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Original Article

Distinct Roles of Cathepsin K and Cathepsin L IN Osteoclastic Bone Resorption

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Pages 189-204 | Published online: 07 Jul 2009

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Read on this site (2)

Dieter Brömme & Fabien Lecaille. (2009) Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opinion on Investigational Drugs 18:5, pages 585-600.
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Han-Jung Chae, Ki-Chan Ha, Geun-Youn Lee, Sun-Kyung Yang, Ki-Jung Yun, Eun-Cheol Kim, Sun-Hee Kim, Soo-Wan Chae & Hyung-Ryong Kim. (2007) Interleukin-6 and Cyclic AMP Stimulate Release of Cathepsin B in Human Osteoblasts. Immunopharmacology and Immunotoxicology 29:2, pages 155-172.
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Articles from other publishers (22)

Sufei Jiang, Yiwei Xiong, Wenyi Zhang, Junpeng Zhu, Dan Cheng, Yongsheng Gong, Yan Wu, Hui Qiao & Hongtuo Fu. (2022) Molecular Characterization of a Novel Cathepsin L in Macrobrachium nipponense and Its Function in Ovary Maturation. Frontiers in Endocrinology 12.
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Henrietta O. Fasanya & Dietmar W. Siemann. (2020) The Role of Cathepsins in the Growth of Primary and Secondary Neoplasia in the Bone. Osteology 1:1, pages 3-28.
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Dibyendu Dana & Sanjai K. Pathak. (2020) A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L. Molecules 25:3, pages 698.
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Charit Taneja, Sakshi Gera, Hirotaka Miyashita, Mone Zaidi, Tony Yuen & Se-Min Kim. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 273 278 .
Lijuan Hu, Göran Andersson, Kenneth B. Jonsson, Håkan Melhus & Thomas Lind. (2013) Adamts1 is highly induced in rachitic bones of FGF23 transgenic mice and participates in degradation of non-mineralized bone matrix collagen. Biochemical and Biophysical Research Communications 430:3, pages 901-906.
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Dieter Brömme. (2011) Cysteine Cathepsins and the Skeleton. Clinical Reviews in Bone and Mineral Metabolism 9:2, pages 83-93.
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G. Leto, M. Crescimanno, C. Flandina, M. V. Sepporta & F. M. Tumminello. (2011) Cathepsin L in Normal and Pathological Bone Remodeling. Clinical Reviews in Bone and Mineral Metabolism 9:2, pages 107-121.
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Gaetano Leto, Maria Vittoria Sepporta, Marilena Crescimanno, Carla Flandina & Francesca Maria Tumminello. (2010) Cathepsin L in metastatic bone disease: therapeutic implications. Biological Chemistry 391:6.
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A.A. Venediktova, O.V. Falameeva, N.G. Kolosova, M.A. Sadovoj & T.A. Korolenko. (2010) Cathepsin K and matrix metalloproteases activity in bone tissue of OXYS rats with osteoporosis development. Biomeditsinskaya Khimiya 56:2, pages 274-282.
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A. A. Venediktova, O. V. Falameeva, N. G. Kolosova, M. A. Sadovoj & T. A. Korolenko. (2009) Cathepsin K and matrix metalloprotease activities in bone tissue of the OXYS rats during the development of osteoporosis. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 3:4, pages 393-398.
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Vincent Everts, Evis Daci, Wikky Tigchelaar-Gutter, Kees A. Hoeben, Sophie Torrekens, Geert Carmeliet & Wouter Beertsen. (2008) Plasminogen activators are involved in the degradation of bone by osteoclasts. Bone 43:5, pages 915-920.
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Robert W. Marquis, Ian James, Jin Zeng, Robert E. Lee Trout, Scott Thompson, Attiq Rahman, Dennis S. Yamashita, Ren Xie, Yu Ru, Catherine J. Gress, Simon Blake, Michael A. Lark, Shing-Mei Hwang, Thaddeus Tomaszek, Priscilla Offen, Martha S. Head, Maxwell D. Cummings & Daniel F. Veber. (2005) Azepanone-Based Inhibitors of Human Cathepsin L. Journal of Medicinal Chemistry 48:22, pages 6870-6878.
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Merry Jo Oursler. 2005. Bone Resorption. Bone Resorption 24 33 .
H.S. Brand, U.H. Lerner, A. Grubb, W. Beertsen, A.V. Nieuw Amerongen & V. Everts. (2004) Family 2 cystatins inhibit osteoclast-mediated bone resorption in calvarial bone explants. Bone 35:3, pages 689-696.
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Wendy Potts, Jonathan Bowyer, Huw Jones, David Tucker, Anthony J. Freemont, Andrew Millest, Colin Martin, Wendy Vernon, Diane Neerunjun, Gillian Slynn, Fiona Harper & Rose Maciewicz. (2004) Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy. International Journal of Experimental Pathology 85:2, pages 85-96.
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Aki Nogimura-Otsuka. (2004) Localization of Cathepsin B and L in Rat Periodontal Tissues During Experimental Tooth Movement. International Journal of Oral-Medical Sciences 3:1, pages 1-9.
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Jean-Marie Delaissé, Thomas L. Andersen, Michael T. Engsig, Kim Henriksen, Tine Troen & Laurence Blavier. (2003) Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microscopy Research and Technique 61:6, pages 504-513.
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Karin Tarte, Fenghuang Zhan, John De Vos, Bernard Klein & John ShaughnessyJrJr. (2003) Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation. Blood 102:2, pages 592-600.
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Michael A. Burke, Dorothy Hutter, Rita P. Reshamwala & Janice E. Knepper. (2003) Cathepsin L plays an active role in involution of the mouse mammary gland. Developmental Dynamics 227:3, pages 315-322.
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N. Katunuma, H. Tsuge, M. Nukatsuka & M. Fukushima. (2002) Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis. Advances in Enzyme Regulation 42, pages 159-172.
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N. Katunuma, H. Tsuge, M. Nukatsuka, T. Asao & M. Fukushima. (2002) Structure-Based Design of Specific Cathepsin Inhibitors and Their Application to Protection of Bone Metastases of Cancer Cells. Archives of Biochemistry and Biophysics 397:2, pages 305-311.
Crossref
Mone Zaidi, Bruce Troen, Baljit S. Moonga & Etsuko Abe. (2001) Cathepsin K, Osteoclastic Resorption, and Osteoporosis Therapy. Journal of Bone and Mineral Research 16:10, pages 1747-1749.
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