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Review Article

5-Fluorouracil by Protracted Venous Infusion: A Review of Recent Clinical Studies

Pages 637-642 | Published online: 11 Jun 2009

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Min-Hee Ryu & Yoon-Koo Kang. (2009) ML17032 trial: capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in advanced gastric cancer. Expert Review of Anticancer Therapy 9:12, pages 1745-1751.
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Anthony B. El-Khoueiry & Heinz-Josef Lenz. (2006) Should Continuous Infusion 5-Fluorouracil Become the Standard of Care in the USA as It Is in Europe?. Cancer Investigation 24:1, pages 50-55.
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Thomas Spector. (1993) 5-Ethynyluracil (776C85): an inactivator of uracil reductase that potentiates the antitumour activity of 5-fluorouracil. Current Opinion on Therapeutic Patents 3:12, pages 1751-1754.
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Herbert HurwitzEdith P. MitchellThomas CartwrightAmbrose KwokSylvia HuEdward McKennaYehuda Z. Patt. (2012) A Randomized, Phase II Trial of Standard Triweekly Compared with Dose-Dense Biweekly Capecitabine Plus Oxaliplatin Plus Bevacizumab as First-Line Treatment for Metastatic Colorectal Cancer: XELOX-A-DVS (Dense Versus Standard). The Oncologist 17:7, pages 937-946.
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Jianguo Zhi, Eric Chen, Pierre Major, Ivon Burns, Bridget Robinson, Joe McKendrick, Karen Rittweger, Markus Abt & David Goldstein. (2011) A multicenter, randomized, open-label study to assess the steady-state pharmacokinetics of bevacizumab given with either XELOX or FOLFOX-4 in patients with metastatic colorectal cancer. Cancer Chemotherapy and Pharmacology 68:5, pages 1199-1206.
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Daniel G. HallerJim CassidyStephen J. ClarkeDavid CunninghamEric Van CutsemPaulo M. HoffMace L. RothenbergLeonard B. SaltzHans-Joachim SchmollCarmen AllegraJoseph R. BertinoJean-Yves DouillardBengt G. GustavssonGerard MilanoMichael O'ConnellYoucef RustumJosep TaberneroFrank GilbergFlorin SirzénChris Twelves. (2008) Potential Regional Differences for the Tolerability Profiles of Fluoropyrimidines. Journal of Clinical Oncology 26:13, pages 2118-2123.
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Ikuo Takahashi, Yasunori Emi, Yoshihiro Kakeji, Junji Uchida, Masakazu Fukushima & Yoshihiko Maehara. (2005) Increased Antitumor Activity in Combined Treatment TS-1 and Docetaxel. Oncology 68:2-3, pages 130-137.
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M.P Decatris, S Sundar & K.J O’Byrne. (2004) Platinum-based chemotherapy in metastatic breast cancer: current status. Cancer Treatment Reviews 30:1, pages 53-81.
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Anne-Renee Hartman, Amy Grekowicz, Bert L. Lum, Robert W. Carlson, Christine Schurman, Branimir I. Sikic, Richard Shapiro & Frank E. Stockdale. (2003) Phase I Trial of Uracil–Ftorafur, Leucovorin, and Etoposide: An Active All-oral Regimen for Metastatic Breast Cancer. Breast Cancer Research and Treatment 82:1, pages 61-69.
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Ikuo Takahashi, Yoshihiro Kakeji, Yasunori Emi, Masato Sakurai, Yusuke Yonemura, Yasue Kimura & Yoshihiko Maehara. (2003) S-1 in the treatment of advanced and recurrent gastric cancer: current state and future prospects. Gastric Cancer 6:S1, pages 28-33.
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A.B. BensonIIIIII, E. Mitchell, N. Abramson, B. Klencke, P. Ritch, J.P. Burnham, C. McGuirt, T. Bonny, J. Levin & J. Hohneker. (2002) Oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma. Annals of Oncology 13:4, pages 576-581.
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Miguel Martín. (2001) Platinum Compounds in the Treatment of Advanced Breast Cancer. Clinical Breast Cancer 2:3, pages 190-208.
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Laura Mascia & Piero Luigi Ipata. (2001) Activation pathways of 5-fluorouracil in rat organs and in PC12 cells11Abbreviations: PRPP, 5-phosphoribosyl 1-pyrophosphate; 5-FU, 5-fluorouracil; FUrd, 5-fluorouridine; 5-FUMP, 5-FUDP, and 5-FUTP, 5-fluorouridine 5′-mono-, -di-, and -triphosphate, 5-Fdeoxyuridine, 5-fluoro-2′-deoxyuridine; 5-FdeoxyUMP, 5-FdeoxyUDP, and 5-FdeoxyUTP, 5-fluoro-2′-deoxyuridine 5′-mono-, -di-, and triphosphate; Rib1-P, ribose 1-phosphate; and deoxyRib1-P, 2′-deoxyribose 1-phosphate.. Biochemical Pharmacology 62:2, pages 213-218.
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A. Zambelli, F.S. Robustelli della Cuna, L. Ponchio, G. Ucci, G.A. Da Prada & G. Robustelli della Cuna. (2000) Four-day infusion of fluorouracil plus vinorelbine as salvage treatment of heavily pretreated metastatic breast cancer. Breast Cancer Research and Treatment 61:3, pages 241-247.
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Gamini S. Soori, Robert K. Oldham, Tracy W. Dobbs, Martin J. Bury, Curtis K. Church & Carol DePriest. (2000) Chemo-Biotherapy with 5-Fluorouracil, Leucovorin, and Alpha Interferon in Metastatic Carcinoma of the Colon - A Cancer Biotherapy Research Group [CBRG] Phase II Study. Cancer Biotherapy and Radiopharmaceuticals 15:2, pages 175-183.
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Dolores Gallardo-Rinc�n, Luis F. O�ate-Oca�a & Germ�n Calderillo-Ruiz. (2000) Neoadjuvant Chemotherapy With P-ELF (Cisplatin, Etoposide, Leucovorin, 5-Fluorouracil) Followed by Radical Resection in Patients With Initially Unresectable Gastric Adenocarcinoma: A Phase II Study. Annals of Surgical Oncology 7:1, pages 45-50.
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Marco Colleoni, Giovanni Vicario, Patrizia Nelli, Gigliola Sgarbossa, Francesca Pancheri & Paolo Manente. (2018) Intermittent Continuous Infusion of Fluorouracil and Low-Dose Oral Leucovorin in Pretreated Breast Cancer: A Pilot Study. Tumori Journal 83:3, pages 665-668.
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Toshifusa Nakajima, Keiichiro Ota, Shou Ishihara, Shigekazu Oyama, Mitsumasa Nishi, Yasuhiko Ohashi & Akio Yanagisawa. (1997) Combined intensive chemotherapy and radical surgery for incurable gastric cancer. Annals of Surgical Oncology 4:3, pages 203-208.
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