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Original Article

Treatment of Advanced Malignancies with High-Dose Acetaminophen and N-Acetylcysteine Rescue

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Pages 202-210 | Published online: 11 Jun 2009

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Elizabeth M. Crow, Meghan B. Spyres, Sean P. Boley, Michael Levine & Samuel J. Stellpflug. (2021) Delayed peaks of acetaminophen in overdose patients with concomitant abdominal trauma. Clinical Toxicology 59:1, pages 65-68.
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Wendy Klein-Schwartz & Suzanne Doyon. (2011) Intravenous acetylcysteine for the treatment of acetaminophen overdose. Expert Opinion on Pharmacotherapy 12:1, pages 119-130.
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Patrick J Amar & Eugene R Schiff. (2007) Acetaminophen safety and hepatotoxicity – where do we go from here?. Expert Opinion on Drug Safety 6:4, pages 341-355.
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Ahmed Badawy, Omnia State & Soma Abdelgawad. (2007) N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstetricia et Gynecologica Scandinavica 86:2, pages 218-222.
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Marco L. A Sivilotti, Angela M. Good, Mark C. Yarema, David N. Juurlink & David W. Johnson. (2005) A New Predictor of Toxicity Following Acetaminophen Overdose Based on Pretreatment Exposure. Clinical Toxicology 43:4, pages 229-234.
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Robert O. Wright, Robert Wright, Angela C. Anderson, Samuel L. Lesko, Alan D. Woolf, James G. Linakis & William J. Lewander. (1999) Effect of Metoclopramide Dose on Preventing Emesis After Oral Administration of N-Acetylcysteine for Acetaminophen Overdose. Journal of Toxicology: Clinical Toxicology 37:1, pages 35-42.
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Articles from other publishers (20)

Pavani Pingali, Y. Jeffrey Wu, Rio Boothello, Chetna Sharon, Howard Li, Srinivas Sistla, Nehru Viji Sankaranarayanan, Umesh R. Desai, Anh T. Le, Robert C. Doebele, Leslie L. Muldoon, Bhaumik B. Patel & Alexander Neuwelt. (2021) High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity. Neoplasia 23:3, pages 348-359.
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Hannah J. Gleneadie, Amy H. Baker, Nikolaos Batis, Jennifer Bryant, Yao Jiang, Samuel J.H. Clokie, Hisham Mehanna, Paloma Garcia, Deena M.A. Gendoo, Sally Roberts, Megan Burley, Alfredo A. Molinolo, J. Silvio Gutkind, Ben A. Scheven, Paul R. Cooper, Joanna L. Parish, Farhat L. Khanim & Malgorzata Wiench. (2021) The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress. Cancer Letters 501, pages 172-186.
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Richard Eugene Frye. 2019. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine. The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine 301 330 .
Thomas M. Caparrotta, Daniel J. Antoine & James W. Dear. (2017) Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature. European Journal of Clinical Pharmacology 74:2, pages 147-160.
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Salah Mohamed El Sayed, Hussam Baghdadi, Mohammed Zolaly, Hamdi H. Almaramhy, Mongi Ayat & Jagadish G. Donki. (2017) The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: An evidence-based view. Medical Hypotheses 100, pages 67-77.
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Angela L. Chiew, Geoffrey K. Isbister, Stephen B. Duffull & Nicholas A. Buckley. (2016) Evidence for the changing regimens of acetylcysteine. British Journal of Clinical Pharmacology 81:3, pages 471-481.
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Laurie K. Mischley, James B. Leverenz, Richard C. Lau, Nayak L. Polissar, Moni B. Neradilek, Ali Samii & Leanna J. Standish. (2015) A randomized, double-blind phase I/IIa study of intranasal glutathione in Parkinson's disease. Movement Disorders 30:12, pages 1696-1701.
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Robert G. Hendrickson, Nathanael J. McKeown, Patrick L. West & Christopher R. Burke. (2010) Bactrian (“Double Hump”) Acetaminophen Pharmacokinetics: A Case Series and Review of the Literature. Journal of Medical Toxicology 6:3, pages 337-344.
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Alexander J. Neuwelt, Y. Jeffrey Wu, Narcyz Knap, Marcin Losin, Edward A. Neuwelt, Michael A. Pagel, Steven Warmann, Joerg Fuchs, Piotr Czauderna & Michal Wozniak. (2009) Using Acetaminophen's Toxicity Mechanism to Enhance Cisplatin Efficacy in Hepatocarcinoma and Hepatoblastoma Cell Lines. Neoplasia 11:10, pages 1003-1011.
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Mark C. Yarema, David W. Johnson, Randall J. Berlin, Marco L.A. Sivilotti, Alberto Nettel-Aguirre, Rollin F. Brant, Daniel A. Spyker, Benoit Bailey, Dominic Chalut, Jacques S. Lee, Amy C. Plint, Roy A. Purssell, Tim Rutledge, Catherine A. Seviour, Ian G. Stiell, Margaret Thompson, Jeffrey Tyberg, Richard C. Dart & Barry H. Rumack. (2009) Comparison of the 20-Hour Intravenous and 72-Hour Oral Acetylcysteine Protocols for the Treatment of Acute Acetaminophen Poisoning. Annals of Emergency Medicine 54:4, pages 606-614.
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Halil Ciftci, Ayhan Verit, Murat Savas, Ercan Yeni & Ozcan Erel. (2009) Effects of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status. Urology 74:1, pages 73-76.
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Suzanne Doyon & Wendy Klein-Schwartz. (2009) Hepatotoxicity Despite Early Administration of Intravenous N -Acetylcysteine for Acute Acetaminophen Overdose . Academic Emergency Medicine 16:1, pages 34-39.
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Silas W Smith, Mary Ann Howland, Robert S Hoffman & Lewis S Nelson. (2008) Acetaminophen Overdose with Altered Acetaminophen Pharmacokinetics and Hepatotoxicity Associated with Premature Cessation of Intravenous N-Acetylcysteine Therapy. Annals of Pharmacotherapy 42:9, pages 1333-1339.
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Jiqin Liu, Yasuhiro Yoshida & Uki Yamashita. (2008) DNA-binding activity of NF-κB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase. Molecular Immunology 45:15, pages 3984-3989.
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Irena Manov, Yulia Bashenko, Anat Eliaz-Wolkowicz, Meital Mizrahi, Oded Liran & Theodore C. Iancu. (2007) High-Dose Acetaminophen Inhibits the Lethal Effect of Doxorubicin in HepG2 Cells: The Role of P-glycoprotein and Mitogen-Activated Protein Kinase p44/42 Pathway. Journal of Pharmacology and Experimental Therapeutics 322:3, pages 1013-1022.
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Irena Manov, Yulia Bashenko, Mark Hirsh & Theodore C. Iancu. (2006) Involvement of the Multidrug Resistance P-Glycoprotein in Acetaminophen-Induced Toxicity in Hepatoma-Derived HepG2 and Hep3B Cells. Basic & Clinical Pharmacology & Toxicology 99:3, pages 213-224.
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Ahmed Badawy, Abu Baker El Nashar & Mohamed El Totongy. (2006) Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial. Fertility and Sterility 86:3, pages 647-650.
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Nathan L. Kobrinsky, Diane E. Sjolander, Jacob A. Goldenberg & Thomas C. Ortmeier. (2005) Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N -acetylcysteine rescue . Pediatric Blood & Cancer 45:2, pages 222-225.
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Jedd D Wolchok, Linda Williams, John T Pinto, Martin Fleisher, Susan E Krown, Wen-Jen Hwu, Philip O Livingston, Christine Chang & Paul B Chapman. (2003) Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma. Melanoma Research 13:2, pages 189-196.
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A.G. Valdivia, A. Martínez, F.J. Damián, T. Quezada, R. Ortíz, C. Martínez, J. Llamas, M.L. Rodríguez, L. Yamamoto, F. Jaramillo, M.G. Loarca-Piña & J.L. Reyes. (2001) Efficacy of N-Acetylcysteine to Reduce the Effects of Aflatoxin B1 Intoxication in Broiler Chickens. Poultry Science 80:6, pages 727-734.
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