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Cancer Investigation Volume 27, 2009 - Issue 9
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ORIGINAL ARTICLEClinical Translational Therapeutics

Association of Polymorphisms in Regulatory Regions of Interleukin-12p40 Gene and Cytokine Serum Level with Colorectal Cancer

L. MitevaDepartment of Molecular Biology, Immunology and Genetics, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria.
,
N. StanilovDepartment of Neurosurgery, Surgery and Urology, 2nd Surgery Clinic, University Hospital, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria.
,
T. DeliyskyOncology Center, University School of Medicine, Pleven, Bulgaria.
,
N. MintchevDepartment of Molecular Biology, Immunology and Genetics, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria.
&
S. StanilovaDepartment of Molecular Biology, Immunology and Genetics, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria.
Pages 924-931 | Published online: 15 Oct 2009

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Arseniy E. Yuzhalin & Anton G. Kutikhin. (2012) Interleukin-12: Clinical usage and molecular markers of cancer susceptibility. Growth Factors 30:3, pages 176-191.
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Tiha M Long & Jean-Pierre Raufman. (2011) The diagnostic and prognostic role of cytokines in colon cancer. Gastrointestinal Cancer: Targets and Therapy 1, pages 27-39.
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Yabin Liu, Binghui Li, Lili Wang & Dexian Kong. (2020) A Functional Polymorphism in the Promoter Region of Interleukin-12B Increases the Risk of Colorectal Cancer. BioMed Research International 2020, pages 1-6.
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Lyuba Miteva, Anastasiya Trenova, Georgi Slavov & Spaska Stanilova. (2018) IL12B gene polymorphisms have sex-specific effects in relapsing–remitting multiple sclerosis. Acta Neurologica Belgica 119:1, pages 83-93.
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Ruifen Sun, Fu Jia, Yundan Liang, Lijuan Li, Peng Bai, Fang Yuan, Linbo Gao & Lin Zhang. (2015) Interaction analysis of IL-12A and IL-12B polymorphisms with the risk of colorectal cancer. Tumor Biology 36:12, pages 9295-9301.
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Noyko Stanilov, Lyuba Miteva, Jovcho Jovchev, Geo Cirovski & Spaska Stanilova. (2014) The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer. APMIS 122:12, pages 1223-1229.
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Qiliu Peng, Shan Li, Xianjun Lao, Zhiping Chen, Ruolin Li & Xue Qin. (2014) Interleukin-12B+1188A/C polymorphism contributes to increased hepatocellular carcinoma susceptibility: Evidence from a meta-analysis. Clinics and Research in Hepatology and Gastroenterology 38:6, pages 735-743.
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Eliana Guerriero, Francesca Capone, Fabiola Rusolo, Giovanni Colonna, Giuseppe Castello & Susan Costantini. (2013) Dissimilar cytokine patterns in different human liver and colon cancer cell lines. Cytokine 64:2, pages 584-589.
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Junli WangLegen NongYesheng WeiShanyu QinYou ZhouYujin Tang. (2013) Association of Interleukin-12 Polymorphisms and Serum IL-12p40 Levels with Osteosarcoma Risk. DNA and Cell Biology 32:10, pages 605-610.
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Noyko S. Stanilov, Lyuba D. Miteva, Zlatka G. Dobreva, Jovcho P. Jovchev, Geo M. Cirovski & Spaska A. Stanilova. (2012) Monocytes expression of IL-12 related and IL-10 genes in association with development of colorectal cancer. Molecular Biology Reports 39:12, pages 10895-10902.
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Huilong Chen, Sheng Cheng, Jianmiao Wang, Chao Cao, Hansvin Bunjhoo, Weining Xiong & Yongjian Xu. (2012) Interleukin-12B rs3212227 polymorphism and cancer risk: a meta-analysis. Molecular Biology Reports 39:12, pages 10235-10242.
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Liping Zhou, Fan Yao, Hong Luan, Yinling Wang, Xihua Dong, Wenwen Zhou & Qihui Wang. (2012) Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: Evidence from a meta-analysis of 18 case–control studies. Gene 510:1, pages 71-77.
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Yi-Peng Tao, Wan-Ling Wang, Song-Yue Li, Jian Zhang, Qi-Zhong Shi, Fen Zhao & Bao-Sheng Zhao. (2012) Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer. Journal of Cancer Research and Clinical Oncology 138:11, pages 1891-1900.
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Xiutian SimaJianguo XuQiang LiLin LuoJiangang LiuChao You. (2012) Gene-Gene Interactions Between Interleukin-12A and Interleukin-12B with the Risk of Brain Tumor. DNA and Cell Biology 31:2, pages 219-223.
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Zhao-Quan Huang, Jun-Li Wang, Guo-Gang Pan & Ye-Sheng Wei. (2012) Association of single nucleotide polymorphisms in IL-12 and IL-27 genes with colorectal cancer risk. Clinical Biochemistry 45:1-2, pages 54-59.
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Lyuba D. Miteva, Irena M. Manolova, Mariana G. Ivanova, Rasho K. Rashkov, Rumen M. Stoilov, Maya V. Gulubova & Spaska A. Stanilova. (2010) Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus. Rheumatology International 32:1, pages 53-59.
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A. Ben Chaaben, M. Busson, H. Douik, W. Boukouaci, T. Mamoghli, L. Chaouch, L. Harzallah, S. Dorra, C. Fortier, A. Ghanem, D. Charron, R. Krishnamoorthy, F. Guemira & R. Tamouza. (2011) Association of IL‐12p40 +1188 A/C polymorphism with nasopharyngeal cancer risk and tumor extension. Tissue Antigens 78:2, pages 148-151.
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