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Research Article

Plasma Kisspeptin Levels in Pregnancies with Diabetes and Hypertensive Disease as a Potential Marker of Placental Dysfunction and Adverse Perinatal Outcome

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Pages 78-88 | Published online: 10 Apr 2012

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Pedro Henrique Alcântara da Silva, Lourena Guedes de Melo Romão, Natércia Paula Alves de Freitas, Thiago Ribeiro Carvalho, Maria Eduarda Mendes Pontes Porto, Edward Araujo Júnior & Marcelo Borges Cavalcante. (2023) Kisspeptin as a predictor of miscarriage: a systematic review. The Journal of Maternal-Fetal & Neonatal Medicine 36:1.
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Faustino R. Pérez-López, María T. López-Baena, Seshadri Reddy Varikasuvu, Rebeca Ruiz-Román, Marta Fuentes-Carrasco & Ricardo Savirón-Cornudella. (2021) Preeclampsia and gestational hypertension are associated to low maternal circulating kisspeptin levels: a systematic review and meta-analysis. Gynecological Endocrinology 37:12, pages 1055-1062.
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Articles from other publishers (43)

Fanting Meng, Aiqin Zhao, Haiying Lu, Dan Zou, Bei Dong, Xiaoqing Wang, Li Liu & Sufang Zhou. (2023) KISS1 Gene Variations and Susceptibility to Idiopathic Recurrent Pregnancy Loss. Reproductive Sciences 30:8, pages 2573-2579.
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Bijal Patel, Kanyada Koysombat, Edouard G Mills, Jovanna Tsoutsouki, Alexander N Comninos, Ali Abbara & Waljit S Dhillo. (2023) The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B. Endocrine Reviews.
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Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Larissa da Silva Santana, Acácia Eduarda de Jesus Nascimento & Juneo Freitas Silva. (2023) Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats. International Journal of Molecular Sciences 24:7, pages 6820.
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Marek Gowkielewicz, Aleksandra Lipka, Aleksandra Piotrowska, Marta Szadurska-Noga, Jacek J. Nowakowski, Ewa Lepiarczyk, Marta Wiszpolska, Tomasz Waśniewski, Piotr Dzięgiel, Jerzy Kaleczyc, Mariusz Krzysztof Majewski & Marta Majewska. (2023) Kisspeptin and GPR54 Receptor Expression in Endometrial Cancer Tissue. Cancers 15:4, pages 1228.
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Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Erikles Macedo Barbosa, Letícia Dias Mendonça, Emilly Oliveira Santos, Isabella Oliveira de Macedo, Mário Sergio Lima de Lavor, Raphael Escorsim Szawka, Rogeria Serakides & Juneo Freitas Silva. (2022) Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model. Frontiers in Endocrinology 13.
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Jovanna Tsoutsouki, Bijal Patel, Alexander N. Comninos, Waljit S. Dhillo & Ali Abbara. (2022) Kisspeptin in the Prediction of Pregnancy Complications. Frontiers in Endocrinology 13.
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Magdalena Szydełko-Gorzkowicz, Elżbieta Poniedziałek-Czajkowska, Radzisław Mierzyński, Maciej Sotowski & Bożena Leszczyńska-Gorzelak. (2022) The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review. International Journal of Molecular Sciences 23:12, pages 6611.
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Elizabeth C. Bowdridge, Evan DeVallance, Krista L. Garner, Julie A. Griffith, Kallie Schafner, Madison Seaman, Kevin J. Engels, Kimberley Wix, Thomas P. Batchelor, William T. Goldsmith, Salik Hussain & Timothy R. Nurkiewicz. (2022) Nano-titanium dioxide inhalation exposure during gestation drives redox dysregulation and vascular dysfunction across generations. Particle and Fibre Toxicology 19:1.
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Alexandra D. Hudson & Alexander S. Kauffman. (2022) Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding. Pharmacology & Therapeutics 231, pages 107974.
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Ezekiel Musa, Mushi Matjila & Naomi S. Levitt. (2021) Kisspeptins and Glucose Homeostasis in Pregnancy: Implications for Gestational Diabetes Mellitus—a Review Article. Reproductive Sciences 29:2, pages 321-327.
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Lanlan Fang, Yang Yan, Yibo Gao, Ze Wu, Zhen Wang, Sizhu Yang, Jung-Chien Cheng & Ying-Pu Sun. (2022) TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway. Reproductive Biology and Endocrinology 20:1.
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Ali Abbara, Maya Al-Memar, Maria Phylactou, Elisabeth Daniels, Bijal Patel, Pei C Eng, Rans Nadir, Chioma Izzi-Engbeaya, Sophie A Clarke, Edouard G Mills, Tia Hunjan, Ewa Pacuszka, Lisa Yang, Paul Bech, Tricia Tan, Alexander N Comninos, Tom W Kelsey, Christopher Kyriacou, Hanine Fourie, Tom Bourne & Waljit S Dhillo. (2022) Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications. The Journal of Clinical Endocrinology & Metabolism 107:1, pages e71-e83.
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Edouard GA Mills, Bjial Patel & Waljit S Dhillo. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 139 154 .
Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng & Ying-Pu Sun. (2021) EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression. Cell Communication and Signaling 19:1.
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Serdal Kurt, Funda Eşki & Leyla Mis. (2021) Investigation of the usability of kisspeptin and oxidative stress parameters in the early diagnosis of asymptomatic cystic endometrial hyperplasia in dogs. Reproduction in Domestic Animals 56:12, pages 1529-1535.
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Penghua Fang, Yuqing She, Juan Zhao, Jing Yan, Xizhong Yu, Yu Jin, Qingbo Wei, Zhenwen Zhang & Wenbin Shang. (2021) Emerging roles of kisspeptin/galanin in age-related metabolic disease. Mechanisms of Ageing and Development 199, pages 111571.
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Viviane C. L. Gomes & Jenny L. Sones. (2021) From inhibition of trophoblast cell invasion to proapoptosis: what are the potential roles of kisspeptins in preeclampsia?. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 321:1, pages R41-R48.
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Tatjana Bozanovic, Aleksandar Ljubic & Dušica Ljubić. (2021) Implantation and the Fetal Health. Donald School Journal of Ultrasound in Obstetrics and Gynecology 15:1, pages 81-86.
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Edouard G. Mills, Chioma Izzi-Engbeaya, Ali Abbara, Alexander N. Comninos & Waljit S. Dhillo. (2020) Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour. Nature Reviews Endocrinology 17:2, pages 97-113.
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Sandra K. Szlapinski & David J. Hill. (2020) Metabolic Adaptations to Pregnancy in Healthy and Gestational Diabetic Pregnancies: The Pancreas - Placenta Axis. Current Vascular Pharmacology 19:2, pages 141-153.
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Takuya Watanabe & Kengo Sato. (2020) Roles of the kisspeptin/GPR54 system in pathomechanisms of atherosclerosis. Nutrition, Metabolism and Cardiovascular Diseases 30:6, pages 889-895.
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Aleksandar Ljubic, Dzihan Abazovic, Dusica Ljubic, Andrea Pirkovic & Andjela Perovic. 2020. Induced Abortion and Spontaneous Early Pregnancy Loss - Focus on Management. Induced Abortion and Spontaneous Early Pregnancy Loss - Focus on Management.
R. V. Kapustin, A. O. Drobintseva, E. N. Alekseenkova, A. R. Onopriychuk, O. N. Arzhanova, V. O. Polyakova & I. M. Kvetnoy. (2019) Placental protein expression of kisspeptin-1 (KISS1) and the kisspeptin-1 receptor (KISS1R) in pregnancy complicated by diabetes mellitus or preeclampsia. Archives of Gynecology and Obstetrics 301:2, pages 437-445.
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James E. Bowe, Thomas G. Hill, Katharine F. Hunt, Lorna I.F. Smith, Sian J.S. Simpson, Stephanie A. Amiel & Peter M. Jones. (2019) A role for placental kisspeptin in β cell adaptation to pregnancy. JCI Insight 4:20.
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Kai-Lun Hu, Hongcui Zhao, Yang Yu & Rong Li. (2019) Kisspeptin as a potential biomarker throughout pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology 240, pages 261-266.
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Zelin Lei, Xue Bai, Jianxiu Ma & Qin Yu. (2019) Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice. Molecular Medicine Reports.
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Elizabeth C Bowdridge, Alaeddin B Abukabda, Kevin J Engles, Carroll R McBride, Thomas P Batchelor, William T Goldsmith, Krista L Garner, Sherri Friend & Timothy R Nurkiewicz. (2019) Maternal Engineered Nanomaterial Inhalation During Gestation Disrupts Vascular Kisspeptin Reactivity. Toxicological Sciences 169:2, pages 524-533.
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Kai-Lun Hu, Hsun-Ming Chang, Hong-Cui Zhao, Yang Yu, Rong Li & Jie Qiao. (2018) Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation. Human Reproduction Update 25:3, pages 326-343.
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Chioma Izzi-Engbeaya, Alexander N. Comninos, Sophie A. Clarke, Anne Jomard, Lisa Yang, Sophie Jones, Ali Abbara, Shakunthala Narayanaswamy, Pei Chia Eng, Deborah Papadopoulou, Julia K. Prague, Paul Bech, Ian F. Godsland, Paul Bassett, Caroline Sands, Stephane Camuzeaux, Maria Gomez-Romero, Jake T. M. Pearce, Matthew R. Lewis, Elaine Holmes, Jeremy K. Nicholson, Tricia Tan, Risheka Ratnasabapathy, Ming Hu, Gaelle Carrat, Lorenzo Piemonti, Marco Bugliani, Piero Marchetti, Paul R. Johnson, Stephen J. Hughes, A. M. James Shapiro, Guy A. Rutter & Waljit S. Dhillo. (2018) The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans. Diabetes, Obesity and Metabolism 20:12, pages 2800-2810.
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Sian Simpson, Lorna Smith & James Bowe. (2018) Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus. Current Opinion in Pharmacology 43, pages 59-65.
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Aleksandar Ljubić. (2018) Inverted pyramid of prenatal care – is it enough? Should it be – extended inverted pyramid of prenatal care?. Journal of Perinatal Medicine 46:7, pages 716-720.
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Tina Napso, Hannah E. J. Yong, Jorge Lopez-Tello & Amanda N. Sferruzzi-Perri. (2018) The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation. Frontiers in Physiology 9.
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David J. Hill. 2017. A Practical Manual of Diabetes in Pregnancy. A Practical Manual of Diabetes in Pregnancy 377 392 .
Francesco Andreozzi, Gaia Chiara Mannino, Elettra Mancuso, Rosangela Spiga, Francesco Perticone & Giorgio Sesti. (2017) Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals. PLOS ONE 12:6, pages e0179834.
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Maysoun A. Ziyaraa, Farqad B. Hamdan & Liqaa R. Mousa. (2016) Correlation of Kisspeptin-10 level and fetal well-being in preeclamptic patients. Taiwanese Journal of Obstetrics and Gynecology 55:6, pages 840-846.
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Matthew Beymer, Jo Henningsen, Thibault Bahougne & Valérie Simonneaux. (2016) The role of kisspeptin and RFRP in the circadian control of female reproduction. Molecular and Cellular Endocrinology 438, pages 89-99.
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Sophie A Clarke & Waljit S Dhillo. (2016) Kisspeptin across the human lifespan:evidence from animal studies and beyond. Journal of Endocrinology 229:3, pages R83-R98.
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Mushi Matjila, Robert Millar, Zephne van der Spuy & Arieh Katz. (2016) Elevated placental expression at the maternal–fetal interface but diminished maternal circulatory kisspeptin in preeclamptic pregnancies. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 6:1, pages 79-87.
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Mehboob A. Hussain, Woo-Jin Song & Andrew Wolfe. (2015) There is Kisspeptin – And Then There is Kisspeptin. Trends in Endocrinology & Metabolism 26:10, pages 564-572.
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Holly ClarkeWaljit S. DhilloChanna N. Jayasena. (2015) Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders. Endocrinology and Metabolism 30:2, pages 124.
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Julia K. Prague & Waljit S. Dhillo. (2015) Potential Clinical Use of Kisspeptin. Neuroendocrinology 102:3, pages 238-245.
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Woo-Jin Song, Prosenjit Mondal, Andrew Wolfe, Laura?C. Alonso, Rachel Stamateris, Benny?W.T. Ong, Owen?C. Lim, Kil?S. Yang, Sally Radovick, Horacio?J. Novaira, Emily?A. Farber, Charles?R. Farber, Stephen?D. Turner & Mehboob?A. Hussain. (2014) Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion. Cell Metabolism 19:4, pages 667-681.
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P.J. Mark, M.L. Jones, J.L. Lewis, B.J. Waddell & J.T. Smith. (2013) Kiss1 and Kiss1r mRNA expression in the rat placenta: Changes with gestational age and regulation by glucocorticoids. Placenta 34:8, pages 657-662.
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