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Original Article

Mechanisms of Tumor Promotion: Potential Role of Intercellular Communication

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Pages 511-526 | Published online: 11 Jun 2009

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Roberto Zefferino, Antonella Leone, Simona Piccaluga, Raffaele Cincione & Luigi Ambrosi. (2008) Mercury modulates interplay between IL-1β, TNF-α, and gap junctional intercellular communication in keratinocytes: mitigation by lycopene. Journal of Immunotoxicology 5:4, pages 353-360.
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EMMANUEL FARBER. (2000) RISK ASSESSMENT FOR POSSIBLE CARCINOGENS: A CRITICAL LOOK. Drug Metabolism Reviews 32:2, pages 143-151.
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Rita Loch‐Caruso, IsabelA. Corcos & JamesE. Trosko. (1991) Inhibition of metabolic coupling by metals. Journal of Toxicology and Environmental Health 32:1, pages 33-48.
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Eric M. Silberhorn, Howard P. Glauert & Larry W. Robertson. (1990) Critical Reviews in: Carcinogenicity of Polyhalogenated Biphenyls: PCBs and PBBs. Critical Reviews in Toxicology 20:6, pages 440-496.
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BrendaK. Boutin, JamesT. Peeler & RobertM. Twedt. (1989) Effects of purified altertoxins I, II, and III in the metabolic communication V79 system. Journal of Toxicology and Environmental Health 26:1, pages 75-81.
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Rita Loch-Caruso, James E. Trosko & William J. Larsen. (1985) Inhibited Intercellular Communication as a Mechanistic Link Between Teratogenesis and Carcinogenesis. CRC Critical Reviews in Toxicology 16:2, pages 157-183.
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Articles from other publishers (82)

Maria Angélica Guzmán-Silva. (2023) Revisão e atualização sobre carcinogênese química cutânea. Revista Brasileira de Cancerologia 41:2, pages 93-108.
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Zefferino, Piccoli, Gioia, Capitanio & Conese. (2019) Gap Junction Intercellular Communication in the Carcinogenesis Hallmarks: Is This a Phenomenon or Epiphenomenon?. Cells 8:8, pages 896.
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Stephanie Shishido & Thu Nguyen. (2016) Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells. International Journal of Molecular Sciences 17:2, pages 178.
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Kurt A. Schalper, Daniel Carvajal-Hausdorf & Mauricio P. Oyarzo. (2014) Possible role of hemichannels in cancer. Frontiers in Physiology 5.
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K.G. Manton, Igor Akushevich & Julia KravchenkoK.G. Manton, Igor Akushevich & Julia Kravchenko. 2009. Cancer Mortality and Morbidity Patterns in the U.S. Population. Cancer Mortality and Morbidity Patterns in the U.S. Population 37 87 .
C. Cowles, A. Mally & J.K. Chipman. (2007) Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo. Toxicology 238:1, pages 49-59.
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Akiyoshi Nishikawa, Kimie Sai, Kazushi Okazaki, Hwa-Young Son, Keita Kanki, Madoka Nakajima, Naohide Kinae, Takehiko Nohmi, James E. Trosko, Tohru Inoue & Masao Hirose. (2006) MX, a by-product of water chlorination, lacks in vivo genotoxicity ingpt delta mice but inhibits gap junctional intercellular communication in rat WB cells. Environmental and Molecular Mutagenesis 47:1, pages 48-55.
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Christian Streffer, H. Bolt, D. Føllesdal, P. Hall, J. G. Hengstler, P. Jakob, D. Oughton, K. Prieß, E. Rehbinder & E. SwatonChristian Streffer, H. Bolt, D. Føllesdal, P. Hall, J. G. Hengstler, P. Jakob, D. Oughton, K. Prieß, E. Rehbinder & E. Swaton. 2004. Low Dose Exposures in the Environment. Low Dose Exposures in the Environment 213 256 .
Brad L. Upham, Alisa M. Rummel, Joseph M. Carbone, James E. Trosko, Yanli Ouyang, Robert B. Crawford & Norbert E. Kaminski. (2003) Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line. International Journal of Cancer 104:1, pages 12-18.
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Brad Upham, James rosko & Chia-Cheng Chang. 2002. Biomarkers of Environmentally Associated Disease. Biomarkers of Environmentally Associated Disease.
Kimie Sai, Kyung-Sun Kang, Akihiko Hirose, Ryuichi Hasegawa, James E. Trosko & Tohru Inoue. (2001) Inhibition of apoptosis by pentachlorophenol in v-myc-transfected rat liver epithelial cells: relation to down-regulation of gap junctional intercellular communication. Cancer Letters 173:2, pages 163-174.
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Jürgen Fuchs & Lester PackerJames Klaunig & Lisa Kamendulis. 2001. Environmental Stressors in Health and Disease. Environmental Stressors in Health and Disease.
James E. Trosko. (2001) Commentary: Is the concept of “tumor promotion” a useful paradigm?. Molecular Carcinogenesis 30:3, pages 131-137.
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G ChenB L UphamW SunC C ChangE J RothwellK M ChenH YamasakiJ E Trosko. (2000) Effect of electromagnetic field exposure on chemically induced differentiation of friend erythroleukemia cells.. Environmental Health Perspectives 108:10, pages 967-972.
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Kimie Sai, Jun Kanno, Ryuichi Hasegawa, James E. Trosko & Tohru Inoue. (2000) Prevention of the down-regulation of gap junctional intercellular communication by green tea in the liver of mice fed pentachlorophenol. Carcinogenesis 21:9, pages 1671-1676.
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Kyung-Sun Kang, Byeong-Cheol Kang, Beom-Jun Lee, Jeong-Hwan Che, Guang-Xun Li, James E. Trosko & Yong-Soon Lee. (2000) Preventive effect of epicatechin and ginsenoside Rb2 on the inhibition of gap junctional intercellular communication by TPA and H2O2. Cancer Letters 152:1, pages 97-106.
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M.Ricarda Wilson, Troy W. Close & James E. Trosko. (2000) Cell Population Dynamics (Apoptosis, Mitosis, and Cell–Cell Communication) during Disruption of Homeostasis. Experimental Cell Research 254:2, pages 257-268.
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J E Trosko. (1999) Comments on "What is a tumor promoter?".. Environmental Health Perspectives 107:12.
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Michael Vaccariello, Ashkan Javaherian, Youai Wang, Norbert E. Fusenig & Jonathan A. Garlick. (1999) Cell Interactions Control the Fate of Malignant Keratinocytes in an Organotypic Model of Early Neoplasia. Journal of Investigative Dermatology 113:3, pages 384-391.
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Subhasis Ghoshal, Walter J. Weber,, Alisa M. Rummel, James E. Trosko & Brad L. Upham. (1999) Epigenetic Toxicity of a Mixture of Polycyclic Aromatic Hydrocarbons on Gap Junctional Intercellular Communication Before and After Biodegradation. Environmental Science & Technology 33:7, pages 1044-1050.
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James E Trosko, Chia-Cheng Chang, Brad Upham & Melinda Wilson. (1998) Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication. Toxicology Letters 102-103, pages 71-78.
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B L Upham, L M Weis & J E Trosko. (1998) Modulated gap junctional intercellular communication as a biomarker of PAH epigenetic toxicity: structure-function relationship.. Environmental Health Perspectives 106:suppl 4, pages 975-981.
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Kimie Sai, Brad L Upham, Kyung-Sun Kang, Ryuichi Hasegawa, Tohru Inoue & James E Trosko. (1998) Inhibitory effect of pentachlorophenol on gap junctional intercellular communication in rat liver epithelial cells in vitro. Cancer Letters 130:1-2, pages 9-17.
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Emmanuel Farber. (2016) Gap Junction Intercellular Communication Should Be Altered in Mitosis. Toxicologic Pathology 26:2, pages 260-261.
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Min-Liang Kuo, Shiou-Hwa Jee, Ming-Hong Chou & Tzuu-Huei Ueng. (1998) Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 413:2, pages 143-150.
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J E Trosko. (1998) Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents.. Environmental Health Perspectives 106:suppl 1, pages 331-339.
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L M WeisA M RummelS J MastenJ E TroskoB L Upham. (1998) Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication.. Environmental Health Perspectives 106:1, pages 17-22.
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