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Cancer Investigation Volume 29, 2011 - Issue 10
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CELLULAR AND MOLECULAR BIOLOGY

An Analog of Withaferin A Activates the MAPK and Glutathione “Stress” Pathways and Inhibits Pancreatic Cancer Cell Proliferation

Xiaobing LiuCancer Center, University of Arizona, Tucson, Arizona, USA,
,
Wenqing QiCancer Center, University of Arizona, Tucson, Arizona, USA,
,
Laurence S. CookeCancer Center, University of Arizona, Tucson, Arizona, USA,
,
E. M. Kithsiri WijeratneSouthwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, Tucson, Arizona, USA
,
Ya-ming XuSouthwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, Tucson, Arizona, USA
,
Marilyn T. MarronSouthwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, Tucson, Arizona, USA
,
A. A. Leslie GunatilakaSouthwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, Tucson, Arizona, USA
&
Daruka MahadevanCancer Center, University of Arizona, Tucson, Arizona, USA,Correspondence[email protected]
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Pages 668-675 | Published online: 15 Nov 2011

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Zhichao Xing, Anping Su, Li Mi, Yujie Zhang, Ting He, Yuxuan Qiu, Tao Wei, Zhihui Li, Jingqiang Zhu & Wenshuang Wu. (2023) Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms. Drug Design, Development and Therapy 17, pages 2909-2929.
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Articles from other publishers (10)

Qi Shao, Yechen Feng, Wenwu Wang, Min Wang, Binbin Li, Mario El Tahchi & Yixia Yin. (2019) Drug carrier for sustained release of withaferin A for pancreatic cancer treatment. Journal of Materials Science 55:4, pages 1702-1714.
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Rui Guo, Lu Gan, Wayne Bond Lau, Zheyi Yan, Dina Xie, Erhe Gao, Theodore A Christopher, Bernard L. Lopez, Xinliang Ma & Yajing Wang. (2019) Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling. Circulation Journal 83:8, pages 1726-1736.
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E. M. Kithsiri Wijeratne, Maria C. F. Oliveira, Jair Mafezoli, Ya-Ming Xu, Sandro Minguzzi, Pedro H. J. Batista, Otília D. L. Pessoa, Luke Whitesell & A. A. Leslie Gunatilaka. (2018) Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation. Journal of Natural Products 81:4, pages 825-837.
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Prasanna K. Santhekadur. (2017) Is Withaferin A, a magic bullet for metabolic syndrome?. Biomedicine & Pharmacotherapy 92, pages 1135-1137.
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Ya-Ming Xu, Alan D. Brooks, E. M. Kithsiri Wijeratne, Curtis J. Henrich, Poonam Tewary, Thomas J. Sayers & A. A. Leslie Gunatilaka. (2017) 17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure–Activity Relationships. Journal of Medicinal Chemistry 60:7, pages 3039-3051.
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Mahima Vedi & Evan Prince Sabina. (2016) Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation. Cell Biology and Toxicology 32:5, pages 373-390.
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Ya-Ming Xu, Manping X. Liu, Nathan Grunow, E. M. Kithsiri Wijeratne, Gillian Paine-Murrieta, Stephen Felder, Richard M. Kris & A. A. Leslie Gunatilaka. (2015) Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors. Journal of Medicinal Chemistry 58:17, pages 6984-6993.
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E. M. Kithsiri Wijeratne, Ya-Ming Xu, Ruth Scherz-Shouval, Marilyn T. Marron, Danilo D. Rocha, Manping X. Liu, Leticia V. Costa-Lotufo, Sandro Santagata, Susan Lindquist, Luke Whitesell & A. A. Leslie Gunatilaka. (2014) Structure–Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock Response. Journal of Medicinal Chemistry 57:7, pages 2851-2863.
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Kanika Patel, Ravi B Singh & Dinesh K Patel. (2013) Pharmacological and analytical aspects of withaferin A: A concise report of current scientific literature. Asian Pacific Journal of Reproduction 2:3, pages 238-243.
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Wim Vanden Berghe, Linde Sabbe, Mary Kaileh, Guy Haegeman & Karen Heyninck. (2012) Molecular insight in the multifunctional activities of Withaferin A. Biochemical Pharmacology 84:10, pages 1282-1291.
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