741
Views
61
CrossRef citations to date
0
Altmetric
Review Article

Peptidoglycan biosynthesis machinery: A rich source of drug targets

, &
Pages 295-336 | Received 30 Apr 2010, Accepted 16 Sep 2010, Published online: 22 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Srikanth Jupudi, Mohammed Afzal Azam & Ashish Wadhwani. (2019) Synthesis, molecular docking, binding free energy calculation and molecular dynamics simulation studies of benzothiazol-2-ylcarbamodithioates as Staphylococcus aureus MurD inhibitors. Journal of Receptors and Signal Transduction 39:3, pages 283-293.
Read now
Stephen P East & Lynn L Silver. (2013) Multitarget ligands in antibacterial research: progress and opportunities. Expert Opinion on Drug Discovery 8:2, pages 143-156.
Read now

Articles from other publishers (59)

Alessio Nocentini. 2024. Metalloenzymes. Metalloenzymes 83 91 .
Yufang Li, Xiaozhao Tang, Zushun Yang, Jinze He, Ni Ma, Aixiang Huang & Yanan Shi. (2023) BCp12/PLA combination: A novel antibacterial agent targeting Mur family, DNA gyrase and DHFR. International Journal of Food Microbiology 406, pages 110370.
Crossref
Rok Frlan, Martina Hrast & Stanislav Gobec. (2023) Inhibition of MurA Enzyme from Escherichia coli by Flavonoids and Their Synthetic Analogues . ACS Omega 8:36, pages 33006-33016.
Crossref
Cordula Stefanović, Fiona F. Hager-Mair, Erik Breslmayr, Arturo López-Guzmán, Charlie Lim, Markus Blaukopf, Paul Kosma, Chris Oostenbrink, Roland Ludwig & Christina Schäffer. (2023) Molecular modelling and site-directed mutagenesis provide insight into saccharide pyruvylation by the Paenibacillus alvei CsaB enzyme. Scientific Reports 13:1.
Crossref
Tang Qun, Tiantian Zhou, Jiongkai Hao, Chunmei Wang, Keyu Zhang, Jing Xu, Xiaoyang Wang & Wen Zhou. (2023) Antibacterial activities of anthraquinones: structure–activity relationships and action mechanisms. RSC Medicinal Chemistry 14:8, pages 1446-1471.
Crossref
Choong-Gu Lee, Kwang Hyun Cha, Gi-Cheon Kim, Sin-Hyeog Im & Ho-Keun Kwon. (2023) Exploring probiotic effector molecules and their mode of action in gut–immune interactions. FEMS Microbiology Reviews 47:4.
Crossref
Goncagül Serdaroğlu, Nesimi Uludag, Elvan Üstün & Naki Colak. (2023) A novel series of tetrahydrothieno[2,3- c ]pyridin-2-yl derivatives: fluorescence spectroscopy and BSA binding, ADMET properties, molecular docking, and DFT studies . New Journal of Chemistry 47:25, pages 11945-11963.
Crossref
Qinggen Jiang, Boxi Li, Liangsheng Zhang, Tingting Li, Qiao Hu, Haotian Li, Wenjin Zou, Zhe Hu, Qi Huang & Rui Zhou. (2023) DivIVA Interacts with the Cell Wall Hydrolase MltG To Regulate Peptidoglycan Synthesis in Streptococcus suis. Microbiology Spectrum 11:3.
Crossref
Hong Thuy Vy Nguyen, Xiaorui Chen, Claudia Parada, An-Chi Luo, Orion Shih, U-Ser Jeng, Chia-Ying Huang, Yu-Ling Shih & Che Ma. (2023) Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome. Nature Communications 14:1.
Crossref
Md. Anzarul Haque, Mandeep Singh, Manish Kumar Tripathi, Abdul Samath Ethayathulla & Punit Kaur. (2022) Identification of natural small molecule modulators of MurB from Salmonella enterica serovar Typhi Ty2 strain using computational and biophysical approaches . Proteins: Structure, Function, and Bioinformatics 91:3, pages 363-379.
Crossref
Matthias Engel, Reem K. Fathalla & Christian Ducho. 2023. New Approaches Towards Novel Antibacterial Agents. New Approaches Towards Novel Antibacterial Agents 87 105 .
Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György M. Keserű & Stanislav Gobec. (2022) Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. European Journal of Medicinal Chemistry 243, pages 114752.
Crossref
Reem K. Fathalla, Wolfgang Fröhner, Chantal D. Bader, Patrick D. Fischer, Charlotte Dahlem, Deep Chatterjee, Sebastian Mathea, Alexandra K. Kiemer, Haribabu Arthanari, Rolf Müller, Mohammad Abdel-Halim, Christian Ducho & Matthias Engel. (2022) Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA. Journal of Medicinal Chemistry 65:21, pages 14740-14763.
Crossref
Tatsuro Yoneyama, Abdelsamed I. Elshamy, Junpei Yamada, Walaa A. El-Kashak, Yusuke Kasai, Hiroshi Imagawa, Sayaka Ban, Masaaki Noji & Akemi Umeyama. (2022) Antimicrobial metabolite of Cordyceps tenuipes targeting MurE ligase and histidine kinase via in silico study. Applied Microbiology and Biotechnology 106:19-20, pages 6483-6491.
Crossref
Wanlu Xiao, Yasuharu Satoh, Yasushi Ogasawara & Tohru Dairi. (2022) Biosynthetic Gene Cluster of Linaridin Peptides Contains Epimerase Gene. ChemBioChem 23:12.
Crossref
Brad A. Haubrich, Saman Nayyab, Mika Gallati, Jazmeen Hernandez, Caroline Williams, Andrew Whitman, Tahl Zimmerman, Qiong Li, Yuxing Chen, Cong-Zhao Zhou, Amit Basu & Christopher W. Reid. (2022) Inhibition of Streptococcus pneumoniae growth by masarimycin. Microbiology 168:4.
Crossref
Diksha Raina, Chetan Kumar, Vinod Kumar, Inshad Ali Khan & Saurabh Saran. (2021) Potential Inhibitors Targeting Escherichia coli UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA): An Overview. Indian Journal of Microbiology 62:1, pages 11-22.
Crossref
Marta Acebrón-García-de-Eulate, Joan Mayol-LlinàsMatthew T. O. HollandSo Yeon KimKaren P. Brown, Chiara MarchettiJeannine Hess, Ornella Di PietroVitor Mendes, Chris AbellR. Andres Floto, Anthony G. Coyne & Tom L. Blundell. (2022) Discovery of Novel Inhibitors of Uridine Diphosphate- N -Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients . Journal of Medicinal Chemistry 65:3, pages 2149-2173.
Crossref
Nicholas Banahene, Herbert W. Kavunja & Benjamin M. Swarts. (2021) Chemical Reporters for Bacterial Glycans: Development and Applications. Chemical Reviews 122:3, pages 3336-3413.
Crossref
Zhipeng Gao, Weiming Zhong, Ting Liu, Tianyu Zhao & Jiajing Guo. (2021) Global Proteomic Analysis of Listeria monocytogenes’ Response to Linalool. Foods 10:10, pages 2449.
Crossref
Yashodeep Shinde, Iqrar Ahmad, Sanjay Surana & Harun Patel. (2021) The Mur Enzymes Chink in the Armour of Mycobacterium tuberculosis cell wall. European Journal of Medicinal Chemistry 222, pages 113568.
Crossref
Yinhui Qin, Linlin Xu, Yuetai Teng, Yinhu Wang & Peizhi Ma. (2021) Discovery of novel antibacterial agents: Recent developments in D‐alanyl‐D‐alanine ligase inhibitors. Chemical Biology & Drug Design 98:3, pages 305-322.
Crossref
Katherine A. Black, Lijun Duan, Lungelo Mandyoli, Bruna P. Selbach, Weizhen Xu, Sabine Ehrt, James C. Sacchettini & Kyu Y. Rhee. (2021) Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis . Journal of Experimental Medicine 218:7.
Crossref
Srikanth Jupudi, Mohammed Afzal Azam & Ashish Wadhwani. (2020) Design, synthesis and molecular modelling of phenoxyacetohydrazide derivatives as Staphylococcus aureus MurD inhibitors. Chemical Papers 75:3, pages 1221-1235.
Crossref
Mohammed Afzal Azam & Vyshaag Chembakam veetil Manoj. (2020) An explorative study on diarylquinoline-based inhibitor targeting Enterococcus faecium MurF. Structural Chemistry 32:1, pages 115-125.
Crossref
Taro Shiraishi & Tomohisa Kuzuyama. (2021) Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products. Bioscience, Biotechnology, and Biochemistry 85:1, pages 42-52.
Crossref
Moagi Shaku, Christopher Ealand & Bavesh D. Kana. (2020) Cell Surface Biosynthesis and Remodeling Pathways in Mycobacteria Reveal New Drug Targets. Frontiers in Cellular and Infection Microbiology 10.
Crossref
Salma A. Mokbel, Reem K. Fathalla, Lina Y. El-Sharkawy, Ashraf H. Abadi, Matthias Engel & Mohammad Abdel-Halim. (2020) Synthesis of novel 1,2-diarylpyrazolidin-3-one–based compounds and their evaluation as broad spectrum antibacterial agents. Bioorganic Chemistry 99, pages 103759.
Crossref
Arvind S. Soni, Condarache M. Vacariu, Jeff Y. Chen & Martin E. Tanner. (2020) Synthesis of a meso -Oxa-Diaminopimelic Acid Containing Peptidoglycan Pentapeptide and Coupling to the GlcNAc- anhydro -MurNAc Disaccharide . Organic Letters 22:6, pages 2313-2317.
Crossref
M. I. Abou-Dobara & N. F. Omar. 2020. Engineered Antimicrobial Surfaces. Engineered Antimicrobial Surfaces 33 63 .
Laura Díaz‐Sáez, Leah S. Torrie, Stuart P. McElroy, David Gray & William N. Hunter. (2019) Burkholderia pseudomallei d ‐alanine‐ d ‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target . The FEBS Journal 286:22, pages 4509-4524.
Crossref
Xiaorui Chen, Chi-Huey Wong & Che Ma. (2019) Targeting the Bacterial Transglycosylase: Antibiotic Development from a Structural Perspective. ACS Infectious Diseases 5:9, pages 1493-1504.
Crossref
Arvind S. Soni, Chang Sheng‐Huei Lin, Michael E. P. Murphy & Martin E. Tanner. (2019) Peptides Containing meso ‐Oxa‐Diaminopimelic Acid as Substrates for the Cell‐Shape‐Determining Proteases Csd6 and Pgp2 . ChemBioChem 20:12, pages 1591-1598.
Crossref
Bhautikkumar Patel, Philip Ryan, Vivek Makwana, Matthew Zunk, Santosh Rudrawar & Gary Grant. (2019) Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY. European Journal of Medicinal Chemistry 171, pages 462-474.
Crossref
Karolina Kwiatkowska-Semrau, Marek Wojciechowski, Iwona Gabriel, Sara Crucho & Sławomir Milewski. (2018) Modification of quaternary structure of Candida albicans GlcN-6-P synthase and its desensitization to inhibition by UDP-GlcNAc by site-directed mutagenesis. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1866:11, pages 1181-1189.
Crossref
Xiaolei Wang, Larissa Krasnova, Kevin Binchia Wu, Wei-Shen Wu, Ting-Jen Cheng & Chi-Huey Wong. (2018) Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor. Bioorganic & Medicinal Chemistry Letters 28:16, pages 2708-2712.
Crossref
Tjaša Tibaut, Viktor Drgan & Marjana Novič. (2018) Application of SAR methods toward inhibition of bacterial peptidoglycan metabolizing enzymes. Journal of Chemometrics 32:4.
Crossref
Yasushi Ogasawara & Tohru Dairi. (2018) Peptide Epimerization Machineries Found in Microorganisms. Frontiers in Microbiology 9.
Crossref
Kyle M. Stiers, Jia Xu, Yingying Lee, Zachary R. Addison, Steven R. Van Doren & Lesa J. Beamer. (2017) Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from Bacillus anthracis . ACS Omega 2:11, pages 8445-8452.
Crossref
Kusum Mehla & Jayashree Ramana. (2017) Tapping into Salmonella typhimurium LT2 genome in a quest to explore its therapeutic arsenal: A metabolic network modeling approach. Biomedicine & Pharmacotherapy 86, pages 57-66.
Crossref
Kyle M. Stiers, Andrew G. Muenks & Lesa J. Beamer. 2017. Structural and Mechanistic Enzymology. Structural and Mechanistic Enzymology 265 304 .
Stefan Koppermann & Christian Ducho. (2016) Natural Products at Work: Structural Insights into Inhibition of the Bacterial Membrane Protein MraY. Angewandte Chemie International Edition 55:39, pages 11722-11724.
Crossref
Stefan Koppermann & Christian Ducho. (2016) Naturstoffe bei der Arbeit: strukturelle Einblicke in die Inhibition des bakteriellen Membranproteins MraY. Angewandte Chemie 128:39, pages 11896-11898.
Crossref
Daniel Wiegmann, Stefan Koppermann, Marius Wirth, Giuliana Niro, Kristin Leyerer & Christian Ducho. (2016) Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents. Beilstein Journal of Organic Chemistry 12, pages 769-795.
Crossref
Yanjie Liu, Emilisa Frirdich, Jennifer A. Taylor, Anson C. K. Chan, Kris M. Blair, Jenny Vermeulen, Reuben Ha, Michael E. P. Murphy, Nina R. Salama, Erin C. Gaynor & Martin E. Tanner. (2016) A Bacterial Cell Shape-Determining Inhibitor. ACS Chemical Biology 11:4, pages 981-991.
Crossref
Jed Fisher & Shahriar Mobashery. 2015. Practical Handbook of Microbiology, Third Edition. Practical Handbook of Microbiology, Third Edition 221 264 .
Che-Hsiung Hsu, Mathias Schelwies, Sebastian Enck, Lin-Ya Huang, Shih-Hsien Huang, Yi-Fan Chang, Ting-Jen Rachel Cheng, Wei-Chieh Cheng & Chi-Huey Wong. (2014) Iminosugar C-Glycoside Analogues of α- d -GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition . The Journal of Organic Chemistry 79:18, pages 8629-8637.
Crossref
Martina Hrast, Izidor Sosič, Roman Šink & Stanislav Gobec. (2014) Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorganic Chemistry 55, pages 2-15.
Crossref
Liming Xu, Dongting Wu, Liang Liu, Qi Zheng, Yu Song, Li Ye, Shanshan Sha, Jian Kang, Yi Xin & Yufang Ma. (2014) Characterization of mycobacterial UDP-N-acetylglucosamine enolpyruvyle transferase (MurA). Research in Microbiology 165:2, pages 91-101.
Crossref
Martina Hrast, Marko Anderluh, Damijan Knez, Christopher P. Randall, Hélène Barreteau, Alex J. O'Neill, Didier Blanot & Stanislav Gobec. (2014) Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold. European Journal of Medicinal Chemistry 73, pages 83-96.
Crossref
Stefano Donadio & Margherita Sosio. 2013. Antibiotics. Antibiotics 133 149 .
Navkiran Kaur, Mansimran Khokhar, Vaibhav Jain, P. V. Bharatam, Rajat Sandhir & Rupinder Tewari. (2013) Identification of Druggable Targets for Acinetobacter baumannii Via Subtractive Genomics and Plausible Inhibitors for MurA and MurB. Applied Biochemistry and Biotechnology 171:2, pages 417-436.
Crossref
Mohammad Salem, Jakob Benedict Seidelin, Gerhard Rogler & Ole Haagen Nielsen. (2012) Muramyl dipeptide responsive pathways in Crohn’s disease: from NOD2 and beyond. Cellular and Molecular Life Sciences 70:18, pages 3391-3404.
Crossref
V. Sukhithasri, N. Nisha, Lalitha Biswas, V. Anil Kumar & Raja Biswas. (2013) Innate immune recognition of microbial cell wall components and microbial strategies to evade such recognitions. Microbiological Research 168:7, pages 396-406.
Crossref
Martina Hrast, Samo Turk, Izidor Sosič, Damijan Knez, Christopher P. Randall, Hélène Barreteau, Carlos Contreras-Martel, Andréa Dessen, Alex J. O'Neill, Dominique Mengin-Lecreulx, Didier Blanot & Stanislav Gobec. (2013) Structure–activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. European Journal of Medicinal Chemistry 66, pages 32-45.
Crossref
Ming Wei Chen, Bernhard Lohkamp, Robert Schnell, Julien Lescar & Gunter Schneider. (2013) Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates. PLoS ONE 8:6, pages e66936.
Crossref
Lynn L. Silver. (2013) Viable screening targets related to the bacterial cell wall. Annals of the New York Academy of Sciences 1277:1, pages 29-53.
Crossref
Stéphane Mouilleron, Marie-Ange Badet-Denisot, Ludovic Pecqueur, Karine Madiona, Nadine Assrir, Bernard Badet & Béatrice Golinelli-Pimpaneau. (2012) Structural Basis for Morpheein-type Allosteric Regulation of Escherichia coli Glucosamine-6-phosphate Synthase. Journal of Biological Chemistry 287:41, pages 34533-34546.
Crossref
Ankur Gautam, Praveen Rishi & Rupinder Tewari. (2011) UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments. Applied Microbiology and Biotechnology 92:2, pages 211-225.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.