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Original Article

Prolonged Severe 5-Fluorouracil-Associated Neurotoxicity in a Patient with Dihydropyrimidine Dehydrogenase Deficiency

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Pages 201-205 | Published online: 11 Jun 2009

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Bart F. Werbrouck, Walter J. Pauwels & Jan L. De Bleecker. (2008) A case of 5-fluorouracil-induced peripheral neuropathy. Clinical Toxicology 46:3, pages 264-266.
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Aasems Jacob, Janeesh Sekkath Veedu, Insija Selene, Rishi Raj, Lakshmi Kannan & Reema Patel. (2022) Case report: Uridine triacetate in the management of delayed onset 5-fluorouracil toxicity: A case report and review of literature. Frontiers in Pharmacology 13.
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Muhammad W. Saif. (2019) Capecitabine-induced cerebellar toxicity and TYMS pharmacogenetics. Anti-Cancer Drugs 30:4, pages 431-434.
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Mira Zurayk, Yi-Kong Keung, David Yu & Eddie HL Hu. (2017) Successful use of uridine triacetate (Vistogard) three weeks after capecitabine in a patient with homozygous dihydropyrimidine dehydrogenase mutation: A case report and review of the literature. Journal of Oncology Pharmacy Practice 25:1, pages 234-238.
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Sandeep Kumar, Caroline Aninat, Grégoire Michaux & Fabrice Morel. (2010) Anticancer drug 5-fluorouracil induces reproductive and developmental defects in Caenorhabditis elegans. Reproductive Toxicology 29:4, pages 415-420.
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. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 1407 1419 .
Hanneke W.M. van Laarhoven, Cornelis J.A. Punt, Yvonne J.L. Kamm & Arend Heerschap. (2005) Monitoring fluoropyrimidine metabolism in solid tumors with in vivo 19F magnetic resonance spectroscopy. Critical Reviews in Oncology/Hematology 56:3, pages 321-343.
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N. Mémain, J.-F. Angellier, E. Obadia, E. Angellier, R. Chelha & R. Couprie. (2005) Encéphalopathie aiguë fatale secondaire à un traitement par 5-fluoro-uracile. La Presse Médicale 34:21, pages 1637-1640.
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M. Wasif Saif, Tina E. Wood, Philip J. McGee & Robert B. Diasio. (2004) Peripheral neuropathy associated with capecitabine. Anti-Cancer Drugs 15:8, pages 767-771.
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Mika Endo, Masanori Miwa, Hiroyuki Eda, Masako Ura, Hiromi Tanimura, Tohru Ishikawa, Taeko Miyazaki-Nose, Kazuo Hattori, Nobuo Shimma, Hisafumi Yamada-Okabe & Hideo Ishitsuka. (2003) Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. International Journal of Cancer 106:5, pages 799-805.
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Deborah T. Blumenthal & Richard H. Wheeler. 2003. Cancer Neurology in Clinical Practice. Cancer Neurology in Clinical Practice 405 415 .
Lie Kuo Liem, Lina Hui Lin Choong & Keng Thye Woo. (2002) Porous graphitic carbon shows promise for the rapid screening partial DPD deficiency in lymphocyte dihydropyrimidine dehydrogenase in Chinese, Indian and Malay in Singapore by using semi-automated HPLC-radioassay. Clinical Biochemistry 35:3, pages 181-187.
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Doreen Dobritzsch, Stefano Ricagno, Gunter Schneider, Klaus D. Schnackerz & Ylva Lindqvist. (2002) Crystal Structure of the Productive Ternary Complex of Dihydropyrimidine Dehydrogenase with NADPH and 5-Iodouracil. Journal of Biological Chemistry 277:15, pages 13155-13166.
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Seung Seog Ki, Jin Mo Jeong, Seong Ho Kim, Sook Hyang Jeong, Jin Hyuk Lee, Chul Ju Han, You Cheol Kim, Jhin Oh Lee & Young Joon Hong. (2002) A Case of Neurotoxicity Following 5 - Fluorouracil - based Chemotherapy. The Korean Journal of Internal Medicine 17:1, pages 73-77.
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Sharon J. Gardiner, Evan J. Begg & Bridget A. Robinson. (2012) The Effect of Dihydropyrimidine Dehydrogenase Deficiency on Outcomes with Fluorouracil. Adverse Drug Reactions and Toxicological Reviews 21:1-2, pages 1-16.
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M Wasif Saif, Richard H Wilson, Nancy Harold, Bruce Keith, David S Dougherty & Jean L Grem. (2001) Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil. Anti-Cancer Drugs 12:6, pages 525-531.
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Federico Innocenti, Lalitha Iyer & Mark J. Ratain. (2000) Pharmacogenetics. Clinical Pharmacokinetics 39:5, pages 315-325.
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