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Original Article

Recent Advances in Understanding the Molecular Mechanisms of Tamoxifen Action

Pages 391-396 | Published online: 11 Jun 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Monica Arnedos & Ian Smith. (2007) Progression of endocrine therapies for breast cancer: where are we headed?. Expert Review of Anticancer Therapy 7:11, pages 1651-1664.
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Sharon L Mount & Gamal H Eltabbakh. (2001) Tamoxifen and the female reproductive tract. Expert Opinion on Pharmacotherapy 2:9, pages 1399-1413.
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Articles from other publishers (28)

Effat Davoudi-Monfared. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 923 927 .
Sol Lee, Miyoung Nam, Ah-Reum Lee, Seung-Tae Baek, Min Jung Kim, Ju Seong Kim, Andrew Hyunsoo Kong, Minho Lee, Sook-Jeong Lee, Seon-Young Kim, Dong-Uk Kim & Kwang-Lae Hoe. (2021) Knockdown of vps54 aggravates tamoxifen-induced cytotoxicity in fission yeast. Genomics & Informatics 19:4, pages e39.
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Maya A. Farha & Eric D. Brown. (2019) Drug repurposing for antimicrobial discovery. Nature Microbiology 4:4, pages 565-577.
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Shagufta & Irshad Ahmad. (2018) Tamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives. European Journal of Medicinal Chemistry 143, pages 515-531.
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Brian J. Girard, Tarah M. Regan Anderson, Siya Lem Welch, Julie Nicely, Victoria L. Seewaldt & Julie H. Ostrander. (2015) Cytoplasmic PELP1 and ERRgamma Protect Human Mammary Epithelial Cells from Tam-Induced Cell Death. PLOS ONE 10:3, pages e0121206.
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María Celeste Nicolao, María Celina Elissondo, Guillermo M. Denegri, Alejandra B. Goya & Andrea C. Cumino. (2014) In Vitro and In Vivo Effects of Tamoxifen against Larval Stage Echinococcus granulosus . Antimicrobial Agents and Chemotherapy 58:9, pages 5146-5154.
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Piotr Kowalczyk, Magdalena C. Kowalczyk, Jacob J. Junco, Olga Tolstykh, Tatsuya Kinjo, Ha Truong, Zbigniew Walaszek, Margaret Hanausek & Thomas J. Slaga. (2012) The possible separation of 12‐ O ‐tetradecanoylphorbol‐13‐acetate‐induced skin inflammation and hyperplasia by compound A . Molecular Carcinogenesis 52:6, pages 488-496.
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Eric M. Scholar. 2010. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 8 .
Kristy Dolan, Sara Montgomery, Bradley Buchheit, Louis DiDone, Melanie Wellington & Damian J. Krysan. (2009) Antifungal Activity of Tamoxifen: In Vitro and In Vivo Activities and Mechanistic Characterization. Antimicrobial Agents and Chemotherapy 53:8, pages 3337-3346.
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Joseph C. BakerJr.Jr., Julie H. Ostrander, Siya Lem, Gloria Broadwater, Gregory R. Bean, Nicholas C. D'Amato, Vanessa K. Goldenberg, Craig Rowell, Catherine Ibarra-Drendall, Tracey Grant, Patrick G. Pilie, Shauna N. Vasilatos, Michelle M. Troch, Victoria Scott, Lee G. Wilke, Carolyn Paisie, Sarah M. Rabiner, Alejandro Torres-Hernandez, Carola M. Zalles & Victoria L. Seewaldt. (2008) ESR1 Promoter Hypermethylation Does Not Predict Atypia in RPFNA nor Persistent Atypia after 12 Months Tamoxifen Chemoprevention . Cancer Epidemiology, Biomarkers & Prevention 17:8, pages 1884-1890.
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Kaei NasuNoriyuki TakaiMasakazu NishidaHisashi Narahara. (2017) Tumorigenic Effects of Tamoxifen on the Female Genital Tract. Clinical medicine. Pathology 1, pages CPath.S487.
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Mandana Saadat, Pauline T. Truong, Hosam A. Kader, Caroline H. Speers, Eric Berthelet, Elissa McMurtrie & Ivo A. Olivotto. (2007) Outcomes in patients with primary breast cancer and a subsequent diagnosis of endometrial cancer. Cancer 110:1, pages 31-37.
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S.S. Pendse, S. Behjati, T. Schatton, A. Izawa, M.H. Sayegh & M.H. Frank. (2006) P-Glycoprotein Functions as a Differentiation Switch in Antigen Presenting Cell Maturation. American Journal of Transplantation 6:12, pages 2884-2893.
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Herbert B. Newton. 2006. Handbook of Brain Tumor Chemotherapy. Handbook of Brain Tumor Chemotherapy 21 43 .
Z. Motahari .M. Etebary .E. Azizi .. (2005) Studying the Role of P-glycoprotein in Resistance to Tamoxifen in Humen Breast Cancer T47D Cells by Immunocytochemistry. International Journal of Pharmacology 1:2, pages 112-117.
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Raquel Ferrer-Lorente, Beatriz García-Peláez, José Antonio Fernández-López, Xavier Remesar & Marià Alemany. (2004) Tamoxifen does not prevent the mobilization of body lipids elicited by oleoyl-estrone. Steroids 69:10, pages 661-665.
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Eric C Dietze, Michelle M Troch, Gregory R Bean, Joshua B Heffner, Michelle L Bowie, Paul Rosenberg, Brooke Ratliff & Victoria L Seewaldt. (2004) Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. Oncogene 23:21, pages 3851-3862.
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Elżbieta Senkus-Konefka, Tomasz Konefka & Jacek Jassem. (2004) The effects of tamoxifen on the female genital tract. Cancer Treatment Reviews 30:3, pages 291-301.
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Harold K. Kimelberg, Yiqiang Jin, Carol Charniga & Paul J. Feustel. (2003) Neuroprotective activity of tamoxifen in permanent focal ischemia. Journal of Neurosurgery 99:1, pages 138-142.
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Siamak Salami & Fatemeh Karami-Tehrani. (2003) Biochemical studies of apoptosis induced by tamoxifen in estrogen receptor positive and negative breast cancer cell lines. Clinical Biochemistry 36:4, pages 247-253.
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Matthew E Burow, Christopher B Weldon, Yan Tang, John A McLachlan & Barbara S Beckman. (2001) Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens. The Journal of Steroid Biochemistry and Molecular Biology 78:5, pages 409-418.
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Fatemeh Karami-Tehrani, Siamak Salami & Poneh Mokarram. (2001) Competition of tamoxifen with thyroxine for TBG binding: ligand binding assay and computational data. Clinical Biochemistry 34:8, pages 603-606.
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Steven J. O'Day, Peter D. Boasberg, Tim S. Kristedja, Maureen Martin, He-Jing Wang, Patricia Fournier, Myles Cabot, Michael W. DeGregorio & Guy Gammon. (2001) High-dose tamoxifen added to concurrent biochemotherapy with decrescendo interleukin-2 in patients with metastatic melanoma. Cancer 92:3, pages 609-619.
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Markus H. Frank, Mark D. Denton, Stephen I. Alexander, Samia J. Khoury, Mohamed H. Sayegh & David M. Briscoe. (2001) Specific MDR1 P-Glycoprotein Blockade Inhibits Human Alloimmune T Cell Activation In Vitro. The Journal of Immunology 166:4, pages 2451-2459.
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Eric C. Dietze, L. Elizabeth Caldwell, Svetlana L. Grupin, Mariangela Mancini & Victoria L. Seewaldt. (2001) Tamoxifen but Not 4-Hydroxytamoxifen Initiates Apoptosis in p53(−) Normal Human Mammary Epithelial Cells by Inducing Mitochondrial Depolarization. Journal of Biological Chemistry 276:7, pages 5384-5394.
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R.R. BarakatT.A. GilewskiL. AlmadronesP.E. SaigoE. VenkatramanC. HudisW.J. Hoskins. (2000) Effect of Adjuvant Tamoxifen on the Endometrium in Women With Breast Cancer: A Prospective Study Using Office Endometrial Biopsy. Journal of Clinical Oncology 18:20, pages 3459-3463.
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Ruxandra Mihailescu, Hassan Y. Aboul-Enein & M. D. Efstatide. (2000) Identification of tamoxifen and metabolites in human male urine by GC/MS. Biomedical Chromatography 14:3, pages 180-183.
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Herbert B Newton, Robert C Turowski, Tammie J Stroup & Laura K McCoy. (2016) Clinical Presentation, Diagnosis, and Pharmacotherapy of Patients with Primary Brain Tumors. Annals of Pharmacotherapy 33:7-8, pages 816-832.
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