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ORIGINAL ARTICLEClinical Translational Therapeutics

MMP-9 (Gelatinase B) Expression is Associated With Disease-Free Survival and Disease-Specific Survival in Colorectal Cancer Patients

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Pages 38-43 | Published online: 09 Dec 2009

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Ming-Jie Hsu, Shu-Fen Peng, Fu-Shin Chueh, Chang-Hai Tsai, Fuu-Jen Tsai, Chih-Yang Huang, Chih-Hsin Tang, Jai-Sing Yang, Yuan-Man Hsu, Wen-Wen Huang & Jing-Gung Chung. (2019) Lupeol suppresses migration and invasion via p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells. Bioscience, Biotechnology, and Biochemistry 83:9, pages 1729-1739.
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James A Cotton, Jaye M Platnich, Daniel A Muruve, Humberto B Jijon, Andre G Buret & Paul L Beck. (2016) Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences. International Journal of Interferon, Cytokine and Mediator Research 8, pages 13-34.
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Ola M. Omran & Mostafa Thabet. (2012) Gelatinases A and B Expression in Human Colorectal Cancer in Upper Egypt: A Clinicopathological Study. Ultrastructural Pathology 36:2, pages 108-116.
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Crossref
S Stremitzer, A S Berghoff, N B Volz, W Zhang, D Yang, S Stintzing, Y Ning, Y Sunakawa, S Yamauchi, A Sebio, S Matsusaka, S Okazaki, D Hanna, A Parekh, A Mendez, M D Berger, R El-Khoueiry, P Birner, M Preusser & H-J Lenz. (2015) Genetic variants associated with colorectal brain metastases susceptibility and survival. The Pharmacogenomics Journal 17:1, pages 29-35.
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Crossref
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Crossref
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Crossref
Gricela Lobo, Melina Monasterios, Juan Rodrigues, Neira Gamboa, Mario V. Capparelli, Javier Martínez-Cuevas, Michael Lein, Klaus Jung, Claudia Abramjuk & Jaime Charris. (2015) Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9. European Journal of Medicinal Chemistry 96, pages 281-295.
Crossref
Chun Ren Lim, Michelle Mei Lin Lee, Samuel Chao, Adel Zaatar & Choong Chin Liew. 2015. Biomarkers in Cancer. Biomarkers in Cancer 849 873 .
Myung Ah Lee, Jin-Hee Park, Si Young Rhyu, Seong-Taek Oh, Won-Kyoung Kang & Hee-Na Kim. (2014) Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer. BMC Cancer 14:1.
Crossref
Hongtao Ren, Shuqun Zhang, Hongbing Ma, Yali Wang, Di Liu, Xijing Wang & Zhongwei Wang. (2014) Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway. Acta Biochimica et Biophysica Sinica 46:12, pages 1049-1055.
Crossref
Kasirajan AyyanathanMyung Lee, Jin-Hee Park, Si Rhyu, Seong-Taek Oh, Won-Kyoung Kang & Hee-Na Kim. 2014. Cancer Cell Signaling. Cancer Cell Signaling 81 95 .
Hee Cheol Kim, Yong Sung Kim, Hyun-Woo Oh, Kwoneel Kim, Sang-Seok Oh, Jong-Tae Kim, Bo Yeon Kim, Seon-Jin Lee, Yong-Kyung Choe, Dong Hyeok Kim, Seok-Hyung Kim, Seoung Wan Chae, Kwang Dong Kim & Hee Gu Lee. (2014) Collagen Triple Helix Repeat Containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells. Oncotarget 5:2, pages 519-529.
Crossref
László Herszényi. (2014) Impact of proteolytic enzymes in colorectal cancer development and progression. World Journal of Gastroenterology 20:37, pages 13246.
Crossref
Suzana Angelica Silva Lustosa, Luciano de Souza Viana, Renato José Affonso, Sandra Regina Morini Silva, Marcos Vinicius Araujo Denadai, Silvia Regina Caminada de Toledo, Indhira Dias Oliveira & Delcio Matos. (2014) Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and Dissemination. The Scientific World Journal 2014, pages 1-27.
Crossref
Chun Ren Lim, Michelle Mei Lin Lee, Samuel Chao, Adel Zaatar & Choong Chin Liew. 2014. Biomarkers in Cancer. Biomarkers in Cancer 1 20 .
Lei Zhang, Karen Pickard, Veronika Jenei, Marc D. Bullock, Amanda Bruce, Richard Mitter, Gavin Kelly, Christos Paraskeva, John Strefford, John Primrose, Gareth J. Thomas, Graham Packham & Alex H. Mirnezami. (2013) miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance. Cancer Research 73:21, pages 6435-6447.
Crossref
Li Chunhua, Lin Donglan, Fu Xiuqiong, Zhang Lihua, Fan Qin, Liu Yawei, Zhao Liang, Wen Ge, Jing Linlin, Zeng Ping, Li Kun & Sun Xuegang. (2013) Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT. The Journal of Nutritional Biochemistry 24:10, pages 1766-1775.
Crossref
Elin Hadler-Olsen, Jan-Olof Winberg & Lars Uhlin-Hansen. (2013) Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets. Tumor Biology 34:4, pages 2041-2051.
Crossref
Yan Zeng, Caiyun Liu, Bin Dong, Yuanyuan Li, Beihai Jiang, Ye Xu, Lin Meng, Jian Wu, Like Qu & Chengchao Shou. (2013) Inverse correlation between Naa10p and MMP-9 expression and the combined prognostic value in breast cancer patients. Medical Oncology 30:2.
Crossref
Chun-Yu Li, Peng Yuan, Shu-Sen Lin, Cheng-Fei Song, Wei-Yu Guan, Lu Yuan, Rong-Bin Lai, Ying Gao & Yan Wang. (2012) Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis. Tumor Biology 34:2, pages 735-741.
Crossref
Adam Elzagheid, Fatma Emaetig, Abdelbaset Buhmeida, Matti Laato, Omran El-Faitori, Kari Syrjänen, Yrjö Collan & Seppo Pyrhönen. (2012) Loss of MUC2 expression predicts disease recurrence and poor outcome in colorectal carcinoma. Tumor Biology 34:2, pages 621-628.
Crossref
Yu-long Shi, Tao Xu, Le-ping Li & Xiao-ping Chen. (2013) Over-expression of VEGF and MMP-9 in residual tumor cells of hepatocellular carcinoma after embolization with lipidol. Journal of Huazhong University of Science and Technology [Medical Sciences] 33:1, pages 90-95.
Crossref
Siv K Bøhn, Kjell M Russnes, Amrit K Sakhi, Magne Thoresen, Marit Holden, JanØ Moskaug, Mari C Myhrstad, Ole K Olstad, Sigbjørn Smeland & Rune Blomhoff. (2012) Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients. BMC Cancer 12:1.
Crossref
Yi Zhang, Xiao-Ya Guan, Bin Dong, Min Zhao, Jian-Hui Wu, Xiu-Yun Tian & Chun-Yi Hao. (2012) Expression of MMP-9 and WAVE3 in colorectal cancer and its relationship to clinicopathological features. Journal of Cancer Research and Clinical Oncology 138:12, pages 2035-2044.
Crossref
László Herszényi, István Hritz, Gábor Lakatos, Mária Varga & Zsolt Tulassay. (2012) The Behavior of Matrix Metalloproteinases and Their Inhibitors in Colorectal Cancer. International Journal of Molecular Sciences 13:12, pages 13240-13263.
Crossref
Sahdeo Prasad, Vivek R. Yadav, Bokyung Sung, Simone Reuter, Ramaswamy Kannappan, Amit Deorukhkar, Parmeswaran Diagaradjane, Caimiao Wei, Veerabhadran Baladandayuthapani, Sunil Krishnan, Sushovan Guha & Bharat B. Aggarwal. (2012) Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine. Clinical Cancer Research 18:18, pages 4942-4953.
Crossref
Björn Müller-Edenborn, Birgit Roth-Z'graggen, Kamila Bartnicka, Alain Borgeat, Alexandra Hoos, Lubor Borsig & Beatrice Beck-Schimmer. (2012) Volatile Anesthetics Reduce Invasion of Colorectal Cancer Cells through Down-regulation of Matrix Metalloproteinase-9. Anesthesiology 117:2, pages 293-301.
Crossref
Joshua J. Steffan, Sweaty Koul, Randall B. Meacham & Hari K. Koul. (2012) The Transcription Factor SPDEF Suppresses Prostate Tumor Metastasis. Journal of Biological Chemistry 287:35, pages 29968-29978.
Crossref
Juan R. Rodrigues, Jaime Charris, Rosa Ferrer, Neira Gamboa, Jorge Ángel, Bianca Nitzsche, Michael Hoepfner, Michael Lein, Klaus Jung & Claudia Abramjuk. (2011) Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo. Investigational New Drugs 30:4, pages 1426-1433.
Crossref
ADAM ELZAGHEID, ABDELBASET BUHMEIDA, MATTI LAATO, OMRAN EL‐FAITORI, KARI SYRJÄNEN, YRJÖ COLLAN & SEPPO PYRHÖNEN. (2012) Loss of E‐cadherin expression predicts disease recurrence and shorter survival in colorectal carcinoma. APMIS 120:7, pages 539-548.
Crossref
Omer Bashir, Jian Cao & Stanley Zucker. 2012. Matrix Proteases in Health and Disease. Matrix Proteases in Health and Disease 345 371 .
Jan Dimberg, Karin Ström, Sture Löfgren, Niklas Zar, Mikael Lindh & Andreas Matussek. (2011) DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas. International Journal of Colorectal Disease 27:6, pages 709-714.
Crossref
Songlin Piao, Shu Zhao, Fulin Guo, Jie Xue, Guodong Yao, Zhili Wei, Qi Huang, Yao Sun & Bin Zhang. (2012) Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma. Journal of Cancer Research and Clinical Oncology 138:4, pages 627-635.
Crossref
Dake Chu, Zhengwei Zhao, Yi Zhou, Yunming Li, Jipeng Li, Jianyong Zheng, Qingchuan Zhao & Weizhong Wang. (2011) Matrix Metalloproteinase-9 Is Associated with Relapse and Prognosis of Patients with Colorectal Cancer. Annals of Surgical Oncology 19:1, pages 318-325.
Crossref
László Herszényi, Gábor Lakatos, István Hritz, Mária Zsófia Varga, Gabriel Cierny & Zsolt Tulassay. (2012) The Role of Inflammation and Proteinases in Tumor Progression. Digestive Diseases 30:3, pages 249-254.
Crossref
JAN DIMBERG, KARIN STRÖM, STURE LÖFGREN, NIKLAS ZAR, ANDERS HUGANDER & ANDREAS MATUSSEK. (2011) Expression of the serine protease inhibitor serpinA3 in human colorectal adenocarcinomas. Oncology Letters 2:3, pages 413-418.
Crossref
Kyung Sook Park, Seon Jeong Kim, Kyung Ho Kim & Jin Cheon Kim. (2011) Clinical characteristics of TIMP2, MMP2, and MMP9 gene polymorphisms in colorectal cancer. Journal of Gastroenterology and Hepatology 26:2, pages 391-397.
Crossref
Jian-Rong He, Han Qin, Ze-Feng Ren, Cui Cui, Ying Zhang, Dharshana Ranatunga, Yi-Xin Zeng & Wei-Hua Jia. (2011) MMP-9 expression in peripheral blood mononuclear cells and the association with clinicopathological features and prognosis of nasopharyngeal carcinoma. Clinical Chemistry and Laboratory Medicine 49:4.
Crossref
Zhen Liu, Lixia Li, Zhixiong Yang, Weiren Luo, Xin Li, Huiling Yang, Kaitai Yao, Bin Wu & Weiyi Fang. (2010) Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma. BMC Cancer 10:1.
Crossref
Mumtaz V. Rojiani, Marzenna Wiranowska & Amyn M. Rojiani. 2010. Tumor Microenvironment. Tumor Microenvironment 53 76 .

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