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Miscellaneous Article

Interleukin-4 and Cancer Therapy

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Pages 473-486 | Published online: 11 Jun 2009

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Kim Margolin. (2008) Cytokine therapy in cancer. Expert Opinion on Biological Therapy 8:10, pages 1495-1505.
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Bryce D Beseth, Robert B Cameron, Pamela Leland, Liang You, Frederick Varricchio, Robert J Kreitman, Richard A Maki, David M Jablons, Syed R Husain & Raj K Puri. (2004) Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts. The Annals of Thoracic Surgery 78:2, pages 436-443.
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Kleebsabai SrivannaboonArmen B. ShanafeltElisabetta TodiscoCarla P. ForteFrederick G. BehmSusana C. RaimondiChing-Hon PuiDario Campana. (2001) Interleukin-4 variant (BAY 36-1677) selectively induces apoptosis in acute lymphoblastic leukemia cells. Blood 97:3, pages 752-758.
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P. Leland, J. Taguchi, S. R. Husain, R. J. Kreitman, I. Pastan & R. K. Puri. (2000) Human Breast Carcinoma Cells Express Type II IL-4 Receptors and Are Sensitive to Antitumor Activity of a Chimeric IL-4-Pseudomonas Exotoxin Fusion Protein in vitro and in vivo. Molecular Medicine 6:3, pages 165-178.
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Syed R. Husain, Robert J. Kreitman, Ira Pastan & Raj K. Puri. (1999) Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model. Nature Medicine 5:7, pages 817-822.
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Raj K. Puri. (2016) Toxicologic Pathology of Cytokines, Cytokine Receptors, and Other Recombinant Human Proteins. Toxicologic Pathology 27:1, pages 53-57.
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Atul Maini, G. Hillman, Gabriel P. Haas, Ching Y. Wang, Emily Montecillo, Fasahat Hamzavi, Edson J. Pontes, Pamela Leland, Ira Pastan, Waldemar Debinski & Raj K. Puri. (1997) Interleukin-13 Receptors on Human Prostate Carcinoma Cell Lines Represent a Novel Target for a Chimeric Protein Composed of IL-13 and a Mutated Form of Pseudomonas Exotoxin. The Journal of Urology 158:3, pages 948-953.
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Nicholas I. Obiri, Takashi Murata, Waldemar Debinski & Raj K. Puri. (1997) Modulation of Interleukin (IL)-13 Binding and Signaling by the γc Chain of the IL-2 Receptor. Journal of Biological Chemistry 272:32, pages 20251-20258.
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Syed R. Husain, Parkash Gill, Robert J. Kreitman, Ira Pastan & Raj K. Puri. (1997) Interleukin-4 Receptor Expression on AIDS-Associated Kaposi’s Sarcoma Cells and Their Targeting by a Chimeric Protein Comprised of Circularly Permuted Interleukin-4 and Pseudomonas Exotoxin. Molecular Medicine 3:5, pages 327-338.
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A. Tulpule, B. Joshi, N. DeGuzman, B.M. Espina, R. Mocharnuk, O. Prakash, D. Templeton, A.M. Levine & P.S. Gill. (1997) Interleukin-4 in the treatment of AIDS-related Kaposi’s sarcoma. Annals of Oncology 8:1, pages 79-83.
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Waldemar Debinski, Robyn Miner, Pamela Leland, Nicholas I. Obiri & Raj K. Puri. (1996) Receptor for Interleukin (IL) 13 Does Not Interact with IL4 but Receptor for IL4 Interacts with IL13 on Human Glioma Cells. Journal of Biological Chemistry 271:37, pages 22428-22433.
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Yuh-Min Chen, Wen-Kuang Yang, Jacqueline Whang-Peng, Benjamin Ing-Tiau Kuo & Reury-Perng Perng. (1996) Elevation of Interleukin-10 Levels in Malignant Pleural Effusion. Chest 110:2, pages 433-436.
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James W. Verbsky, Erika A. Bach, Yi-Fu Fang, Liping Yang, David A. Randolph & Larry E. Fields. (1996) Expression of Janus Kinase 3 in Human Endothelial and Other Non-lymphoid and Non-myeloid Cells. Journal of Biological Chemistry 271:24, pages 13976-13980.
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Morihiko Nakamura, Ricardo M. Xavier & Yoshinori Tanigawa. (2005) Monoclonal nonspecific suppressor factor β inhibits interleukin‐4 secretion by a type‐2 helper T cell clone. European Journal of Immunology 25:8, pages 2417-2419.
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Nicholas I. Obiri, Nandita Tandon & Raj K. Puri. (2006) Up‐regulation of intercellular adhesion molecule 1 (ICAM‐1) on human renal cell carcinoma cells by interleukin‐4. International Journal of Cancer 61:5, pages 635-642.
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Elia Younes, Gabriel P. Haas, Daniel Visscher, J. Edson Pontes, Raj K. Puri & Gilda G. Hillman. (1995) Intralesional Treatment of Established Murine Primary Renal Tumor With Interleukin-4: Localized Effect on Primary Tumor With no Impact on Metastases. The Journal of Urology 153:2, pages 490-493.
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Gilda G. Hillman, Elia Younes, Daniel Visscher, Esa Ali, John S. Lam, Emily Montecillo, J.Edson Pontes, Gabriel P. Haas & Raj K. Puri. (1995) Systemic treatment with interleukin-4 induces regression of pulmonary metastases in a murine renal cell carcinoma model. Cellular Immunology 160:2, pages 257-263.
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Raj K. Puri. 1996. Cytokines: Interleukins and Their Receptors. Cytokines: Interleukins and Their Receptors 143 185 .
Waldemar Debinski, Raj K. Puri & Ira Pastan. (1994) Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimericPseudomonas exotoxin. International Journal of Cancer 58:5, pages 744-748.
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Raj K. Puri, Pamela Leland, Robert J. Kreitman & Ira Pastan. (2006) Human neurological cancer cells express interleukin‐4 (IL‐4) receptors which are targets for the toxic effects of IL4‐ pseudomonas exotoxin chimeric protein . International Journal of Cancer 58:4, pages 574-581.
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Warren J. Leonard, Masayuki Noguchi, Sarah M. Russell & O. Wesley McBride. (2006) The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc. Immunological Reviews 138:1, pages 61-86.
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