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Cancer Investigation Volume 34, 2016 - Issue 1
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Original Articles

Angiopoietin-2 May Be Involved in the Resistance to Bevacizumab in Recurrent Glioblastoma

Marianne LabussièreSorbonne Universités, Universite Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, Paris, France;Institut National de la Santé et de la Recherche Médicale, U 1127, Paris, France;Centre Nationale de la Recherche Scientifique, UMR 7225, Paris, France
,
Caroline CheneauSorbonne Universités, Universite Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, Paris, France;Institut National de la Santé et de la Recherche Médicale, U 1127, Paris, France;Centre Nationale de la Recherche Scientifique, UMR 7225, Paris, France
,
Claudia PrahstInstitut National de la Santé et de la Recherche Médicale, U 833, Paris, France;Collège de France, Paris, France
,
Jaime Gállego Pérez-LarrayaAssistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2, Paris, France
,
Patrizia FarinaAssistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2, Paris, France
,
Giuseppe LombardiAssistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2, Paris, France
,
Karima MokhtariSorbonne Universités, Universite Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, Paris, France;Institut National de la Santé et de la Recherche Médicale, U 1127, Paris, France;Centre Nationale de la Recherche Scientifique, UMR 7225, Paris, France;Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Laboratoire de Neuropathologie R. Escourolle, Paris, France;OncoNeuroTek, Paris, France
,
Amithys RahimianOncoNeuroTek, Paris, France
,
Jean-Yves DelattreSorbonne Universités, Universite Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, Paris, France;Institut National de la Santé et de la Recherche Médicale, U 1127, Paris, France;Centre Nationale de la Recherche Scientifique, UMR 7225, Paris, France;Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2, Paris, France;OncoNeuroTek, Paris, France
,
Anne EichmannInstitut National de la Santé et de la Recherche Médicale, U 833, Paris, France;Collège de France, Paris, France
&
Marc SansonSorbonne Universités, Universite Pierre et Marie Curie, Centre de Recherche de l’Institut du Cerveau et de la Moelle épinière, Paris, France;Institut National de la Santé et de la Recherche Médicale, U 1127, Paris, France;Centre Nationale de la Recherche Scientifique, UMR 7225, Paris, France;Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie 2, Paris, France;OncoNeuroTek, Paris, FranceCorrespondence[email protected]
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Pages 39-44 | Received 15 Jan 2015, Accepted 27 Aug 2015, Published online: 06 Jan 2016

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Casey Anthony, Nikol Mladkova-Suchy & David Cory Adamson. (2019) The evolving role of antiangiogenic therapies in glioblastoma multiforme: current clinical significance and future potential. Expert Opinion on Investigational Drugs 28:9, pages 787-797.
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Giorgia Marisi, Emanuela Scarpi, Alessandro Passardi, Oriana Nanni, Flavia Pagan, Martina Valgiusti, Andrea Casadei Gardini, Luca Maria Neri, Giovanni Luca Frassineti, Dino Amadori & Paola Ulivi. (2018) IL-8 and thrombospondin-1 as prognostic markers in patients with metastatic colorectal cancer receiving bevacizumab. Cancer Management and Research 10, pages 5659-5666.
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Articles from other publishers (25)

L. Brisson, L. Henrique Geraldo, A. Bikfalvi & T. Mathivet. (2023) The strange Microenvironment of Glioblastoma. Revue Neurologique 179:5, pages 490-501.
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Shan Min Chin, Giacomo Reina, Ngoc Do Quyen Chau, Tanguy Chabrol, Didier Wion, Ali Bouamrani, Emmanuel Gay, Yuta Nishina, Alberto Bianco & François Berger. (2023) Functional Graphene for Peritumoral Brain Microenvironment Modulation Therapy in Glioblastoma. Small 19:18.
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Eunhyeong Lee, Eun-Ah Lee, Eunji Kong, Haemin Chon, Melissa Llaiqui-Condori, Cheon Ho Park, Beom Yong Park, Nu Ri Kang, Jin-San Yoo, Hyun-Soo Lee, Hyung-Seok Kim, Sung-Hong Park, Seung-Won Choi, Dietmar Vestweber, Jeong Ho Lee, Pilhan Kim, Weon Sup Lee & Injune Kim. (2023) An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone. Experimental & Molecular Medicine 55:2, pages 470-484.
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Asimina Nikolakopoulou, Dimitris Tsakogiannis, Flora Zagouri, Eleni Zografos, Lamprini Tzioga, Grigorios Stratakos, Nikolaos Koulouris, Konstantinos Syrigos & Garyfalia Bletsa. (2022) Baseline Ang-2 Serum Levels as a Predictive Factor for Survival in NSCLC and SCLC. Life 12:12, pages 2092.
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Amir Barzegar Behrooz, Zahra Talaie, Fatemeh Jusheghani, Marek J. Łos, Thomas Klonisch & Saeid Ghavami. (2022) Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma. International Journal of Molecular Sciences 23:3, pages 1353.
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Huan Wang, Jianxin Guo, Tianze Wang, Kai Wang, Zhuojun Wu & Tianze Sun. (2021) Efficacy and safety of bevacizumab in the treatment of adult gliomas: a systematic review and meta-analysis. BMJ Open 11:12, pages e048975.
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Reinhard Angermann, Teresa Rauchegger, Yvonne Nowosielski, Christof Seifarth, Stefan Egger, Martina T. Kralinger, Gerhard F. Kieselbach & Claus Zehetner. (2020) Systemic counterregulatory response of angiopoietin‐2 after aflibercept therapy for nAMD: a potential escape mechanism. Acta Ophthalmologica 99:6.
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Hamza Ali, Romée Harting, Ralph de Vries, Meedie Ali, Thomas Wurdinger & Myron G. Best. (2021) Blood-Based Biomarkers for Glioma in the Context of Gliomagenesis: A Systematic Review. Frontiers in Oncology 11.
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Charly Helaine, Aurélie E. Ferré, Marine M. Leblond, Elodie A. Pérès, Myriam Bernaudin, Samuel Valable & Edwige Petit. (2020) Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study. Cancers 12:12, pages 3585.
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Istafa J. Raza, Campbell A. Tingate, Panagiota Gkolia, Lorena Romero, Jin W. Tee & Martin K. Hunn. (2020) Blood Biomarkers of Glioma in Response Assessment Including Pseudoprogression and Other Treatment Effects: A Systematic Review. Frontiers in Oncology 10.
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Kunal S Patel, Sameer Kejriwal, Samasuk Thammachantha, Courtney Duong, Adrian Murillo, Lynn K Gordon, Timothy F Cloughesy, Linda Liau, William Yong, Isaac Yang & Madhuri Wadehra. (2020) Increased epithelial membrane protein 2 expression in glioblastoma after treatment with bevacizumab. Neuro-Oncology Advances 2:1.
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Ling Gao, Xi Yang, Cheng Yi & Hong Zhu. (2019) Adverse Events of Concurrent Immune Checkpoint Inhibitors and Antiangiogenic Agents: A Systematic Review. Frontiers in Pharmacology 10.
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Gergely Solecki, Matthias Osswald, Daniel Weber, Malte Glock, Miriam Ratliff, Hans-Joachim Müller, Oliver Krieter, Yvonne Kienast, Wolfgang Wick & Frank Winkler. (2019) Differential Effects of Ang-2/VEGF-A Inhibiting Antibodies in Combination with Radio- or Chemotherapy in Glioma. Cancers 11:3, pages 314.
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Weibin Hou & Stefan Duensing. 2019. Tumor Angiogenesis. Tumor Angiogenesis 293 310 .
Alice West, Vanessa Tsui, Stanley Stylli, Hong Nguyen, Andrew Morokoff, Andrew Kaye & Rodney Luwor. (2018) The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review). Oncology Letters.
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Dai Fukumura, Jonas Kloepper, Zohreh Amoozgar, Dan G. Duda & Rakesh K. Jain. (2018) Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nature Reviews Clinical Oncology 15:5, pages 325-340.
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David A. Reardon, Andrew B. Lassman, David Schiff, Shakeeb A. Yunus, Elizabeth R. Gerstner, Timothy F. Cloughesy, Eudocia Quant Lee, Sarah C. Gaffey, Jennifer Barrs, Jennifer Bruno, Alona Muzikansky, Daniel G. Duda, Rakesh K. Jain & Patrick Y. Wen. (2018) Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma. Cancer 124:7, pages 1438-1448.
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Siobhan Conroy, Frank A.E. Kruyt, Michiel Wagemakers, Krishna P.L. Bhat & Wilfred F.A. den Dunnen. (2018) IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma. Oncotarget 9:21, pages 15721-15731.
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Ru Huang, Wenchao Gu, Bin Sun & Lei Gao. (2018) Identification of COL4A1 as a potential gene conferring trastuzumab resistance in gastric cancer based on bioinformatics analysis. Molecular Medicine Reports.
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Taek-Keun Kim, Chang Sik Park, Jihye Jang, Mi Ra Kim, Hee-Jun Na, Kangseung Lee, Hyun Jung Kim, Kyun Heo, Byong Chul Yoo, Young-Myeong Kim, Je-Wook Lee, Su Jin Kim, Eun Sung Kim, Dae Young Kim, Kiweon Cha, Tae Gyu Lee & Sukmook Lee. (2018) Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a. Molecular Oncology 12:3, pages 356-372.
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Jennifer Jeck, Rebecca Kassubek, Jan Coburger, Simone Edenhofer, Stefan S. Schönsteiner, Albert C. Ludolph, Bernd Schmitz, Jens Engelke, Regine Mayer-Steinacker, Jan Lewerenz & Lars Bullinger. (2018) Bevacizumab in temozolomide refractory high-grade gliomas: single-centre experience and review of the literature. Therapeutic Advances in Neurological Disorders 11, pages 175628561775359.
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Thiago Cabral, Luiz H. Lima, Luiz Guilherme M. Mello, Júlia Polido, Éverton P. Correa, Akiyoshi Oshima, Jimmy Duong, Pedro Serracarbassa, Caio V. Regatieri, Vinit B. Mahajan & Rubens Belfort Jr.. (2018) Bevacizumab Injection in Patients with Neovascular Age-Related Macular Degeneration Increases Angiogenic Biomarkers. Ophthalmology Retina 2:1, pages 31-37.
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Ryota Tamura, Toshihide Tanaka, Keisuke Miyake, Kazunari Yoshida & Hikaru Sasaki. (2017) Bevacizumab for malignant gliomas: current indications, mechanisms of action and resistance, and markers of response. Brain Tumor Pathology 34:2, pages 62-77.
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