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Review Article

Probiotics and the BSH-related cholesterol lowering mechanism: a Jekyll and Hyde scenario

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Pages 392-401 | Received 30 May 2013, Accepted 21 Dec 2013, Published online: 27 Feb 2014

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J. ShibayamaM. GotoT. KudaM. FukunagaH. TakahashiB. Kimura. (2019) Effect of rice bran fermented with Saccharomyces cerevisiae and Lactobacillus plantarum on gut microbiome of mice fed high-sucrose diet . Beneficial Microbes 10:7, pages 811-821.
Crossref
Lidong Guo, Liqun Wang, Fei Liu, Bailiang Li, Yaru Tang, Shangfu Yu, Danqing Zhang & Guicheng Huo. (2019) Effect of bile salt hydrolase-active Lactobacillus plantarum KLDS 1.0344 on cholesterol metabolism in rats fed a high-cholesterol diet. Journal of Functional Foods 61, pages 103497.
Crossref
Zhen Luo, Xue Xu, Sen Zhao, Takami Sho, Wenli Luo, Jing Zhang, Weina Xu, Kong Hon & Jianxiong Xu. (2019) Inclusion of microbe-derived antioxidant during pregnancy and lactation attenuates high-fat diet-induced hepatic oxidative stress, lipid disorders, and NLRP3 inflammasome in mother rats and offspring. Food & Nutrition Research 63:0.
Crossref
Alok Kumar Mishra, Shravanthi S Kumar & Asit Ranjan Ghosh. (2019) Probiotic Enterococcus faecalis AG5 effectively assimilates cholesterol and produces fatty acids including propionate . FEMS Microbiology Letters 366:4.
Crossref
Guangqiang Wang, Minghui Zhang, Jianxin Zhao, Yongjun Xia, Phoency F.-H. Lai & Lianzhong Ai. (2018) A Surface Protein From Lactobacillus plantarum Increases the Adhesion of Lactobacillus Strains to Human Epithelial Cells. Frontiers in Microbiology 9.
Crossref
Ming-Chia Hsieh, Wan-Hua Tsai, Yu-Pang Jheng, Shih-Li Su, Shu-Yi Wang, Chi-Chen Lin, Yi-Hsing Chen & Wen-Wei Chang. (2018) The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial. Scientific Reports 8:1.
Crossref
Ana Y. Bustos, Graciela Font de Valdez, Silvina Fadda & María P. Taranto. (2018) New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health. Food Research International 112, pages 250-262.
Crossref
Paige V. Bauer, Frank A. Duca, T.M. Zaved Waise, Helen J. Dranse, Brittany A. Rasmussen, Akshita Puri, Mozhgan Rasti, Catherine A. O'Brien & Tony K.T. Lam. (2018) Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis. Cell Metabolism 27:3, pages 572-587.e6.
Crossref
Mark Houston. 2018. Integrative Medicine. Integrative Medicine 264 275.e5 .
Libor Vítek. (2017) Bile Acids in the Treatment of Cardiometabolic Diseases. Annals of Hepatology 16, pages S43-S52.
Crossref
Meijing Liu, Changhui Liu, Hao Chen, Xiaotao Huang, Xiaohui Zeng, Juncheng Zhou & Suiqing Mi. (2017) Prevention of cholesterol gallstone disease by schaftoside in lithogenic diet-induced C57BL/6 mouse model. European Journal of Pharmacology 815, pages 1-9.
Crossref
B.S. Rashmi & D. Gayathri. (2017) Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line . Journal of Applied Microbiology 123:3, pages 759-772.
Crossref
Xiao-lei Zhang, Yan-feng Wu, Yu-shan Wang, Xin-zhe Wang, Chun-hong Piao, Jun-mei Liu, Yan-long Liu & Yu-hua Wang. (2017) The protective effects of probiotic-fermented soymilk on high-fat diet-induced hyperlipidemia and liver injury. Journal of Functional Foods 30, pages 220-227.
Crossref
Wenjing Geng & Jun Lin. (2017) Bacterial bile salt hydrolase: an intestinal microbiome target for enhanced animal health. Animal Health Research Reviews 17:2, pages 148-158.
Crossref
Lidong Guo, Tingting Li, Yaru Tang, Lijie Yang & Guicheng Huo. (2015) Probiotic properties of E nterococcus strains isolated from traditional naturally fermented cream in C hina . Microbial Biotechnology 9:6, pages 737-745.
Crossref
Piotr Jarocki, Marcin Podleśny, Paweł Glibowski & Zdzisław Targoński. (2014) A New Insight into the Physiological Role of Bile Salt Hydrolase among Intestinal Bacteria from the Genus Bifidobacterium. PLoS ONE 9:12, pages e114379.
Crossref
Pei-Lei Tan & Min-Tze Liong. (2014) In silico approaches for probiotic-derived bioactives. Trends in Biotechnology 32:12, pages 599-601.
Crossref

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