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Critical Reviews in Biotechnology Volume 12, 1992 - Issue 3
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Research Article

The Discovery of Cell Wall Active Antibacterial Antibiotics

Hans H. Gadebusch Merck Sharp & Dohme Research Laboratories, Rahway, NJ, 07065
,
Edward O. Stapley Merck Sharp & Dohme Research Laboratories, Rahway, NJ, 07065
&
Sheldon B. Zimmerman Merck Sharp & Dohme Research Laboratories, Rahway, NJ, 07065
Pages 225-243 | Published online: 27 Sep 2008

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Sheo B Singh, Katherine Young & Lynn Miesel. (2011) Screening strategies for discovery of antibacterial natural products. Expert Review of Anti-infective Therapy 9:8, pages 589-613.
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Luiza H Galarion, Jennifer K Mitchell, Christopher P Randall & Alex J O’Neill. (2023) An extensively validated whole-cell biosensor for specific, sensitive and high-throughput detection of antibacterial inhibitors targeting cell-wall biosynthesis. Journal of Antimicrobial Chemotherapy 78:3, pages 646-655.
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Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György M. Keserű & Stanislav Gobec. (2022) Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. European Journal of Medicinal Chemistry 243, pages 114752.
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Yu-Ping Wang, Yen-Hao Chen, I-Cheng Hung, Po-Hsun Chu, Yu-Han Chang, Yi-Tsung Lin, Hung-Chih Yang & Jin-Town Wang. (2022) Transporter Genes and fosA Associated With Fosfomycin Resistance in Carbapenem-Resistant Klebsiella pneumoniae. Frontiers in Microbiology 13.
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Christopher R. Fullenkamp, Yen-Pang Hsu, Ellen M. Quardokus, Gengxiang Zhao, Carole A. Bewley, Michael VanNieuwenhze & Gary A. Sulikowski. (2020) Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in B. subtilis . Journal of the American Chemical Society 142:38, pages 16161-16166.
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Yingying Cao, Qingyao Peng, Shanni Li, Zixin Deng & Jiangtao Gao. (2019) The intriguing biology and chemistry of fosfomycin: the only marketed phosphonate antibiotic. RSC Advances 9:72, pages 42204-42218.
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Lynn L. Silver. (2017) Fosfomycin: Mechanism and Resistance. Cold Spring Harbor Perspectives in Medicine 7:2, pages a025262.
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Lynn L. Silver. (2016) Appropriate Targets for Antibacterial Drugs. Cold Spring Harbor Perspectives in Medicine 6:12, pages a030239.
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María Jesús Santesmases. (2015) The Bacterial Cell Wall in the Antibiotic Era: An Ontology in Transit Between Morphology and Metabolism, 1940s–1960s. Journal of the History of Biology 49:1, pages 3-36.
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Clifford D. Mol, Alexei Brooun, Douglas R. Dougan, Mark T. Hilgers, Leslie W. Tari, Robert A. Wijnands, Mark W. Knuth, Duncan E. McRee & Ronald V. Swanson. (2003) Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP- N -Acetylmuramic Acid: l -Alanine Ligase (MurC) from Haemophilus influenzae . Journal of Bacteriology 185:14, pages 4152-4162.
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Sheryl A Hyland & Matt S Anderson. (2003) A high-throughput solid-phase extraction assay capable of measuring diverse polyprenyl phosphate: sugar-1-phosphate transferases as exemplified by the WecA, MraY, and MurG proteins. Analytical Biochemistry 317:2, pages 156-165.
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Hairong Wang, Guohua Zhang & Jun Ning. (2003) First synthesis of β-d-Galf-(1→3)-d-Galp—the repeating unit of the backbone structure of the O-antigenic polysaccharide present in the lipopolysaccharide (LPS) of the genus Klebsiella. Carbohydrate Research 338:10, pages 1033-1037.
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Maria D.F.S. Barbosa, Harold O. Ross, Milton C. Hillman, Raymond P. Meade, Michael G. Kurilla & David L. Pompliano. (2002) A Multitarget Assay for Inhibitors of Membrane-Associated Steps of Peptidoglycan Biosynthesis. Analytical Biochemistry 306:1, pages 17-22.
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Maria D. F. S. Barbosa, Gaoyun Yang, Jie Fang, Michael G. Kurilla & David L. Pompliano. (2002) Development of a Whole-Cell Assay for Peptidoglycan Biosynthesis Inhibitors. Antimicrobial Agents and Chemotherapy 46:4, pages 943-946.
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Francis W. D'Souza, Joseph D. Ayers, Patrick R. McCarren & Todd L. Lowary. (2000) Arabinofuranosyl Oligosaccharides from Mycobacteria:  Synthesis and Effect of Glycosylation on Ring Conformation and Hydroxymethyl Group Rotamer Populations. Journal of the American Chemical Society 122:7, pages 1251-1260.
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Joaquim Trias & Zhengyu Yuan. (1999) Mining bacterial cell wall biosynthesis with new tools: multitarget screens. Drug Resistance Updates 2:6, pages 358-362.
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Kenny K. Wong, David W. Kuo, Renee M. Chabin, Carole Fournier, Laura D. Gegnas, Sherman T. Waddell, Frank Marsilio, Barbara Leiting & David L. Pompliano. (1998) Engineering a Cell-Free Murein Biosynthetic Pathway:  Combinatorial Enzymology in Drug Discovery. Journal of the American Chemical Society 120:51, pages 13527-13528.
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Mikhail F. Gordeev, Gary W. Luehr, Hon C. Hui, Eric M. Gordon & Dinesh V. Patel. (1998) Combinatorial chemistry of natural products: Solid phase synthesis of D- and L-cycloserine derivatives. Tetrahedron 54:52, pages 15879-15890.
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Kenny K. Wong & David L. Pompliano. 1998. Resolving the Antibiotic Paradox. Resolving the Antibiotic Paradox 197 217 .
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