131
Views
34
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLESCellular and Molecular Biology

Limonene Exerts Antiproliferative Effects and Increases Nitric Oxide Levels on a Lymphoma Cell Line by Dual Mechanism of the ERK Pathway: Relationship with Oxidative Stress

, , , , &
Pages 135-145 | Published online: 07 Dec 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Daniele Fraternale, Maria Cristina Albertini, Alexander Rudov, Guido Flamini, Donata Ricci, Angela Bisio, Michela Battistelli & Augusto Accorsi. (2013) Salvia x jamensis J. Compton: Trichomes, essential oil constituents and cytotoxic-apoptotic activity. Natural Product Research 27:17, pages 1583-1588.
Read now

Articles from other publishers (33)

Rafael Carlos Ferreira, Sâmia Sousa Duarte, Valgrícia Matias de Sousa, Ramon Ramos Marques de Souza, Karinne Kelly Gadelha Marques, Renata Albuquerque de Abrantes, Yuri Mangueira do Nascimento, Natália Ferreira de Sousa, Marcus Tullius Scotti, Luciana Scotti, Josean Fechine Tavares, Juan Carlos Ramos Gonçalves, Marcelo Sobral da Silva & Marianna Vieira Sobral. (2023) The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways. Pharmaceuticals 16:11, pages 1553.
Crossref
Shahid Rasool, Muhammad Ibrahim, Mulazim Hussain, Muhammad Ajmal Shah & Adnan Amin. 2023. Phytonutrients in the Treatment of Gastrointestinal Cancer. Phytonutrients in the Treatment of Gastrointestinal Cancer 209 230 .
Taghreed A. Majrashi, Saad Ali Alshehri, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Mohammad Alrouji, Asma M. Alshahrani, Anas Shamsi & Akhtar Atiya. (2023) Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics. Nutrients 15:7, pages 1704.
Crossref
Viktoriia Cherkasova, Bo Wang, Marta Gerasymchuk, Anna Fiselier, Olga Kovalchuk & Igor Kovalchuk. (2022) Use of Cannabis and Cannabinoids for Treatment of Cancer. Cancers 14:20, pages 5142.
Crossref
Deepa Mandal & Tithi Parija. (2022) Anticancer Mechanism of D-limonene: An Updated Review and Therapeutic Possibilities. Current Cancer Therapy Reviews 18:3, pages 193-201.
Crossref
Hiva Alipanah, Mojtaba Farjam, Elham Zarenezhad, Ghazaal Roozitalab & Mahmoud Osanloo. (2021) Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers. BMC Complementary Medicine and Therapies 21:1.
Crossref
Heitor Gomes de Araújo‐Filho, Jucilene F. dos Santos, Mikaella T. B. Carvalho, Laurent Picot, Ingrid Fruitier‐Arnaudin, Hugo Groult, Lucindo J. Quintans‐Júnior & Jullyana S.S. Quintans. (2021) Anticancer activity of limonene: A systematic review of target signaling pathways. Phytotherapy Research 35:9, pages 4957-4970.
Crossref
Zahra Lorigooini, Shakiba Nasiri Boroujeni, Mohammad Sayyadi-Shahraki, Mohammad Rahimi-Madiseh, Elham Bijad & Hossein Amini-khoei. (2021) Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress. Behavioural Neurology 2021, pages 1-8.
Crossref
Jorge Touma, Myriam Navarro, Betsabet Sepúlveda, Alequis Pavon, Gino Corsini, Katia Fernández, Claudia Quezada, Angelo Torres, María José Larrazabal-Fuentes, Adrian Paredes, Ivan Neira, Matías Ferrando, Flavia Bruna, Alejandro Venegas & Jessica Bravo. (2020) The Chemical Compositions of Essential Oils Derived from Cryptocarya alba and Laurelia sempervirens Possess Antioxidant, Antibacterial and Antitumoral Activity Potential. Molecules 25:23, pages 5600.
Crossref
Thais Pádua Freitas, Isabela Barroso Taver, Poliana Cristina Spricigo, Lucas Bueno do Amaral, Eduardo Purgatto & Angelo Pedro Jacomino. (2020) Volatile Compounds and Physicochemical Quality of Four Jabuticabas (Plinia sp.). Molecules 25:19, pages 4543.
Crossref
Heitor G. Araújo-Filho, Erik W.M. Pereira, Luana Heimfarth, Brenda Souza Monteiro, Fabiolla Rocha Santos Passos, Pollyana Siqueira-Lima, Sathiyabama R. Gandhi, Márcio Roberto Viana dos Santos, Jackson Roberto Guedes da Silva Almeida, Laurent Picot, Raphaël Grougnet, Ray S. Almeida, Henrique Douglas Melo Coutinho, Lucindo J. Quintans-Júnior, Natália Martins & Jullyana S.S. Quintans. (2020) Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement. International Immunopharmacology 86, pages 106766.
Crossref
Andrea M. Tomko, Erin G. Whynot, Lee D. Ellis & Denis J. Dupré. (2020) Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis. Cancers 12:7, pages 1985.
Crossref
Heitor Augusto Otaviano Cavalcante, Saulo Euclides Silva-Filho, Luiz Alexandre Marques Wiirzler, Gabriel Fernando Esteves Cardia, Nancy Sayuri Uchida, Francielli Maria de Souza Silva-Comar, Ciomar Aparecida Bersani-Amado & Roberto Kenji Nakamura Cuman. (2019) Effect of (-)-α-Bisabolol on the Inflammatory Response in Systemic Infection Experimental Model in C57BL/6 Mice. Inflammation 43:1, pages 193-203.
Crossref
Neha Verma, Anita Yadav, Surbhi Bal, Ranjan Gupta & Neeraj Aggarwal. (2018) In Vitro Studies on Ameliorative Effects of Limonene on Cadmium-Induced Genotoxicity in Cultured Human Peripheral Blood Lymphocytes. Applied Biochemistry and Biotechnology 187:4, pages 1384-1397.
Crossref
Claire E. Palma, Philip S. Cruz, Don Theon C. Cruz, Adrienne Marrie S. Bugayong & Agnes L. Castillo. (2019) Chemical composition and cytotoxicity of Philippine calamansi essential oil. Industrial Crops and Products 128, pages 108-114.
Crossref
Yusif M. Mukhtar, Michael Adu-Frimpong, Ximing Xu & Jiangnan Yu. (2018) Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs. Bioscience Reports 38:6.
Crossref
A. Bouyahya, J. Abrini, Y. Bakri & N. Dakka. (2018) Les huiles essentielles comme agents anticancéreux : actualité sur le mode d’action. Phytothérapie 16:5, pages 254-267.
Crossref
Laura Berliocchi, Carlotta Chiappini, Annagrazia Adornetto, Debora Gentile, Silvia Cerri, Rossella Russo, Giacinto Bagetta & Maria Tiziana Corasaniti. (2018) Early LC3 lipidation induced by d -limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells. Phytomedicine 40, pages 98-105.
Crossref
Habib Mosbah, Hanen Louati, Mohamed Ali Boujbiha, Hassiba Chahdoura, Mejdi Snoussi, Guido Flamini, Roberta Ascrizzi, Ali Bouslema, Lotfi Achour & Boulbaba Selmi. (2018) Phytochemical characterization, antioxidant, antimicrobial and pharmacological activities of Feijoa sellowiana leaves growing in Tunisia. Industrial Crops and Products 112, pages 521-531.
Crossref
Xifeng Wang, Gang Li & Wei Shen. (2017) Protective effects of D‑Limonene against transient cerebral ischemia in stroke‑prone spontaneously hypertensive rats. Experimental and Therapeutic Medicine.
Crossref
Ling Han, Xiaoyang Xia, Xia Xiang, Fenghong Huang & Zhen Zhang. (2017) Protective effects of canolol against hydrogen peroxide-induced oxidative stress in AGS cells. RSC Advances 7:68, pages 42826-42832.
Crossref
A. Bouyahya, J. Abrini, Y. Bakri & N. Dakka. (2016) Les huiles essentielles comme agents anticancéreux : actualité sur le mode d’actionEssential oils as anticancer agents: news on mode of action. Phytothérapie.
Crossref
Feitosa Alves Mateus, Feitosa Alves Vanessa, do Amaral Ramalho Josu eacute, Eduardo Nunes Dias Guilherme, Mendes de Oliveira Kardil acirc ndia, Brito Lira Andressa, Golzio dos Santos S oacute crates, N oacute brega de Almeida Reinaldo & de F aacute tima Formiga Melo Diniz Margareth. (2016) Preclinical evaluation of repeated dose toxicity and anxiolytic activity of monoterpene R - (+) limonene via inhalation. African Journal of Pharmacy and Pharmacology 10:29, pages 598-603.
Crossref
Renzo Martino, María Laura Barreiro Arcos, Rosario Alonso, Valeria Sülsen, Graciela Cremaschi & Claudia Anesini. (2016) Polyphenol-Rich Fraction from Larrea divaricata and its Main Flavonoid Quercetin-3-Methyl Ether Induce Apoptosis in Lymphoma Cells Through Nitrosative Stress . Phytotherapy Research 30:7, pages 1128-1136.
Crossref
Jie Bai, Yi Zheng, Gang Wang & Ping Liu. (2016) Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway. Oxidative Medicine and Cellular Longevity 2016, pages 1-12.
Crossref
Rossella Russo, Maria Gilda Valentina Cassiano, Antonella Ciociaro, Annagrazia Adornetto, Giuseppe Pasquale Varano, Carlotta Chiappini, Laura Berliocchi, Cristina Tassorelli, Giacinto Bagetta & Maria Tiziana Corasaniti. (2014) Role of D-Limonene in Autophagy Induced by Bergamot Essential Oil in SH-SY5Y Neuroblastoma Cells. PLoS ONE 9:11, pages e113682.
Crossref
Aliye Aras, Muhammed Javed Iqbal, Syed Kamran-Ul-Hassan Naqvi, Yusuf Can Gercek, Kadir Boztas, Maria Luisa Gasparri, Iryna Shatynska-Mytsyk, Sundas Fayyaz & Ammad Ahmad Farooqi. (2014) Anticancer Activity of Essential Oils: Targeting of Protein Networks in Cancer Cells. Asian Pacific Journal of Cancer Prevention 15:19, pages 8047-8050.
Crossref
Jean-François Lesgards, Nicolas Baldovini, Nicolas Vidal & Sylvia Pietri. (2014) Anticancer Activities of Essential Oils Constituents and Synergy with Conventional Therapies: A Review. Phytotherapy Research 28:10, pages 1423-1446.
Crossref
Shahla Shojaei, Amir Kiumarsi, Adel Rezaei Moghadam, Javad Alizadeh, Hassan Marzban & Saeid Ghavami. 2014. Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids. Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids 7 32 .
Thakur G. Singh, Ashish K. Rehni & Sandeep K. Arora. (2013) Pharmacological modulation of farnesyltransferase subtype I attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. Behavioural Pharmacology 24:8, pages 668-677.
Crossref
SHU-SHENG JIA, GUANG-PENG XI, MING ZHANG, YAN-BO CHEN, BO LEI, XIN-SHU DONG & YAN-MEI YANG. (2012) Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells. Oncology Reports 29:1, pages 349-354.
Crossref
Lianet Monzote, Gabrielle M. Hill, Armando Cuellar, Ramón Scull & William N. Setzer. (2012) Chemical Composition and Anti-Proliferative Properties of Bursera graveolens Essential Oil . Natural Product Communications 7:11, pages 1934578X1200701.
Crossref
SC Chaudhary, MS Siddiqui, M Athar & M Sarwar Alam. (2012) d -Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis . Human & Experimental Toxicology 31:8, pages 798-811.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.