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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 11, 1994 - Issue 2
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Original Article

The Effect of Old Age on the Free-Running Period of Circadian Rhythms in Rat

, , &
Pages 103-112 | Received 10 Feb 1993, Accepted 31 Aug 1993, Published online: 07 Jul 2009

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Robert L. Gannon. (2015) Circadian clock speed increases during aging in the male Syrian hamster: A large-scale study. Chronobiology International 32:8, pages 1168-1171.
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J. Devin McAuley, JonathanP. Miller & KevinC. H. Pang. (2004) Age-Related Changes in the Spontaneous Motor Rhythms of theSenescence-Accelerated Mouse (SAMP8). Experimental Aging Research 30:1, pages 113-127.
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D. Weinert. (2000) AGE-DEPENDENT CHANGES OF THE CIRCADIAN SYSTEM. Chronobiology International 17:3, pages 261-283.
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W. Witting, D. Boerma, G.C. Koster‐Van Hoffen, D.F. Swaab & M. Mirmiran. (1995) Light suppresses frequency and endogenous amplitude of the circadian system in nocturnal animals. Biological Rhythm Research 26:5, pages 477-485.
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Mehrshad Sadria & Anita T. Layton. (2021) Aging affects circadian clock and metabolism and modulates timing of medication. iScience 24:4, pages 102245.
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Anita Jagota, Kowshik Kukkemane & Neelesh Babu Thummadi. 2020. Models, Molecules and Mechanisms in Biogerontology. Models, Molecules and Mechanisms in Biogerontology 443 463 .
Qiong-Bin Zhu, Ai-Min Bao & Dick Swaab. (2019) Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies. Neuroscience Bulletin 35:2, pages 253-266.
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Isa Kolbe, María Paz Carrasco-Benso, Jesús Lόpez-Mínguez, Juan Luján, Frank A. J. L. Scheer, Henrik Oster & Marta Garaulet. (2018) Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients. The FASEB Journal 33:1, pages 175-180.
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Sudhansu Chokroverty. 2017. Sleep Disorders Medicine. Sleep Disorders Medicine 1115 1138 .
Koliane Ouk, Juliet Aungier & A. Jennifer Morton. (2016) Progressive gene dose-dependent disruption of the methamphetamine-sensitive circadian oscillator-driven rhythms in a knock-in mouse model of Huntington's disease. Experimental Neurology 286, pages 69-82.
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Brianne A. Kent. (2014) Synchronizing an aging brain: can entraining circadian clocks by food slow Alzheimer’s disease?. Frontiers in Aging Neuroscience 6.
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Oren Froy. (2013) Circadian aspects of energy metabolism and aging. Ageing Research Reviews 12:4, pages 931-940.
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Alejandro Lucas-Sánchez, Pedro Francisco Almaida-Pagán, Antonio Martinez-Nicolas, Juan Antonio Madrid, Pilar Mendiola & Jorge de Costa. (2013) Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin. Experimental Gerontology 48:5, pages 507-516.
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Wenyu Luo, Wen‐Feng Chen, Zhifeng Yue, Dechun Chen, Mallory Sowcik, Amita Sehgal & Xiangzhong Zheng. (2012) Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. Aging Cell 11:3, pages 428-438.
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Jeanne F. Duffy, Sean W. Cain, Anne-Marie Chang, Andrew J. K. Phillips, Mirjam Y. Münch, Claude Gronfier, James K. Wyatt, Derk-Jan Dijk, Kenneth P. WrightJr.Jr. & Charles A. Czeisler. (2011) Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proceedings of the National Academy of Sciences 108:supplement_3, pages 15602-15608.
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Oren Froy. (2011) Circadian Rhythms, Aging, and Life Span in Mammals. Physiology 26:4, pages 225-235.
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Roee Gutman, Yoni Genzer, Nava Chapnik, Ruth Miskin & Oren Froy. (2011) Long-lived mice exhibit 24h locomotor circadian rhythms at young and old age. Experimental Gerontology 46:7, pages 606-609.
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Sudhansu Chokroverty. 2011. Medicina de los Trastornos del Sueño. Medicina de los Trastornos del Sueño 606 620 .
Mark W. Mahowald & Milton G. Ettinger. 2011. Medicina de los Trastornos del Sueño. Medicina de los Trastornos del Sueño 581 590 .
S. R. Pandi-Perumal, D. Warren Spence & Vijay Kumar Sharma. 2010. Principles and Practice of Geriatric Sleep Medicine. Principles and Practice of Geriatric Sleep Medicine 3 21 .
Violetta Pilorz, Stephan Steinlechner & Henrik Oster. (2009) Age and oestrus cycle-related changes in glucocorticoid excretion and wheel-running activity in female mice carrying mutations in the circadian clock genes Per1 and Per2. Physiology & Behavior 96:1, pages 57-63.
Crossref
Sudhansu Chokroverty. 2009. Sleep Disorders Medicine. Sleep Disorders Medicine 606 620 .
Mark W. Mahowald & Milton G. Ettinger. 2009. Sleep Disorders Medicine. Sleep Disorders Medicine 581 590 .
P. Vivanco, V. Ortiz, M. A. Rol & J. A. Madrid. (2007) Looking for the keys to diurnality downstream from the circadian clock: role of melatonin in a dual-phasing rodent, Octodon degus. Journal of Pineal Research 42:3, pages 280-290.
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Kevin C. H. Pang, Jonathan P. Miller, Ashley Fortress & J. Devin McAuley. (2006) Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8). AGE 28:3, pages 283-296.
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Caroline Kopp, Volker Ressel, Esther Wigger & Irene Tobler. (2006) Influence of estrus cycle and ageing on activity patterns in two inbred mouse strains. Behavioural Brain Research 167:1, pages 165-174.
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F. Cayetanot, E. J. W. Van Someren, M. Perret & F. Aujard. (2016) Shortened Seasonal Photoperiodic Cycles Accelerate Aging of the Diurnal and Circadian Locomotor Activity Rhythms in a Primate. Journal of Biological Rhythms 20:5, pages 461-469.
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David Resuehr & James Olcese. (2005) Caloric restriction and melatonin substitution: Effects on murine circadian parameters. Brain Research 1048:1-2, pages 146-152.
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Roberto Refinetti. (2004) Non-stationary time series and the robustness of circadian rhythms. Journal of Theoretical Biology 227:4, pages 571-581.
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Kevin C.H Pang, Jonathan P Miller & J.Devin McAuley. (2004) Circadian rhythms in SAMP8: a longitudinal study of the effects of age and experience. Neurobiology of Aging 25:1, pages 111-123.
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Josef Berger. (2003) Why do circadian biorhythms age?. Journal of Applied Biomedicine 1:2, pages 77-84.
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Clarke G. Tankersley, Rafael Irizarry, Susan E. Flanders, Richard Rabold & Robert Frank. (2003) Unstable heart rate and temperature regulation predict mortality in AKR/J mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 284:3, pages R742-R750.
Crossref
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Crossref
Shin Yamazaki, Marty Straume, Hajime Tei, Yoshiyuki Sakaki, Michael Menaker & Gene D. Block. (2002) Effects of aging on central and peripheral mammalian clocks. Proceedings of the National Academy of Sciences 99:16, pages 10801-10806.
Crossref
J.Devin McAuley, Jonathan P Miller, Eric Beck, Z.Michael Nagy & Kevin C.H Pang. (2002) Age-related disruptions in circadian timing: evidence for “split” activity rhythms in the SAMP8. Neurobiology of Aging 23:4, pages 625-632.
Crossref
M.H. Bassant & F. Poindessous-Jazat. (2002) Sleep-related increase in activity of mesopontine neurons in old rats. Neurobiology of Aging 23:4, pages 615-624.
Crossref
Makoto Asai, Yuko Yoshinobu, Satoshi Kaneko, Akiko Mori, Takato Nikaido, Takahiro Moriya, Masashi Akiyama & Shigenobu Shibata. (2001) Circadian profile ofPer gene mRNA expression in the suprachiasmatic nucleus, paraventricular nucleus, and pineal body of aged rats. Journal of Neuroscience Research 66:6, pages 1133-1139.
Crossref
F Aujard, O Dkhissi-Benyahya, I Fournier, B Claustrat, A Schilling, H.M Cooper & M Perret. (2001) Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus. Neuroscience 105:2, pages 403-412.
Crossref
Adam R. Kendall, Alfred J. Lewy & Robert L. Sack. (2016) Effects of Aging on the Intrinsic Circadian Period of Totally Blind Humans. Journal of Biological Rhythms 16:1, pages 87-95.
Crossref
Daniel E. Kolker & Fred W. Turek. 2001. Functional Neurobiology of Aging. Functional Neurobiology of Aging 869 882 .
H. Timothy. Monk & C. Phyllis. Zee. 2001. Handbook of Behavioral Neurobiology. Handbook of Behavioral Neurobiology 603 623 .
Fred W. Turek, Kathryn Scarbrough, Planen Penev, Susan Labyak, verónica S. Valentinuzzi & Olivier Reeth. 2001. Handbook of Behavioral Neurobiology. Handbook of Behavioral Neurobiology 291 317 .
Makoto Asai, Masayuki Ikeda, Masashi Akiyama, Itsuki Oshima & Shigenobu Shibata. (2000) Administration of melatonin in drinking water promotes the phase advance of light–dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8. Brain Research 876:1-2, pages 220-224.
Crossref
Emmanuelle Apartis, Frédérique Poindessous-Jazat, Jacques Epelbaum & Marie H. Bassant. (2000) Age-related changes in rhythmically bursting activity in the medial septum of rats. Brain Research 876:1-2, pages 37-47.
Crossref
A Mailloux, C Benstaali, A Bogdan, A Auzéby & Y Touitou. (1999) Body temperature and locomotor activity as marker rhythms of aging of the circadian system in rodents. Experimental Gerontology 34:6, pages 733-740.
Crossref
Jeanne F Duffy, N Viswanathan & Fred C Davis. (1999) Free-running circadian period does not shorten with age in female Syrian hamsters. Neuroscience Letters 271:2, pages 77-80.
Crossref
Roger B. McDonald, Tana M. Hoban-Higgins, Rodney C. Ruhe, Charles A. Fuller & Barbara A. Horwitz. (1999) Alterations in endogenous circadian rhythm of core temperature in senescent Fischer 344 rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276:3, pages R824-R830.
Crossref
Susan E. Labyak, Fred W. TurekEdward P. Wallen & Phyllis C. Zee. (1998) Effects of bright light on age-related changes in the locomotor activity of Syrian hamsters. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274:3, pages R830-R839.
Crossref
Plamen D. Penev, Phyllis C. Zee & Fred W. Turek. (1997) Quantitative analysis of the age-related fragmentation of hamster 24-h activity rhythms. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273:6, pages R2132-R2137.
Crossref
Verónica S. Valentinuzzi, Kathryn Scarbrough, Joseph S. Takahashi & Fred W. Turek. (1997) Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273:6, pages R1957-R1964.
Crossref
E.J Sánchez-Barceló, M Megias, R Verduga & D Crespo. (1997) Differences Between the Circadian System of Two Strains of Senescence-Accelerated Mice (SAM). Physiology & Behavior 62:6, pages 1225-1229.
Crossref
M. Mirmiran, E.J.W. van Someren & D.F. Swaab. (1996) Is brain plasticity preserved during aging and in Alzheimer's disease?. Behavioural Brain Research 78:1, pages 43-48.
Crossref
W. Witting, D. van der Werf & M. Mirmiran. (1996) An on-line automated sleep-wake classification system for laboratory animals. Journal of Neuroscience Methods 66:2, pages 109-112.
Crossref
Bryan L. Myers & Pietro Badia. (1995) Changes in circadian rhythms and sleep quality with aging: Mechanisms and interventions. Neuroscience & Biobehavioral Reviews 19:4, pages 553-571.
Crossref

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