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PRECLINICAL

Carnitine Administration Reduces Cytokine Levels, Improves Food Intake, and Ameliorates Body Composition in Tumor-Bearing Rats

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Pages 696-700 | Published online: 15 Nov 2011

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Alessio Molfino, Maria Ida Amabile, Antonella Giorgi, Massimo Monti, Vito D’Andrea & Maurizio Muscaritoli. (2019) Investigational drugs for the treatment of cancer cachexia: a focus on phase I and phase II clinical trials. Expert Opinion on Investigational Drugs 28:8, pages 733-740.
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Alessio Molfino, Simona De Luca, Maurizio Muscaritoli, Gennaro Citro, Lucia Fazi, Alessia Mari, Cesarina Ramaccini, Filippo Rossi Fanelli & Alessandro Laviano. (2013) Timing of antioxidant supplementation is critical in improving anorexia in an experimental model of cancer. International Journal of Food Sciences and Nutrition 64:5, pages 570-574.
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Tomas Koltai, Stephan J. Reshkin, Fátima Baltazar & Larry Fliegel. 2021. Prostate Cancer Metabolism. Prostate Cancer Metabolism 71 135 .
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Jennifer G. Le-Rademacher & Aminah Jatoi. 2020. Abeloff's Clinical Oncology. Abeloff's Clinical Oncology 593 597.e1 .
Y. Masoumi-Ardakani Masoumi-Ardakani, H. Fallah & B. Shahouzehi. (2019) Carnitine effects on serum and pancreas inflammatory response in diabetic rats. The Ukrainian Biochemical Journal 91:6, pages 59-66.
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Mark F. McCarty, Simon Iloki-Assanga & Lidianys Maria Lewis Lujany. (2019) Nutraceutical targeting of TLR4 signaling has potential for prevention of cancer cachexia. Medical Hypotheses 132, pages 109326.
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Zaira Aversa, Paola Costelli & Maurizio Muscaritoli. (2017) Cancer-induced muscle wasting: latest findings in prevention and treatment. Therapeutic Advances in Medical Oncology 9:5, pages 369-382.
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Alessio Molfino, Alessandro Iannace, Maria Chiara Colaiacomo, Alessio Farcomeni, Alessandra Emiliani, Gianfranco Gualdi, Alessandro Laviano & Filippo Rossi Fanelli. (2017) Cancer anorexia: hypothalamic activity and its association with inflammation and appetite-regulating peptides in lung cancer. Journal of Cachexia, Sarcopenia and Muscle 8:1, pages 40-47.
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Antonio J. Blanca, María V. Ruiz-Armenta, Sonia Zambrano, José L. Miguel-Carrasco, José L. Arias, Miguel Arévalo, Alfonso Mate, Oscar Aramburu & Carmen M. Vázquez. (2016) Inflammatory and fibrotic processes are involved in the cardiotoxic effect of sunitinib: Protective role of l -carnitine. Toxicology Letters 241, pages 9-18.
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Alessio Molfino, Maria Ida Amabile, Massimo Monti, Filippo Rossi Fanelli & Maurizio Muscaritoli. (2015) Carnitine for the treatment of cachexia: Lights and shadows. International Journal of Cardiology 198, pages 180-181.
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Alessio Molfino, Maurizio Muscaritoli & Filippo Rossi Fanelli. (2015) Anorexia Assessment in Patients With Cancer: A Crucial Issue to Improve the Outcome. Journal of Clinical Oncology 33:13, pages 1513-1513.
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Alessio Molfino, Gianfranco Gioia, Filippo Rossi Fanelli & Alessandro Laviano. (2015) Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia. Mediators of Inflammation 2015, pages 1-7.
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Xiaoya Xu, Man Jiang, Ying Zhang, Yuli Bi & Mingyong Han. (2014) Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor. Molecular Medicine Reports.
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Z. Altun, Y. Olgun, P. Ercetin, S. Aktas, G. Kirkim, B. Serbetcioglu, N. Olgun & E. A. Guneri. (2014) Protective effect of acetyl- l -carnitine against cisplatin ototoxicity: role of apoptosis-related genes and pro-inflammatory cytokines . Cell Proliferation 47:1, pages 72-80.
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Aminah Jatoi. 2014. Abeloff's Clinical Oncology. Abeloff's Clinical Oncology 620 625 .
Ebru Orsal, Zekai Halici, Yasin Bayir, Elif Cadirci, Habib Bilen, Irmak Ferah, Ali Aydin, Seckin Ozkanlar, Arif Kursad Ayan, Bedri Seven & Seda Ozaltin. (2013) The role of carnitine on ovariectomy and inflammation-induced osteoporosis in rats. Experimental Biology and Medicine 238:12, pages 1406-1412.
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Robert Ringseis, Janine Keller & Klaus Eder. (2013) Mechanisms underlying the anti-wasting effect of l-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies. European Journal of Nutrition 52:5, pages 1421-1442.
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. (2012) Current World Literature. Current Opinion in Supportive & Palliative Care 6:4, pages 543-552.
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Sílvia Busquets, Roberto Serpe, Míriam Toledo, Angélica Betancourt, Enrica Marmonti, Marcel Orpí, Fabrizio Pin, Eva Capdevila, Clelia Madeddu, Francisco J. López-Soriano, Giovanni Mantovani, Antonio Macciò & Josep M. Argilés. (2012) l-Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer. Clinical Nutrition 31:6, pages 889-895.
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Ricardo A. CrucianiJenny J. ZhangJudith ManolaDavid CellaBilal AnsariMichael J. Fisch. (2012) L-Carnitine Supplementation for the Management of Fatigue in Patients With Cancer: An Eastern Cooperative Oncology Group Phase III, Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Clinical Oncology 30:31, pages 3864-3869.
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Srinivas Sonne, Prem S. Shekhawat, Dietrich Matern, Vadivel Ganapathy & Leszek Ignatowicz. (2012) Carnitine Deficiency in OCTN2−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response. PLoS ONE 7:10, pages e47729.
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