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Annals of Medicine Volume 31, 1999 - Issue 5
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Editorial Article

Why do we fail with penicillin in the treatment of group A streptococcus infections?

Sblomo Sela Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University Tel-Hashomer Hospital, Tel-Aviv, IsraelCorrespondence[email protected]
&
Asher Barzilai Pediatric Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Hashomer Hospital, Tel-Aviv, Israel
Pages 303-307 | Published online: 08 Jul 2009

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Ross J Davidson. (2019) In vitro activity and pharmacodynamic/pharmacokinetic parameters of clarithromycin and azithromycin: why they matter in the treatment of respiratory tract infections. Infection and Drug Resistance 12, pages 585-596.
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Jennifer Cable, Rino Rappuoli, Elizabeth J. Klemm, Gagandeep Kang, Ankur Mutreja, Gavin J. Wright, Mariagrazia Pizza, Sowmya Ajay Castro, Joseph P. Hoffmann, Galit Alter, Andrea Carfi, Andrew J. Pollard, Florian Krammer, Ravindra K. Gupta, Caroline E. Wagner, Viviane Machado, Kayvon Modjarrad, Lawrence Corey, Peter B. Gilbert, Gordon Dougan, Nicole Lurie, Pamela J. Bjorkman, Christopher Chiu, Elisa Nemes, Stephen B. Gordon, Andrew C. Steer, Thomas Rudel, Catherine A. Blish, John Tyler Sandberg, Kiva Brennan, Keith P. Klugman, Lynda M. Stuart, Shabir A. Madhi & Christopher L. Karp. (2022) Innovative vaccine approaches—a Keystone Symposia report. Annals of the New York Academy of Sciences 1511:1, pages 59-86.
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Sowmya Ajay Castro & Helge C. Dorfmueller. (2021) A brief review on Group A Streptococcus pathogenesis and vaccine development. Royal Society Open Science 8:3.
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Magnus G. Jespersen, Jake A. Lacey, Steven Y.C. Tong & Mark R. Davies. (2020) Global genomic epidemiology of Streptococcus pyogenes. Infection, Genetics and Evolution 86, pages 104609.
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Kirsten S Vannice, Jessica Ricaldi, Srinivas Nanduri, Ferric C Fang, John B Lynch, Chloe Bryson-Cahn, Theodore Wright, Jeff Duchin, Meagan Kay, Sopio Chochua, Chris A Van Beneden & Bernard Beall. (2020) Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics. Clinical Infectious Diseases 71:1, pages 201-204.
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Fatma Jendoubi, Manfred Rohde & Jörg Christoph Prinz. (2019) Intracellular Streptococcal Uptake and Persistence: A Potential Cause of Erysipelas Recurrence. Frontiers in Medicine 6.
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Chuan Chiang-Ni, Yong-An Shi, Chih-Ho Lai & Cheng-Hsun Chiu. (2018) Cytotoxicity and Survival Fitness of Invasive covS Mutant of Group A Streptococcus in Phagocytic Cells. Frontiers in Microbiology 9.
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Laura Bonofiglio, Paula Gagetti, Gabriela García Gabarrot, Sara Kaufman, Marta Mollerach, Inés Toresani, Laura Vigliarolo, Martha von Specht & Horacio A. Lopardo. (2018) Susceptibility to β-lactams in β-hemolytic streptococci. Revista Argentina de Microbiología 50:4, pages 431-435.
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Hugh H. Russell, Liqing Zhou & Shiranee Sriskandan. (2009) Rapid screen for epithelial internalization of Tn917-mutagenized Streptococcus pyogenes. Journal of Microbiological Methods 78:1, pages 34-39.
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Anna Stjernquist-Desatnik & Arne Orrling. (2009) Pharyngotonsillitis. Periodontology 2000 49:1, pages 140-150.
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Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 162 166 .
Chuan Chiang-Ni & Jiunn-Jong Wu. (2008) Effects of Streptococcal Pyrogenic Exotoxin B on Pathogenesis of Streptococcus pyogenes. Journal of the Formosan Medical Association 107:9, pages 677-685.
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Matthew E. Falagas, Evridiki K. Vouloumanou, Dimitrios K. Matthaiou, Anastasios M. Kapaskelis & Drosos E. Karageorgopoulos. (2008) Effectiveness and Safety of Short-Course vs Long-Course Antibiotic Therapy for Group A β-Hemolytic Streptococcal Tonsillopharyngitis: A Meta-analysis of Randomized Trials. Mayo Clinic Proceedings 83:8, pages 880-889.
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Matthew E. Falagas, Evridiki K. Vouloumanou, Dimitrios K. Matthaiou, Anastasios M. Kapaskelis & Drosos E. Karageorgopoulos. (2008) Effectiveness and Safety of Short-Course vs Long-Course Antibiotic Therapy for Group A β-Hemolytic Streptococcal Tonsillopharyngitis: A Meta-analysis of Randomized Trials. Mayo Clinic Proceedings 83:8, pages 880-889.
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Jason N. Cole, Anna Henningham, Christine M. Gillen, Vidiya Ramachandran & Mark J. Walker. (2008) Human pathogenic streptococcal proteomics and vaccine development. PROTEOMICS – Clinical Applications 2:3, pages 387-410.
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Vincenzo Savini, Chiara Catavitello, Marzia Talia, Assunta Manna, Franca Pompetti, Giovanni Di Bonaventura, Nicola Di Giuseppe, Fabio Febbo, Andrea Balbinot, Silvia Di Zacomo, Francesca Esattore & Domenico D'Antonio. (2008) β-Lactam Failure in Treatment of Two Group G Streptococcus dysgalactiae subsp. equisimilis Pharyngitis Patients . Journal of Clinical Microbiology 46:2, pages 814-816.
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Hiroshi Sakata. (2008) Comparative study of 5-day cefcapene-pivoxil and 10-day amoxicillin or cefcapene-pivoxil for treatment of group A streptococcal pharyngitis in children. Journal of Infection and Chemotherapy 14:3, pages 208-212.
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E. L. Kaplan, G. S. Chhatwal & M. Rohde. (2006) Reduced Ability of Penicillin to Eradicate Ingested Group A Streptococci from Epithelial Cells: Clinical and Pathogenetic Implications. Clinical Infectious Diseases 43:11, pages 1398-1406.
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Itzhak Brook. (2005) A pooled comparison of cefdinir and penicillin in the treatment of group a β-hemolytic streptococcal pharyngotonsillitis. Clinical Therapeutics 27:8, pages 1266-1273.
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Juan Carlos Sanz, María de los Ángeles Bascones, Fernando Martín & Juan Antonio Sáez-Nieto. (2005) Escarlatina recurrente por reinfección reciente causada por cepas no relacionadas de Streptococcus pyogenes. Enfermedades Infecciosas y Microbiología Clínica 23:6, pages 388-389.
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Ulrich Schwarz-Linek, Ewa S. Pilka, Andrew R. Pickford, Jung Hwa Kim, Magnus Höök, Iain D. Campbell & Jennifer R. Potts. (2004) High Affinity Streptococcal Binding to Human Fibronectin Requires Specific Recognition of Sequential F1 Modules. Journal of Biological Chemistry 279:37, pages 39017-39025.
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Mehran J Marouni, Asher Barzilai, N Keller, Eitan Rubinstein & Shlomo Sela. (2004) Intracellular survival of persistent Group A streptococci in cultured epithelial cells. International Journal of Medical Microbiology 294:1, pages 27-33.
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UB Schaad. (2004) Acute Streptococcal Tonsillopharyngitis: A Review of Clinical Efficacy and Bacteriological Eradication. Journal of International Medical Research 32:1, pages 1-13.
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Mehran J. Marouni & Shlomo Sela. (2004) Fate of Streptococcus pyogenes and epithelial cells following internalization. Journal of Medical Microbiology 53:1, pages 1-7.
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Osnat Eyal, Jeries Jadoun, Arcady Bitler, Ehud Skutelski & Shlomo Sela. (2003) Role of M3 protein in the adherence and internalization of an invasive Streptococcus pyogenes strain by epithelial cells . FEMS Immunology & Medical Microbiology 38:3, pages 205-213.
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Gabriella Molinari, Manfred Rohde, Susanne R. Talay, Gursharan S. Chhatwal, Susanne Beckert & Andreas Podbielski. (2001) The role played by the group A streptococcal negative regulator Nra on bacterial interactions with epithelial cells. Molecular Microbiology 40:1, pages 99-114.
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MICHAEL E. PICHICHERO & W. MANFORD GOOCHIIIIII. (2000) Comparison of cefdinir and penicillin V in the treatment of pediatric streptococcal tonsillopharyngitis. The Pediatric Infectious Disease Journal 19:Supplement, pages S171-S173.
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SI Bandak, Turnak, BS Allen, LD Bolzon & DA Preston. (2000) ORAL ANTIMICROBIAL SUSCEPTIBILITIES OF STREPTOCOCCUS PYOGENES RECENTLY ISOLATED IN FIVE COUNTRIES . International Journal of Clinical Practice 54:9, pages 585-588.
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