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Cancer Investigation Volume 1, 1983 - Issue 3
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Original Article

Production and Characterization of Monoclonal Antibodies against Human Malignant Melanoma

Meenhard Herlyn The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
,
Zenon Steplewski The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
,
Dorothee Herlyn The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
,
Wallace H. Clark The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
,
Alonzo H. Ross The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
,
Magdalena Blaszczyk The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
,
Koon Y. Pak The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
&
Hilary Koprowski The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania; Pigmented Lesion Study Group, Comprehensive Cancer Center University of Pennsylvania, Philadelphia, Pennsylvania
 show all
Pages 215-224 | Published online: 11 Jun 2009

Citations (51)

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Read on this site (2)

Philip J. Moldofsky, John Powe, Nancy Dona Hammond & John R. Hansell. (1987) Tumor Detection Using Radiolabeled Monoclonal Antibodies. CRC Critical Reviews in Clinical Laboratory Sciences 25:4, pages 313-351.
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Peter Mersey. (1985) Review of Melanoma Antigens Recognized by Monoclonal Antibodies (MAbs). Their Functional Significance and Applications in Diagnosis and Treatment of Melanoma. Pathology 17:2, pages 346-354.
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Articles from other publishers (49)

Magdalena Thurin. (2021) Tumor-Associated Glycans as Targets for Immunotherapy: The Wistar Institute Experience/Legacy. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 40:3, pages 89-100.
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Elisa Tamburini, Alice Dallatomasina, Jade Quartararo, Barbara Cortelazzi, Domenica Mangieri, Mirca Lazzaretti & Roberto Perris. (2018) Structural deciphering of the NG2/CSPG4 proteoglycan multifunctionality. The FASEB Journal 33:3, pages 3112-3128.
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. (2014) Hilary Koprowski, MD: A Lifetime of Work. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 33:3, pages A-1-A-43.
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Dorothee Herlyn, Brigitte Birebent, Nese Akis, Enkhtsetseg Purev, Rajasekharan Somasundaram, Edith Mitchell, Henry Maguire, Ludger Staib & Michael Mastrangelo. 2003. 287 298 .
Haruhiko Maruyama, Melinda Sperlagh, Jan Zaloudik, Shaohong Liang, Kiyoshi Mizuki, Carla Molthoff & Dorothee Herlyn. (2002) Immunization procedures for anti-idiotypic antibody induction in mice and rats. Journal of Immunological Methods 264:1-2, pages 121-133.
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Nese Akis, Claudia Andl & Dawei Zhou. (2002) A mixed hemadsorption assay for detection of cell surface binding anti-tumor antibodies in human sera. Journal of Immunological Methods 261:1-2, pages 119-127.
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Weimin Qi, Birgit C. Schultes, Dan Liu, Michelle Kuzma, Wendy Decker & Ragupathy Madiyalakan. (2001) Characterization of an Anti-MUC1 Monoclonal Antibody with Potential as a Cancer Vaccine. Hybridoma and Hybridomics 20:5-6, pages 313-324.
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Ludger Staib, Brigitte Birebent, Rajasekharan Somasundaram, Enkhtsetseg Purev, Heidi Braumüller, Christian Leeser, Norbert Küttner, Weiping Li, Dawei Zhu, Jun Diao, William Wunner, David Speicher, Hans-Günther Beger, Hong Song & Dorothee Herlyn. (2001) Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients. International Journal of Cancer 92:1, pages 79-87.
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MANABU NAKASHIMA, TAKESHI WATANABE, HILARY KOPROWSKI & ZENON STEPLEWSKI. (1996) HLA-B-Restricted, CD8 + Cytolytic Human T Cell Clones Derived from a Melanoma-Invaded Lymph Node . Hybridoma 15:2, pages 147-154.
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Haruhiko Maruyama, Andrea Benden, Weiping Li, Jan Zaloudik, Takashi Koido, Jean Luc Taupin, Bruce Acres, Rajasekharan Somasundaram, Marie Prewett & Dorothee Herlyn. (1996) Monoclonal anti-idiotypic antibody functionally mimics the human gastrointestinal carcinoma epitope GA733. International Journal of Cancer 65:4, pages 547-553.
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MANABU NAKASHIMA, MAGDALENA JANISZEWSKA, ZENON STEPLEWSKI, TAKESHI WATANABE, LYNN SCHUCHTER & HILARY KOPROWSKI. (1994) Proliferation, Phenotype, and Cytotoxicity of Human Lymphocytes Isolated from Lymph Nodes Invaded by Melanoma Cells. Hybridoma 13:3, pages 241-246.
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DOROTHEE HERLYN, JAN ZALOUDIK, RAJASEKHARAN SOMASUNDARAM, LUTZ JACOB, ANDREA BENDEN & MICHAEL MASTANGELO. (1993) Anti-Idiotype Vaccine in Colorectal Cancer Patients. Hybridoma 12:5, pages 515-520.
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A.M. Suburo, X.-H. Gu, G. Moscoso, A. Ross, G. Terenghi & J.M. Polak. (1992) Developmental pattern and distribution of nerve growth factor low-affinity receptor immunoreactivity in human spinal cord and dorsal root ganglia: Comparison with synaptophysin, neurofilament and neuropeptide immunoreactivities. Neuroscience 50:2, pages 467-482.
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A. H. Ross, G. Sobue, H. Hotta & U. R. Reddy. 1991. Neuronal Growth Factors. Neuronal Growth Factors 27 38 .
Dorothee Herlyn, Koji Adachi, Hilary Koprowski & Meenhard Herlyn. 1991. Melanoma Research: Genetics, Growth Factors, Metastases, and Antigens. Melanoma Research: Genetics, Growth Factors, Metastases, and Antigens 105 118 .
Usha Rani Reddy, Gita Venkatakrishnan, Gerd G. Maul, Amit K. Roy & Alonzo H. Ross. (1990) Transient expression of full-length and truncated forms of the human nerve growth factor receptor. Molecular Brain Research 8:2, pages 137-141.
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Gert Claus, Christoph Winkler, JÜRgen Lohmeyer, Fritz Anders & Manfred Schartl. (2006) Oncofetal antigen in Xiphophorus detected by monoclonal antibodies directed against melanoma‐associated antigens . International Journal of Cancer 45:1, pages 136-142.
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Charles W. Taylor & Evan M. Hersh. 1990. Immunopharmacology Reviews. Immunopharmacology Reviews 89 157 .
Jadranka Jambrosic, Maria Laura Mancianti, Robert Ricciardi, Ben‐Ami Sela, Hilary Koprowski & Meenhard Herlyn. (2006) Transformation of normal human melanocytes and non‐malignant nevus cells by adenovirus 12‐SV40 hybrid virus. International Journal of Cancer 44:6, pages 1117-1123.
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Anil Nanda, Boleslaw Liwnicz, Barbara F. Atkinson, Ben-Ami Sela, Hiroshi Takahashi, Paul H. Belser, Perry Black, Hilary Koprowski & Dorothee Herlyn. (1989) Monoclonal antibodies with cytotoxic reactivities against human gliomas. Journal of Neurosurgery 71:6, pages 892-897.
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Ronald Jay Rothman, Bice Perussia, Dorothee Herlyn & Leonard Warren. (1989) Antibody-dependent cytotoxicity mediated by natural killer cells is enhanced by castanospermine-induced alterations of IgG glycosylation. Molecular Immunology 26:12, pages 1113-1123.
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Franz Hefti & Deborah C. Mash. (1989) Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease. Neurobiology of Aging 10:1, pages 75-87.
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Maria Laura. Mancianti, Meenhard. Herlyn, Deborah. Weil, Jadranka. Jambrosic, Ulrich. Rodeck, Dorothea. Becker, Leila. Diamond, Wallace H. Clark & Hilary. Koprowski. (1988) Growth and Phenotoypic Characteristics of Human Nevus Cells in Culture. Journal of Investigative Dermatology 90:2, pages 134-141.
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James L. Murray, Michael W. Unger & Samuel E. Halpern. (1988) Radioimmunodetection of cancer with monoclonal antibodies: Current status, problems, and future directions. Critical Reviews in Oncology/Hematology 8:3, pages 227-253.
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James L. Murray, Lamk M. Lamki & Michael G. Rosenblum. 1988. Malignant Melanoma: Biology, Diagnosis, and Therapy. Malignant Melanoma: Biology, Diagnosis, and Therapy 123 153 .
Abdolmohammad Rostami, Gen Sobue, Robert P. Lisak & David E. Pleasure. (1987) A monoclonal antibody to Schwann cell surface membrane recognizes a cAMP inducible epitope. Brain Research 425:2, pages 205-211.
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Gary M. Stuhlmiller, Timothy L. Darrow, Dale M. Haupt & H. F. Seigler. (1987) Immune response of chimpanzee to purified melanoma 250 kilodalton tumor-associated antigen. Cancer Immunology, Immunotherapy 25:3, pages 193-200.
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Alonzo H. Ross, Dorothee Herlyn & Hilary Koprowski. (1987) Purification of monoclonal antibodies from ascites using ABx liquid chromatography column. Journal of Immunological Methods 102:2, pages 227-231.
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L. K. J. Sikora, D. J. Demetrick, W. T. Dixon, L. M. Jerry, A. Pinto, S. J. Urbanski & W. Temple. (1987) Characterization of a novel neuroglandular antigen (NGA) expressed on abnormal human melanocytes. International Journal of Cancer 39:2, pages 138-145.
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Kazuo Maeda & Kowichi Jimbow. (1987) Development of MoAB HMSA-2 for melanosomes of human melanoma and its application to immunohistopathologic diagnosis of neoplastic melanocytes. Cancer 59:3, pages 415-423.
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Meenhard Herlyn, Ulrich Rodeck & Hilary Koprowski. 1987. 189 221 .
John R. Harper & Ralph A. Reisfeld. 1987. Biology of Proteoglycans. Biology of Proteoglycans 345 366 .
Dorothee Herlyn, Alonzo H. Ross, Dimitrios Iliopoulos & Hilary Koprowski. (1987) Induction of specific immunity to human colon carcinoma by anti-idiotypic antibodies to monoclonal antibody CO17-1A. European Journal of Immunology 17:11, pages 1649-1652.
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ALONZO H. ROSS, MEENHARD HERLYN, GERD G. MAUL, HILARY KOPROWSKI, MARK BOTHWELL, MOSES CHAO, DAVID PLEASURE & KENNETH H. SONNENFELD. (1986) The Nerve Growth Factor Receptor in Normal and Transformed Neural Crest Cells. Annals of the New York Academy of Sciences 486:1 Neurofibromat, pages 115-123.
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Barbara A. Gilchrest, Valori Treloar, Anita M. Grassi, Mina Yaar, George Szabo & Evelyn Flynn. (1986) Characteristics of Cultivated Adult Human Nevocellular Nevus Cells. Journal of Investigative Dermatology 87:1, pages 102-107.
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Peter Hersey, Anne Edwards, Gennaro D'Alessandro & Malcolm MacDonald. (1986) Phase II study of vaccinia melanoma cell lysates (VMCL) as adjuvant to surgical treatment of stage II melanoma. Cancer Immunology, Immunotherapy 22:3, pages 221-231.
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Dorothee Herlyn, John Powe, Dieter L. Munz, Abass Alavi, Meenhard Herlyn, George E. Meinken, Suresh C. Srivastava & Hilary Koprowski. (1986) Radioimmunodetection of human tumor xenografts by monoclonal antibody F(ab′)2 fragments. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 13:4, pages 401-405.
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J Thurin, M Herlyn, O Hindsgaul, N Strömberg, K A Karlsson, D Elder, Z Steplewski & H Koprowski. (1985) Proton NMR and fast-atom bombardment mass spectrometry analysis of the melanoma-associated ganglioside 9-O-acetyl-GD3.. Journal of Biological Chemistry 260:27, pages 14556-14563.
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Alonzo H. Ross, Bernhard Dietzschold, Donna M. Jackson, James J. EarleyJr.Jr., Barbara D.F. Ghrist, Barbara Atkinson & Hilary Koprowski. (1985) Isolation and amino terminal sequencing of a novel melanoma-associated antigen. Archives of Biochemistry and Biophysics 242:2, pages 540-548.
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Meenhard Herlyn, Magdalena Blaszczyk, Jeannette Bennicelli, Henry F. Sears, Carolyn Ernst, Alonzo H. Ross & Hilary Koprowski. (1985) Selection of monoclonal antibodies detecting serodiagnostic human tumor markers. Journal of Immunological Methods 80:1, pages 107-116.
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Hilary Koprowski, Meenhard Herlyn, Gloria Balaban, Annette Parmiter, Alonzo Ross & Peter Nowell. (1985) Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma. Somatic Cell and Molecular Genetics 11:3, pages 297-302.
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Dorothee Herlyn, Meenhard Herlyn, Zenon Steplewski & Hilary Koprowski. (1985) Monoclonal anti-human tumor antibodies of six isotypes in cytotoxic reactions with human and murine effector cells. Cellular Immunology 92:1, pages 105-114.
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Zenon Steplewski, Henry F. Sears & Hilary Koprowski. 1985. Immunity to Cancer. Immunity to Cancer 97 107 .
Z. Steplewski, M. Blaszczyk, D. Herlyn, M. Herlyn & H. Koprowski. 1985. Monoclonal Antibodies and Breast Cancer. Monoclonal Antibodies and Breast Cancer 134 149 .
Dorothee Herlyn, Meenhard Herlyn, Alonzo H. Ross, Carolyn Ernst, Barbara Atkinson & Hilary Koprowski. (1984) Efficient selection of human tumor growth-inhibiting monoclonal antibodies. Journal of Immunological Methods 73:1, pages 157-167.
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Gloria Balaban, Meenhard Herlyn, DuPont GuerryIVIV, Rebecca Bartolo, Hilary Koprowski, Wallace H. Clark & Peter C. Nowell. (1984) Cytogenetics of human malignant melanoma and premalignant lesions. Cancer Genetics and Cytogenetics 11:4, pages 429-439.
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GARY M. STUHLMILLER, MICHAEL J. BOROWITZ & H. F. SEIGLER. (1984) D6.1, A Murine Antimelanoma Monoclonal Antibody from Congenitally Athymic Nude Mice Immunized with Purified Melanoma Tumorassociated Antigen. Hybridoma 3:4, pages 333-346.
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Meenhard Herlyn, Beverly Lange, Jeannette Bennicelli, Magdalena Blaszczyk, Dupont GuerryIVIV & Hilary Koprowski. (1984) Increased levels of circulating HLA-DR antigen in sera of patients with acute lymphoblastoid leukemia. Leukemia Research 8:3, pages 323-334.
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Alonzo H. Ross, Giulio Cossu, Meenhard Herlyn, John R. Bell, Zenon Steplewski & Hilary Koprowski. (1983) Isolation and chemical characterization of a melanoma-associated proteoglycan antigen. Archives of Biochemistry and Biophysics 225:1, pages 370-383.
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