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Cancer Investigation Volume 28, 2010 - Issue 3
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ORIGINAL ARTICLESCellular and Molecular Biology

Effects of Naturally Occurring Polymethyoxyflavonoids on Cell Growth, P-Glycoprotein Function, Cell Cycle, and Apoptosis of Daunorubicin-Resistant T Lymphoblastoid Leukemia Cells

Kimiko IshiiDepartments of Clinical Pharmacology and Clinical Molecular Genetics, School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan
,
Sachiko TanakaDepartments of Clinical Pharmacology and Clinical Molecular Genetics, School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan
,
Keisuke KagamiDepartments of Clinical Pharmacology and Clinical Molecular Genetics, School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan
,
Kayo HenmiDepartments of Clinical Pharmacology and Clinical Molecular Genetics, School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan
,
Hiroo ToyodaDepartments of Clinical Pharmacology and Clinical Molecular Genetics, School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan
,
Toshikazu KaiseDepartments of Clinical Pharmacology and Clinical Molecular Genetics, School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan
&
Toshihiko HiranoDepartments of Clinical Pharmacology and Clinical Molecular Genetics, School of Pharmacy, Department of Environmental Chemodynamics, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan
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Pages 220-229 | Published online: 28 Oct 2009

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Yun-Yi Chen, Jiao-Jiao Liang, Deng-Liang Wang, Jie-Biao Chen, Jin-Ping Cao, Yue Wang & Chong-De Sun. (2023) Nobiletin as a chemopreventive natural product against cancer, a comprehensive review. Critical Reviews in Food Science and Nutrition 63:23, pages 6309-6329.
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Shadab Md, Nabil A. Alhakamy, Priyanka Sharma, Mohammad Shahnawaze Ansari & Bapi Gorain. (2022) Nanocarrier-based co-delivery approaches of chemotherapeutics with natural P-glycoprotein inhibitors in the improvement of multidrug resistance cancer therapy. Journal of Drug Targeting 30:8, pages 801-818.
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Xue Wu, Haijun Zhang, Jumah Masoud Mohammad Salmani, Rong Fu & Baoan Chen. (2016) Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors. OncoTargets and Therapy 9, pages 2935-2943.
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Katrin Sak. (2014) Site-Specific Anticancer Effects of Dietary Flavonoid Quercetin. Nutrition and Cancer 66:2, pages 177-193.
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Jian Cheng, Lin Cheng, Baoan Chen, Guohua Xia, Chong Gao, Huihui Song, Wen Bao, Qinglong Guo, Haiwei Zhang & Xuemei Wang. (2012) Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line. International Journal of Nanomedicine 7, pages 2843-2852.
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Aveen N. Adham, Sara Abdelfatah, Alaadin Naqishbandi, Yoshikazu Sugimoto, Edmond Fleischer & Thomas Efferth. (2022) Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection. Phytomedicine 100, pages 154064.
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Waseem Raza, Suaib Luqman & Abha Meena. (2020) Prospects of tangeretin as a modulator of cancer targets/pathways. Pharmacological Research 161, pages 105202.
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Jui-Hung Yen, Ching-Yen Lin, Chin-Hsien Chuang, Hsien-Kuo Chin, Ming-Jiuan Wu & Pei-Yi Chen. (2020) Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells. Cells 9:4, pages 877.
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Yen-Chen Tung, Ya-Chun Chou, Wei-Lun Hung, An-Chin Cheng, Roch-Chui Yu, Chi-Tang Ho & Min-Hsiung Pan. (2019) Polymethoxyflavones: Chemistry and Molecular Mechanisms for Cancer Prevention and Treatment. Current Pharmacology Reports 5:2, pages 98-113.
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Pei-Yi Chen, Yu-Ting Chen, Wan-Yun Gao, Ming-Jiuan Wu & Jui-Hung Yen. (2018) Nobiletin Down-Regulates c-KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells. Journal of Agricultural and Food Chemistry 66:51, pages 13423-13434.
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Luhua Meng, Xuejun Xia, Yanfang Yang, Jun Ye, Wujun Dong, Panpan Ma, Yiqun Jin & Yuling Liu. (2016) Co-encapsulation of paclitaxel and baicalein in nanoemulsions to overcome multidrug resistance via oxidative stress augmentation and P-glycoprotein inhibition. International Journal of Pharmaceutics 513:1-2, pages 8-16.
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Grace KZS Dourado, Joy M Stanilka, Susan S Percival & Thais B Cesar. (2015) Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line. Asian Pacific Journal of Cancer Prevention 16:15, pages 6491-6499.
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Ming-Der Shi, Yi-Chen Liao, Yuan-Wei Shih & Li-Yu Tsai. (2013) Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. Phytomedicine 20:8-9, pages 743-752.
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Chiu-Mei Lin, Yen-Hsu Chen, Jiann-Ruey Ong, Hon-Ping Ma, Kou-Gi Shyu & Kuan-Jen Bai. (2012) Functional Role of Wogonin in Anti-Angiogenesis. The American Journal of Chinese Medicine 40:02, pages 415-427.
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Yi-Chieh Lee, Tsan-Hwang Cheng, Jung-Shin Lee, Jiun-Hwan Chen, Yi-Chen Liao, Yao Fong, Cheng-Hsun Wu & Yuan-Wei Shih. (2010) Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells. Molecular and Cellular Biochemistry 347:1-2, pages 103-115.
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