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Original Article

Expression of the HGF/SF Receptor, c-met, and Its Ligand in Human Colorectal Cancers

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Pages 513-521 | Published online: 11 Jun 2009

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Elizabeth C Smyth, Francesco Sclafani & David Cunningham. (2014) Emerging molecular targets in oncology: clinical potential of MET/hepatocyte growth-factor inhibitors. OncoTargets and Therapy 7, pages 1001-1014.
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Articles from other publishers (34)

Ivonne Olmedo, Daniela Martínez, Javiera Carrasco-Rojas & José A. Jara. (2023) Mitochondria in oral cancer stem cells: Unraveling the potential drug targets for new and old drugs. Life Sciences 331, pages 122065.
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Jian‐feng Yao, Xiao‐jun Li, Li‐kun Yan, Sai He, Jian‐bao Zheng, Xiao‐rong Wang, Pei‐hua Zhou, Li Zhang, Guang‐bing Wei & Xue‐jun Sun. (2019) Role of HGF/c‐Met in the treatment of colorectal cancer with liver metastasis. Journal of Biochemical and Molecular Toxicology 33:6.
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Sadaf Ghanaatgar-Kasbi, Shadi Khorrami, Amir Avan, Seyed A. Aledavoud & Gordon A. Ferns. (2019) Targeting the C-MET/HGF Signaling Pathway in Pancreatic Ductal Adenocarcinoma. Current Pharmaceutical Design 24:39, pages 4619-4625.
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Toshimitsu Yamaoka, Sojiro Kusumoto, Koichi Ando, Motoi Ohba & Tohru Ohmori. (2018) Receptor Tyrosine Kinase-Targeted Cancer Therapy. International Journal of Molecular Sciences 19:11, pages 3491.
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Michael A. Schumacher, Soula Danopoulos, Denise Al Alam & Mark R. Frey. 2018. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 71 101 .
Yinghui Zhou, William M. Rideout, Angela Bressel, Sireesha Yalavarthi, Tong Zi, Darren Potz, Samuel Farlow, Joelle Brodeur, Anthony Monti, Shailaja Reddipalli, Qiurong Xiao, Steve Bottega, Bin Feng, M. Isabel Chiu, Marcus Bosenberg & Joerg Heyer. (2014) Spontaneous Genomic Alterations in a Chimeric Model of Colorectal Cancer Enable Metastasis and Guide Effective Combinatorial Therapy. PLoS ONE 9:8, pages e105886.
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Abdel-Majid Khatib. (2013) Proprotein Convertases: Discovery, Characteristics, and Link to Tumor Progression and Metastasis. Colloquium Series on Protein Activation and Cancer 2:1, pages 1-86.
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Shawna Leslie Organ, J Rafael Sierra & Ming-Sound Tsao. (2012) Therapeutic potential of c-MET inhibitors: background and clinical data. Clinical Investigation 2:3, pages 301-315.
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Yao Liu, Qiaoyan Li & Liwei Zhu. (2018) Expression of the Hepatocyte Growth Factor and C-Met in Colon Cancer: Correlation with Clinicopathological Features and Overall Survival. Tumori Journal 98:1, pages 105-112.
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John F. Kuemmerle, John A. Barnard & Kirk M. McHugh. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 199 277 .
Shawna Leslie Organ & Ming-Sound Tsao. (2011) An overview of the c-MET signaling pathway. Therapeutic Advances in Medical Oncology 3:1_suppl, pages S7-S19.
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Shawna L. Organ, Jiefei Tong, Paul Taylor, Jonathan R. St-Germain, Roya Navab, Michael F. Moran & Ming-Sound Tsao. (2011) Quantitative Phospho-Proteomic Profiling of Hepatocyte Growth Factor (HGF)-MET Signaling in Colorectal Cancer. Journal of Proteome Research 10:7, pages 3200-3211.
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Jimmy Bernier, Walid Chababi, Véronique Pomerleau & Caroline Saucier. (2010) Oncogenic engagement of the Met receptor is sufficient to evoke angiogenic, tumorigenic, and metastatic activities in rat intestinal epithelial cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 299:3, pages G677-G686.
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Caroline Saucier & Nathalie Rivard. 2010. Metastasis of Colorectal Cancer. Metastasis of Colorectal Cancer 205 241 .
Michael J. Gray & Gary E. Gallick. 2010. Mechanisms of Oncogenesis. Mechanisms of Oncogenesis 19 41 .
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Udai S. Kammula, Eleanor J. Kuntz, Todd D. Francone, Zhaoshi Zeng, Jinru Shia, Ron G. Landmann, Philip B. Paty & Martin R. Weiser. (2007) Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Letters 248:2, pages 219-228.
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Amellia M. Laidlaw, Ben Copeland, Christopher M. Ross & Jennifer E. Hardingham. (2006) Extent of over-expression of hepatocyte growth factor receptor in colorectal tumours is dependent on the choice of normaliser. Biochemical and Biophysical Research Communications 341:4, pages 1017-1021.
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Addolorata Maria Luce Coluccia, Daniela Benati, Hafedh Dekhil, Annamaria De Filippo, Cathy Lan & Carlo Gambacorti-Passerini. (2006) SKI-606 Decreases Growth and Motility of Colorectal Cancer Cells by Preventing pp60(c-Src)–Dependent Tyrosine Phosphorylation of β-Catenin and Its Nuclear Signaling. Cancer Research 66:4, pages 2279-2286.
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John A. Barnard & Kirk M. McHugh. 2006. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 183 246 .
Geraldine Siegfried, Michel Chrètien & Abdel-Majid Khatib. 2006. Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs). Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (PCs) 67 88 .
Jinhua Wen, Kunio Matsumoto, Naoko Taniura, Daisaku Tomioka & Toshikazu Nakamura. (2004) Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene Therapy 11:6, pages 419-430.
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Takeshi Kubota, Hitoshi Fujiwara, Hisashi Amaike, Kazuhiro Takashima, Satoshi Inada, Kiyoto Atsuji, Mamoru Yoshimura, Kunio Matsumoto, Toshikazu Nakamura & Hisakazu Yamagishi. (2005) Reduced HGF expression in subcutaneous CT26 tumor genetically modified to secrete NK4 and its possible relation with antitumor effects. Cancer Science 95:4, pages 321-327.
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Kunio Matsumoto & Toshikazu Nakamura. 2004. Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention. Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention 143 193 .
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AM Jubb, TH Landon, J Burwick, TQ Pham, GD Frantz, B Cairns, P Quirke, FV Peale & KJ Hillan. (2003) Quantitative analysis of colorectal tissue microarrays by immunofluorescence and in situ hybridization . The Journal of Pathology 200:5, pages 577-588.
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Syed A Ahmad, Russell S Berman & Lee M Ellis. (2003) Biology of colorectal liver metastases. Surgical Oncology Clinics of North America 12:1, pages 135-150.
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Abdel-Majid Khatib, Géraldine Siegfried, Michel Chrétien, Peter Metrakos & Nabil G. Seidah. (2002) Proprotein Convertases in Tumor Progression and Malignancy. The American Journal of Pathology 160:6, pages 1921-1935.
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Geert van Leenders, Bianca van Balken, Tilly Aalders, Christina Hulsbergen‐van de Kaa, Dirk Ruiter & Jack Schalken. (2002) Intermediate cells in normal and malignant prostate epithelium express c‐MET: Implications for prostate cancer invasion. The Prostate 51:2, pages 98-107.
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Newton Alexander Chiang Shuek Wong & Massimo Pignatelli. (2002) β-Catenin—A Linchpin in Colorectal Carcinogenesis?. The American Journal of Pathology 160:2, pages 389-401.
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Rong Wang, Linda D. Ferrell, Saadia Faouzi, Jacquelyn J. Maher & J. Michael Bishop. (2001) Activation of the Met Receptor by Cell Attachment Induces and Sustains Hepatocellular Carcinomas in Transgenic Mice. The Journal of Cell Biology 153:5, pages 1023-1034.
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Russell S. Berman, Charles A. PorteraJr.Jr. & Lee M. Ellis. 2001. Liver-Directed Therapy for Primary and Metastatic Liver Tumors. Liver-Directed Therapy for Primary and Metastatic Liver Tumors 183 206 .
Guan-Hua Lai, Svetlana Radaeva, Toshikazu Nakamura & Alphonse E. Sirica. (2000) Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated “intestinal-type” biliary cancer chemically induced in rat liver. Hepatology 31:6, pages 1257-1265.
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Charles A PorteraJr.Jr., Russell S Berman & Lee M Ellis. (1998) Molecular determinants of colon cancer metastasis. Surgical Oncology 7:3-4, pages 183-195.
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