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Cancer Investigation Volume 9, 1991 - Issue 1
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Original Article

Methotrexate and Childhood Leukemia

Olafur G. Jonsson Department of Pediatrics and Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
&
Barton A. Kamen Department of Pediatrics and Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
Pages 53-60 | Published online: 11 Jun 2009

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Shu-Guang Liu, Zhi-Gang Li, Lei Cui, Chao Gao, Wei-Jing Li & Xiao-Xi Zhao. (2011) Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population. Leukemia & Lymphoma 52:6, pages 1030-1040.
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Tunc Fisgin, Nese Yarali, Abdurrahman Kara, Ceyhun Bozkurt, Dilek Birgen, Ulya Erten & Feride Duru. (2004) HEMOSTATIC SIDE EFFECTS OF HIGH-DOSE METHOTREXATE IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA. Pediatric Hematology and Oncology 21:1, pages 77-83.
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Articles from other publishers (14)

Julie M. Fischer, Oranooj Lertkovit, Scott C. Howard, Chatchawin Assanasen & Archie Bleyer. (2023) Severe Methotrexate Toxicity Following a Capizzi Cycle in an Obese Adolescent With Acute Lymphoblastic Leukemia and Hepatic Steatosis. Journal of Pediatric Hematology/Oncology.
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Shin-ichi Tsujimoto, Masakatsu Yanagimachi, Reo Tanoshima, Kevin Y. Urayama, Fumiko Tanaka, Noriko Aida, Hiroaki Goto & Shuichi Ito. (2016) Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies . Pediatric Blood & Cancer 63:11, pages 1983-1989.
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Carolyn M. Summers, Andrea L. Hammons, Jasbir Arora, Suhong Zhang, Jeanine Jochems, Ian A. Blair & Alexander S. Whitehead. (2014) Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. European Journal of Pharmacology 732, pages 60-67.
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Robin E. Norris & Peter C. Adamson. (2009) Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. Cancer Chemotherapy and Pharmacology 65:6, pages 1125-1130.
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Noriko Shimasaki, Tetsuya Mori, Hazuki Samejima, Reiko Sato, Hiroyuki Shimada, Naohisa Yahagi, Chiharu Torii, Hiroki Yoshihara, Yusuke Tanigawara, Takao Takahashi & Kenjiro Kosaki. (2006) Effects of Methylenetetrahydrofolate Reductase and Reduced Folate Carrier 1 Polymorphisms on High-Dose Methotrexate-Induced Toxicities in Children With Acute Lymphoblastic Leukemia or Lymphoma. Journal of Pediatric Hematology/Oncology 28:2, pages 64-68.
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Shinji KishiJames GrienerCheng ChengSoma DasEdwin H. CookDeqing PeiMelissa HudsonJeffrey RubnitzJohn T. SandlundChing-Hon PuiMary V. Relling. (2003) Homocysteine, Pharmacogenetics, and Neurotoxicity in Children With Leukemia. Journal of Clinical Oncology 21:16, pages 3084-3091.
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J. Rodríguez Flores, J. J. Berzas Nevado, G. Castañeda Peñalvo & M. I. Rodríguez Cáceres. (2002) Micellar electrokinetic capillary chromatographic method for simultaneous determination of drugs used to treat advanced breast cancer. Chromatographia 56:5-6, pages 283-288.
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Mehmet Totan, Ayhan Dagdemir, Ali Riza Ak, Davut Albayrak & Sukru Kucukoduk. (2001) Effects of high‐dose methotrexate on the hemostatic system in childhood acute lymphoblastic leukemia. Medical and Pediatric Oncology 36:4, pages 429-433.
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Susanne Renner, Zyrafete Kuçi, Hubert d'Cruze, Dietrich Niethammer & Gernot Bruchelt. (2000) Isotachophoretic analysis of the dihydrofolate reductase reaction in the presence of methotrexate and ascorbic acid. Electrophoresis 21:14, pages 2828-2833.
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Matthew J Barnes, Gordon A Taylor & David R Newell. (2000) Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells. Biochemical Pharmacology 59:4, pages 321-328.
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Barton A. Kamen & Richard I. Drachtman. 2000. Methotrexate. Methotrexate 49 63 .
Richard Gorlick, Erdem Goker, Tanya Trippett, Mark Waltham, Debabrata Banerjee & Joseph R. Bertino. (1996) Intrinsic and Acquired Resistance to Methotrexate in Acute Leukemia. New England Journal of Medicine 335:14, pages 1041-1048.
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J.C. Bernini, D.W. Fort, J.C. Griener, B.J. Kane, W.B. Chappell, B.A. Kamen & B.A. Kamen. (1995) Aminophylline for methotrexate-induced neurotoxicity. The Lancet 345:8949, pages 544-547.
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Mary E. Teresi, Charles E. Riggs, Paul M. Webster, Michael J. Adams, Patrick K. Noonan & John P. O'Donnell. (2016) Bioequivalence of Two Methotrexate Formulations in Psoriatic and Cancer Patients. Annals of Pharmacotherapy 27:12, pages 1434-1438.
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