Advanced search
Publication Cover
Critical Reviews in Biotechnology Volume 35, 2015 - Issue 2
Submit an article Journal homepage
1,154
Views
46
CrossRef citations to date
0
Altmetric
Review Article

Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy

Neus Ferrer-MirallesInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, ;Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, and ;CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, Barcelona, Spain
,
Escarlata Rodríguez-CarmonaInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, ;Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, and ;CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, Barcelona, Spain
,
José Luis CorcheroInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, ;Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, and ;CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, Barcelona, Spain
,
Elena García-FruitósInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, ;Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, and ;CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, Barcelona, Spain
,
Esther VázquezInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, ;Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, and ;CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, Barcelona, Spain
&
Antonio VillaverdeInstitut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, ;Department de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain, and ;CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Bellaterra, Barcelona, SpainCorrespondence[email protected]
Pages 209-221 | Received 28 Jan 2013, Accepted 05 Jun 2013, Published online: 09 Oct 2013

Citations (46)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Sandip Debnath, Dibyendu Seth, Sourish Pramanik, Sanchari Adhikari, Parimita Mondal, Dechen Sherpa, Deepjyoti Sen, Dattatreya Mukherjee & Nobendu Mukerjee. (2022) A comprehensive review and meta-analysis of recent advances in biotechnology for plant virus research and significant accomplishments in human health and the pharmaceutical industry. Biotechnology and Genetic Engineering Reviews 0:0, pages 1-33.
Read now
Amit Mahajan & Sarabjeet Singh Sidhu. (2018) Enhancing biocompatibility of Co-Cr alloy implants via electrical discharge process. Materials Technology 33:8, pages 524-531.
Read now
Shi-Zhen Wang, Yong-Hui Zhang, Hong Ren, Ya-Li Wang, Wei Jiang & Bai-Shan Fang. (2017) Strategies and perspectives of assembling multi-enzyme systems. Critical Reviews in Biotechnology 37:8, pages 1024-1037.
Read now

Articles from other publishers (43)

Jorge João & Duarte Miguel F. Prazeres. (2023) Manufacturing of non-viral protein nanocages for biotechnological and biomedical applications. Frontiers in Bioengineering and Biotechnology 11.
Crossref
Xiaoxi ChangChenyan LvGuanghua Zhao. (2023) A Dual Function of Ferritin (Animal and Plant): Its Holo Form for Iron Supplementation and Apo Form for Delivery Systems. Annual Review of Food Science and Technology 14:1, pages 113-133.
Crossref
Eric Voltà-Durán, Eloi Parladé, Naroa Serna, Antonio Villaverde, Esther Vazquez & Ugutz Unzueta. (2023) Endosomal escape for cell-targeted proteins. Going out after going in. Biotechnology Advances 63, pages 108103.
Crossref
Srividhya Venkataraman & Kathleen Hefferon. 2023. Agricultural Biotechnology. Agricultural Biotechnology 43 72 .
Roger Fernández, Aida Carreño, Rosa Mendoza, Antoni Benito, Neus Ferrer-Miralles, María Virtudes Céspedes & José Luis Corchero. (2022) Escherichia coli as a New Platform for the Fast Production of Vault-like Nanoparticles: An Optimized Protocol. International Journal of Molecular Sciences 23:24, pages 15543.
Crossref
Christian K. O. Dzuvor, Bhuvana K. Shanbhag, Tayyaba Younas, Hsin-Hui Shen, Victoria S. Haritos & Lizhong He. (2022) Engineering Self-Assembled Endolysin Nanoparticles against Antibiotic-Resistant Bacteria. ACS Applied Bio Materials 5:10, pages 4993-5003.
Crossref
Marianna Teixeira de Pinho Favaro, Jan Atienza-Garriga, Carlos Martínez-Torró, Eloi Parladé, Esther Vázquez, José Luis Corchero, Neus Ferrer-Miralles & Antonio Villaverde. (2022) Recombinant vaccines in 2022: a perspective from the cell factory. Microbial Cell Factories 21:1.
Crossref
Ksenia Mitusova, Oleksii O. Peltek, Timofey E. Karpov, Albert R. Muslimov, Mikhail V. Zyuzin & Alexander S. Timin. (2022) Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches. Journal of Nanobiotechnology 20:1.
Crossref
Yuanxin Li, Jing Sun, Jingjing Li, Kai Liu & Hongjie Zhang. (2022) Engineered protein nanodrug as an emerging therapeutic tool. Nano Research 15:6, pages 5161-5172.
Crossref
Iram Saba, Kaiser Wani, Suriya Rehman & Vipin Singh. 2022. Nanotechnology for Infectious Diseases. Nanotechnology for Infectious Diseases 541 553 .
Arun K. Kotha, Rama Kashikar, Paras Famta, Saurabh Shah, Saurabh Srivastava & Mahavir Bhupal Chougule. 2022. Nanomaterials for Cancer Detection Using Imaging Techniques and Their Clinical Applications. Nanomaterials for Cancer Detection Using Imaging Techniques and Their Clinical Applications 225 259 .
Zhihuan Liao, Li Tu, Xuejian Li, Xing-Jie Liang & Shuaidong Huo. (2021) Virus-inspired nanosystems for drug delivery. Nanoscale 13:45, pages 18912-18924.
Crossref
Srividhya Venkataraman & Kathleen Hefferon. (2021) Application of Plant Viruses in Biotechnology, Medicine, and Human Health. Viruses 13:9, pages 1697.
Crossref
Patricia Álamo, Juan Cedano, Oscar Conchillo-Sole, Olivia Cano-Garrido, Lorena Alba-Castellon, Naroa Serna, Anna Aviñó, Luis Miguel Carrasco-Diaz, Alejandro Sánchez-Chardi, Carlos Martinez-Torró, Alberto Gallardo, Montserrat Cano, Ramon Eritja, Antonio Villaverde, Ramon Mangues, Esther Vazquez & Ugutz Unzueta. (2021) Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines. Acta Biomaterialia 130, pages 211-222.
Crossref
Sathyamoorthy Bhaskar, Steven Thng & Sierin Lim. (2021) Engineered Protein Nanocages for Targeted and Enhanced Dermal Melanocyte Cellular Uptake. Advanced NanoBiomed Research 1:7, pages 2000115.
Crossref
Chenxi Zhang, Xiaorong Zhang & Guanghua Zhao. (2020) Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine. Nanomaterials 10:9, pages 1894.
Crossref
Hèctor López-Laguna, Rafael Cubarsi, Ugutz Unzueta, Ramón Mangues, Esther Vázquez & Antonio Villaverde. (2019) Endosomal escape of protein nanoparticles engineered through humanized histidine-rich peptides. Science China Materials 63:4, pages 644-653.
Crossref
Young Hun Chung, Hui Cai & Nicole F. Steinmetz. (2020) Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications. Advanced Drug Delivery Reviews 156, pages 214-235.
Crossref
Abha Chaudhary & Ram Dhan Yadav. (2019) A review on virus protein self-assembly. Journal of Nanoparticle Research 21:11.
Crossref
Febrina Sandra, Nisar Ul Khaliq, Anwar Sunna & Andrew Care. (2019) Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging. Nanomaterials 9:9, pages 1329.
Crossref
Naroa Serna, Julieta M Sánchez, Ugutz Unzueta, Laura Sánchez-García, Alejandro Sánchez-Chardi, Ramón Mangues, Esther Vázquez & Antonio Villaverde. (2019) Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles. Nanotechnology 30:11, pages 115101.
Crossref
Martina Garni, Riccardo Wehr, Saziye Yorulmaz Avsar, Christoph John, Cornelia Palivan & Wolfgang Meier. (2019) Polymer membranes as templates for bio-applications ranging from artificial cells to active surfaces. European Polymer Journal 112, pages 346-364.
Crossref
Hèctor López-Laguna, Ugutz Unzueta, Oscar Conchillo-Solé, Alejandro Sánchez-Chardi, Mireia Pesarrodona, Olivia Cano-Garrido, Eric Voltà, Laura Sánchez-García, Naroa Serna, Paolo Saccardo, Ramón Mangues, Antonio Villaverde & Esther Vázquez. (2019) Assembly of histidine-rich protein materials controlled through divalent cations. Acta Biomaterialia 83, pages 257-264.
Crossref
Julieta M. Sánchez, Laura Sánchez-García, Mireia Pesarrodona, Naroa Serna, Alejandro Sánchez-Chardi, Ugutz Unzueta, Ramón Mangues, Esther Vázquez & Antonio Villaverde. (2018) Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles. Biomacromolecules 19:9, pages 3788-3797.
Crossref
Naohiro Terasaka, Yusuke Azuma & Donald Hilvert. (2018) Laboratory evolution of virus-like nucleocapsids from nonviral protein cages. Proceedings of the National Academy of Sciences 115:21, pages 5432-5437.
Crossref
Naroa Serna, Laura Sánchez-García, Ugutz Unzueta, Raquel Díaz, Esther Vázquez, Ramón Mangues & Antonio Villaverde. (2018) Protein-Based Therapeutic Killing for Cancer Therapies. Trends in Biotechnology 36:3, pages 318-335.
Crossref
Marianna Teixeira de Pinho Favaro, Laura Sánchez-García, Alejandro Sánchez-Chardi, Mónica Roldán, Ugutz Unzueta, Naroa Serna, Olivia Cano-Garrido, Adriano Rodrigues Azzoni, Neus Ferrer-Miralles, Antonio Villaverde & Esther Vázquez. (2018) Protein nanoparticles are nontoxic, tuneable cell stressors. Nanomedicine 13:3, pages 255-268.
Crossref
Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, Mónica Roldán, Alejandro Sánchez-Chardi, Ramón Mangues, Antonio Villaverde & Esther Vázquez. (2017) Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks . Nanotechnology 28:50, pages 505102.
Crossref
Nasser Awwad, Ali Alshahrani, Kamel Saleh & Mohamed Hamdy. (2017) A Novel Method to Improve the Anticancer Activity of Natural-Based Hydroxyapatite against the Liver Cancer Cell Line HepG2 Using Mesoporous Magnesia as a Micro-Carrier. Molecules 22:12, pages 1947.
Crossref
Naroa Serna, María Virtudes Céspedes, Laura Sánchez-García, Ugutz Unzueta, Rita Sala, Alejandro Sánchez-Chardi, Francisco Cortés, Neus Ferrer-Miralles, Ramón Mangues, Esther Vázquez & Antonio Villaverde. (2017) Peptide-Based Nanostructured Materials with Intrinsic Proapoptotic Activities in CXCR4 + Solid Tumors . Advanced Functional Materials 27:32, pages 1700919.
Crossref
Sathyamoorthy Bhaskar & Sierin Lim. (2017) Engineering protein nanocages as carriers for biomedical applications. NPG Asia Materials 9:4, pages e371-e371.
Crossref
Jie Chen, Xiuwen Guan, Yingying Hu, Huayu Tian & Xuesi Chen. (2017) Peptide-Based and Polypeptide-Based Gene Delivery Systems. Topics in Current Chemistry 375:2.
Crossref
Mireia Pesarrodona, Eva Crosas, Rafael Cubarsi, Alejandro Sánchez-Chardi, Paolo Saccardo, Ugutz Unzueta, Fabian Rueda, Laura Sanchez-García, Naroa Serna, Ramón Mangues, Neus Ferrer-Miralles, Esther Vázquez & Antonio Villaverde. (2017) Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles. Nanoscale 9:19, pages 6427-6435.
Crossref
Fabián Rueda, Brigitte Gasser, Alejandro Sánchez-Chardi, Mònica Roldán, Sandra Villegas, Verena Puxbaum, Neus Ferrer-Miralles, Ugutz Unzueta, Esther Vázquez, Elena Garcia-Fruitós, Diethard Mattanovich & Antonio Villaverde. (2016) Functional inclusion bodies produced in the yeast Pichia pastoris. Microbial Cell Factories 15:1.
Crossref
Olivia Cano-Garrido, Alejandro Sánchez-Chardi, Sílvia Parés, Irene Giró, Witold I. Tatkiewicz, Neus Ferrer-Miralles, Imma Ratera, Antonino Natalello, Rafael Cubarsi, Jaume Veciana, Àlex Bach, Antonio Villaverde, Anna Arís & Elena Garcia-Fruitós. (2016) Functional protein-based nanomaterial produced in microorganisms recognized as safe: A new platform for biotechnology. Acta Biomaterialia 43, pages 230-239.
Crossref
Olivia Cano-Garrido, María Virtudes Céspedes, Ugutz Unzueta, Paolo Saccardo, Mònica Roldán, Alejandro Sánchez-Chardi, Rafael Cubarsi, Esther Vázquez, Ramon Mangues, Elena García-Fruitós & Antonio Villaverde. (2016) CXCR4 + -targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis . Nanomedicine 11:18, pages 2387-2398.
Crossref
Naroa Serna, María Virtudes Céspedes, Paolo Saccardo, Zhikun Xu, Ugutz Unzueta, Patricia Álamo, Mireia Pesarrodona, Alejandro Sánchez-Chardi, Mónica Roldán, Ramón Mangues, Esther Vázquez, Antonio Villaverde & Neus Ferrer-Miralles. (2016) Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 12:5, pages 1241-1251.
Crossref
Fabián Rueda, María Virtudes Céspedes, Oscar Conchillo-Solé, Alejandro Sánchez-Chardi, Joaquin Seras-Franzoso, Rafael Cubarsi, Alberto Gallardo, Mireia Pesarrodona, Neus Ferrer-Miralles, Xavier Daura, Esther Vázquez, Elena García-Fruitós, Ramón Mangues, Ugutz Unzueta & Antonio Villaverde. (2015) Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials. Advanced Materials 27:47, pages 7816-7822.
Crossref
Denis Arutyunov & Christine M. Szymanski. (2015) A novel DNA-binding protein from Campylobacter jejuni bacteriophage NCTC12673 . FEMS Microbiology Letters 362:21, pages fnv160.
Crossref
Matteo Palma, John G. Hardy, Ghazal Tadayyon, Maria Farsari, Shalom J. Wind & Manus J. Biggs. (2015) Advances in Functional Assemblies for Regenerative Medicine. Advanced Healthcare Materials 4:16, pages 2500-2519.
Crossref
Hugo Peluffo, Ugutz Unzueta, María Luciana Negro-Demontel, Zhikun Xu, Esther Váquez, Neus Ferrer-Miralles & Antonio Villaverde. (2015) BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS. Biotechnology Advances 33:2, pages 277-287.
Crossref
María Virtudes Céspedes, Ugutz Unzueta, Witold Tatkiewicz, Alejandro Sánchez-Chardi, Oscar Conchillo-Solé, Patricia Álamo, Zhikun Xu, Isolda Casanova, José Luis Corchero, Mireia Pesarrodona, Juan Cedano, Xavier Daura, Imma Ratera, Jaume Veciana, Neus Ferrer-Miralles, Esther Vazquez, Antonio Villaverde & Ramón Mangues. (2014) In Vivo Architectonic Stability of Fully de Novo Designed Protein-Only Nanoparticles . ACS Nano 8:5, pages 4166-4176.
Crossref
Ugutz Unzueta, Paolo Saccardo, Joan Domingo-Espín, Juan Cedano, Oscar Conchillo-Solé, Elena García-Fruitós, María Virtudes Céspedes, José Luis Corchero, Xavier Daura, Ramón Mangues, Neus Ferrer-Miralles, Antonio Villaverde & Esther Vázquez. (2014) Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery. Nanomedicine: Nanotechnology, Biology and Medicine 10:3, pages 535-541.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.