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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 33, 2016 - Issue 4
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Lithium and bipolar disorder: Impacts from molecular to behavioural circadian rhythms

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Huirong Luo, Xueqian Wang, Yinlin Zhang, Junyao Li, Renqin Hu, Zheng Zhang, Qian Liao, Xiaoxin Zhou, Wei Deng, Jian Yang & Qinghua Luo. (2023) Can circadian rhythm predict changes in neurocognitive functioning in bipolar disorder: protocol of a 12-month longitudinal cohort study based on research domain criteria. Annals of Medicine 55:2.
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D. Grillault Laroche, E. Curis, F. Bellivier, C. Nepost, G. Gross, B. Etain & C. Marie-Claire. (2021) Network of co-expressed circadian genes, childhood maltreatment and sleep quality in bipolar disorders. Chronobiology International 38:7, pages 986-993.
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Pierre A. Geoffroy, Emmanuel Curis, Cindie Courtin, Jeverson Moreira, Thomas Morvillers, Bruno Etain, Jean-Louis Laplanche, Frank Bellivier & Cynthia Marie-Claire. (2018) Lithium response in bipolar disorders and core clock genes expression. The World Journal of Biological Psychiatry 19:8, pages 619-632.
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Kyu Young Lee, Yong Min Ahn, Se Hyun Kim, Hee-Gyoo Kang & Eun-Jeong Joo. (2018) Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics. Nordic Journal of Psychiatry 72:8, pages 599-604.
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Julia Maruani, George Anderson, Bruno Etain, Michel Lejoyeux, Frank Bellivier & Pierre A. Geoffroy. (2018) The neurobiology of adaptation to seasons: Relevance and correlations in bipolar disorders. Chronobiology International 35:10, pages 1335-1353.
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Hannah K. Dollish, Mariya Tsyglakova & Colleen A. McClung. (2023) Circadian rhythms and mood disorders: Time to see the light. Neuron.
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Alessandro Cuomo, Pietro Carmellini, Maria Luisa Garo, Giovanni Barillà, Claudia Libri, Alessandro Spiti, Arianna Goracci, Simone Bolognesi & Andrea Fagiolini. (2022) Effectiveness of light therapy as adjunctive treatment in bipolar depression: A pilot study. Journal of Affective Disorders.
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Nicholas Meyer, Allison G Harvey, Steven W Lockley & Derk-Jan Dijk. (2022) Circadian rhythms and disorders of the timing of sleep. The Lancet 400:10357, pages 1061-1078.
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Hadi Zadeh-Haghighi & Christoph Simon. (2022) Magnetic field effects in biology from the perspective of the radical pair mechanism. Journal of The Royal Society Interface 19:193.
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Laura Palagini, Pierre A. Geoffroy, Mario Miniati, Giulio Perugi, Giovanni Biggio, Donatella Marazziti & Dieter Riemann. (2021) Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review. CNS Spectrums 27:3, pages 298-308.
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Lisa Ferrand, Vincent Hennion, Ophelia Godin, Frank Bellivier, Jan Scott & Bruno Etain. (2022) Which Actigraphy Dimensions Predict Longitudinal Outcomes in Bipolar Disorders?. Journal of Clinical Medicine 11:8, pages 2204.
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Philipp Ritter, Bettina Soltmann, Cathrin Sauer, Abdulbaki Yakac, Lynn Boekstaegers, Mirjam Reichard, Konstanze Koenitz, Michael Bauer, Henry Güldner, Stefanie Neumann, Falk Wieland & Debra J. Skene. (2022) Supersensitivity of Patients With Bipolar I Disorder to Light-Induced Phase Delay by Narrow Bandwidth Blue Light. Biological Psychiatry Global Open Science 2:1, pages 28-35.
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Ute Lewitzka. 2022. Suicide Risk Assessment and Prevention. Suicide Risk Assessment and Prevention 1141 1158 .
E.F. Uçak & K. Altınbaş. (2021) P.0112 Evaluation of circadian rhythm parameters and NR1D1 single nucleotide polymorphism relationship to predict lithium response in bipolar disorder. European Neuropsychopharmacology 53, pages S81-S82.
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Jan Scott, Mohamed Lajnef, Romain Icick, Frank Bellivier, Cynthia Marie-Claire & Bruno Etain. (2021) A Comparison of Different Approaches to Clinical Phenotyping of Lithium Response: A Proof of Principle Study Employing Genetic Variants of Three Candidate Circadian Genes. Pharmaceuticals 14:11, pages 1072.
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Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata & Tsuyoshi Kitajima. (2021) Association between circadian activity rhythms and mood episode relapse in bipolar disorder: a 12-month prospective cohort study. Translational Psychiatry 11:1.
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Ni Xu, Kiyomi Shinohara, Kate E. A. Saunders, John R. Geddes & Andrea Cipriani. (2021) Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta‐analysis. Bipolar Disorders 23:5, pages 445-453.
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So Yung Yang, Kyung Sue Hong, Youngah Cho, Eun-Young Cho, Yujin Choi, Yongkang Kim, Taesung Park, Kyooseob Ha & Ji Hyun Baek. (2021) Association between the Arylalkylamine N-Acetyltransferase (AANAT) Gene and Seasonality in Patients with Bipolar Disorder. Psychiatry Investigation 18:5, pages 453-462.
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Diana Y. Wei & Peter J. Goadsby. (2021) Cluster headache pathophysiology — insights from current and emerging treatments. Nature Reviews Neurology 17:5, pages 308-324.
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Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata & Tsuyoshi Kitajima. (2020) Higher prevalence of intentional self-harm in bipolar disorder with evening chronotype: A finding from the APPLE cohort study. Journal of Affective Disorders 277, pages 727-732.
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Roger S McIntyre, Michael Berk, Elisa Brietzke, Benjamin I Goldstein, Carlos López-Jaramillo, Lars Vedel Kessing, Gin S Malhi, Andrew A Nierenberg, Joshua D Rosenblat, Amna Majeed, Eduard Vieta, Maj Vinberg, Allan H Young & Rodrigo B Mansur. (2020) Bipolar disorders. The Lancet 396:10265, pages 1841-1856.
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Lia Bertrand, Clément Bourguignon, Serge Beaulieu, Kai-Florian Storch & Outi Linnaranta. (2020) Suicidal Ideation and Insomnia in Bipolar Disorders: Idéation suicidaire et insomnie dans les troubles bipolaires. The Canadian Journal of Psychiatry 65:11, pages 802-810.
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Nicholas Meyer, Sophie M Faulkner, Robert A McCutcheon, Toby Pillinger, Derk-Jan Dijk & James H MacCabe. (2020) Sleep and Circadian Rhythm Disturbance in Remitted Schizophrenia and Bipolar Disorder: A Systematic Review and Meta-analysis. Schizophrenia Bulletin 46:5, pages 1126-1143.
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Sandra J. Rosenthal, Travis Josephs, Oleg Kovtun & Richard McCarty. (2020) Seasonal effects on bipolar disorder: A closer look. Neuroscience & Biobehavioral Reviews 115, pages 199-219.
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Tsutomu Takahashi, Daiki Sasabayashi, Murat Yücel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Michio Suzuki, Christos Pantelis, Gin S. Malhi & Nicholas B. Allen. (2020) Pineal Gland Volume in Major Depressive and Bipolar Disorders. Frontiers in Psychiatry 11.
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Yiming Chen, Wu Hong & Yiru Fang. (2020) Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review. General Psychiatry 33:1, pages e100127.
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Bryan Maloney, Yokesh Balaraman, Yunlong Liu, Nipun Chopra, Howard J. Edenberg, John Kelsoe, John I. Nurnberger & Debomoy K. Lahiri. (2019) Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer’s disease. Scientific Reports 9:1.
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John F. Gottlieb, Francesco Benedetti, Pierre A. Geoffroy, Tone E. G. Henriksen, Raymond W. Lam, Greg Murray, James Phelps, Dorothy Sit, Holly A. Swartz, Marie Crowe, Bruno Etain, Ellen Frank, Namni Goel, Bartholomeus C. M. Haarman, Maree Inder, Håvard Kallestad, Seong Jae Kim, Klaus Martiny, Ybe Meesters, Richard Porter, Rixt F. Riemersma‐van der Lek, Philipp S. Ritter, Peter F. J. Schulte, Jan Scott, Joseph C. Wu, Xin Yu & Shenghao Chen. (2019) The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology. Bipolar Disorders 21:8, pages 741-773.
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Fabien Pifferi, Jacques Epelbaum & Fabienne Aujard. (2019) Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia. Frontiers in Pharmacology 10.
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Mira Park, Soon Ae Kim, Jaeyong Yee, Jieun Shin, Kyu Young Lee & Eun-Jeong Joo. (2019) Significant role of gene–gene interactions of clock genes in mood disorder. Journal of Affective Disorders 257, pages 510-517.
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R. A. Bekker & Yu. V. Bykov. (2019) Lithium Preparations in Psychiatry, Addiction Medicine and Neurology. Part II. Biochemical Mechanisms of Its Action. Acta Biomedica Scientifica (East Siberian Biomedical Journal) 4:2, pages 80-100.
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Andrea Aguglia, Gianluca Serafini, Andrea Escelsior, Giovanna Canepa, Mario Amore & Giuseppe Maina. (2019) Maximum Temperature and Solar Radiation as Predictors of Bipolar Patient Admission in an Emergency Psychiatric Ward. International Journal of Environmental Research and Public Health 16:7, pages 1140.
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Julia Maruani & Pierre Alexis Geoffroy. (2019) Bright Light as a Personalized Precision Treatment of Mood Disorders. Frontiers in Psychiatry 10.
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Alexandra K. Gold & Gustavo Kinrys. (2019) Treating Circadian Rhythm Disruption in Bipolar Disorder. Current Psychiatry Reports 21:3.
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Pierre A. Geoffroy. (2018) Clock Genes and Light Signaling Alterations in Bipolar Disorder: When the Biological Clock Is Off. Biological Psychiatry 84:11, pages 775-777.
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Mariam M. Morchiladze, Tamila K. Silagadze & Zurab K. Silagadze. (2018) Visceral theory of sleep and origins of mental disorders. Medical Hypotheses 120, pages 22-27.
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Yoshikazu Takaesu. (2018) Circadian rhythm in bipolar disorder: A review of the literature. Psychiatry and Clinical Neurosciences 72:9, pages 673-682.
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Thomaz Oliveira, Victor Marinho, Valécia Carvalho, Francisco Magalhães, Kaline Rocha, Carla Ayres, Silmar Teixeira, Monara Nunes, Victor Hugo Bastos & Giovanny R Pinto. (2018) Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder. Bipolar Disorders 20:6, pages 515-522.
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P. S. Ritter, J. Schwabedal, M. Brandt, W. Schrempf, F. Brezan, A. Krupka, C. Sauer, A. Pfennig, M. Bauer, B. Soltmann & E. Nikitin. (2018) Sleep spindles in bipolar disorder - a comparison to healthy control subjects. Acta Psychiatrica Scandinavica 138:2, pages 163-172.
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Gregory M. Brown, Roger S. McIntyre, Joshua Rosenblat & Rüdiger Hardeland. (2018) Depressive disorders: Processes leading to neurogeneration and potential novel treatments. Progress in Neuro-Psychopharmacology and Biological Psychiatry 80, pages 189-204.
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Pierre A. Geoffroy & Sunthavy Yeim. 2018. Understanding Depression. Understanding Depression 123 141 .
Atul R. Mahableshwarkar, Joseph R. Calabrese, Thomas A. Macek, Kumar Budur, Adedeji Adefuye, Xinxin Dong, Elizabeth Hanson & Gary S. Sachs. (2017) Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: A phase 3, randomized controlled trial. Journal of Affective Disorders 221, pages 275-282.
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Matias C.A. Melo, Rafael L.C. Abreu, Vicente B. Linhares Neto, Pedro F.C. de Bruin & Veralice M.S. de Bruin. (2017) Chronotype and circadian rhythm in bipolar disorder: A systematic review. Sleep Medicine Reviews 34, pages 46-58.
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Eleni Merkouri Papadima, Paola Niola, Carla Melis, Claudia Pisanu, Donatella Congiu, Cristiana Cruceanu, Juan Pablo Lopez, Gustavo Turecki, Raffaella Ardau, Giovanni Severino, Caterina Chillotti, Maria Del Zompo & Alessio Squassina. (2017) Evidence towards RNA Binding Motif (RNP1, RRM) Protein 3 (RBM3) as a Potential Biomarker of Lithium Response in Bipolar Disorder Patients. Journal of Molecular Neuroscience 62:3-4, pages 304-308.
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Andrea Aguglia, Antonio Borsotti & Giuseppe Maina. (2017) Bipolar disorders: is there an influence of seasonality or photoperiod?. Revista Brasileira de Psiquiatria 40:1, pages 6-11.
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Samira S. Valvassori, Wilson R. Resende, Gustavo Dal-Pont, Heron Sangaletti-Pereira, Fernanda F. Gava, Bruna R. Peterle, André F. Carvalho, Roger B. Varela, Felipe Dal-Pizzol & João Quevedo. (2017) Lithium ameliorates sleep deprivation-induced mania-like behavior, hypothalamic-pituitary-adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice. Bipolar Disorders 19:4, pages 246-258.
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Jeverson Moreira, Cindie Courtin, Pierre A. Geoffroy, Emmanuel Curis, Frank Bellivier & Cynthia, Marie-Claire. (2017) Lithium response in bipolar disorder: No difference in GADL1 gene expression between cell lines from excellent-responders and non-responders. Psychiatry Research 251, pages 217-220.
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Ather Muneer. (2017) Mixed States in Bipolar Disorder: Etiology, Pathogenesis and Treatment. Chonnam Medical Journal 53:1, pages 1.
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Pierre Alexis Geoffroy, Ludovic Samalin, Pierre-Michel Llorca, Emmanuel Curis & Frank Bellivier. (2016) Influence of lithium on sleep and chronotypes in remitted patients with bipolar disorder. Journal of Affective Disorders 204, pages 32-39.
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P. A. Geoffroy, B. Etain, M. Lajnef, E-H. Zerdazi, C. Brichant-Petitjean, U. Heilbronner, L. Hou, F. Degenhardt, M. Rietschel, F. J. McMahon, T. G. Schulze, S. Jamain, C. Marie-Claire & F. Bellivier. (2016) Circadian genes and lithium response in bipolar disorders: associations with PPARGC1A (PGC-1 α ) and RORA . Genes, Brain and Behavior 15:7, pages 660-668.
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