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Original Article

Evidence That Star and MLN64 act on the Outer Mitochondrial Membrane as Molten Globules

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Pages 629-637 | Published online: 07 Jul 2009

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Shamshad Cockcroft & Kathryn Garner. (2011) Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action?. Critical Reviews in Biochemistry and Molecular Biology 46:2, pages 89-117.
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Munishwar Nath Gupta & Vladimir N. Uversky. (2023) Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins. International Journal of Molecular Sciences 24:3, pages 2424.
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Kristina V. Tugaeva, James Titterington, Dmitriy V. Sotnikov, Eugene G. Maksimov, Alfred A. Antson & Nikolai N. Sluchanko. (2020) Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14‐3‐3 protein family. The FEBS Journal 287:18, pages 3944-3966.
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Barbara J. Clark. (2020) The START-domain proteins in intracellular lipid transport and beyond. Molecular and Cellular Endocrinology 504, pages 110704.
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Vimal Selvaraj, Douglas M Stocco & Barbara J Clark. (2018) Current knowledge on the acute regulation of steroidogenesis†. Biology of Reproduction 99:1, pages 13-26.
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Florian A Horenkamp, Diana P Valverde, Jodi Nunnari & Karin M Reinisch. (2018) Molecular basis for sterol transport by St ART ‐like lipid transfer domains . The EMBO Journal 37:6.
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Elisa Balboa, Juan Castro, María-José Pinochet, Gonzalo I. Cancino, Nuria Matías, P J Sáez, Alexis Martínez, Alejandra R. Álvarez, Carmen Garcia-Ruiz, José C. Fernandez-Checa & Silvana Zanlungo. (2017) MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content. Redox Biology 12, pages 274-284.
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Jessica Monreal-Flores, María Teresa Espinosa-García, Alejandro García-Regalado, Fabian Arechavaleta-Velasco & Federico Martínez. (2017) The heat shock protein 60 promotes progesterone synthesis in mitochondria of JEG-3 cells. Reproductive Biology 17:2, pages 154-161.
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Pia Elustondo, Laura A. Martin & Barbara Karten. (2017) Mitochondrial cholesterol import. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862:1, pages 90-101.
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Laura A. Martin, Barry E. Kennedy & Barbara Karten. (2014) Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function. Journal of Bioenergetics and Biomembranes 48:2, pages 137-151.
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James L. Thomas & Himangshu S. Bose. (2015) Regulation of human 3-beta-hydroxysteroid dehydrogenase type-2 (3βHSD2) by molecular chaperones and the mitochondrial environment affects steroidogenesis. The Journal of Steroid Biochemistry and Molecular Biology 151, pages 74-84.
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Fabien Alpy & Catherine L. Tomasetto. 2014. Cholesterol Transporters of the START Domain Protein Family in Health and Disease. Cholesterol Transporters of the START Domain Protein Family in Health and Disease 119 138 .
Daniel Rodriguez-Agudo, Maria Calderon-Dominguez, Miguel Angel Medina, Shunlin Ren, Gregorio Gil & William M. Pandak. (2012) ER stress increases StarD5 expression by stabilizing its mRNA and leads to relocalization of its protein from the nucleus to the membranes. Journal of Lipid Research 53:12, pages 2708-2715.
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Andrzej T. Slominski, Tae-Kang Kim, Jianjun Chen, Minh N. Nguyen, Wei Li, Charles R. Yates, Trevor Sweatman, Zorica Janjetovic & Robert C. Tuckey. (2012) Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes. The International Journal of Biochemistry & Cell Biology 44:11, pages 2003-2018.
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Daniel Rodriguez-Agudo, Maria Calderon-Dominguez, Shunlin Ren, Dalila Marques, Kaye Redford, Miguel Angel Medina-Torres, Phillip Hylemon, Gregorio Gil & William M. Pandak. (2011) Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1811:10, pages 597-606.
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Mark Charman, Barry E. Kennedy, Nolan Osborne & Barbara Karten. (2010) MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein. Journal of Lipid Research 51:5, pages 1023-1034.
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Faye Borthwick, Janice M. Taylor, Chris Bartholomew & Annette Graham. (2009) Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human macrophages. FEBS Letters 583:7, pages 1147-1153.
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Himangshu S. Bose, Randy M. Whittal, Mahuya Bose & Dilip Debnath. (2009) Hydrophobic Core of the Steroidogenic Acute Regulatory Protein for Cholesterol Transport. Biochemistry 48:6, pages 1198-1209.
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John G. Pastorino & Jan B. Hoek. (2008) Regulation of hexokinase binding to VDAC. Journal of Bioenergetics and Biomembranes 40:3, pages 171-182.
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Mahuya Bose, Randy M. Whittal, C. Gary Gairola & Himangshu S. Bose. (2008) Molecular mechanism of reduction in pregnenolone synthesis by cigarette smoke. Toxicology and Applied Pharmacology 229:1, pages 56-64.
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Marta Murcia, José D. Faráldo-Gómez, Frederick R. Maxfield & Benoît Roux. (2006) Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol. Journal of Lipid Research 47:12, pages 2614-2630.
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Fabien Alpy & Catherine Tomasetto. (2005) Give lipids a START: the StAR-related lipid transfer (START) domain in mammals. Journal of Cell Science 118:13, pages 2791-2801.
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Fabien Alpy, Vinoth K. Latchumanan, Valérie Kedinger, Agnes Janoshazi, Christoph Thiele, Corinne Wendling, Marie-Christine Rio & Catherine Tomasetto. (2005) Functional Characterization of the MENTAL Domain. Journal of Biological Chemistry 280:18, pages 17945-17952.
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Caleb B. Kallen. (2004) Steroid hormone synthesis in pregnancy. Obstetrics and Gynecology Clinics of North America 31:4, pages 795-816.
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Shunlin Ren, Phillip Hylemon, Dalila Marques, Elizabeth Hall, Kaye Redford, Gregorio Gil & William M. Pandak. (2004) Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis. Journal of Lipid Research 45:11, pages 2123-2131.
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Clive P. Morgan, Alison Skippen, Bruno Segui, Andrew Ball, Victoria Allen-Baume, Banafshe Larijani, Judith Murray-Rust, Neil McDonald, Gopal Sapkota, Nick Morrice & Shamshad Cockcroft. (2004) Phosphorylation of a Distinct Structural Form of Phosphatidylinositol Transfer Protein α at Ser166 by Protein Kinase C Disrupts Receptor-mediated Phospholipase C Signaling by Inhibiting Delivery of Phosphatidylinositol to Membranes. Journal of Biological Chemistry 279:45, pages 47159-47171.
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JENNIFER M. BOWEN-SHAUVER & GEULA GIBORI. 2004. The Ovary. The Ovary 201 230 .
CLEMENT K.M. HO, LANE K. CHRISTENSON & JEROME F. STRAUSSIIIIII. 2004. The Ovary. The Ovary 93 110 .
Aida Uribe, Jerome F. Strauss, III & Federico Martı́nez. (2003) Contact sites from human placental mitochondria: Characterization and role in progesterone synthesis. Archives of Biochemistry and Biophysics 413:2, pages 172-181.
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Murray Thomson. (2003) Does cholesterol use the mitochondrial contact site as a conduit to the steroidogenic pathway?. BioEssays 25:3, pages 252-258.
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John C. Achermann, Joshua J. Meeks, Baxter Jeffs, Urmi Das, Peter E. Clayton, Charles G.D. Brook & J.Larry Jameson. (2001) Molecular and Structural Analysis of Two Novel STAR Mutations in Patients with Lipoid Congenital Adrenal Hyperplasia. Molecular Genetics and Metabolism 73:4, pages 354-357.
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