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Cancer Investigation Volume 18, 2000 - Issue 4
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Miscellaneous Article

Histamine: A Novel Approach to Cancer Immunotherapy

Kristoffer Hellstrand Departments of Virology, University of Göteborg Göteborg, SwedenCorrespondence[email protected]
,
Mats Brune Departments of Hematology, University of Göteborg Göteborg, Sweden
,
Peter Naredi Departments of Surgery, University of Göteborg Göteborg, Sweden
,
Ulf-Henrik Mellqvist Departments of Hematology, University of Göteborg Göteborg, Sweden
,
Markus Hansson Departments of Virology, University of Göteborg Göteborg, Sweden
,
Kurt R. Gehlsen Maxim Pharmaceuticals, San Diego, California
&
Svante Hermodsson Departments of Virology, University of Göteborg Göteborg, Sweden
 show all
Pages 347-355 | Published online: 11 Jun 2009

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Miguel Ángel Medina, José Luis Urdiales, Carlos Rodríguez-Caso, Francisco Javier Ramírez & Francisca Sánchez-Jiménez. (2003) Biogenic Amines and Polyamines: Similar Biochemistry for Different Physiological Missions and Biomedical Applications. Critical Reviews in Biochemistry and Molecular Biology 38:1, pages 23-59.
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Mariángeles Clauzure, Mónica A. Táquez Delgado, Jude M. Phillip, Maria V. Revuelta, Leandro Cerchietti & Vanina A. Medina. (2022) Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma. International Journal of Molecular Sciences 23:3, pages 1378.
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María de la Paz Sarasola, Mónica A. Táquez Delgado, Melisa B. Nicoud & Vanina A. Medina. (2021) Histamine in cancer immunology and immunotherapy. Current status and new perspectives. Pharmacology Research & Perspectives 9:5.
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Hirotada Otsuka, Yasuo Endo, Hiroshi Ohtsu, Satoshi Inoue, Mutsuki Kuraoka, Miki Koh, Hideki Yagi, Masanori Nakamura & Satoshi Soeta. (2020) Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice. The Anatomical Record 304:5, pages 1136-1150.
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Hirotada Otsuka, Yasuo Endo, Hiroshi Ohtsu, Satoshi Inoue, Syunya Noguchi, Masanori Nakamura & Satoshi Soeta. (2021) Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments. International Journal of Hematology.
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Noelia A Massari, Melisa B Nicoud & Vanina A Medina. (2018) Histamine receptors and cancer pharmacology: an update. British Journal of Pharmacology 177:3, pages 516-538.
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Niloofar Anooshiravani, Sairaman Nagarajan, Maria-Anna Vastardi & Rauno Joks. (2019) Inverse association of asthma and hay fever with cancer in the 2015 National Health Interview Survey database. Annals of Allergy, Asthma & Immunology 123:2, pages 219-220.
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Melisa B. Nicoud, Karina Formoso & Vanina A. Medina. (2019) Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications. Frontiers in Pharmacology 10.
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Ebru Aydin, Junko Johansson, Faisal Hayat Nazir, Kristoffer Hellstrand & Anna Martner. (2017) Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis. Cancer Immunology Research 5:9, pages 804-811.
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Noelia A. Massari, Melisa B. Nicoud, Lorena Sambuco, Graciela P. Cricco, Diego J. Martinel Lamas, María V. Herrero Ducloux, Horacio Blanco, Elena S. Rivera & Vanina A. Medina. (2017) Histamine therapeutic efficacy in metastatic melanoma: Role of histamine H4 receptor agonists and opportunity for combination with radiation. Oncotarget 8:16, pages 26471-26491.
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Jing Cui, Gang Xu, Jinzhong Liu, Zhigang Pang, Jon Florholmen & Guanglin Cui. (2012) The Expression of Non-Mast Histamine in Tumor Associated Microvessels in Human Colorectal Cancers. Pathology & Oncology Research 19:2, pages 311-316.
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María Teresa García Sanz, Francisco Javier González Barcala, José Manuel Álvarez Dobaño & Luis Valdés Cuadrado. (2011) Asthma and risk of lung cancer. Clinical and Translational Oncology 13:10, pages 728-730.
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Roger Mouawad, Marie Sebert, Judith Michels, Joel Bloch, Jean-Philippe Spano & David Khayat. (2010) Treatment for metastatic malignant melanoma: Old drugs and new strategies. Critical Reviews in Oncology/Hematology 74:1, pages 27-39.
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Livia Simon Sarkadi. 2008. Process‐Induced Food Toxicants. Process‐Induced Food Toxicants 321 361 .
ZHENFENG LI, JINZHONG LIU, FUAI TANG, YIQING LIU, HELGE L. WALDUM & GUANGLIN CUI. (2008) Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas . APMIS 116:12, pages 1034-1042.
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Michelle C. Turner, Yue Chen, Daniel Krewski & Parviz Ghadirian. (2006) An overview of the association between allergy and cancer. International Journal of Cancer 118:12, pages 3124-3132.
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Paul R. WalkerSadik A. KhuderWalter D.Y. QuanJr.Jr.. (2005) Continuous Infusion Interleukin-2 and Antihistamines in Metastatic Kidney Cancer. Cancer Biotherapy and Radiopharmaceuticals 20:5, pages 487-490.
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Takeshi Natori, Masataka Sata, Ryozo Nagai & Masatoshi Makuuchi. (2005) Cimetidine inhibits angiogenesis and suppresses tumor growth. Biomedicine & Pharmacotherapy 59:1-2, pages 56-60.
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Maria Evangelista-Dean, Nawazish Khan & Walter QuanJr.Jr.. (2004) Continuous Infusion Interleukin-2 and Antihistamines in Melanoma: A Retrospective Review Showing Activity of This Combination. Cancer Biotherapy and Radiopharmaceuticals 19:6, pages 754-757.
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Ithaar H. Derweesh, Luis Molto, Charles Tannenbaum, Patricia Rayman, Christina Moon, Cynthia Combs, Thomas Olencki, Paul Elson, Ronald M. Bukowski & James H. Finke. 2004. Cancer Immunotherapy at the Crossroads. Cancer Immunotherapy at the Crossroads 119 144 .
Simone Mocellin, Carlo Riccardo Rossi, Donato Nitti, Mario Lise & Francesco M. Marincola. (2003) Dissecting tumor responsiveness to immunotherapy: the experience of peptide-based melanoma vaccines. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1653:2, pages 61-71.
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Miriam Huber, Ulrike Sarrazin & Stefan Zeuzem. 2003. Viral Infections and Treatment. Viral Infections and Treatment 295 367 .
Gabriella Pár, Júlia Szekeres-Barthó, Edit Buzás, Erna Pap & András Falus. (2003) Impaired Reproduction of Histamine Deficient (histidine-decarboxylase Knockout) Mice is Caused Predominantly by a Decreased Male Mating Behavior. American Journal of Reproductive Immunology 50:2, pages 152-158.
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Simone Mocellin, Monica Panelli, Ena Wang, Carlo Riccardo Rossi & Francesco M Marincola. (2018) Tumor Microenvironment: What have we Learned Studying the Immune Response in this Puzzling Battlefield?. Tumori Journal 88:6, pages 437-444.
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J C Becker, P Terheyden, E Kämpgen, S Wagner, C Neumann, D Schadendorf, A Steinmann, G Wittenberg, W Lieb & E-B Bröcker. (2002) Treatment of disseminated ocular melanoma with sequential fotemustine, interferon α, and interleukin 2. British Journal of Cancer 87:8, pages 840-845.
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Mark Middleton, Mark Sarno, Sanjiv S. Agarwala, John Glaspy, Aziz Laurent, Kelly McMasters, Peter Naredi, Steven O'Day, Eric Whitman, Sarah Danson, Rebecca Cosford & Kurt Gehlsen. (2013) Pharmacokinetics of Histamine Dihydrochloride in Healthy Volunteers and Cancer Patients: Implications for Combined Immunotherapy with Interleukin‐2. The Journal of Clinical Pharmacology 42:7, pages 774-781.
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Sanjiv S. AgarwalaJohn GlaspySteven J. O’DayMalcolm MitchellJohn GutheilEric WhitmanRene GonzalezEvan HershLynn FeunRobert BeltFrank MeyskensKristoffer HellstrandDiana WoodJohn M. KirkwoodKurt R. GehlsenPeter Naredi. (2002) Results From a Randomized Phase III Study Comparing Combined Treatment With Histamine Dihydrochloride Plus Interleukin-2 Versus Interleukin-2 Alone in Patients With Metastatic Melanoma. Journal of Clinical Oncology 20:1, pages 125-133.
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Steven J. O'day, Christina J. Kim & Douglas S. Reintgen. (2017) Metastatic Melanoma: Chemotherapy to Biochemotherapy. Cancer Control 9:1, pages 31-38.
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Hiroshi Ohtsu, Satoshi Tanaka, Tadashi Terui, Yoshio Hori, Yoko Makabe-Kobayashi, Gunnar Pejler, Elena Tchougounova, Lars Hellman, Marina Gertsenstein, Noriyasu Hirasawa, Eiko Sakurai, Edit Buzás, Péter Kovács, György Csaba, Ágnes Kittel, Mikiko Okada, Masahiro Hara, Lynn Mar, Keiko Numayama-Tsuruta, Satsuki Ishigaki-Suzuki, Kazuo Ohuchi, Atsushi Ichikawa, András Falus, Takehiko Watanabe & András Nagy. (2001) Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Letters 502:1-2, pages 53-56.
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Siegfried Matzku & Margot Z??ller. (2001) Specific Immunotherapy of Cancer in Elderly Patients. Drugs & Aging 18:9, pages 639-664.
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Masahiro NISHIBORI, Hideo KOHKA-TAKAHASHI & Shuji MORI. (2001) Regulation of cytokine production by histamine through H2-receptor stimulation.. Folia Pharmacologica Japonica 118:1, pages 29-35.
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Prasanta K. Ray, Tanya Das & Gaurisankar Sa. 2001. Protein Adaptations and Signal Transduction. Protein Adaptations and Signal Transduction 195 202 .

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