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Lajos Haracska, Satya Prakash & Louise Prakash. (2000) Replication past O6-Methylguanine by Yeast and Human DNA Polymerase η. Molecular and Cellular Biology 20:21, pages 8001-8007.
Read now
Read now
Nathalie Berthet, Didier Boturyn & Jean-François Constant. (1999) DNA repair inhibitors. Expert Opinion on Therapeutic Patents 9:4, pages 401-415.
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Articles from other publishers (49)
Xiao-Yu Wu, Jing Zhai, Xiang- Kun Huan, Wen-Wen Xu, Jun Tian & Bagher Farhood. (2023) A Systematic Review of the Therapeutic Potential of Resveratrol During
Colorectal Cancer Chemotherapy. Mini-Reviews in Medicinal Chemistry 23:10, pages 1137-1152.
Crossref
Crossref
Zahid H. Siddik. 2017. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine
1
8
.
Larissa Costa de Almeida, Felipe Antunes Calil, João Agostinho Machado-Neto & Leticia Veras Costa-Lotufo. (2021) DNA damaging agents and DNA repair: From carcinogenesis to cancer therapy. Cancer Genetics 252-253, pages 6-24.
Crossref
Crossref
Philip G. Penketh, Hugh S Williamson, Raymond P. Baumann & Krishnamurthy Shyam. (2021) Design Strategy for the EPR Tumor-Targeting of 1,2-Bis(sulfonyl)-1-alkylhydrazines. Molecules 26:2, pages 259.
Crossref
Crossref
Rafał Krętowski, Danuta Drozdowska, Beata Kolesińska, Zbigniew Kamiński, Justyna Frączyk & Marzanna Cechowska-Pasko. (2019) The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines. Investigational New Drugs 37:5, pages 984-993.
Crossref
Crossref
Saba Hadidi, Farshad Shiri & Mohammadsaleh Norouzibazaz. (2019) A DFT study of the degradation mechanism of anticancer drug carmustine in an aqueous medium. Structural Chemistry 30:4, pages 1315-1321.
Crossref
Crossref
Farshad Shiri, Mohammadsaleh Norouzibazaz, Ako Yari & Avat Taherpour. (2018) A DFT study of both the hydrolytic degradation and protonation of semustine in variation conditions of pH and interaction of drug with DNA nucleobases. Structural Chemistry 29:5, pages 1465-1474.
Crossref
Crossref
Dorthe Aasland, Thomas R. Reich, Maja T. Tomicic, Olivier J. Switzeny, Bernd Kaina & Markus Christmann. (2018)
Repair gene O
6
-methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation
. Journal of Neurochemistry 144:2, pages 139-151.
Crossref
Crossref
Philip G. Penketh, Richard A. Finch, Rachel Sauro, Raymond P. Baumann, Elena S. Ratner & Krishnamurthy Shyam. (2018) pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs. Chemical Biology & Drug Design 91:1, pages 62-74.
Crossref
Crossref
Talita D. Melo-Hanchuk, Priscila Ferreira Slepicka, Gabriela Vaz Meirelles, Fernanda Luisa Basei, Diogo Ventura Lovato, Daniela Campos Granato, Bianca Alves Pauletti, Romenia Ramos Domingues, Adriana Franco Paes Leme, Alessandra Luiza Pelegrini, Guido Lenz, Stefan Knapp, Jonathan M. Elkins & Jörg Kobarg. (2017) NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. Scientific Reports 7:1.
Crossref
Crossref
Laura Annovazzi, Marta Mellai & Davide Schiffer. (2017) Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma. Cancers 9:6, pages 57.
Crossref
Crossref
Zahid H. Siddik. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine
1
20
.
Philip G. Penketh, Krishnamurthy Shyam, Raymond P. Baumann, Rui Zhu, Kimiko Ishiguro, Alan C. Sartorelli & Elena S. Ratner. (2016) When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments. Analytical Biochemistry 508, pages 34-37.
Crossref
Crossref
Maja T. Tomicic, Ruth Meise, Dorthe Aasland, Nancy Berte, Rebekka Kitzinger, Oliver H. Krämer, Bernd Kaina & Markus Christmann. (2015) Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget 6:32, pages 33755-33768.
Crossref
Crossref
Krishnamurthy Shyam, Philip G. Penketh, Raymond P. Baumann, Rick A. Finch, Rui Zhu, Yong-Lian Zhu & Alan C. Sartorelli. (2015) Antitumor Sulfonylhydrazines: Design, Structure–Activity Relationships, Resistance Mechanisms, and Strategies for Improving Therapeutic Utility. Journal of Medicinal Chemistry 58:9, pages 3639-3671.
Crossref
Crossref
Maja T. Tomicic, Dorthe Aasland, Steffen C. Naumann, Ruth Meise, Christina Barckhausen, Bernd Kaina & Markus Christmann. (2014) Translesion Polymerase η Is Upregulated by Cancer Therapeutics and Confers Anticancer Drug Resistance. Cancer Research 74:19, pages 5585-5596.
Crossref
Crossref
Philip G. Penketh, Eric Patridge, Krishnamurthy Shyam, Raymond P. Baumann, Rui Zhu, Kimiko Ishiguro & Alan C. Sartorelli. (2014)
Influence of Glutathione and Glutathione
S
-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine
. Chemical Research in Toxicology 27:8, pages 1440-1449.
Crossref
Crossref
Philip G. Penketh, Krishnamurthy Shyam, Rui Zhu, Raymond P. Baumann, Kimiko Ishiguro & Alan C. Sartorelli. (2014) Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and KS119W. Chemical Research in Toxicology 27:5, pages 818-833.
Crossref
Crossref
Rui Zhu, Raymond P. Baumann, Eric Patridge, Philip G. Penketh, Krishnamurthy Shyam, Kimiko Ishiguro & Alan C. Sartorelli. (2013) Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells. Bioorganic & Medicinal Chemistry Letters 23:6, pages 1853-1859.
Crossref
Crossref
John R. Silber, Michael S. Bobola, A. Blank & Marc C. Chamberlain. (2012) O6-Methylguanine-DNA methyltransferase in glioma therapy: Promise and problems. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826:1, pages 71-82.
Crossref
Crossref
Anthony E. Pegg. (2011) Multifaceted Roles of Alkyltransferase and Related Proteins in DNA Repair, DNA Damage, Resistance to Chemotherapy, and Research Tools. Chemical Research in Toxicology 24:5, pages 618-639.
Crossref
Crossref
Laurent Gate & Kenneth D. Tew. 2011. Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures
61
85
.
Kimiko Ishiguro, Yong-Lian Zhu, Krishnamurthy Shyam, Philip G. Penketh, Raymond P. Baumann & Alan C. Sartorelli. (2010) Quantitative relationship between guanine O6-alkyl lesions produced by Onrigin™ and tumor resistance by O6-alkylguanine-DNA alkyltransferase. Biochemical Pharmacology 80:9, pages 1317-1325.
Crossref
Crossref
Angelo Guainazzi & Orlando D. Schärer. (2010) Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy. Cellular and Molecular Life Sciences 67:21, pages 3683-3697.
Crossref
Crossref
Kimiko Ishiguro, Krishnamurthy Shyam, Philip G. Penketh & Alan C. Sartorelli. (2008) Development of an O6-alkylguanine–DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O6-benzylguanine to the protein. Analytical Biochemistry 383:1, pages 44-51.
Crossref
Crossref
Qingming FangAnne M. NoronhaSebastian P. MurphyChristopher J. WildsJulie L. TubbsJohn A. TainerGoutam ChowdhuryF. Peter GuengerichAnthony E. Pegg. (2008)
Repair of
O
6
-G-Alkyl-
O
6
-G Interstrand Cross-Links by Human
O
6
-Alkylguanine-DNA Alkyltransferase
. Biochemistry 47:41, pages 10892-10903.
Crossref
Crossref
Philip G. Penketh, Raymond P. Baumann, Kimiko Ishiguro, Krishnamurthy Shyam, Helen A. Seow & Alan C. Sartorelli. (2008) Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species. Leukemia Research 32:10, pages 1546-1553.
Crossref
Crossref
Luís F.Z. Batista, Wynand P. Roos, Markus Christmann, Carlos F.M. Menck & Bernd Kaina. (2007)
Differential Sensitivity of Malignant Glioma Cells to Methylating and Chloroethylating Anticancer Drugs: p53 Determines the Switch by Regulating
xpc, ddb2
, and DNA Double-Strand Breaks
. Cancer Research 67:24, pages 11886-11895.
Crossref
Crossref
LIJIAO ZHAO, RUGANG ZHONG & YAN ZHEN. (2011) AN ONIOM STUDY ON THE CROSSLINKED BASE PAIRS IN DNA REACTED WITH CHLOROETHYLNITROSOUREAS. Journal of Theoretical and Computational Chemistry 06:03, pages 631-639.
Crossref
Crossref
Julie L. Tubbs, Anthony E. Pegg & John A. Tainer. (2007) DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair 6:8, pages 1100-1115.
Crossref
Crossref
Li-Jiao Zhao, Ru-Gang Zhong & Yan Zhen. (2007) ONIOM Study on the DNA Interstrand Crosslinks by the Chloroethylnitrosoureas. ONIOM Study on the DNA Interstrand Crosslinks by the Chloroethylnitrosoureas.
Jawad Alzeer & Orlando D. Schärer. (2006) A modified thymine for the synthesis of site-specific thymine-guanine DNA interstrand crosslinks. Nucleic Acids Research 34:16, pages 4458-4466.
Crossref
Crossref
Achour Seridi, Jean‐Yves Winum, Mekki Kadri, Mohamed Abdaoui & Jean‐Louis Montero. (2006) Study on the Decomposition of 2‐Chloroethylnitro‐ sosulfamides (CENS) in Serum Using HPLC On‐line Solid Phase Extraction. Archiv der Pharmazie 339:9, pages 521-526.
Crossref
Crossref
Kimiko Ishiguro, Krishnamurthy Shyam, Philip G. Penketh & Alan C. Sartorelli. (2005)
Role of
O
6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine
. Molecular Cancer Therapeutics 4:11, pages 1755-1763.
Crossref
Crossref
Michael S. Bobola, John R. Silber, Richard G. Ellenbogen, J. Russell Geyer, A. Blank & Ryan D. Goff. (2005) O6-Methylguanine-DNA Methyltransferase, O6-Benzylguanine, and Resistance to Clinical Alkylators in Pediatric Primary Brain Tumor Cell Lines. Clinical Cancer Research 11:7, pages 2747-2755.
Crossref
Crossref
Zahid H. Siddik. 2005. The Cancer Handbook. The Cancer Handbook.
Orlando D. Schärer. (2005) DNA Interstrand Crosslinks: Natural and Drug‐Induced DNA Adducts that Induce Unique Cellular Responses. ChemBioChem 6:1, pages 27-32.
Crossref
Crossref
Michael S. Bobola, Mary J. Emond, A. Blank, Elizabeth H. Meade, Douglas D. Kolstoe, Mitchel S. Berger, Robert C. Rostomily, Daniel L. Silbergeld, Alexander M. Spence & John R. Silber. (2004) Apurinic Endonuclease Activity in Adult Gliomas and Time to Tumor Progression after Alkylating Agent-Based Chemotherapy and after Radiotherapy. Clinical Cancer Research 10:23, pages 7875-7883.
Crossref
Crossref
Anton B. Guliaev, B. Singer & Bo Hang. (2004) Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts. DNA Repair 3:10, pages 1311-1321.
Crossref
Crossref
Timothy M. Kuzel. (2003) Systemic chemotherapy for the treatment of mycosis fungoides and Sezary syndrome. Dermatologic Therapy 16:4, pages 355-361.
Crossref
Crossref
Timothy M Kuzel, Richard Junghans & Francine M Foss. (2003) Novel agents for cutaneous T-cell lymphoma. Hematology/Oncology Clinics of North America 17:6, pages 1459-1466.
Crossref
Crossref
Orlando D. Schärer. (2003) Chemie und Biologie der DNA‐Reparatur. Angewandte Chemie 115:26, pages 3052-3082.
Crossref
Crossref
E. Debiton, A.-L. Glasser, C. Marchenay, C. Rolhion, J.-C. Maurizis & J.-C. Madelmont. (2002) Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N 2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells. Melanoma Research 12:5, pages 417-427.
Crossref
Crossref
M. Eileen Dolan. 2002. Encyclopedia of Cancer. Encyclopedia of Cancer
99
106
.
G.Robbin Westerhof, Julian D Down, Irene Blokland, Michelle Wood, Adrie Boudewijn, Amanda J Watson, Alan T McGown, Rob E Ploemacher & Geoffrey P Margison. (2001) O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells. Experimental Hematology 29:5, pages 633-638.
Crossref
Crossref
Philip G Penketh, Krishnamurthy Shyam & Alan C Sartorelli. (2000) Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas. Biochemical Pharmacology 59:3, pages 283-291.
Crossref
Crossref
Thomas M. Rünger, Steffen Emmert, Dirk Schadendorf, Caroline Diem, Bernd Epe & Doris Hellfritsch. (2000) Alterations of DNA Repair in Melanoma Cell Lines Resistant to Cisplatin, Fotemustine, or Etoposide. Journal of Investigative Dermatology 114:1, pages 34-39.
Crossref
Crossref
Mark J. Hickman & Leona D. Samson. (1999) Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proceedings of the National Academy of Sciences 96:19, pages 10764-10769.
Crossref
Crossref
Sheng Hong Tseng, Michael S. Bobola, Mitchel S. Berger & John R. Silber. (1999) Characterization of paclitaxel (Taxol®) sensitivity in human glioma-
and medulloblastoma-derived cell lines. Neuro-Oncology 1:2, pages 101-108.
Crossref
Crossref