. S. Heng. (2000) Role of Base Plate Rotational Speed in Controlling Spheroid Size Distribution and Minimizing Oversize Particle Formation During Spheroid Production by Rotary Processing. Drug Development and Industrial Pharmacy 26:9, pages 953-963.
Read now
Jan Vertommen, Patrick Rombaut, Armand Michoel & Renaat Kinget. (1998) Estimation of the Amount of Water Removed by Gap and Atomization Air Streams During Pelletization in a Rotary Processor. Pharmaceutical Development and Technology 3:1, pages 63-72.
Read now
E. A. Hosny, G. M. El-Mahrouk & M. W. Gouda. (1998) Formulation and in Vitro and in Vivo Availability of Diclofenac Sodium Enteric-Coated Beads. Drug Development and Industrial Pharmacy 24:7, pages 661-666.
Read now

Articles from other publishers (30)

Marcel Langner, Biwen Zhou, Florian Priese & Bertram Wolf. (2023) Statistical Investigation of Rotary Fluidized Bed Agglomeration Process with Tangential Spray and In-Line Particle Size Measurement for PAT Process Control. Processes 11:4, pages 1066.
Crossref
Jan Macku, Katerina Kubova, Martina Urbanova, Jan Muselik, Ales Franc, Gabriela Koutna, Miroslava Pavelkova, David Vetchy, Josef Masek, Eliska Maskova & Jiri Brus. (2022) Rational Design of Self-Emulsifying Pellet Formulation of Thymol: Technology Development Guided by Molecular-Level Structure Characterization and Ex Vivo Testing. Pharmaceutics 14:8, pages 1545.
Crossref
Evelin Gutiérrez Moreno, José A. Rodriguez Ávila & Julián Cruz Borbolla. 2022. Quality Control Applications in the Pharmaceutical and Medical Device Manufacturing Industry. Quality Control Applications in the Pharmaceutical and Medical Device Manufacturing Industry 1 23 .
Jiří Zeman, Sylvie Pavloková, David Vetchý, Adam Staňo, Zdeněk Moravec, Lukáš Matějovský & Vladimír Pitschmann. (2021) Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection. Pharmaceutics 13:11, pages 1860.
Crossref
Marcel Langner, Ivonne Kitzmann, Anna-Lena Ruppert, Inken Wittich & Bertram Wolf. (2020) In-line particle size measurement and process influences on rotary fluidized bed agglomeration. Powder Technology 364, pages 673-679.
Crossref
Jakub Vysloužil, David Vetchý, Jiří Zeman, Oldřich Farsa, Aleš Franc, Jan Gajdziok, Jan Vysloužil, Katarína Ficeriová, Pavel Kulich, Zbyněk Kobliha & Vladimír Pitschmann. (2018) Pellet patented technology for fast and distinct visual detection of cholinesterase inhibitors in liquids. Journal of Pharmaceutical and Biomedical Analysis 161, pages 206-213.
Crossref
Nilesh Desai & Ravindra Purohit. (2017) Development of Novel High Density Gastroretentive Multiparticulate Pulsatile Tablet of Clopidogrel Bisulfate Using Quality by Design Approach. AAPS PharmSciTech 18:8, pages 3208-3218.
Crossref
James C. DiNunzio & James W. McGinity. 2017. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 451 475 .
Richard Sidwell, Jason Hansell, Manish Rane & Ali R. Rajabi-Siahboomi. 2017. Multiparticulate Drug Delivery. Multiparticulate Drug Delivery 5 35 .
Dana Sabadková, Aleš Franc, Jan Muselík & David Neumann. (2016) Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes. Acta Pharmaceutica 66:2, pages 257-267.
Crossref
Navjot Kanwar, Rakesh Kumar & V.R. Sinha. (2015) Preparation and Evaluation of Multi-Particulate System (Pellets) of Prasugrel Hydrochloride. Open Pharmaceutical Sciences Journal 2:1, pages 74-80.
Crossref
James C. DiNunzio & James W. McGinity. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 2979 3004 .
Rahul Dixit & Shivanand Puthli. (2009) Fluidization technologies: Aerodynamic principles and process engineering. Journal of Pharmaceutical Sciences 98:11, pages 3933-3960.
Crossref
Lucia Zema, Luca Palugan, Alessandra Maroni, Anastasia Foppoli, Maria Edvige Sangalli & Andrea Gazzaniga. (2008) The Use of ß-Cyclodextrin in the Manufacturing of Disintegrating Pellets with Improved Dissolution Performances. AAPS PharmSciTech 9:2.
Crossref
L. Zema, L. Palugan, M. Cerea, A. Foppoli, A. Maroni & M.E. Sangalli. (2008) Pelletization of a β-cyclodextrin-acetaminophen interaction compound in a rotary fluid bed granulator: an optimization study. Journal of Drug Delivery Science and Technology 18:3, pages 197-202.
Crossref
J. Bouffard, H. Dumont, F. Bertrand & R. Legros. (2007) Optimization and scale-up of a fluid bed tangential spray rotogranulation process. International Journal of Pharmaceutics 335:1-2, pages 54-62.
Crossref
Peter Kleinebudde & Klaus Knop. 2007. Granulation. Granulation 779 811 .
S. Salar Behzadi, Silvester Ölzant, Reinhard Länger, Christian Koban, Frank M. Unger & Helmut Viernstein. (2006) Investigation of the stability of tablets prepared from sucrose and citric acid anhydride utilizing response surface methodology. European Food Research and Technology 223:2, pages 238-245.
Crossref
Jakob Kristensen & Vibeke Wallaert Hansen. (2017) Wet granulation in rotary processor and fluid bed: Comparison of granule and tablet properties. AAPS PharmSciTech 7:1, pages E153-E162.
Crossref
Jakob Kristensen. (2005) Direct pelletization in a rotary processor controlled by torque measurements. III. Investigation of microcrystalline cellulose and lactose grade. AAPS PharmSciTech 6:3, pages E495-E503.
Crossref
Sharareh Salar Behzadi, Johanna Klocker, Herbert Hüttlin, Peter Wolschann & Helmut Viernstein. (2005) Validation of fluid bed granulation utilizing artificial neural network. International Journal of Pharmaceutics 291:1-2, pages 139-148.
Crossref
Thomas Vilhelmsen, Jakob Kristensen & Torben Schæfer. (2004) Melt pelletization with polyethylene glycol in a rotary processor. International Journal of Pharmaceutics 275:1-2, pages 141-153.
Crossref
E.S. Korakianiti, D.M. Rekkas, P.P. Dallas & N.H. Choulis. (2004) Sequential optimization of a pelletization process in a fluid bed rotor granulator. Journal of Drug Delivery Science and Technology 14:3, pages 207-214.
Crossref
Herbert StickerHerbert Sticker. 2003. Arzneiformen-Entwicklung. Arzneiformen-Entwicklung 73 96 .
P.G Paterakis, E.S Korakianiti, P.P Dallas & D.M Rekkas. (2002) Evaluation and simultaneous optimization of some pellets characteristics using a 33 factorial design and the desirability function. International Journal of Pharmaceutics 248:1-2, pages 51-60.
Crossref
Jon Gabrielsson, Nils‐Olof Lindberg & Torbjörn Lundstedt. (2002) Multivariate methods in pharmaceutical applications. Journal of Chemometrics 16:3, pages 141-160.
Crossref
Evdokia S. Korakianiti, Dimitrios M. Rekkas, Paraskevas P. Dallas & Nikolaos H. Choulis. (2000) Optimization of the pelletization process in a fluid-bed rotor granulator using experimental design. AAPS PharmSciTech 1:4, pages 71-75.
Crossref
Jakob Kristensen, Torben Schæfer & Peter Kleinebudde. (2000) Direct pelletization in a rotary processor controlled by torque measurements. II: Effects of changes in the content of microcrystalline cellulose. AAPS PharmSci 2:3, pages 45-52.
Crossref
J. Vertommen & R. Kinget. (1998) Pellets as a dosage form for drugs in aquaculture: technological aspects. Journal of Applied Ichthyology 14:3-4, pages 259-264.
Crossref
J. Vertommen, P. Rombaut & R. Kinget. (1998) Internal and external structure of pellets made in a rotary processor. International Journal of Pharmaceutics 161:2, pages 225-236.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.